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Northwestern University Feinberg School of Medicine
Kathleen J. Green Lab

Publications

Learn more about the work that we do in the Green laboratory through our recent publications.

  1. Tong X, Burks HE, Ren Z, Koetsier JL, Roth-Carter QR, Green KJ  Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFV600E-induced Cellular Senescence in Human Melanocytes.  J Invest Dermatol  2024 Nov 22;. pii:S0022-202X(24)02955-5
  2. Green KJ, Pokorny J, Jarrell B  Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.  Bioessays  2024 Nov;46(11):e2400135. pii:2400135
  3. Nanavati BN, Noordstra I, Lwin AKO, Brooks JW, Rae J, Parton RG, Verma S, Duszyc K, Green KJ, Yap AS  The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis.  Curr Biol  2024 Sep 09;34(17):4081-4090.e5. doi:10.1016/j.cub.2024.07.074
  4. Harmon RM, Ayers JL, McCarthy EF, Kowalczyk AP, Green KJ, Simpson CL  Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease.  J Invest Dermatol  2024 Aug 28;. pii:S0022-202X(24)01925-0
  5. Perl AL, Pokorny JL, Green KJ  Desmosomes at a glance.  J Cell Sci  2024 Jun 15;137(12). pii:jcs261899
  6. Selgrade DF, Fullenkamp DE, Chychula IA, Li B, Dellefave-Castillo L, Dubash AD, Ohiri J, Monroe TO, Blancard M, Tomar G  et al.  Susceptibility to innate immune activation in genetically mediated myocarditis.  J Clin Invest  2024 May 16;134(13). pii:e180254
  7. Burks HE, Pokorny JL, Koetsier JL, Roth-Carter QR, Arnette CR, Gerami P, Seykora JT, Johnson JL, Ren Z, Green KJ  Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration.  J Cell Biol  2023 Nov 06;222(11). pii:e202212031
  8. Hegazy M, Green KJ  Retromer Chaperones: Potential Therapeutics for Treatment of Skin Disease?  J Invest Dermatol  2023 Sep;143(9):1634-1637. doi:10.1016/j.jid.2023.05.003
  9. Roth-Carter QR, Burks HE, Ren Z, Koetsier JL, Tsoi LC, Harms PW, Xing X, Kirma J, Harmon RM, Godsel LM  et al.  Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis.  JCI Insight  2023 Aug 22;8(16). pii:e168955
  10. Perl AL, Koetsier JL, Green KJ  PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus.  Sci Rep  2023 Aug 05;13(1):12720. pii:12720
  11. Wang J, Fu Y, Huang W, Biswas R, Banerjee A, Broussard JA, Zhao Z, Wang D, Bjerke G, Raghavan S  et al.  MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells.  Proc Natl Acad Sci U S A  2023 May 30;120(22):e2220635120. pii:e2220635120
  12. Rübsam M, Püllen R, Tellkamp F, Bianco A, Peskoller M, Bloch W, Green KJ, Merkel R, Hoffmann B, Wickström SA  et al.  Polarity signaling balances epithelial contractility and mechanical resistance.  Sci Rep  2023 May 12;13(1):7743. pii:7743
  13. Nanavati BN, Noordstra I, Verma S, Duszyc K, Green KJ, Yap AS  Desmosome-anchored intermediate filaments facilitate tension-sensitive RhoA signaling for epithelial homeostasis.  bioRxiv  2023 Feb 23;. pii:2023.02.23.529786
  14. Tong X, Burks HE, Ren Z, Koetsier JL, Roth-Carter QR, Green KJ  Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAFV600E-induced cellular senescence in human melanocytes.  bioRxiv  2023 Feb 17;. pii:2023.02.16.528886
  15. Spindler V, Gerull B, Green KJ, Kowalczyk AP, Leube R, Marian AJ, Milting H, Müller EJ, Niessen C, Payne AS  et al.  Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting.  J Cell Sci  2023 Jan 01;136(1). pii:jcs260832
  16. Hegazy M, Koetsier JL, Huffine AL, Broussard JA, Godsel BM, Cohen-Barak E, Sprecher E, Wolfgeher DJ, Kron SJ, Godsel LM  et al.  Epidermal stratification requires retromer-mediated desmoglein-1 recycling.  Dev Cell  2022 Dec 19;57(24):2683-2698.e8. doi:10.1016/j.devcel.2022.11.010
  17. Roth-Carter QR, Koetsier JL, Broussard JA, Green KJ  Organotypic Human Skin Cultures Incorporating Primary Melanocytes.  Curr Protoc  2022 Sep;2(9):e536. pii:e536
  18. Green KJ, Niessen CM, Rübsam M, Perez White BE, Broussard JA  The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function.  Front Cell Dev Biol  2022;10:903696. pii:903696
  19. Broussard JA, Green KJ  Plectin pulls it together, coupling the cortical actin and intermediate filament cytoskeletons.  J Cell Biol  2022 Mar 07;221(3). pii:e202201054
  20. Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL, Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE  et al.  Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.  J Clin Invest  2022 Feb 01;132(3). pii:e144363
  21. Hegazy M, Perl AL, Svoboda SA, Green KJ  Desmosomal Cadherins in Health and Disease.  Annu Rev Pathol  2022 Jan 24;17:47-72. doi:10.1146/annurev-pathol-042320-092912
  22. Indra I, Troyanovsky RB, Green KJ, Troyanovsky SM  Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex.  Mol Biol Cell  2021 Sep 01;32(19):1824-1837. doi:10.1091/mbc.E21-01-0001
  23. Broussard JA, Koetsier JL, Hegazy M, Green KJ  Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function.  Curr Biol  2021 Aug 09;31(15):3275-3291.e5. doi:10.1016/j.cub.2021.05.021
  24. Raya-Sandino A, Luissint AC, Kusters DHM, Narayanan V, Flemming S, Garcia-Hernandez V, Godsel LM, Green KJ, Hagen SJ, Conway DE  et al.  Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2.  Mol Biol Cell  2021 Apr 15;32(8):753-768. doi:10.1091/mbc.E20-12-0775
  25. Hegazy M, Cohen-Barak E, Koetsier JL, Najor NA, Arvanitis C, Sprecher E, Green KJ, Godsel LM  Proximity Ligation Assay for Detecting Protein-Protein Interactions and Protein Modifications in Cells and Tissues in Situ.  Curr Protoc Cell Biol  2020 Dec;89(1):e115. doi:10.1002/cpcb.115
  26. Green KJ, Roth-Carter Q, Niessen CM, Nichols SA  Tracing the Evolutionary Origin of Desmosomes.  Curr Biol  2020 May 18;30(10):R535-R543. doi:10.1016/j.cub.2020.03.047
  27. Broussard JA, Jaiganesh A, Zarkoob H, Conway DE, Dunn AR, Espinosa HD, Janmey PA, Green KJ  Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.  J Cell Sci  2020 Mar 16;133(6). pii:jcs228031
  28. Arnette CR, Roth-Carter QR, Koetsier JL, Broussard JA, Burks HE, Cheng K, Amadi C, Gerami P, Johnson JL, Green KJ  Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling.  Pigment Cell Melanoma Res  2020 Mar;33(2):305-317. doi:10.1111/pcmr.12826
  29. Cohen-Barak E, Godsel LM, Koetsier JL, Hegazy M, Kushnir-Grinbaum D, Hammad H, Danial-Farran N, Harmon R, Khayat M, Bochner R  et al.  The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome.  J Invest Dermatol  2020 Mar;140(3):556-567.e9. doi:10.1016/j.jid.2019.08.433
  30. Green KJ, Jaiganesh A, Broussard JA  Desmosomes:  Essential contributors to an integrated intercellular junction network.  F1000Res  2019;8. pii:F1000 Faculty Rev-2150
  31. Elliott PM, Anastasakis A, Asimaki A, Basso C, Bauce B, Brooke MA, Calkins H, Corrado D, Duru F, Green KJ  et al.  Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report.  Eur J Heart Fail  2019 Aug;21(8):955-964. doi:10.1002/ejhf.1534
  32. Valenzuela-Iglesias A, Burks HE, Arnette CR, Yalamanchili A, Nekrasova O, Godsel LM, Green KJ  Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.  Mol Cancer Res  2019 May;17(5):1195-1206. doi:10.1158/1541-7786.MCR-18-0048

View Green's Full Bibliography