Improving the prevention, diagnosis, treatment and prognosis of HFpEF.


The Shah Lab

Heart failure with preserved ejection fraction (HFpEF) accounts for more than 50 percent of all heart failure cases and is associated with high morbidity and mortality. HFpEF prevalence is increasing with the aging population and the ongoing epidemics of obesity, diabetes and hypertension. HFpEF is under-recognized, diagnosis can be challenging and there are few proven therapies for HFpEF. Therefore, in 2007, Sanjiv Shah, MD, started the world's first dedicated clinical program for HFpEF at Northwestern University Feinberg School of Medicine with the goal of improving the prevention, diagnosis, treatment and prognosis of HFpEF.

Dr. Shah headshot

Lab Leadership

Sanjiv J. Shah, MD
Director, Center for Deep Phenotyping and Precision Therapeutics at the Institute for Augmented Intelligence in Medicine
Neil J. Stone, MD, Professor
Professor of Cardiology in the Department of Medicine

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Updates From the Lab

Cardiac Amylidsis

Cardiac Amyloidosis

Endomyocardial biopsy in cardiac amyloidosis using hematoxylin and eosin stain (left panel) and a sulfated alcian blue stain (right panel). The left panel shows a prominent interstitium which is expanded by an acellular, eosinophilic substance. The myocardial cells are of uneven size and are often vacuolated. The massive amyloid deposits are identified by a positive affinity for sulfated alcian blue (producing a green color), a histochemical reaction equivalent to the Congo red stain.


Congratulations to Ravi Patel for receiving the NUCATS KL2 career development award, as well as winning the Department of Medicine’s Jameson Research award for the top fellow in the DOM for their research during their fellowship.