About Our Lab
The regulation of gene transcription by RNA polymerase II is critical for development and differentiation, and its misregulation contributes to the pathogenesis of many cancers, including leukemia. The overall goal of our laboratory is to define the molecular mechanisms underlying leukemogenesis and to identify potential targets for therapy through detailed studies of proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation.
Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G. Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub 2018 Aug 9. PMID:30100186
Impactful science as the guiding principle. Shilatifard A. Sci Adv. 2018 Jul
Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma. Morgan MA, Shilatifard A. Cancer Cell. 2018 Jun
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. Wang L, Zhao Z, Ozark PA, Fantini D, Marshall SA, Rendleman EJ, Cozzolino KA, Louis N, He X, Morgan MA, Takahashi YH, Collings CK, Smith ER, Ntziachristos P, Savas JN, Zou L, Hashizume R, Meeks JJ, Shilatifard A. Nat Med. 2018 Jun
Enhancer Logic and Mechanics in Development and Disease. Rickels R, Shilatifard A. Trends Cell Biol. 2018 May
Born to run: control of transcription elongation by RNA polymerase II. Chen FX, Smith ER, Shilatifard A. Nat Rev Mol Cell Biol. 2018 Jul