Publications
Learn more about the work that we do in the Green laboratory through our recent publications.
- Green KJ, Pokorny J, Jarrell B Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis. Bioessays 2024 Nov;46(11):e2400135. doi:10.1002/bies.202400135
- Nanavati BN, Noordstra I, Lwin AKO, Brooks JW, Rae J, Parton RG, Verma S, Duszyc K, Green KJ, Yap AS The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis. Curr Biol 2024 Sep 09;34(17):4081-4090.e5. doi:10.1016/j.cub.2024.07.074
- Harmon RM, Ayers JL, McCarthy EF, Kowalczyk AP, Green KJ, Simpson CL Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease. J Invest Dermatol 2024 Aug 28;. pii:S0022-202X(24)01925-0
- Perl AL, Pokorny JL, Green KJ Desmosomes at a glance. J Cell Sci 2024 Jun 15;137(12). pii:jcs261899
- Selgrade DF, Fullenkamp DE, Chychula IA, Li B, Dellefave-Castillo L, Dubash AD, Ohiri J, Monroe TO, Blancard M, Tomar G et al. Susceptibility to innate immune activation in genetically mediated myocarditis. J Clin Invest 2024 May 16;134(13). pii:e180254
- Burks HE, Pokorny JL, Koetsier JL, Roth-Carter QR, Arnette CR, Gerami P, Seykora JT, Johnson JL, Ren Z, Green KJ Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration. J Cell Biol 2023 Nov 06;222(11). pii:e202212031
- Hegazy M, Green KJ Retromer Chaperones: Potential Therapeutics for Treatment of Skin Disease? J Invest Dermatol 2023 Sep;143(9):1634-1637. doi:10.1016/j.jid.2023.05.003
- Roth-Carter QR, Burks HE, Ren Z, Koetsier JL, Tsoi LC, Harms PW, Xing X, Kirma J, Harmon RM, Godsel LM et al. Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis. JCI Insight 2023 Aug 22;8(16). pii:e168955
- Perl AL, Koetsier JL, Green KJ PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus. Sci Rep 2023 Aug 05;13(1):12720. pii:12720
- Wang J, Fu Y, Huang W, Biswas R, Banerjee A, Broussard JA, Zhao Z, Wang D, Bjerke G, Raghavan S et al. MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells. Proc Natl Acad Sci U S A 2023 May 30;120(22):e2220635120. pii:e2220635120
- Rübsam M, Püllen R, Tellkamp F, Bianco A, Peskoller M, Bloch W, Green KJ, Merkel R, Hoffmann B, Wickström SA et al. Polarity signaling balances epithelial contractility and mechanical resistance. Sci Rep 2023 May 12;13(1):7743. pii:7743
- Nanavati BN, Noordstra I, Verma S, Duszyc K, Green KJ, Yap AS Desmosome-anchored intermediate filaments facilitate tension-sensitive RhoA signaling for epithelial homeostasis. bioRxiv 2023 Feb 23;. pii:2023.02.23.529786
- Tong X, Burks HE, Ren Z, Koetsier JL, Roth-Carter QR, Green KJ Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAFV600E-induced cellular senescence in human melanocytes. bioRxiv 2023 Feb 17;. pii:2023.02.16.528886
- Spindler V, Gerull B, Green KJ, Kowalczyk AP, Leube R, Marian AJ, Milting H, Müller EJ, Niessen C, Payne AS et al. Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting. J Cell Sci 2023 Jan 01;136(1). pii:jcs260832
- Hegazy M, Koetsier JL, Huffine AL, Broussard JA, Godsel BM, Cohen-Barak E, Sprecher E, Wolfgeher DJ, Kron SJ, Godsel LM et al. Epidermal stratification requires retromer-mediated desmoglein-1 recycling. Dev Cell 2022 Dec 19;57(24):2683-2698.e8. doi:10.1016/j.devcel.2022.11.010
- Roth-Carter QR, Koetsier JL, Broussard JA, Green KJ Organotypic Human Skin Cultures Incorporating Primary Melanocytes. Curr Protoc 2022 Sep;2(9):e536. pii:e536
- Green KJ, Niessen CM, Rübsam M, Perez White BE, Broussard JA The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function. Front Cell Dev Biol 2022;10:903696. pii:903696
- Broussard JA, Green KJ Plectin pulls it together, coupling the cortical actin and intermediate filament cytoskeletons. J Cell Biol 2022 Mar 07;221(3). pii:e202201054
- Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL, Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE et al. Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J Clin Invest 2022 Feb 01;132(3). pii:e144363
- Hegazy M, Perl AL, Svoboda SA, Green KJ Desmosomal Cadherins in Health and Disease. Annu Rev Pathol 2022 Jan 24;17:47-72. doi:10.1146/annurev-pathol-042320-092912
- Indra I, Troyanovsky RB, Green KJ, Troyanovsky SM Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex. Mol Biol Cell 2021 Sep 01;32(19):1824-1837. doi:10.1091/mbc.E21-01-0001
- Broussard JA, Koetsier JL, Hegazy M, Green KJ Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function. Curr Biol 2021 Aug 09;31(15):3275-3291.e5. doi:10.1016/j.cub.2021.05.021
- Raya-Sandino A, Luissint AC, Kusters DHM, Narayanan V, Flemming S, Garcia-Hernandez V, Godsel LM, Green KJ, Hagen SJ, Conway DE et al. Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Mol Biol Cell 2021 Apr 15;32(8):753-768. doi:10.1091/mbc.E20-12-0775
- Hegazy M, Cohen-Barak E, Koetsier JL, Najor NA, Arvanitis C, Sprecher E, Green KJ, Godsel LM Proximity Ligation Assay for Detecting Protein-Protein Interactions and Protein Modifications in Cells and Tissues in Situ. Curr Protoc Cell Biol 2020 Dec;89(1):e115. doi:10.1002/cpcb.115
- Green KJ, Roth-Carter Q, Niessen CM, Nichols SA Tracing the Evolutionary Origin of Desmosomes. Curr Biol 2020 May 18;30(10):R535-R543. doi:10.1016/j.cub.2020.03.047
- Broussard JA, Jaiganesh A, Zarkoob H, Conway DE, Dunn AR, Espinosa HD, Janmey PA, Green KJ Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network. J Cell Sci 2020 Mar 16;133(6). pii:jcs228031
- Arnette CR, Roth-Carter QR, Koetsier JL, Broussard JA, Burks HE, Cheng K, Amadi C, Gerami P, Johnson JL, Green KJ Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling. Pigment Cell Melanoma Res 2020 Mar;33(2):305-317. doi:10.1111/pcmr.12826
- Cohen-Barak E, Godsel LM, Koetsier JL, Hegazy M, Kushnir-Grinbaum D, Hammad H, Danial-Farran N, Harmon R, Khayat M, Bochner R et al. The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome. J Invest Dermatol 2020 Mar;140(3):556-567.e9. doi:10.1016/j.jid.2019.08.433
- Green KJ, Jaiganesh A, Broussard JA Desmosomes: Essential contributors to an integrated intercellular junction network. F1000Res 2019;8. pii:F1000 Faculty Rev-2150
- Elliott PM, Anastasakis A, Asimaki A, Basso C, Bauce B, Brooke MA, Calkins H, Corrado D, Duru F, Green KJ et al. Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report. Eur J Heart Fail 2019 Aug;21(8):955-964. doi:10.1002/ejhf.1534
- Valenzuela-Iglesias A, Burks HE, Arnette CR, Yalamanchili A, Nekrasova O, Godsel LM, Green KJ Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner. Mol Cancer Res 2019 May;17(5):1195-1206. doi:10.1158/1541-7786.MCR-18-0048