This study is enrolling participants with a diagnosis of heart failure with preserved ejection fraction (HFpEF). This is a condition that causes patients to be short of breath and limited in what they can do in their daily lives. Currently, there are no approved drugs for this condition. Researchers are trying to find new therapies for this condition. The purpose of this study is to test whether Potassium Nitrate (KNO3) will improve how people with HFpEF can exercise. In HFpEF, patients are limited in their ability to do all the things they want to do, and exercise as much as they would like, due to becoming tired and short of breath early. We do not know exactly why these limitations occur. There is some evidence that in addition to problems with the heart, patients with HFpEF also have problems with their arteries and muscles that affect their ability to exercise. Potassium Nitrate has been shown to improve how muscles work and also improve blood flow to working muscles in the body in healthy individuals. We previously conducted a pilot study with our KNO3 pills and found them to be safe in subjects with HFpEF. We would like to now study our pills in a large study to see if we can improve exercise in HFpEF. The use of Potassium Nitrate in this study is investigational. Potassium Nitrate has not been approved by the Food and Drug Administration (FDA) for the use being evaluated in this study

This study is recruiting patients who have been diagnosed with Heart Failure with Preserved Ejection Fraction. The study will test whether a drug called mavacamten can lower blood levels of cardiac troponin (a marker of heart muscle injury) and/or NT-proBNP (a marker of heart wall stress). These “biomarkers” are increased in the blood of some people with HFpEF. Additionally, the main research study will provide preliminary information regarding tolerability and safety of mavacamten treatment in HFpEF. Mavacamten is an investigational drug. This means that it has not been approved by the Food and Drug Administration (FDA) or any regulatory agency for routine clinical use, including the treatment of HFpEF

This study is enrolling patients who have been referred for a treadmill exercise stress test. The purpose of this study is to see if there is a relationship between the chemicals and proteins found in human blood and urine and those found in human sweat. The study will also look to see how the chemicals and proteins in human blood, urine, and sweat may change depending on if a person is at rest or doing a stressful activity such as exercising on a treadmill.

This study is enrolling patients who have a diagnosis of congestive heart failure in their medical record, and is interested in determining whether one can use an automated, computer-based method to diagnose a specific cause of heart failure (“transthyretin cardiac amyloidosis”) based on other diagnoses in the medical record. Transthyretin cardiac amyloidosis is a rare disease that results from a protein in the body that becomes misfolded and starts depositing into the heart, a process known as amyloidosis. Because of these proteins getting into the heart muscle, the heart can get stiff and weak, thereby leading to congestive heart failure. Typically this form of heart disease (cardiac amyloidosis) is diagnosed late in its course and it associated with poor survival. However, there are now treatments for this disease, so earlier diagnosis is better. A machine learning (artificial intelligence)-based method to find potential patients with cardiac amyloidosis has been developed. This computer program automates finding patients who may have cardiac amyloidosis based on their other diagnoses in the electronic health record. This study seeks to validate the computer algorithm prospectively to see if it can be useful in patients to determine whether or not cardiac amyloidosis is the cause of heart failure.

This study is enrolling patients diagnosed with a form of heart failure that is characterized by a weakened heart muscle that appears to be pumping in a normal manner. This condition is called “heart failure with preserved ejection fraction” or HFpEF. Patient's heart failure is not responding well to the medicine that their doctor has prescribed, and they continue to have symptoms. Their doctor has determined that the health problems and symptoms they are experiencing may be due to a significant increase in the pressure of one of the chambers in the heart. This pressure build-up causes a variety of symptoms, including tiredness, difficulty breathing, and reduced ability to exercise/walk. This study will evaluate a new device (the “Axon System”) designed to reduce the build-up of pressure described above. The relief of this pressure may reduce some or all of the symptoms they are experiencing. The Axon System is not yet approved by the US Food and Drug Administration (FDA) and is considered investigational. 

The greater splanchnic nerve (“GSN”) is a nerve that connects to the intestines, liver and spleen. It also communicates with the brain and controls a large volume of the venous blood flow in the body. Researchers believe that in patients with HFpEF the GSN is over-stimulated which causes the body to move more blood into the central veins and lungs. This results in the symptoms experienced, such as shortness of breath with exercise and swelling in the arms or legs. Researchers at Axon decided to study if altering the function of the GSN can improve the symptoms of patients with HFpEF. The purpose of this study is to evaluate the safety and potential benefits of ablation (destruction) of one side of the GSN in patients with HFpEF. Ablation of the GSN is performed for other types of conditions, usually for pain relief in patients with abdominal cancer or chronic pain.

This study is enrolling patients who have transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) which is a disease caused by change in a protein called transthyretin (TTR). This change can either be sporadic which is known as wild-type (wtATTR-CM) or due to a mutation of the TTR gene which is hereditary (hATTR-CM). In both cases, these changes can cause the TTR to clump and build up in certain parts of the body such as the nervous system, stomach, intestines, and heart. This build up is called an amyloid deposit. Amyloid deposits can sometimes cause heart disease or neuropathy (nerve damage). When amyloid is deposited into the heart, it can result in a condition referred to as cardiomyopathy. ION-682884 is an investigational drug. “Investigational” means that ION-682884 is not yet approved for use in any settings outside of clinical research studies like this one and is considered experimental. ION-682884 reduces the level of TTR in the blood of animals and healthy volunteers tested to date. Reducing the amount of TTR in the blood may reduce the amount of amyloid deposits in the body and may keep cardiomyopathy from getting worse over time. However, it is not known if ION-682884 will help cardiomyopathy. The purpose of this study is to evaluate the safety of ION-682884 and determine if it can help people with this type of cardiomyopathy.

This study is enrolling patients at Northwestern Memorial Hospital with a history of heart failure with preserved ejection fraction and diabetes mellitus. Doctors at Northwestern University want to better understand if combining three different types of medicines at low doses into one pill can simplify and improve treatment for people who are prone to retaining fluid because of a condition called heart failure with preserved ejection fraction. Specifically, this is the most common type of heart failure and occurs with a normal ejection fraction or squeezing capacity of the heart muscle. Because patients with diabetes mellitus and heart failure with preserved ejection fraction are more likely to retain fluid, we are studying people with both of these conditions. The medicines being used in this study - bumetanide, eplerenone, and dapagliflozin- are all approved by the Food and Drug Administration (FDA) and commonly prescribed by medical providers for heart failure with preserved ejection fraction (bumetanide and eplerenone) and diabetes mellitus (dapagliflozin). In this study, they will be combined into one pill, a “Low-Dose Triple Polydiuretic Therapy” or “LDTPT” to see if LDTPT leads to reduction in NT-proBNP, a hormone which is high among persons who have heart failure with preserved ejection fraction. The (FDA) has not approved the LDTPT pill for general use and its use in this study is experimental.

A prospective cohort study applying proteomic techniques to identify blood-based biomarkers associated with worse baroreceptor reflex response to Valsalva in participants undergoing cardiac catheterization.

This study is enrolling patients to use a wearable insertable cardiac monitor to better understand the various sounds that the heart makes during cardiac tests. You are being asked to participate in this study because Boston Scientific Corporation (BSC) is making a device called the insertable cardiac monitor (ICM) that measures certain heart functions. The device also works when it is placed on top of the chest. BSC made a more comfortable, wearable version of the device to use in this study. The wearable device is called the wearable cardiac monitor (WCM). As part of the study, the WCM will collect data during tests while taped to the skin. The tests include leg raise exercises, lying down, sitting and/or standing, and an optional submaximal exercise test for participants the study doctor determines appropriate. There may also be an echocardiogram during these tests. An echocardiogram takes pictures of the heart using sounds waves created by the heart. The purpose of this study is to collect data during a series of tests to see if the WCM can detect signals related to heart failure. This data will be compared to the data obtained by the echocardiogram.

A Multi-Center, Unblinded, Single-Arm Study to Evaluate Sex Differences in the Acute Effects of PL-3994 on Myocardial cGMP Enhancement and Hemodynamics in Heart Failure with Preserved Ejection Fraction

The primary goal of this study is to investigate the prevalence of coronary microvascular dysfunction in HFpEF patients as measured by Transthoracic Doppler Echocardiography (TDE) - assisted Coronary Flow Reserve (CFR).

This study will determine the efficacy of AG10 in the treatment of subjects with symptomatic transthyretin amyloid cardiomyopathy

This study is enrolling patient who have heart failure (inability of the heart to pump blood with normal efficiency).The purpose of this study is to find out if a drug called dapagliflozin would be effective in improving the blood tests and symptoms related to your heart failure. To do this, dapagliflozin will be compared with placebo. The placebo is a pill that will look like dapagliflozin but will not have active ingredients. Dapagliflozin lowers glucose (sugar) levels in the blood by blocking the effect of specific molecules (small particles) in the body called sodium-glucose transporters. Under normal circumstances, the sodium-glucose transporters in the kidney prevent glucose in your blood stream from leaving the body through urine. Dapagliflozin inhibits the sodium-glucose transporters and lowers the blood glucose by allowing glucose removal through the urine. Dapagliflozin may also mildly decrease body weight and lower blood pressure in certain patients. Decreasing body weight and lowering blood pressure may improve the blood tests and symptoms related to heart failure.

This study examines ion exchange at the gut epithelium and microbial dysbiosis in order to understand their role in Right-Sided Heart Failure and venous congestion.

The primary objective of this non-interventional pilot study is to measure and quantify daily activity in patients with chronic heart failure under real-life conditions by already approved devices

The primary purpose of this study is to better understand HFpEF development by investigating how sex differences between males and females affect cardiac, skeletal, vascular, and adipose tissue’s structure and function. 

MESA is a study of the characteristics of subclinical cardiovascular disease and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.  MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84.  The heart failure ancillary study aims to determine the prevalence, pathogenesis, and phenomics of early heart failure among 3,500 older adults attending the MESA Year-15 exam.

Role of Female Sex and Hormone Status on HFpEF Pathophysiology and Therapy

Real Life Multimarker Monitoring in Patients with Heart Failure

A long-term, multicenter, single-arm, open-label extension of the SERENADE study, to assess the safety and efficacy of macitentan in subjects with heart failure with preserved ejection fraction and pulmonary vascular disease

The primary objective of this trial is to evaluate the clinical efficacy and safety of the IASD System II in symptomatic heart failure patients with an LV ejection fraction ≥40%, and elevated left sided filling pressures despite standard Guideline Directed Medical Therapy (GDMT).  Participants will be randomized 1:1 to an Implant Group or a non-implant Control group, and then followed for 1 year and annually every 12 months for a total of 5 years after index procedure and implant. Participants in the control group will have the option to cross-over to receive the study device after the 24 month visit.

The purpose of this study is to look at the efficacy and safety of the “Study Drug” neladenoson bialanate (BAY 1067197), and to learn more about how the body processes it. This study is recruiting patients who have heart failure with normal ejection fraction (a measurement of the percentage of blood leaving the heart each time it pumps). 

The purpose of this research study is to compare the effects over 30 months of the study drug, tafamidis meglumine (hereafter called tafamidis) at two different doses (20 mg and 80 mg) with placebo to find out which is better for treating TTR-CM.

The purpose of this research study is to test if 200 mg of LCZ696 twice a day, compared to 160 mg of valsartan twice a day, is safe and effective in reducing the complications of heart failure, such as hospitalization for heart failure and death from cardiovascular causes. 

The purpose of this study is to evaluate the potential effectiveness, outcomes, and safety (before, during, and after study procedures) of the Corvia Medical, Inc. IASD® System II (“the study device”) in the treatment of patients with heart failure symptoms and relatively normal pumping of the heart.

The purpose of this study is to test if an investigational study drug, Inorganic Sodium Nitrite Solution (AIR-001) inhaled through a nebulizer (a hand held breathing device), is safe and can improve the ability to tolerate all forms of physical activity including exercise and thus improve quality of life in people who have chronic heart failure.  

The objective of this study is to evaluate the safety and efficacy of 3 dose levels of IW-1973 compared with placebo when administered daily for approximately 12 weeks to patients with HFpEF. The study will evaluate the effect of oral IW-1973 on peak exercise capacity in patients with HFpEF, with or without permanent or persistent atrial fibrillation.

The primary objective of this study is to evaluate the safety and tolerability of AG10 administered to adult patients with symptomatic transthyretin amyloid cardiomyopathy (ATTRCM)

The purpose of this study is to collect information on patients who have transthyretin-associated amyloidosis in order to understand the disease better and improve the care of patients.

The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.

The purpose of the study is to determine if an investigational drug called CLR325 (“the study drug”) is safe and tolerable in heart failure patients.  This is the first time it will be studied in patients with heart failure.

This is a longitudinal, multi-center, study exploring blood expression levels of a predefined set of disease and fibrosis biomarkers in post-ADHF patients, stable HF patients and hypertensive subjects without heart failure.

The purpose of this study is to learn more about the safety and effects of the study drug, tafamidis meglumine, to find the best dose for treating transthyretin amyloid cardiomyopathy (TTR-CM), and to provide participants of this study with tafamidis following completion of that protocol. Participants in this extension will be followed for up to 60 months, with clinic visits and telephone contacts every 6 months.

This study examines the genetic determinants of cardiac contractility.  Specifically, the focus of this study is to search for quantitative trait loci in the human genome and then identify specific SNPs within these loci that influence cardiac contractility.

The purpose of this study is to find out whether a drug called “macitentan” works and is safe in patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Vascular Disease.

REVAMP is a feasibility study in heart failure with preserved ejection fraction (HFpEF) patients who have normal to small left ventricular volumes and evidence of hypertrophy. The pacemaker Sleep function will be used in order to deliver a 5 hour block of sustained pacing at 100 bpm during the night for 4-8 weeks. The purpose is to investigate whether this elevated pacing therapy is tolerated and whether there is a signal of efficacy.

An Open-Label Extension and Safety Monitoring Study of Patients with Symptomatic Transthyretin Cardiomyopathy Who Have Completed the Phase II Study AG10-201

A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients with Heart Failure and Preserved Left Ventricular Ejection Fraction (PH-HFpEF)

INTREPID: A Phase 3 Open-label, Multicenter Study to Evaluate the Long-term Safety and Tolerability of Inhaled LIQ861 (Treprostinil) in Pulmonary Arterial Hypertension (WHO Group 1) Patients

An Open-Label Rollover Study of Levosimendan in Patients with Pulmonary Hypertension with Heart Failure and Preserved Left Ventricular Ejection Fraction (PH-HFpEF)

This study will determine the efficacy of AG10 in the treatment of subjects with symptomatic transthyretin amyloid cardiomyopathy