Northwestern University Feinberg School of Medicine

Kathleen Green Lab

Our Lab

Welcome to the Green Lab website!

Our vision is to define how cell communication and cooperation drive tissue form and function. Just as communication between people is essential for our society to thrive, so too is communication between cells in a multicellular organism essential for its existence. Our group shares a passion for understanding how cells physically stick together to provide mechanical strength to tissues and how adhesion molecules convert mechanical and other environmental cues into signals that drive individual and collective cell behaviors in development, differentiation and disease. We convert our curiosity-driven research into practical knowledge that can help us diagnose and treat adhesion-related diseases, including inherited, autoimmune and bacterial-toxin mediated skin disease, heart disease and cancer. The Green laboratory is dedicated to an open, collaborative, congenial research environment promoting high impact research while mentoring students and fellows for a future as independent scientists, educators and professionals in allied fields. Enjoy our website, and please contact any one of us if you need further information.

What we do

What we do: In the Green lab we study sub-cellular to supra-cellular biology, from molecule to man. We are elucidating the machinery that mechanically and chemically couples cells in tissues, and determining how interference with this machinery can lead to human disease. This figure illustrates the organizational levels of biology, from gross anatomic to atomic levels of resolution. We study humans with desmosome-related disease (upper left), regenerate human epidermis in vitro from isolated cells (middle upper), generate animal models of human disease (middle lower), and carry out analysis at cellular, subcellular, molecular, and sub-molecular/atomic levels. We can also assess how human mutations alter protein dynamics in cells, and through these approaches understand the underlying molecular basis for the disease. (images from: Norgett, et al. 2000. Hum. Mol. Gen.; Samuelov, et al. 2013. Nat. Genet.; Choi, et al. 2002. Nat. Struct. Biol.; O’Keefe, et al. 1989. J. Biol. Chem.)

Kathleen J Green, PhD

Kathleen J Green, PhD
Joseph L. Mayberry, Sr. Professor of Pathology
Professor of Dermatology
Associate Director of Basic Sciences, Robert H. Lurie Comprehensive Cancer Center

Dr. Green’s Curriculum Vitae

Dr. Green’s Biosketch

Useful Links