Northwestern University Feinberg School of Medicine
Shilatifard Laboratory
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Recent Publications

publications-nov-2022

  1. Morgan MAJ, Shilatifard A  Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription.  Sci Adv  2023 Apr 21;9(16):eadg6593. pii:eadg6593
  2. Soliman SHA, Cisneros WJ, Iwanaszko M, Aoi Y, Ganesan S, Walter M, Zeidner JM, Mishra RK, Kim EY, Wolinsky SM  et al.  Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C.  Sci Adv  2023 Mar 10;9(10):eadf2468. pii:eadf2468
  3. Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M  et al.  Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt.  Microbiol Spectr  2023 Feb 14;11(1):e0314422. pii:e03144-22
  4. Fong KW, Zhao JC, Lu X, Kim J, Piunti A, Shilatifard A, Yu J  PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.  Mol Cell  2022 Dec 15;82(24):4611-4626.e7. doi:10.1016/j.molcel.2022.11.010
  5. Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S  et al.  Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.  J Antimicrob Chemother  2022 Oct 28;77(11):2956-2959. doi:10.1093/jac/dkac245
  6. Thorp HH, Shilatifard A, Yeagle P  Editorial retraction.  Sci Adv  2022 Oct 21;8(42):eadf3052. doi:10.1126/sciadv.adf3052
  7. Zhao Z, Rendleman EJ, Szczepanski AP, Morgan MA, Wang L, Shilatifard A  CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS.  Sci Adv  2022 Oct 07;8(40):eadd3339. pii:eadd3339
  8. Piunti A, Meghani K, Yu Y, Robertson AG, Podojil JR, McLaughlin KA, You Z, Fantini D, Chiang M, Luo Y  et al.  Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma.  Sci Adv  2022 Oct 07;8(40):eabo8043. pii:eabo8043
  9. Aoi Y, Shah AP, Ganesan S, Soliman SHA, Cho BK, Goo YA, Kelleher NL, Shilatifard A  SPT6 functions in transcriptional pause/release via PAF1C recruitment.  Mol Cell  2022 Sep 15;82(18):3412-3423.e5. doi:10.1016/j.molcel.2022.06.037
  10. Shilatifard A  The dire need for federal support of molecular research, then and now.  Sci Adv  2022 Jun 10;8(23):eadd1030. doi:10.1126/sciadv.add1030
  11. Morgan M, Shiekhattar R, Shilatifard A, Lauberth SM  It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.  Mol Cell  2022 Jun 02;82(11):1981-1991. doi:10.1016/j.molcel.2022.04.008
  12. Piunti A, Shilatifard A  Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer.  Nat Rev Mol Cell Biol  2022 Jun;23(6):444. doi:10.1038/s41580-022-00495-6
  13. Cenik BK, Sze CC, Ryan CA, Das S, Cao K, Douillet D, Rendleman EJ, Zha D, Khan NH, Bartom E  et al.  A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells.  Proc Natl Acad Sci U S A  2022 May 10;119(19):e2118385119. pii:e2118385119
  14. Ishi Y, Zhang Y, Zhang A, Sasaki T, Piunti A, Suri A, Watanabe J, Abe K, He X, Katagi H  et al.  Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors.  Mol Cancer Ther  2022 May 04;21(5):715-726. doi:10.1158/1535-7163.MCT-21-0646
  15. Shilatifard A  On Healthy Scientific Debates.  Sci Adv  2022 Apr;8(13):eabq1534. doi:10.1126/sciadv.abq1534
  16. Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzińska E, Lee AS, Bailey AO, Gaynes MN, Huang J  et al.  UBR7 acts as a histone chaperone for post-nucleosomal histone H3.  EMBO J  2021 Dec 15;40(24):e108307. pii:e108307
  17. Morgan MAJ, Popova IK, Vaidya A, Burg JM, Marunde MR, Rendleman EJ, Dumar ZJ, Watson R, Meiners MJ, Howard SA  et al.  A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.  Genes Dev  2021 Dec 01;35(23-24):1642-1656. doi:10.1101/gad.348766.121
  18. Dasilva LF, Blumenthal E, Beckedorff F, Cingaram PR, Gomes Dos Santos H, Edupuganti RR, Zhang A, Dokaneheifard S, Aoi Y, Yue J  et al.  Integrator enforces the fidelity of transcriptional termination at protein-coding genes.  Sci Adv  2021 Nov 05;7(45):eabe3393. pii:eabe3393
  19. Aoi Y, Takahashi YH, Shah AP, Iwanaszko M, Rendleman EJ, Khan NH, Cho BK, Goo YA, Ganesan S, Kelleher NL  et al.  SPT5 stabilization of promoter-proximal RNA polymerase II.  Mol Cell  2021 Nov 04;81(21):4413-4424.e5. doi:10.1016/j.molcel.2021.08.006
  20. Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I  et al.  Dietary palmitic acid promotes a prometastatic memory via Schwann cells.  Nature  2021 Nov;599(7885):485-490. doi:10.1038/s41586-021-04075-0
  21. Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C  et al.  TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.  Clin Cancer Res  2021 Oct 15;27(20):5669-5680. doi:10.1158/1078-0432.CCR-21-0312
  22. Lai WKM, Mariani L, Rothschild G, Smith ER, Venters BJ, Blanda TR, Kuntala PK, Bocklund K, Mairose J, Dweikat SN  et al.  A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells.  Genome Res  2021 Sep;31(9):1663-1679. doi:10.1101/gr.275472.121
  23. Shilatifard A  Expanding the breadth and depth of Science Advances.  Sci Adv  2021 Aug;7(34). pii:eabl3664
  24. Katagi H, Takata N, Aoi Y, Zhang Y, Rendleman EJ, Blyth GT, Eckerdt FD, Tomita Y, Sasaki T, Saratsis AM  et al.  Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma.  Neuro Oncol  2021 Aug 02;23(8):1348-1359. doi:10.1093/neuonc/noab009
  25. Wang J, Huang TY, Hou Y, Bartom E, Lu X, Shilatifard A, Yue F, Saratsis A  Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.  Sci Adv  2021 Jun;7(23). pii:eabg4126
  26. Forte E, Ayaloglu Butun F, Marinaccio C, Schipma MJ, Piunti A, Schroeder MW, Kandpal M, Shilatifard A, Abecassis M, Hummel M  Epigenetic reprogramming of host and viral genes by Human Cytomegalovirus infection in Kasumi-3 myeloid progenitor cells at early times post-infection.  J Virol  2021 May 10;95(11). pii:e00183-21
  27. Wang L, Birch NW, Zhao Z, Nestler CM, Kazmer A, Shilati A, Blake A, Ozark PA, Rendleman EJ, Zha D  et al.  Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia.  Nat Cancer  2021 May;2(5):515-526. doi:10.1038/s43018-021-00199-4
  28. Piunti A, Shilatifard A  The roles of Polycomb repressive complexes in mammalian development and cancer.  Nat Rev Mol Cell Biol  2021 May;22(5):326-345. doi:10.1038/s41580-021-00341-1
  29. Shilatifard A  Building on a strong foundation.  Sci Adv  2021 Apr;7(17). pii:eabi7814
  30. Kurihara C, Lecuona E, Wu Q, Yang W, Núñez-Santana FL, Akbarpour M, Liu X, Ren Z, Li W, Querrey M  et al.  Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment.  JCI Insight  2021 Mar 22;6(6). pii:e147282
  31. Schachner LF, Jooß K, Morgan MA, Piunti A, Meiners MJ, Kafader JO, Lee AS, Iwanaszko M, Cheek MA, Burg JM  et al.  Decoding the protein composition of whole nucleosomes with Nuc-MS.  Nat Methods  2021 Mar;18(3):303-308. doi:10.1038/s41592-020-01052-9
  32. Shilatifard A, Yeagle P  Editorial expression of concern.  Sci Adv  2021 Feb;7(8). pii:eabh0587
  33. Zheng B, Aoi Y, Shah AP, Iwanaszko M, Das S, Rendleman EJ, Zha D, Khan N, Smith ER, Shilatifard A  Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression.  Genes Dev  2021 Feb 01;35(3-4):273-285. doi:10.1101/gad.346106.120
  34. Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA  et al.  Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.  Nature  2021 Feb;590(7847):635-641. doi:10.1038/s41586-020-03148-w
  35. Cenik BK, Shilatifard A  COMPASS and SWI/SNF complexes in development and disease.  Nat Rev Genet  2021 Jan;22(1):38-58. doi:10.1038/s41576-020-0278-0