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Since the lab was founded in 2007, the Northwestern HFpEF Program has been instrumental in understanding:

  • the pathogenesis of HFpEF development
  • the pathophysiology of the complex HFpEF syndrome
  • sub-phenotyping of HFpEF with machine learning
  • improving clinical trial enrollment and testing novel therapies for HFpEF

In our laboratory, we continue to study these aspects of the HFpEF syndrome in animal and cellular models, large-scale population-based epidemiology studies, HFpEF clinical trials and in clinical physiological studies in patients with prevalent HFpEF. Major tools used in our laboratory include speckle-tracking echocardiography, ventricular-arterial coupling analyses, invasive and non-invasive pressure-volume analysis and machine learning. 

Research in our laboratory focuses on the following areas; choose one to read about our studies in depth:


If you are interest in learning more about a study or inquire if you would be eligible to enroll, you can locate the study's contact information through the Bluhm Cardiovascular Institute - Clinical Trials webpage or through the CTU Regulatory Team email at