Since the lab was founded in 2007, the Northwestern HFpEF Program has been instrumental in understanding:
- the pathogenesis of HFpEF development
- the pathophysiology of the complex HFpEF syndrome
- sub-phenotyping of HFpEF with machine learning
- improving clinical trial enrollment and testing novel therapies for HFpEF
In our laboratory, we continue to study these aspects of the HFpEF syndrome in animal and cellular models, large-scale population-based epidemiology studies, HFpEF clinical trials and in clinical physiological studies in patients with prevalent HFpEF. Major tools used in our laboratory include speckle-tracking echocardiography, ventricular-arterial coupling analyses, invasive and non-invasive pressure-volume analysis and machine learning.
Research in our laboratory focuses on the following areas; choose one to read about our studies in depth: