Tissue Engineering and Biomaterials
Our research focus is regenerative medicine, specifically tissue engineering and biomaterials in urologic, gastrointestinal and vascular regeneration models. We study the regenerative applications of combining novel elastomeric scaffolds with specific stem and progenitor cell populations, and utilize nanomolecules and small molecules to customize microenvironments suited to specific regenerative processes.
Projects include investigation of mesenchymal stem cells and hematopoietic stem/progenitor cells for design of tissue grafts with enhanced functionality, implementation of small molecules and nanomolecules to promote regeneration, use of small molecules to influence cell fate, establishing new urologic tissue reconstruction models and approaches, developing treatment strategies for inflammation-based urologic conditions, and the synthesis of novel anti-inflammatory peptide amphiphiles to aid in the regenerative process and combat specific disease types.
Sharma Lab Collaborations
Dr Earl Cheng, NU Dept of Urology and Division Head, Lurie Children's Pediatric Urology
Ameer Research Group (Dr Guillermo Ameer, NU Dept of Biomedical Engineering, SQI)
Chow Lab, Lehigh University Depts of Material Science and Engineering and Bioengineering
Dr Matthias Hofer, NU Dept of Urology
Dr Catherine Hunter, NU Depts of Surgery (Division of Pediatric Surgery) and Pediatrics, Lurie Children's Division of Pediatric Surgery
Kibbe Lab (Dr Melina Kibbe, NU Dept of Surgery, SQI)
Lurie Children's - Divisions of Pediatric Orthopaedic Surgery, Pediatric Surgery and Pediatric Urology
NU - Depts of Surgery (Division of Pediatric Surgery) and Urology
Dr Si Oottamasathien, University of Utah Health Care Dept of Surgery - Division of Urology