Publications

Learn more about the work that we do in the Burridge laboratory through our recent publications.

Pozo-Agundo A, García-Rodríguez S, Antúnez-Rodríguez A, Chica-Redecillas L, Cejas RB, Lyra-Leite D, Porras-Quesada P, Gómez-Sánchez J, Mirón-Pozo B, Álvarez-Cubero MJ, Burridge PW, Martin F, Martínez-González LJ, Dávila-Fajardo CL Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes. Eur J Pharmacol 2026 Jan 20;1012:178484 PMID: 41423083, PMCID:
Fonoudi H, Burridge PW NFE2L2 in the spotlight: a transcriptional clue to paediatric cancer treatment cardiotoxicity. Eur Heart J 2025 Nov 28; PMID: 41312758, PMCID:
Neupane A, Petrykey K, Li K, French J, Zhou X, Wang J, Im C, Dixon SB, Ehrhardt MJ, Mulrooney DA, Jefferies JL, Gramatges MM, Chow EJ, Bhatia S, Robison LL, Ness KK, Hudson MM, Burridge PW, Armstrong GT, Yasui Y, Sapkota Y TTN and BAG3 in Cancer Therapy-Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer. JAMA Netw Open 2025 Jun 2;8(6):e2515793 PMID: 40540274, PMCID: PMC12181783
Petrykey K, Chen Y, Neupane A, French JN, Wang H, Xiang H, Dixon SB, Vukadinovich C, Im C, Ehrhardt MJ, Mulrooney DA, Sharafeldin N, Wang X, Howell RM, Jefferies JL, Burridge PW, Oeffinger KC, Gramatges MM, Bhatia S, Robison LL, Ness KK, Hudson MM, Chow EJ, Armstrong GT, Yasui Y, Sapkota Y Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer. Ann Oncol 2025 Oct;36(10):1203-1211 PMID: 40480553, PMCID: PMC12354194
Wang X, Singh P, Cejas RB, Zhou L, Sharafeldin N, Trainor PJ, Landier W, Cheng C, Hageman L, Wang F, Sapkota Y, Yasui Y, Hudson MM, Chow EJ, Armenian SH, Neglia JP, Hawkins DS, Ginsberg JP, Burridge PW, Armstrong GT, Bhatia S DNA Damage Response and Repair Genes and Anthracycline-Induced Cardiomyopathy in Childhood Cancer Survivors: A Report From the Children's Oncology Group and the Childhood Cancer Survivor Study. Circ Genom Precis Med 2025 Apr;18(2):e004813 PMID: 40151933, PMCID: PMC11999796
Weddle CJ, Blancard M, Uche N, Pongpamorn P, Cejas RB, Burridge PW Examining patient-specific responses to PARP inhibitors in a novel, human induced pluripotent stem cell-based model of breast cancer. NPJ Precis Oncol 2025 Feb 25;9(1):53 PMID: 40000798, PMCID: PMC11862011
Adli M, Przybyla L, Burdett T, Burridge PW, Cacheiro P, Chang HY, Engreitz JM, Gilbert LA, Greenleaf WJ, Hsu L, Huangfu D, Hung LH, Kundaje A, Li S, Parkinson H, Qiu X, Robson P, Schürer SC, Shojaie A, Skarnes WC, Smedley D, Studer L, Sun W, Vidović D, Vierbuchen T, White BS, Yeung KY, Yue F, Zhou T, MorPhiC Consortium MorPhiC Consortium: towards functional characterization of all human genes. Nature 2025 Feb;638(8050):351-359 PMID: 39939790, PMCID: PMC12088665
Poudel S, Shrestha H, Pan Y, Li Q, Li K, Im C, Dixon SB, Ehrhardt MJ, Mulrooney DA, Zhou S, Tan H, High AA, Burridge PW, Bhatia S, Jefferies JL, Ness KK, Hudson MM, Robison LL, Armstrong GT, Peng J, Ky B, Yasui Y, Sapkota Y Serum Proteins Predict Treatment-Related Cardiomyopathy Among Survivors of Childhood Cancer. JACC CardioOncol 2025 Jan;7(1):56-67 PMID: 39896123, PMCID: PMC11782007
Tatekoshi Y, Chen C, Shapiro JS, Chang HC, Blancard M, Lyra-Leite DM, Burridge PW, Feinstein M, D'Aquila R, Hsue P, Ardehali H Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. Elife 2024 Sep 27;13 PMID: 39331464, PMCID: PMC11434618
Selgrade DF, Fullenkamp DE, Chychula IA, Li B, Dellefave-Castillo L, Dubash AD, Ohiri J, Monroe TO, Blancard M, Tomar G, Holgren C, Burridge PW, George AL Jr, Demonbreun AR, Puckelwartz MJ, George SA, Efimov IR, Green KJ, McNally EM Susceptibility to innate immune activation in genetically mediated myocarditis. J Clin Invest 2024 May 16;134(13) PMID: 38768074, PMCID: PMC11213508
Fetterman KA, Blancard M, Lyra-Leite DM, Vanoye CG, Fonoudi H, Jouni M, DeKeyser JL, Lenny B, Sapkota Y, George AL Jr, Burridge PW Independent compartmentalization of functional, metabolic, and transcriptional maturation of hiPSC-derived cardiomyocytes. Cell Rep 2024 May 28;43(5):114160 PMID: 38678564, PMCID: PMC11247623
Pinheiro EA, DeKeyser JM, Lenny B, Sapkota Y, Burridge PW Nilotinib-induced alterations in endothelial cell function recapitulate clinical vascular phenotypes independent of ABL1. Sci Rep 2024 Mar 26;14(1):7123 PMID: 38532120, PMCID: PMC10966048
Fonoudi H, Jouni M, Cejas RB, Magdy T, Blancard M, Ge N, Shah DA, Lyra-Leite DM, Neupane A, Gharib M, Jiang Z, Sapkota Y, Burridge PW Functional Validation of Doxorubicin-Induced Cardiotoxicity-Related Genes. JACC CardioOncol 2024 Feb;6(1):38-50 PMID: 38510289, PMCID: PMC10950437
Salloum FN, Tocchetti CG, Ameri P, Ardehali H, Asnani A, de Boer RA, Burridge P, Cabrera JÁ, de Castro J, Córdoba R, Costa A, Dent S, Engelbertsen D, Fernández-Velasco M, Fradley M, Fuster JJ, Galán-Arriola C, García-Lunar I, Ghigo A, González-Neira A, Hirsch E, Ibáñez B, Kitsis RN, Konety S, Lyon AR, Martin P, Mauro AG, Mazo Vega MM, Meijers WC, Neilan TG, Rassaf T, Ricke-Hoch M, Sepulveda P, Thavendiranathan P, van der Meer P, Fuster V, Ky B, López-Fernández T, International Cardio-Oncology Society Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review. JACC CardioOncol 2023 Dec;5(6):715-731 PMID: 38205010, PMCID: PMC10774781
Sharafeldin N, Zhou L, Singh P, Crossman DK, Wang X, Hageman L, Landier W, Blanco JG, Burridge PW, Sapkota Y, Yasui Y, Armstrong GT, Robison LL, Hudson MM, Oeffinger K, Chow EJ, Armenian SH, Weisdorf DJ, Bhatia S Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors: A Report From COG-ALTE03N1, BMTSS, and CCSS. JACC CardioOncol 2023 Dec;5(6):807-818 PMID: 38205005, PMCID: PMC10774788
Chiang DY, Verkerk AO, Victorio R, Shneyer BI, van der Vaart B, Jouni M, Narendran N, Kc A, Sampognaro JR, Vetrano-Olsen F, Oh JS, Buys E, de Jonge B, Shah DA, Kiviniemi T, Burridge PW, Bezzina CR, Akhmanova A, MacRae CA The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circ Res 2024 Jan 5;134(1):46-59 PMID: 38095085, PMCID: PMC11889334
Cejas RB, Petrykey K, Sapkota Y, Burridge PW Anthracycline Toxicity: Light at the End of the Tunnel? Annu Rev Pharmacol Toxicol 2024 Jan 23;64:115-134 PMID: 37788492, PMCID: PMC11260185
Arzt M, Gao B, Mozneb M, Pohlman S, Cejas RB, Liu Q, Huang F, Yu C, Zhang Y, Fan X, Jenkins A, Giuliano AE, Burridge PW, Cui X, Sharma A Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy. Stem Cell Reports 2023 Oct 10;18(10):1913-1924 PMID: 37657447, PMCID: PMC10656302
Singh P, Zhou L, Shah DA, Cejas RB, Crossman DK, Jouni M, Magdy T, Wang X, Sharafeldin N, Hageman L, McKenna DE, Horvath S, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Burridge PW, Bhatia S Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy. Sci Rep 2023 Aug 4;13(1):12683 PMID: 37542143, PMCID: PMC10403495
Romero-Tejeda M, Fonoudi H, Weddle CJ, DeKeyser JM, Lenny B, Fetterman KA, Magdy T, Sapkota Y, Epting CL, Burridge PW A novel transcription factor combination for direct reprogramming to a spontaneously contracting human cardiomyocyte-like state. J Mol Cell Cardiol 2023 Sep;182:30-43 PMID: 37421991, PMCID: PMC10495191
Singh P, Crossman DK, Zhou L, Wang X, Sharafeldin N, Hageman L, Blanco JG, Burridge PW, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Bhatia S Haptoglobin Gene Expression and Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A COG-ALTE03N1 Report. JACC CardioOncol 2023 Jun;5(3):392-401 PMID: 37397079, PMCID: PMC10308004
Lyra-Leite DM, Copley RR, Freeman PP, Pongpamorn P, Shah D, McKenna DE, Lenny B, Pinheiro EA, Weddle CJ, Gharib M, Javed H, Fonoudi H, Sapkota Y, Burridge PW Nutritional requirements of human induced pluripotent stem cells. Stem Cell Reports 2023 Jun 13;18(6):1371-1387 PMID: 37315525, PMCID: PMC10277817
Romero-Tejeda M, Fonoudi H, Weddle CJ, DeKeyser JM, Lenny B, Fetterman KA, Magdy T, Sapkota Y, Epting C, Burridge PW A Novel Transcription Factor Combination for Direct Reprogramming to a Spontaneously Contracting Human Cardiomyocyte-like State. bioRxiv 2023 Mar 15; PMID: 36993577, PMCID: PMC10055062
Wang X, Singh P, Zhou L, Sharafeldin N, Landier W, Hageman L, Burridge P, Yasui Y, Sapkota Y, Blanco JG, Oeffinger KC, Hudson MM, Chow EJ, Armenian SH, Neglia JP, Ritchey AK, Hawkins DS, Ginsberg JP, Robison LL, Armstrong GT, Bhatia S Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors. J Clin Oncol 2023 Mar 20;41(9):1758-1769 PMID: 36508697, PMCID: PMC10043563
Blancard M, Fetterman KA, Burridge PW Pharmacogenomic Screening of Drug Candidates using Patient-Specific hiPSC-Derived Cardiomyocyte High-Throughput Calcium Imaging. Methods Mol Biol 2022;2547:241-253 PMID: 36068467, PMCID: PMC11247644
Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming. STAR Protoc 2022 Sep 16;3(3):101560 PMID: 36035804, PMCID: PMC9405110
Sapkota Y, Ehrhardt MJ, Qin N, Wang Z, Liu Q, Qiu W, Shelton K, Shao Y, Plyler E, Mulder HL, Easton J, Michael JR, Burridge PW, Wang X, Wilson CL, Jefferies JL, Chow EJ, Oeffinger KC, Morton LM, Li C, Yang JJ, Zhang J, Bhatia S, Mulrooney DA, Hudson MM, Robison LL, Armstrong GT, Yasui Y A Novel Locus on 6p21.2 for Cancer Treatment-Induced Cardiac Dysfunction Among Childhood Cancer Survivors. J Natl Cancer Inst 2022 Aug 8;114(8):1109-1116 PMID: 35698272, PMCID: PMC9360468
Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, Anys S, Minois D, Arnaud M, Duchateau J, Wijeyeratne YD, Muir A, Papadakis M, Castelletti S, Torchio M, Ortuño CG, Lacunza J, Giachino DF, Cerrato N, Martins RP, Campuzano O, Van Dooren S, Thollet A, Kyndt F, Mazzanti A, Clémenty N, Bisson A, Corveleyn A, Stallmeyer B, Dittmann S, Saenen J, Noël A, Honarbakhsh S, Rudic B, Marzak H, Rowe MK, Federspiel C, Le Page S, Placide L, Milhem A, Barajas-Martinez H, Beckmann BM, Krapels IP, Steinfurt J, Winkel BG, Jabbari R, Shoemaker MB, Boukens BJ, Škorić-Milosavljević D, Bikker H, Manevy F, Lichtner P, Ribasés M, Meitinger T, Müller-Nurasyid M, KORA-Study Group, Veldink JH, van den Berg LH, Van Damme P, Cusi D, Lanzani C, Rigade S, Charpentier E, Baron E, Bonnaud S, Lecointe S, Donnart A, Le Marec H, Chatel S, Karakachoff M, Bézieau S, London B, Tfelt-Hansen J, Roden D, Odening KE, Cerrone M, Chinitz LA, Volders PG, van de Berg MP, Laurent G, Faivre L, Antzelevitch C, Kääb S, Arnaout AA, Dupuis JM, Pasquie JL, Billon O, Roberts JD, Jesel L, Borggrefe M, Lambiase PD, Mansourati J, Loeys B, Leenhardt A, Guicheney P, Maury P, Schulze-Bahr E, Robyns T, Breckpot J, Babuty D, Priori SG, Napolitano C, Nantes Referral Center for inherited cardiac arrhythmia, de Asmundis C, Brugada P, Brugada R, Arbelo E, Brugada J, Mabo P, Behar N, Giustetto C, Molina MS, Gimeno JR, Hasdemir C, Schwartz PJ, Crotti L, McKeown PP, Sharma S, Behr ER, Haissaguerre M, Sacher F, Rooryck C, Tan HL, Remme CA, Postema PG, Delmar M, Ellinor PT, Lubitz SA, Gourraud JB, Tanck MW, George AL Jr, MacRae CA, Burridge PW, Dina C, Probst V, Wilde AA, Schott JJ, Redon R, Bezzina CR Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat Genet 2022 May;54(5):735 PMID: 35474365, PMCID:
Magdy T, Burridge PW Prime time for doxorubicin-induced cardiotoxicity genetic testing. Pharmacogenomics 2022 Apr;23(6):335-338 PMID: 35380470, PMCID: PMC9006338
Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, Anys S, Minois D, Arnaud M, Duchateau J, Wijeyeratne YD, Muir A, Papadakis M, Castelletti S, Torchio M, Ortuño CG, Lacunza J, Giachino DF, Cerrato N, Martins RP, Campuzano O, Van Dooren S, Thollet A, Kyndt F, Mazzanti A, Clémenty N, Bisson A, Corveleyn A, Stallmeyer B, Dittmann S, Saenen J, Noël A, Honarbakhsh S, Rudic B, Marzak H, Rowe MK, Federspiel C, Le Page S, Placide L, Milhem A, Barajas-Martinez H, Beckmann BM, Krapels IP, Steinfurt J, Winkel BG, Jabbari R, Shoemaker MB, Boukens BJ, Škorić-Milosavljević D, Bikker H, Manevy F, Lichtner P, Ribasés M, Meitinger T, Müller-Nurasyid M, KORA-Study Group, Veldink JH, van den Berg LH, Van Damme P, Cusi D, Lanzani C, Rigade S, Charpentier E, Baron E, Bonnaud S, Lecointe S, Donnart A, Le Marec H, Chatel S, Karakachoff M, Bézieau S, London B, Tfelt-Hansen J, Roden D, Odening KE, Cerrone M, Chinitz LA, Volders PG, van de Berg MP, Laurent G, Faivre L, Antzelevitch C, Kääb S, Arnaout AA, Dupuis JM, Pasquie JL, Billon O, Roberts JD, Jesel L, Borggrefe M, Lambiase PD, Mansourati J, Loeys B, Leenhardt A, Guicheney P, Maury P, Schulze-Bahr E, Robyns T, Breckpot J, Babuty D, Priori SG, Napolitano C, Nantes Referral Center for inherited cardiac arrhythmia, de Asmundis C, Brugada P, Brugada R, Arbelo E, Brugada J, Mabo P, Behar N, Giustetto C, Molina MS, Gimeno JR, Hasdemir C, Schwartz PJ, Crotti L, McKeown PP, Sharma S, Behr ER, Haissaguerre M, Sacher F, Rooryck C, Tan HL, Remme CA, Postema PG, Delmar M, Ellinor PT, Lubitz SA, Gourraud JB, Tanck MW, George AL Jr, MacRae CA, Burridge PW, Dina C, Probst V, Wilde AA, Schott JJ, Redon R, Bezzina CR Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat Genet 2022 Mar;54(3):232-239 PMID: 35210625, PMCID: PMC9376964
Magdy T, Jouni M, Kuo HH, Weddle CJ, Lyra-Leite D, Fonoudi H, Romero-Tejeda M, Gharib M, Javed H, Fajardo G, Ross CJD, Carleton BC, Bernstein D, Burridge PW Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity. Circulation 2022 Jan 25;145(4):279-294 PMID: 34874743, PMCID: PMC8792344
Magdy T, Jiang Z, Jouni M, Fonoudi H, Lyra-Leite D, Jung G, Romero-Tejeda M, Kuo HH, Fetterman KA, Gharib M, Burmeister BT, Zhao M, Sapkota Y, Ross CJ, Carleton BC, Bernstein D, Burridge PW RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy. Cell Stem Cell 2021 Dec 2;28(12):2076-2089.e7 PMID: 34525346, PMCID: PMC8642268
Marchal GA, Jouni M, Chiang DY, Pérez-Hernández M, Podliesna S, Yu N, Casini S, Potet F, Veerman CC, Klerk M, Lodder EM, Mengarelli I, Guan K, Vanoye CG, Rothenberg E, Charpentier F, Redon R, George AL Jr, Verkerk AO, Bezzina CR, MacRae CA, Burridge PW, Delmar M, Galjart N, Portero V, Remme CA Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs. Circ Res 2021 Jul 23;129(3):349-365 PMID: 34092082, PMCID: PMC8298292
Lyra-Leite DM, Fonoudi H, Gharib M, Burridge PW An updated protocol for the cost-effective and weekend-free culture of human induced pluripotent stem cells. STAR Protoc 2021 Mar 19;2(1):100213 PMID: 33786455, PMCID: PMC7988236
Huang KM, Zavorka Thomas M, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen T, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu S, Burridge PW, Sparreboom A Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proc Natl Acad Sci U S A 2021 Feb 2;118(5) PMID: 33495337, PMCID: PMC7865186
Magdy T, Burridge PW Use of hiPSC to explicate genomic predisposition to anthracycline-induced cardiotoxicity. Pharmacogenomics 2021 Jan;22(1):41-54 PMID: 33448871, PMCID: PMC7923254
Pérez-Hernández M, Leo-Macias A, Keegan S, Jouni M, Kim JC, Agullo-Pascual E, Vermij S, Zhang M, Liang FX, Burridge P, Fenyo D, Rothenberg E, Delmar M Structural and Functional Characterization of a Na(v)1.5-Mitochondrial Couplon. Circ Res 2021 Feb 5;128(3):419-432 PMID: 33342222, PMCID: PMC7864872
Liu X, De la Cruz E, Gu X, Balint L, Oxendine-Burns M, Terrones T, Ma W, Kuo HH, Lantz C, Bansal T, Thorp E, Burridge P, Jakus Z, Herz J, Cleaver O, Torres M, Oliver G Lymphoangiocrine signals promote cardiac growth and repair. Nature 2020 Dec;588(7839):705-711 PMID: 33299187, PMCID: PMC7770123
Sapkota Y, Qin N, Ehrhardt MJ, Wang Z, Chen Y, Wilson CL, Estepp J, Rai P, Hankins JS, Burridge PW, Jefferies JL, Zhang J, Hudson MM, Robison LL, Armstrong GT, Mulrooney DA, Yasui Y Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry. Cancer Res 2021 May 1;81(9):2556-2565 PMID: 33288658, PMCID: PMC8137513
Fonoudi H, Burridge PW Cellular model systems to study cardiovascular injury from chemotherapy. J Thromb Thrombolysis 2021 May;51(4):890-896 PMID: 33051807, PMCID: PMC10150647
Potet F, Egecioglu DE, Burridge PW, George AL Jr GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol 2020 Nov;98(5):540-547 PMID: 32938719, PMCID:
Burridge PW, Thorp EB Doxorubicin-Induced Ascension of Resident Cardiac Macrophages. Circ Res 2020 Aug 14;127(5):628-630 PMID: 32790526, PMCID: PMC7430044
Dainis A, Zaleta-Rivera K, Ribeiro A, Chang ACH, Shang C, Lan F, Burridge PW, Liu WR, Wu JC, Chang ACY, Pruitt BL, Wheeler M, Ashley E Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes. Physiol Genomics 2020 Jul 1;52(7):293-303 PMID: 32567507, PMCID: PMC7468691
Lyra-Leite DM, Burridge PW Pluripotent Stem Cell Modeling of Anticancer Therapy-Induced Cardiotoxicity. Curr Cardiol Rep 2020 Jun 19;22(8):56 PMID: 32562096, PMCID: PMC11260186
Fonoudi H, Lyra-Leite DM, Javed HA, Burridge PW Generating a Cost-Effective, Weekend-Free Chemically Defined Human Induced Pluripotent Stem Cell (hiPSC) Culture Medium. Curr Protoc Stem Cell Biol 2020 Jun;53(1):e110 PMID: 32463953, PMCID: PMC7338045
Singh P, Wang X, Hageman L, Chen Y, Magdy T, Landier W, Ginsberg JP, Neglia JP, Sklar CA, Castellino SM, Dreyer ZE, Hudson MM, Robison LL, Blanco JG, Relling MV, Burridge P, Bhatia S Association of GSTM1 null variant with anthracycline-related cardiomyopathy after childhood cancer-A Children's Oncology Group ALTE03N1 report. Cancer 2020 Sep 1;126(17):4051-4058 PMID: 32413235, PMCID: PMC7423633
Magdy T, Kuo HH, Burridge PW Precise and Cost-Effective Nanopore Sequencing for Post-GWAS Fine-Mapping and Causal Variant Identification. iScience 2020 Apr 24;23(4):100971 PMID: 32203907, PMCID: PMC7096756
Pinheiro EA, Magdy T, Burridge PW Human In Vitro Models for Assessing the Genomic Basis of Chemotherapy-Induced Cardiovascular Toxicity. J Cardiovasc Transl Res 2020 Jun;13(3):377-389 PMID: 32078739, PMCID: PMC7365753
Kuo HH, Gao X, DeKeyser JM, Fetterman KA, Pinheiro EA, Weddle CJ, Fonoudi H, Orman MV, Romero-Tejeda M, Jouni M, Blancard M, Magdy T, Epting CL, George AL Jr, Burridge PW Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture. Stem Cell Reports 2020 Feb 11;14(2):256-270 PMID: 31928950, PMCID: PMC7013200
Gintant G, Burridge P, Gepstein L, Harding S, Herron T, Hong C, Jalife J, Wu JC Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association. Circ Res 2019 Oct 25;125(10):e75-e92 PMID: 31533542, PMCID: PMC7398423
Wren LM, Jiménez-Jáimez J, Al-Ghamdi S, Al-Aama JY, Bdeir A, Al-Hassnan ZN, Kuan JL, Foo RY, Potet F, Johnson CN, Aziz MC, Carvill GL, Kaski JP, Crotti L, Perin F, Monserrat L, Burridge PW, Schwartz PJ, Chazin WJ, Bhuiyan ZA, George AL Jr Genetic Mosaicism in Calmodulinopathy. Circ Genom Precis Med 2019 Sep;12(9):375-385 PMID: 31454269, PMCID: PMC6751013
Hilfiker-Kleiner D, Ardehali H, Fischmeister R, Burridge P, Hirsch E, Lyon AR Late onset heart failure after childhood chemotherapy. Eur Heart J 2019 Mar 7;40(10):798-800 PMID: 30753420, PMCID: PMC6821336
Magdy T, Burridge PW Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease. Cell Stem Cell 2019 Feb 7;24(2):203-205 PMID: 30735646, PMCID: PMC7375859
Pinheiro EA, Fetterman KA, Burridge PW hiPSCs in cardio-oncology: deciphering the genomics. Cardiovasc Res 2019 Apr 15;115(5):935-948 PMID: 30689737, PMCID: PMC6452310
Waas M, Weerasekera R, Kropp EM, Romero-Tejeda M, Poon EN, Boheler KR, Burridge PW, Gundry RL Are These Cardiomyocytes? Protocol Development Reveals Impact of Sample Preparation on the Accuracy of Identifying Cardiomyocytes by Flow Cytometry. Stem Cell Reports 2019 Feb 12;12(2):395-410 PMID: 30686762, PMCID: PMC6373208
Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc 2018 Dec;13(12):3018-3041 PMID: 30413796, PMCID: PMC6502639
Strigli A, Raab C, Hessler S, Huth T, Schuldt AJT, Alzheimer C, Friedrich T, Burridge PW, Luedde M, Schwake M Doxorubicin induces caspase-mediated proteolysis of KV7.1. Commun Biol 2018;1:155 PMID: 30302399, PMCID: PMC6162258
Sharma A, Zhang Y, Buikema JW, Serpooshan V, Chirikian O, Kosaric N, Churko JM, Dzilic E, Shieh A, Burridge PW, Wu JC, Wu SM Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep 2018 Apr 26;8(1):6618 PMID: 29700394, PMCID: PMC5920079
Magdy T, Burridge PW The future role of pharmacogenomics in anticancer agent-induced cardiovascular toxicity. Pharmacogenomics 2018 Jan;19(2):79-82 PMID: 29199515, PMCID:
Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling. Stem Cells 2018 Feb;36(2):265-277 PMID: 29086457, PMCID: PMC5785460
Magdy T, Schuldt AJT, Wu JC, Bernstein D, Burridge PW Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems. Annu Rev Pharmacol Toxicol 2018 Jan 6;58:83-103 PMID: 28992430, PMCID: PMC7386286
Zhang S, Yeap XY, DeBerge M, Naresh NK, Wang K, Jiang Z, Wilcox JE, White SM, Morrow JP, Burridge PW, Procissi D, Scott EA, Frazier W, Thorp EB Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. JACC Basic Transl Sci 2017 Aug;2(4):386-397 PMID: 28920097, PMCID: PMC5595371
Flevaris P, Khan SS, Eren M, Schuldt AJT, Shah SJ, Lee DC, Gupta S, Shapiro AD, Burridge PW, Ghosh AK, Vaughan DE Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-β and Cardiac Fibrosis. Circulation 2017 Aug 15;136(7):664-679 PMID: 28588076, PMCID: PMC5784400
Yang X, Park SH, Chang HC, Shapiro JS, Vassilopoulos A, Sawicki KT, Chen C, Shang M, Burridge PW, Epting CL, Wilsbacher LD, Jenkitkasemwong S, Knutson M, Gius D, Ardehali H Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest 2017 Apr 3;127(4):1505-1516 PMID: 28287409, PMCID: PMC5373873
Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med 2017 Feb 15;9(377) PMID: 28202772, PMCID: PMC5409837
Magdy T, Burmeister BT, Burridge PW Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing? Pharmacol Ther 2016 Dec;168:113-125 PMID: 27609196, PMCID: PMC5140687
Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell 2016 Sep 1;19(3):311-25 PMID: 27545504, PMCID: PMC5087997
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med 2016 May;22(5):547-56 PMID: 27089514, PMCID: PMC5086256
Burridge PW, Sharma A, Wu JC Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine. Annu Rev Genet 2015;49:461-84 PMID: 26631515, PMCID: PMC4962619
Burridge PW, Holmström A, Wu JC Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells. Curr Protoc Hum Genet 2015 Oct 6;87:21.3.1-21.3.15 PMID: 26439715, PMCID: PMC4597313
Sharma A, Li G, Rajarajan K, Hamaguchi R, Burridge PW, Wu SM Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation. J Vis Exp 2015 Mar 18;(97) PMID: 25867738, PMCID: PMC4401368
Burridge PW, Diecke S, Matsa E, Sharma A, Wu H, Wu JC Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol 2016;1353:119-30 PMID: 25690476, PMCID: PMC4962608
Burridge PW, Metzler SA, Nakayama KH, Abilez OJ, Simmons CS, Bruce MA, Matsuura Y, Kim P, Wu JC, Butte M, Huang NF, Yang PC Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes. Am J Transl Res 2014;6(6):724-35 PMID: 25628783, PMCID: PMC4297340
Diecke S, Lu J, Lee J, Termglinchan V, Kooreman NG, Burridge PW, Ebert AD, Churko JM, Sharma A, Kay MA, Wu JC Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci Rep 2015 Jan 28;5:8081 PMID: 25628230, PMCID: PMC4308704
Bernstein D, Burridge P Patient-Specific Pluripotent Stem Cells in Doxorubicin Cardiotoxicity: A New Window Into Personalized Medicine. Prog Pediatr Cardiol 2014 Dec 1;37(1-2):23-27 PMID: 25530693, PMCID: PMC4267060
Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. Eur Heart J 2015 Apr 1;36(13):806-16 PMID: 25368203, PMCID: PMC4381134
Bhattacharya S, Burridge PW, Kropp EM, Chuppa SL, Kwok WM, Wu JC, Boheler KR, Gundry RL High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry. J Vis Exp 2014 Sep 23;(91):52010 PMID: 25286293, PMCID: PMC4448667
Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med 2014 Sep 24;6(255):255ra130 PMID: 25253673, PMCID: PMC4215699
Boheler KR, Bhattacharya S, Kropp EM, Chuppa S, Riordon DR, Bausch-Fluck D, Burridge PW, Wu JC, Wersto RP, Chan GC, Rao S, Wollscheid B, Gundry RL A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. Stem Cell Reports 2014 Jul 8;3(1):185-203 PMID: 25068131, PMCID: PMC4110789
Mahairaki V, Ryu J, Peters A, Chang Q, Li T, Park TS, Burridge PW, Talbot CC Jr, Asnaghi L, Martin LJ, Zambidis ET, Koliatsos VE Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties. Stem Cells Dev 2014 Dec 15;23(24):2996-3010 PMID: 25027006, PMCID: PMC4267410
Sharma A, Marceau C, Hamaguchi R, Burridge PW, Rajarajan K, Churko JM, Wu H, Sallam KI, Matsa E, Sturzu AC, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circ Res 2014 Aug 29;115(6):556-66 PMID: 25015077, PMCID: PMC4149868
Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S, Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC Chemically defined generation of human cardiomyocytes. Nat Methods 2014 Aug;11(8):855-60 PMID: 24930130, PMCID: PMC4169698
Matsa E, Burridge PW, Wu JC Human stem cells for modeling heart disease and for drug discovery. Sci Transl Med 2014 Jun 4;6(239):239ps6 PMID: 24898747, PMCID: PMC4215696
Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers DM, Wu JC Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 2013 Sep 10;128(11 Suppl 1):S3-13 PMID: 24030418, PMCID: PMC3855862
Churko JM, Burridge PW, Wu JC Generation of human iPSCs from human peripheral blood mononuclear cells using non-integrative Sendai virus in chemically defined conditions. Methods Mol Biol 2013;1036:81-8 PMID: 23807788, PMCID: PMC6430631
Burridge PW, Zambidis ET Highly efficient directed differentiation of human induced pluripotent stem cells into cardiomyocytes. Methods Mol Biol 2013;997:149-61 PMID: 23546754, PMCID:
Mordwinkin NM, Burridge PW, Wu JC A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards. J Cardiovasc Transl Res 2013 Feb;6(1):22-30 PMID: 23229562, PMCID: PMC3556463
Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, Burridge P, Wu JC MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells 2013 Feb;31(2):259-68 PMID: 23136034, PMCID: PMC3572288
Thompson SA, Burridge PW, Lipke EA, Shamblott M, Zambidis ET, Tung L Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model. J Mol Cell Cardiol 2012 Jul;53(1):15-23 PMID: 22713758, PMCID: PMC3956050
Gu E, Chen WY, Gu J, Burridge P, Wu JC Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. Theranostics 2012;2(4):335-45 PMID: 22509197, PMCID: PMC3326720
Burridge PW, Keller G, Gold JD, Wu JC Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell 2012 Jan 6;10(1):16-28 PMID: 22226352, PMCID: PMC3255078
Gundry RL, Burridge PW, Boheler KR Pluripotent stem cell heterogeneity and the evolving role of proteomic technologies in stem cell biology. Proteomics 2011 Oct;11(20):3947-61 PMID: 21834136, PMCID: PMC3311164
Burridge PW, Thompson S, Millrod MA, Weinberg S, Yuan X, Peters A, Mahairaki V, Koliatsos VE, Tung L, Zambidis ET A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. PLoS One 2011 Apr 8;6(4):e18293 PMID: 21494607, PMCID: PMC3072973
Peters A, Burridge PW, Pryzhkova MV, Levine MA, Park TS, Roxbury C, Yuan X, Péault B, Zambidis ET Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol 2010;54(6-7):965-90 PMID: 20563986, PMCID: PMC3510983
Priddle H, Allegrucci C, Burridge P, Munoz M, Smith NM, Devlin L, Sjoblom C, Chamberlain S, Watson S, Young LE, Denning C Derivation and characterisation of the human embryonic stem cell lines, NOTT1 and NOTT2. In Vitro Cell Dev Biol Anim 2010 Apr;46(3-4):367-75 PMID: 20177995, PMCID:
Burridge PW, Anderson D, Priddle H, Barbadillo Muñoz MD, Chamberlain S, Allegrucci C, Young LE, Denning C Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells 2007 Apr;25(4):929-38 PMID: 17185609, PMCID:
Priddle H, Jones DR, Burridge PW, Patient R Hematopoiesis from human embryonic stem cells: overcoming the immune barrier in stem cell therapies. Stem Cells 2006 Apr;24(4):815-24 PMID: 16306149, PMCID:
Allegrucci C, Denning CN, Burridge P, Steele W, Sinclair KD, Young LE Human embryonic stem cells as a model for nutritional programming: an evaluation. Reprod Toxicol 2005 Sep-Oct;20(3):353-67 PMID: 15975761, PMCID:
Gregory SG, Sekhon M, Schein J, Zhao S, Osoegawa K, Scott CE, Evans RS, Burridge PW, Cox TV, Fox CA, Hutton RD, Mullenger IR, Phillips KJ, Smith J, Stalker J, Threadgold GJ, Birney E, Wylie K, Chinwalla A, Wallis J, Hillier L, Carter J, Gaige T, Jaeger S, Kremitzki C, Layman D, Maas J, McGrane R, Mead K, Walker R, Jones S, Smith M, Asano J, Bosdet I, Chan S, Chittaranjan S, Chiu R, Fjell C, Fuhrmann D, Girn N, Gray C, Guin R, Hsiao L, Krzywinski M, Kutsche R, Lee SS, Mathewson C, McLeavy C, Messervier S, Ness S, Pandoh P, Prabhu AL, Saeedi P, Smailus D, Spence L, Stott J, Taylor S, Terpstra W, Tsai M, Vardy J, Wye N, Yang G, Shatsman S, Ayodeji B, Geer K, Tsegaye G, Shvartsbeyn A, Gebregeorgis E, Krol M, Russell D, Overton L, Malek JA, Holmes M, Heaney M, Shetty J, Feldblyum T, Nierman WC, Catanese JJ, Hubbard T, Waterston RH, Rogers J, de Jong PJ, Fraser CM, Marra M, McPherson JD, Bentley DR A physical map of the mouse genome. Nature 2002 Aug 15;418(6899):743-50 PMID: 12181558, PMCID: