Improving the prevention, diagnosis, treatment and prognosis of HFpEF.

The Shah Lab

Heart failure with preserved ejection fraction (HFpEF) accounts for more than 50 percent of all heart failure cases and is associated with high morbidity and mortality. HFpEF prevalence is increasing with the aging population and the ongoing epidemics of obesity, diabetes and hypertension. HFpEF is under-recognized, diagnosis can be challenging and there are few proven therapies for HFpEF. Therefore, in 2007, Sanjiv Shah, MD, started the world's first dedicated clinical program for HFpEF at Northwestern University Feinberg School of Medicine with the goal of improving the prevention, diagnosis, treatment and prognosis of HFpEF.

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Lab Leadership

Sanjiv J. Shah, MD
Director, Center for Deep Phenotyping and Precision Therapeutics at the Institute for Augmented Intelligence in Medicine
Neil J. Stone, MD, Professor
Professor of Cardiology in the Department of Medicine

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Updates From the Lab

The HeartShare Study and The Future of HFpEF Research

Dr. Patrick McCarthy interviews Dr. Sanjiv Shah on the long-term impact of the HeartShare Study on heart failure with preserved ejection fraction research.

Check out our latest video in the Double Take miniseries from the New England Journal of Medicine

In this final episode of the miniseries on HFpEF from NEJM, patients describe what living with HFpEF is like. This patient-focused video explains the condition and offers practical approaches to managing it as a chronic illness.

HFpEF Explained

Part 1 - Prevalence, New Advances, and How to Diagnose

Part 2 - Managing HFpEF in Primary Care

Dr. Sanjiv Shah Named to 2025 Highly Cited Researchers List

The "Highly Cited Researchers" list, published by Clarivate Analytics identifies investigators who have demonstrated significant influence in their field. The honor indicates investigators who have authored multiple papers that rank in the top 1% of citations in their respective field in the world.