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Northwestern University Feinberg School of Medicine
Shilatifard Laboratory

Shilatifard Laboratory

News from the Shilatifard Lab

Uncoupling Histone H3K4 trimethylation from transcription

A recent publication in Nature Genetics from the Simpson Querrey Institute for Epigenetics describes the balance between COMPASS, PRC2, and DNA methylation. This discovery disentangles Histone H3 K4 trimethylation from transcription and reveals how these players work in concert to dictate transcriptional decisions.

Balancing Regulation of Gene Expression in Cancer

Mutations in the COMPASS and Polycomb families of chromatin modifiers have been identified that disrupt the balanced regulation of gene expression (Wang et al., Nature Medicine 2018) (Piunti & Shilatifard, Science 2016). Researchers have discovered mechanisms to restore expression of tumor suppressor genes in several cancers, including bladder cancer, which are being evaluated in ongoing clinical trials.

New Findings on DNA Transcription Mechanisms

Read about Yuki Aoi's et al., Molecular Cell 2020 paper from the Shilatifard laboratory.

Christie Sze Receives Award

Christie Sze has been chosen for the Eighth Annual Driskill Scholar Award. Congratulations Christie!

Epigenetics and Cancer with Ali Shilatifard

Northwestern University Feinberg School of Medicine's Breakthroughs Podcast features Ali Shilatifard.

 

Ali Shilatifard’s Lab

Welcome to Ali Shilatifard’s Lab. Learn more about the work Ali and his lab are doing in order to reveal the causes of childhood leukemia by investigating the role of epigenetics in cancer.

What We Do

The regulation of gene expression by RNA polymerase II is essential for development and differentiation, and its misregulation contributes to the pathogenesis of many forms of cancers. The goal of our laboratory is to define the molecular mechanisms underlying cancer pathogenesis and to identify potential targets for therapy. These studies have been done through detailed understanding of proteins and protein complexes that regulate chromatin modifications, transcriptional initiation, and transcriptional elongation. Several of such findings from our lab our now under clinical studies for the treatment of bladder cancer and pediatric brain tumors.

Taking A Northwestern Direction

“Northwestern isn’t just a compass point on a map. Here, it’s a mindset. A Northwestern Direction is a journey that each one of us creates and defines as our own. There’s always a new adventure, a new idea, and a new discovery—no matter what path you pursue.”

Read about Dr. Shilatifard's Northwestern Direction

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