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Northwestern University Feinberg School of Medicine
Shilatifard Laboratory

Shilatifard Laboratory

What We Do

The regulation of gene transcription by RNA polymerase II is critical for development and differentiation, and its misregulation contributes to the pathogenesis of many cancers, including leukemia. The overall goal of our laboratory is to define the molecular mechanisms underlying leukemogenesis and to identify potential targets for therapy through detailed studies of proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation.

News from the Shilatifard Lab

New Findings on DNA Transcription Mechanisms

Read the news release about a recent publication by first author Yuki Aoi, PhD in the Shilatifard Laboratory.

Christie Sze Receives Award

Christie Sze has been chosen for the Eighth Annual Driskill Scholar Award. Congratulations Christie!

Epigenetics and Cancer with Ali Shilatifard

Northwestern University Feinberg School of Medicine's Breakthroughs Podcast features Ali Shilatifard.


Ali Shilatifard’s Lab

Welcome to Ali Shilatifard’s Lab. Learn more about the work Ali and his lab are doing in order to reveal the causes of childhood leukemia by investigating the role of epigenetics in cancer.

Taking A Northwestern Direction

“Northwestern isn’t just a compass point on a map. Here, it’s a mindset. A Northwestern Direction is a journey that each one of us creates and defines as our own. There’s always a new adventure, a new idea, and a new discovery—no matter what path you pursue.”

Read about Dr. Shilatifard's Northwestern Direction

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