Northwestern University Feinberg School of Medicine

Krainc Laboratory

Krainc Lab News and Announcements

2019

 

December

Dan Ysselstein publishes in Nature Communications with Maria Nguyen, Tiffany Young, Alex Severino, and Michael Schwake: "LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients." https://www.nature.com/articles/s41467-019-13413-w. Highlighted in Feinberg news: https://news.feinberg.northwestern.edu/2020/01/genetics-offers-new-therapeutic-opportunities-for-parkinsons-disease/

October

Lena Burbulla publishes in Science Translational Medicine with Sohee Jeon, Jianbin Zheng and Pingping Song: "A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease." https://stm.sciencemag.org/content/11/514/eaau6870.short. Highlighted in Feinberg news: https://news.feinberg.northwestern.edu/2019/10/personalized-approach-to-parkinsons-treatment/

September

Wesley Peng passes his Ph.D. qualifying exam for NUIN (Northwestern University Interdepartmental Neuroscience Program) and is awarded the F30 NRSA Predoctoral fellowship from NIH (NIA)!

July

Yvette Wong and Wesley Peng publish in Developmental Cell,  “Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2”.  Highlighted in Feinberg news: https://news.feinberg.northwestern.edu/2019/07/mitochondrial-defects-contribute-to-muscular-disease/

April

Niccolo Mencacci is awarded the Movement Disorders Fellowship from the Parkinson’s Foundation!

Yvette Wong is awarded the Distinguished Scholars Fellowship from the Warren Alpert Foundation which supports postdoctoral researchers of exceptional creativity in the basic neurosciences!

Soojin Kim is awarded the 2019 IBRO World Congress Travel Award from the Society of Neuroscience!

March

Dan Ysselstein publishes his Review in Movement Disorders: "Emerging links between pediatric lysosomal storage diseases and adult parkinsonism." https://onlinelibrary.wiley.com/doi/full/10.1002/mds.27631

Yvette Wong publishes her Review in Trends in Cell Biology with Soojin Kim and Wesley Peng: "Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis." https://www.sciencedirect.com/science/article/pii/S0962892419300261?via%3Dihub

February

Katarina Trajkovic publishes in Plos One with Clarissa Valdez and Dan Ysselstein: "Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes." https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211727

Jianbin Zheng publishes in Journal of Medicinal Chemistry with Sohee Jeon, Weilan Jiang, Lena Burbulla, Dan Ysselstein and Kristine Oevel: "Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase." https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01294

Maria Ngyuen publishes her Review in Trends in Neurosciences with Yvette Wong, Dan Ysselstein and Alex Severino: "Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease." https://www.sciencedirect.com/science/article/pii/S0166223618302820?via%3Dihub

2018

December

Maria Nguyen successfully defends her Ph.D. thesis for NUIN (Northwestern University Interdepartmental Neuroscience Program) - Congrats!

November

Clarissa Valdez successfully defends her Ph.D. thesis for NUIN (Northwestern University Interdepartmental Neuroscience Program) - Congrats!

Maria Nguyen is awarded the Society for Neuroscience 2018 Trainee Professional Development Award!

October

Dimitri Krainc is awarded the 2018 American Neurological Association (ANA) Soriano Award and delivered a keynote lecture at the ANA's Presidential Symposium! https://news.feinberg.northwestern.edu/2018/11/krainc-honored-at-american-neurological-association-meeting/

Lena Burbulla publishes in Brain: "Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells." https://academic.oup.com/brain/article/141/10/3052/5087794

September

Soojin Kim passes her Ph.D. qualifying exam for NUIN (Northwestern University Interdepartmental Neuroscience Program)!

Yvette Wong is awarded the K99/R00 Pathway to Independence Award from NIH (NINDS)!

June

MJ Kim publishes in Human Molecular Genetics with Sohee Jeon and Lena Burbulla: "Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function." https://academic.oup.com/hmg/article/27/11/1972/4951460

May

Maria Nguyen publishes in PNAS: "LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease." https://www.pnas.org/content/115/21/5576.long

https://news.feinberg.northwestern.edu/2018/05/early-synaptic-dysfunction-found-in-parkinsons-disease/

Jianbin Zheng publishes in Journal of the American Chemical Society (JACS) with Long Chen, Dan Ysselstein and Michael Schwake: "β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site." https://pubs.acs.org/doi/10.1021/jacs.7b13003

April

Yvette Wong is awarded the Keystone Symposia Scholarship for the Mitochondrial Biology Meeting 2018!

March

Niccolo Mencacci publishes in Annals of Neurology: "Recessive mutations in >VPS13D cause childhood onset movement disorders." https://onlinelibrary.wiley.com/doi/full/10.1002/ana.25204#

February

Yvette Wong publishes in Nature with Dan Ysselstein: "Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis." https://www.nature.com/articles/nature25486

2017

December

Clarissa Valdez publishes in Human Molecular Genetics with Yvette Wong and Michael Schwake: "Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients." https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddx364

Yvette Wong is awarded a Travel Award for the 2017 ASCB Doorstep Meeting, Cell Biology of Degeneration and Repair in the Nervous System!

November

Niccolo Mencacci publishes in Movement Disorder: "A PDE10A de novo mutation causes childhood‐onset chorea with diurnal fluctuations" https://onlinelibrary.wiley.com/doi/full/10.1002/mds.27175

Yvette Wong is awarded the Society for Neuroscience 2017 Trainee Professional Development Award!

October

Dimitri Krainc publishes in Neurology with Maria Usenovic and Yvette Wong: "Analysis of blood-based gene expression in idiopathic Parkinson disease." https://n.neurology.org/content/89/16/1676.long

September

Clarissa Valdez is awarded the F99/K00 Blueprint D-SPAN Award from NIH (NINDS)!

Lena Burbulla publishes in Science with Pingping Song, Yvette Wong, Sohee Jeon and Judith Blanz: "Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease." 

Katarina Trajkovic publishes in Journal of Neuroscience with Hyun Jeong: "Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway." http://www.jneurosci.org/content/37/37/9000.long

May

Yvette Wong is awarded the F32 Postdoctoral NRSA Fellowship from NIH (NINDS)!

Niccolo Mencacci is awarded the 2017 David Marsden Award from Dystonia Europe for an outstanding publication in dystonia research!

February

Yvette Wong publishes her Review in Nature Medicine: "α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies." https://www.nature.com/articles/nm.4269

MJ Kim publishes in Human Molecular Genetics with Yvette Wong: "The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking." https://academic.oup.com/hmg/article/26/4/729/2937789

January

Jessica McDonald publishes her Review in Annual Review of Medicine:  "Lysosomal Proteins as a Therapeutic Target in Neurodegeneration." https://www.annualreviews.org/doi/full/10.1146/annurev-med-050715-104432?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed