Feinberg Home > Home >
Publications
Publications
Recent Publications
Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S et al.
Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.
Nat Immunol
2024 Oct 04;. doi:10.1038/s41590-024-01975-x Shilatifard A, Lauberth SM
Editorial overview: Breaking boundaries: new frontiers in chromatin regulation for cancer therapy.
Curr Opin Genet Dev
2024 Oct;88:102255. doi:10.1016/j.gde.2024.102255 Cisneros WJ, Soliman SHA, Walter M, Simons LM, Cornish D, De Fabritiis S, Halle AW, Kim EY, Wolinsky SM, Lorenzo-Redondo R et al.
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal.
PLoS Pathog
2024 Sep;20(9):e1012083. pii:e1012083 Markov NS, Ren Z, Senkow KJ, Grant RA, Gao CA, Malsin ES, Sichizya L, Kihshen H, Helmin KA, Jovisic M et al.
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia.
Nat Immunol
2024 Sep;25(9):1607-1622. doi:10.1038/s41590-024-01914-w Gantner BN, Palma FR, Kayzuka C, Lacchini R, Foltz DR, Backman V, Kelleher N, Shilatifard A, Bonini MG
Histone oxidation as a new mechanism of metabolic control over gene expression.
Trends Genet
2024 Sep;40(9):739-746. doi:10.1016/j.tig.2024.05.012 Sonn JY, Kim W, Iwanaszko M, Aoi Y, Li Y, Parkitny L, Brissette JL, Weiner L, Al-Ramahi I, Botas J et al.
MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription.
bioRxiv
2024 Jul 01;. pii:2024.06.30.601446 Gold S, Shilatifard A
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain-containing factors.
Curr Opin Genet Dev
2024 Jun;86:102181. doi:10.1016/j.gde.2024.102181 Maroso M, Smith KT, Stajic J, Smith HJ, Yeston JS, Ash C, Shilatifard A, Charneski C, Nusinovich Y, Szuromi P et al.
In Science Journals.
Science
2024 May 10;384(6696):632-634. doi:10.1126/science.adq2871 Soliman SHA, Iwanaszko M, Zheng B, Gold S, Howard BC, Das M, Chakrabarty RP, Chandel NS, Shilatifard A
Transcriptional elongation control of hypoxic response.
Proc Natl Acad Sci U S A
2024 Apr 09;121(15):e2321502121. pii:e2321502121 Sahu U, Villa E, Reczek CR, Zhao Z, O'Hara BP, Torno MD, Mishra R, Shannon WD, Asara JM, Gao P et al.
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.
Science
2024 Mar 29;383(6690):1484-1492. doi:10.1126/science.adh2771 Cisneros WJ, Walter M, Soliman SHA, Simons LM, Cornish D, Halle AW, Kim EY, Wolinsky SM, Shilatifard A, Hultquist JF
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal.
bioRxiv
2024 Mar 01;. pii:2024.03.01.582881 Vignieri S, Lavine MS, Yeston JS, Suleymanov Y, Olingy C, Ash C, Matsiko A, Smith HJ, Alderton G, Nusinovich Y et al.
In Science Journals.
Science
2024 Feb 16;383(6684):715-717. doi:10.1126/science.ado6282 Shilatifard A
Cytoplasmic transcription factor sequestration drives the pathogenesis of a rearranged leukemia.
J Clin Invest
2024 Feb 15;134(4). pii:e179105 Nakayama C, Daigaku Y, Aoi Y, Fang Q, Kimura H, Shilatifard A, Tellier M, Nojima T
NELF coordinates Pol II transcription termination and DNA replication initiation.
bioRxiv
2024 Feb 01;. pii:2024.01.31.578294 Zhao Z, Aoi Y, Philips CN, Meghani KA, Gold SR, Yu Y, John LS, Qian J, Zeidner JM, Meeks JJ et al.
Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment.
Proc Natl Acad Sci U S A
2023 Dec 26;120(52):e2310063120. pii:e2310063120 Shilatifard A
For the love of Science…Advances.
Sci Adv
2023 Dec 15;9(50):eadn1134. pii:eadn1134 Morgan MAJ, Mohammad Parast S, Iwanaszko M, Aoi Y, Yoo D, Dumar ZJ, Howard BC, Helmin KA, Liu Q, Thakur WR et al.
ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster.
Sci Adv
2023 Nov 24;9(47):eadj1261. pii:eadj1261 Aoi Y, Shilatifard A
Transcriptional elongation control in developmental gene expression, aging, and disease.
Mol Cell
2023 Nov 16;83(22):3972-3999. doi:10.1016/j.molcel.2023.10.004 Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A et al.
Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Nat Cell Biol
2023 Oct;25(10):1478-1494. doi:10.1038/s41556-023-01225-6 Zheng B, Gold S, Iwanaszko M, Howard BC, Wang L, Shilatifard A
Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation.
Mol Cell
2023 Aug 17;83(16):2896-2910.e4. doi:10.1016/j.molcel.2023.06.032 Smith HJ, Nusinovich Y, Osborne IS, Vignieri S, Jiang D, Shilatifard A, Olingy C, Simonti C, Lavine MS, Yeston JS et al.
In Science Journals.
Science
2023 Aug 11;381(6658):642-644. doi:10.1126/science.adk1876 Takata N, Miska JM, Morgan MA, Patel P, Billingham LK, Joshi N, Schipma MJ, Dumar ZJ, Joshi NR, Misharin AV et al.
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis.
Nat Commun
2023 Jul 14;14(1):4129. pii:4129 Shilatifard A
The power of altruism in academic science.
Sci Adv
2023 Jul 07;9(27):eadj3883. pii:eadj3883 Zhao Z, Cao K, Watanabe J, Philips CN, Zeidner JM, Ishi Y, Wang Q, Gold SR, Junkins K, Bartom ET et al.
Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations.
J Clin Invest
2023 Jul 03;133(13). pii:e169993 Morgan MAJ, Shilatifard A
Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription.
Sci Adv
2023 Apr 21;9(16):eadg6593. pii:eadg6593 Soliman SHA, Cisneros WJ, Iwanaszko M, Aoi Y, Ganesan S, Walter M, Zeidner JM, Mishra RK, Kim EY, Wolinsky SM et al.
Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C.
Sci Adv
2023 Mar 10;9(10):eadf2468. pii:eadf2468 Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M et al.
Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt.
Microbiol Spectr
2023 Feb 14;11(1):e0314422. pii:e03144-22 Fong KW, Zhao JC, Lu X, Kim J, Piunti A, Shilatifard A, Yu J
PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.
Mol Cell
2022 Dec 15;82(24):4611-4626.e7. doi:10.1016/j.molcel.2022.11.010 Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S et al.
Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.
J Antimicrob Chemother
2022 Oct 28;77(11):2956-2959. doi:10.1093/jac/dkac245 Thorp HH, Shilatifard A, Yeagle P
Editorial retraction.
Sci Adv
2022 Oct 21;8(42):eadf3052. pii:eadf3052 Zhao Z, Rendleman EJ, Szczepanski AP, Morgan MA, Wang L, Shilatifard A
CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS.
Sci Adv
2022 Oct 07;8(40):eadd3339. pii:eadd3339 Piunti A, Meghani K, Yu Y, Robertson AG, Podojil JR, McLaughlin KA, You Z, Fantini D, Chiang M, Luo Y et al.
Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma.
Sci Adv
2022 Oct 07;8(40):eabo8043. pii:eabo8043 Aoi Y, Shah AP, Ganesan S, Soliman SHA, Cho BK, Goo YA, Kelleher NL, Shilatifard A
SPT6 functions in transcriptional pause/release via PAF1C recruitment.
Mol Cell
2022 Sep 15;82(18):3412-3423.e5. doi:10.1016/j.molcel.2022.06.037 Shilatifard A
The dire need for federal support of molecular research, then and now.
Sci Adv
2022 Jun 10;8(23):eadd1030. pii:eadd1030 Morgan M, Shiekhattar R, Shilatifard A, Lauberth SM
It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.
Mol Cell
2022 Jun 02;82(11):1981-1991. doi:10.1016/j.molcel.2022.04.008 Piunti A, Shilatifard A
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer.
Nat Rev Mol Cell Biol
2022 Jun;23(6):444. doi:10.1038/s41580-022-00495-6 Cenik BK, Sze CC, Ryan CA, Das S, Cao K, Douillet D, Rendleman EJ, Zha D, Khan NH, Bartom E et al.
A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells.
Proc Natl Acad Sci U S A
2022 May 10;119(19):e2118385119. pii:e2118385119 Ishi Y, Zhang Y, Zhang A, Sasaki T, Piunti A, Suri A, Watanabe J, Abe K, He X, Katagi H et al.
Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors.
Mol Cancer Ther
2022 May 04;21(5):715-726. doi:10.1158/1535-7163.MCT-21-0646 Shilatifard A
On Healthy Scientific Debates.
Sci Adv
2022 Apr;8(13):eabq1534. pii:eabq1534