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Morgan MAJ, Shilatifard A
Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription.
Sci Adv
2023 Apr 21;9(16):eadg6593. pii:eadg6593 Soliman SHA, Cisneros WJ, Iwanaszko M, Aoi Y, Ganesan S, Walter M, Zeidner JM, Mishra RK, Kim EY, Wolinsky SM et al.
Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C.
Sci Adv
2023 Mar 10;9(10):eadf2468. pii:eadf2468 Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M et al.
Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt.
Microbiol Spectr
2023 Feb 14;11(1):e0314422. pii:e03144-22 Fong KW, Zhao JC, Lu X, Kim J, Piunti A, Shilatifard A, Yu J
PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.
Mol Cell
2022 Dec 15;82(24):4611-4626.e7. doi:10.1016/j.molcel.2022.11.010 Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S et al.
Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.
J Antimicrob Chemother
2022 Oct 28;77(11):2956-2959. doi:10.1093/jac/dkac245 Thorp HH, Shilatifard A, Yeagle P
Editorial retraction.
Sci Adv
2022 Oct 21;8(42):eadf3052. doi:10.1126/sciadv.adf3052 Zhao Z, Rendleman EJ, Szczepanski AP, Morgan MA, Wang L, Shilatifard A
CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS.
Sci Adv
2022 Oct 07;8(40):eadd3339. pii:eadd3339 Piunti A, Meghani K, Yu Y, Robertson AG, Podojil JR, McLaughlin KA, You Z, Fantini D, Chiang M, Luo Y et al.
Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma.
Sci Adv
2022 Oct 07;8(40):eabo8043. pii:eabo8043 Aoi Y, Shah AP, Ganesan S, Soliman SHA, Cho BK, Goo YA, Kelleher NL, Shilatifard A
SPT6 functions in transcriptional pause/release via PAF1C recruitment.
Mol Cell
2022 Sep 15;82(18):3412-3423.e5. doi:10.1016/j.molcel.2022.06.037 Shilatifard A
The dire need for federal support of molecular research, then and now.
Sci Adv
2022 Jun 10;8(23):eadd1030. doi:10.1126/sciadv.add1030 Morgan M, Shiekhattar R, Shilatifard A, Lauberth SM
It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.
Mol Cell
2022 Jun 02;82(11):1981-1991. doi:10.1016/j.molcel.2022.04.008 Piunti A, Shilatifard A
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer.
Nat Rev Mol Cell Biol
2022 Jun;23(6):444. doi:10.1038/s41580-022-00495-6 Cenik BK, Sze CC, Ryan CA, Das S, Cao K, Douillet D, Rendleman EJ, Zha D, Khan NH, Bartom E et al.
A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells.
Proc Natl Acad Sci U S A
2022 May 10;119(19):e2118385119. pii:e2118385119 Ishi Y, Zhang Y, Zhang A, Sasaki T, Piunti A, Suri A, Watanabe J, Abe K, He X, Katagi H et al.
Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors.
Mol Cancer Ther
2022 May 04;21(5):715-726. doi:10.1158/1535-7163.MCT-21-0646 Shilatifard A
On Healthy Scientific Debates.
Sci Adv
2022 Apr;8(13):eabq1534. doi:10.1126/sciadv.abq1534 Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzińska E, Lee AS, Bailey AO, Gaynes MN, Huang J et al.
UBR7 acts as a histone chaperone for post-nucleosomal histone H3.
EMBO J
2021 Dec 15;40(24):e108307. pii:e108307 Morgan MAJ, Popova IK, Vaidya A, Burg JM, Marunde MR, Rendleman EJ, Dumar ZJ, Watson R, Meiners MJ, Howard SA et al.
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.
Genes Dev
2021 Dec 01;35(23-24):1642-1656. doi:10.1101/gad.348766.121 Dasilva LF, Blumenthal E, Beckedorff F, Cingaram PR, Gomes Dos Santos H, Edupuganti RR, Zhang A, Dokaneheifard S, Aoi Y, Yue J et al.
Integrator enforces the fidelity of transcriptional termination at protein-coding genes.
Sci Adv
2021 Nov 05;7(45):eabe3393. pii:eabe3393 Aoi Y, Takahashi YH, Shah AP, Iwanaszko M, Rendleman EJ, Khan NH, Cho BK, Goo YA, Ganesan S, Kelleher NL et al.
SPT5 stabilization of promoter-proximal RNA polymerase II.
Mol Cell
2021 Nov 04;81(21):4413-4424.e5. doi:10.1016/j.molcel.2021.08.006 Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I et al.
Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
Nature
2021 Nov;599(7885):485-490. doi:10.1038/s41586-021-04075-0 Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C et al.
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.
Clin Cancer Res
2021 Oct 15;27(20):5669-5680. doi:10.1158/1078-0432.CCR-21-0312 Lai WKM, Mariani L, Rothschild G, Smith ER, Venters BJ, Blanda TR, Kuntala PK, Bocklund K, Mairose J, Dweikat SN et al.
A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells.
Genome Res
2021 Sep;31(9):1663-1679. doi:10.1101/gr.275472.121 Shilatifard A
Expanding the breadth and depth of Science Advances.
Sci Adv
2021 Aug;7(34). pii:eabl3664 Katagi H, Takata N, Aoi Y, Zhang Y, Rendleman EJ, Blyth GT, Eckerdt FD, Tomita Y, Sasaki T, Saratsis AM et al.
Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma.
Neuro Oncol
2021 Aug 02;23(8):1348-1359. doi:10.1093/neuonc/noab009 Wang J, Huang TY, Hou Y, Bartom E, Lu X, Shilatifard A, Yue F, Saratsis A
Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.
Sci Adv
2021 Jun;7(23). pii:eabg4126 Forte E, Ayaloglu Butun F, Marinaccio C, Schipma MJ, Piunti A, Schroeder MW, Kandpal M, Shilatifard A, Abecassis M, Hummel M
Epigenetic reprogramming of host and viral genes by Human Cytomegalovirus infection in Kasumi-3 myeloid progenitor cells at early times post-infection.
J Virol
2021 May 10;95(11). pii:e00183-21 Wang L, Birch NW, Zhao Z, Nestler CM, Kazmer A, Shilati A, Blake A, Ozark PA, Rendleman EJ, Zha D et al.
Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia.
Nat Cancer
2021 May;2(5):515-526. doi:10.1038/s43018-021-00199-4 Piunti A, Shilatifard A
The roles of Polycomb repressive complexes in mammalian development and cancer.
Nat Rev Mol Cell Biol
2021 May;22(5):326-345. doi:10.1038/s41580-021-00341-1 Shilatifard A
Building on a strong foundation.
Sci Adv
2021 Apr;7(17). pii:eabi7814 Kurihara C, Lecuona E, Wu Q, Yang W, Núñez-Santana FL, Akbarpour M, Liu X, Ren Z, Li W, Querrey M et al.
Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment.
JCI Insight
2021 Mar 22;6(6). pii:e147282 Schachner LF, Jooß K, Morgan MA, Piunti A, Meiners MJ, Kafader JO, Lee AS, Iwanaszko M, Cheek MA, Burg JM et al.
Decoding the protein composition of whole nucleosomes with Nuc-MS.
Nat Methods
2021 Mar;18(3):303-308. doi:10.1038/s41592-020-01052-9 Shilatifard A, Yeagle P
Editorial expression of concern.
Sci Adv
2021 Feb;7(8). pii:eabh0587 Zheng B, Aoi Y, Shah AP, Iwanaszko M, Das S, Rendleman EJ, Zha D, Khan N, Smith ER, Shilatifard A
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression.
Genes Dev
2021 Feb 01;35(3-4):273-285. doi:10.1101/gad.346106.120 Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA et al.
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.
Nature
2021 Feb;590(7847):635-641. doi:10.1038/s41586-020-03148-w Cenik BK, Shilatifard A
COMPASS and SWI/SNF complexes in development and disease.
Nat Rev Genet
2021 Jan;22(1):38-58. doi:10.1038/s41576-020-0278-0