Skip to main content
Northwestern University Feinberg School of Medicine
Shilatifard Laboratory

Recent Publications

publications-nov-2022

  1. Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S  et al.  Author Correction: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.  Nat Immunol  2025 Feb;26(2):323. doi:10.1038/s41590-025-02076-z
  2. Aoi Y, Iravani L, Mroczek IC, Gold S, Howard BC, Shilatifard A  SPT5 regulates RNA polymerase II stability via Cullin 3-ARMC5 recognition.  Sci Adv  2025 Jan 24;11(4):eadt5885. pii:eadt5885
  3. Cenik BK, Aoi Y, Iwanaszko M, Howard BC, Morgan MA, Andersen GD, Bartom ET, Shilatifard A  TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome.  Mol Cell  2024 Dec 19;84(24):4929-4944.e8. doi:10.1016/j.molcel.2024.11.007
  4. Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S  et al.  Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.  Nat Immunol  2024 Nov;25(11):2097-2109. doi:10.1038/s41590-024-01975-x
  5. Gold S, Shilatifard A  Epigenetic therapies targeting histone lysine methylation: complex mechanisms and clinical challenges.  J Clin Invest  2024 Oct 15;134(20). pii:e183391
  6. Shilatifard A, Lauberth SM  Editorial overview: Breaking boundaries: new frontiers in chromatin regulation for cancer therapy.  Curr Opin Genet Dev  2024 Oct;88:102255. doi:10.1016/j.gde.2024.102255
  7. Cisneros WJ, Soliman SHA, Walter M, Simons LM, Cornish D, De Fabritiis S, Halle AW, Kim EY, Wolinsky SM, Lorenzo-Redondo R  et al.  Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal.  PLoS Pathog  2024 Sep;20(9):e1012083. pii:e1012083
  8. Markov NS, Ren Z, Senkow KJ, Grant RA, Gao CA, Malsin ES, Sichizya L, Kihshen H, Helmin KA, Jovisic M  et al.  Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia.  Nat Immunol  2024 Sep;25(9):1607-1622. doi:10.1038/s41590-024-01914-w
  9. Gantner BN, Palma FR, Kayzuka C, Lacchini R, Foltz DR, Backman V, Kelleher N, Shilatifard A, Bonini MG  Histone oxidation as a new mechanism of metabolic control over gene expression.  Trends Genet  2024 Sep;40(9):739-746. doi:10.1016/j.tig.2024.05.012
  10. Sonn JY, Kim W, Iwanaszko M, Aoi Y, Li Y, Parkitny L, Brissette JL, Weiner L, Al-Ramahi I, Botas J  et al.  MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription.  bioRxiv  2024 Jul 01;. pii:2024.06.30.601446
  11. Gold S, Shilatifard A  Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain-containing factors.  Curr Opin Genet Dev  2024 Jun;86:102181. doi:10.1016/j.gde.2024.102181
  12. Maroso M, Smith KT, Stajic J, Smith HJ, Yeston JS, Ash C, Shilatifard A, Charneski C, Nusinovich Y, Szuromi P  et al.  In Science Journals.  Science  2024 May 10;384(6696):632-634. doi:10.1126/science.adq2871
  13. Soliman SHA, Iwanaszko M, Zheng B, Gold S, Howard BC, Das M, Chakrabarty RP, Chandel NS, Shilatifard A  Transcriptional elongation control of hypoxic response.  Proc Natl Acad Sci U S A  2024 Apr 09;121(15):e2321502121. pii:e2321502121
  14. Sahu U, Villa E, Reczek CR, Zhao Z, O'Hara BP, Torno MD, Mishra R, Shannon WD, Asara JM, Gao P  et al.  Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.  Science  2024 Mar 29;383(6690):1484-1492. doi:10.1126/science.adh2771
  15. Cisneros WJ, Walter M, Soliman SHA, Simons LM, Cornish D, Halle AW, Kim EY, Wolinsky SM, Shilatifard A, Hultquist JF  Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal.  bioRxiv  2024 Mar 01;. pii:2024.03.01.582881
  16. Vignieri S, Lavine MS, Yeston JS, Suleymanov Y, Olingy C, Ash C, Matsiko A, Smith HJ, Alderton G, Nusinovich Y  et al.  In Science Journals.  Science  2024 Feb 16;383(6684):715-717. doi:10.1126/science.ado6282
  17. Shilatifard A  Cytoplasmic transcription factor sequestration drives the pathogenesis of a rearranged leukemia.  J Clin Invest  2024 Feb 15;134(4). pii:e179105
  18. Nakayama C, Daigaku Y, Aoi Y, Fang Q, Kimura H, Shilatifard A, Tellier M, Nojima T  NELF coordinates Pol II transcription termination and DNA replication initiation.  bioRxiv  2024 Feb 01;. pii:2024.01.31.578294
  19. Zhao Z, Aoi Y, Philips CN, Meghani KA, Gold SR, Yu Y, John LS, Qian J, Zeidner JM, Meeks JJ  et al.  Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment.  Proc Natl Acad Sci U S A  2023 Dec 26;120(52):e2310063120. pii:e2310063120
  20. Shilatifard A  For the love of Science…Advances.  Sci Adv  2023 Dec 15;9(50):eadn1134. pii:eadn1134
  21. Morgan MAJ, Mohammad Parast S, Iwanaszko M, Aoi Y, Yoo D, Dumar ZJ, Howard BC, Helmin KA, Liu Q, Thakur WR  et al.  ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster.  Sci Adv  2023 Nov 24;9(47):eadj1261. pii:eadj1261
  22. Aoi Y, Shilatifard A  Transcriptional elongation control in developmental gene expression, aging, and disease.  Mol Cell  2023 Nov 16;83(22):3972-3999. doi:10.1016/j.molcel.2023.10.004
  23. Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A  et al.  Iron drives anabolic metabolism through active histone demethylation and mTORC1.  Nat Cell Biol  2023 Oct;25(10):1478-1494. doi:10.1038/s41556-023-01225-6
  24. Zheng B, Gold S, Iwanaszko M, Howard BC, Wang L, Shilatifard A  Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation.  Mol Cell  2023 Aug 17;83(16):2896-2910.e4. doi:10.1016/j.molcel.2023.06.032
  25. Smith HJ, Nusinovich Y, Osborne IS, Vignieri S, Jiang D, Shilatifard A, Olingy C, Simonti C, Lavine MS, Yeston JS  et al.  In Science Journals.  Science  2023 Aug 11;381(6658):642-644. doi:10.1126/science.adk1876
  26. Takata N, Miska JM, Morgan MA, Patel P, Billingham LK, Joshi N, Schipma MJ, Dumar ZJ, Joshi NR, Misharin AV  et al.  Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis.  Nat Commun  2023 Jul 14;14(1):4129. pii:4129
  27. Shilatifard A  The power of altruism in academic science.  Sci Adv  2023 Jul 07;9(27):eadj3883. pii:eadj3883
  28. Zhao Z, Cao K, Watanabe J, Philips CN, Zeidner JM, Ishi Y, Wang Q, Gold SR, Junkins K, Bartom ET  et al.  Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations.  J Clin Invest  2023 Jul 03;133(13). pii:e169993
  29. Morgan MAJ, Shilatifard A  Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription.  Sci Adv  2023 Apr 21;9(16):eadg6593. pii:eadg6593
  30. Soliman SHA, Cisneros WJ, Iwanaszko M, Aoi Y, Ganesan S, Walter M, Zeidner JM, Mishra RK, Kim EY, Wolinsky SM  et al.  Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C.  Sci Adv  2023 Mar 10;9(10):eadf2468. pii:eadf2468
  31. Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M  et al.  Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt.  Microbiol Spectr  2023 Feb 14;11(1):e0314422. pii:e03144-22