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Core Lab Studies


Characterizing HIV-related Diastolic Dysfunction

The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.


Prevalence Of Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction

The primary goal in the present study will be to investigate prevalence of coronary microvascular dysfunction in HFpEF patients as measured by Transthoracic Doppler Echocardiography (TDE) - assisted Coronary Flow Reserve (CFR).


Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics

The purpose of this study is to determine the association between indices of cardiac mechanics (particularly global longitudinal strain, early diastolic strain rate, and early and late diastolic tissue velocities) and incident heart failure in the Cardiovascular Health Study (CHS).


Multi Ethnic Study of Atherosclerosis - Early Heart Failure

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.  MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84.  The heart failure ancillary study aims to determine the prevalence, pathogenesis, and phenomics of early heart failure among 3,500 older adults attending the MESA Year-15 exam.


American Heart Association Go Red For Women

The primary purpose of this study is to better understand HFpEF development by investigating how sex differences between males and females affect cardiac, skeletal, vascular, and adipose tissue’s structure and function. 


Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) Heart Failure (HF) Study

The overall objective of the SPIROMICS HF study is to examine heart-lung interactions to suggest new diagnostic and therapeutic strategies for COPD and HF. The study will examine specific cardiopulmonary pathophysiological abnormalities in a variety of COPD subtypes, with echocardiography as a key component in determining the cardiac pathophysiology that is unique to each COPD subtype. The other major components include a cardiopulmonary MRI and cardiac risk factors.


 Hypertension Genetic Epidemiology Network


Northwestern University Echocardiography Core Laboratory

Strain Analysis for PRESERVED-HF