Publications
Learn more about the work that we do in the Alan Hauser Laboratory through our recent publications.
- Turner TL, Mitra SD, Kochan TJ, Pincus NB, Lebrun-Corbin M, Cheung BH, Gatesy SW, Afzal T, Nozick SH, Ozer EA et al. Taxonomic characterization of Pseudomonas hygromyciniae sp. nov., a novel species discovered from a commercially purchased antibiotic. Microbiol Spectr 2023 Sep 22;:e0183821. doi:10.1128/spectrum.01838-21
- Atassi G, Medernach R, Scheetz M, Nozick S, Rhodes NJ, Murphy-Belcaster M, Murphy KR, Alisoltani A, Ozer EA, Hauser AR Genomics of Aminoglycoside Resistance in Pseudomonas aeruginosa Bloodstream Infections at a United States Academic Hospital. Microbiol Spectr 2023 Jun 15;11(3):e0508722. pii:e05087-22
- Inniss NL, Kochan TJ, Minasov G, Wawrzak Z, Chang C, Tan K, Shuvalova L, Kiryukhina O, Pshenychnyi S, Wu R et al. A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae. Microbiol Resour Announc 2023 Feb 16;12(2):e0101322. pii:e01013-22
- Cherny KE, Muscat EB, Balaji A, Mukherjee J, Ozer EA, Angarone MP, Hauser AR, Sichel JS, Amponsah E, Kociolek LK Association Between Clostridium innocuum and Antibiotic-Associated Diarrhea in Adults and Children: A Cross-sectional Study and Comparative Genomics Analysis. Clin Infect Dis 2023 Feb 08;76(3):e1244-e1251. doi:10.1093/cid/ciac483
- Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S et al. Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia. J Antimicrob Chemother 2022 Oct 28;77(11):2956-2959. doi:10.1093/jac/dkac245
- Pincus NB, Rosas-Lemus M, Gatesy SWM, Bertucci HK, Brunzelle JS, Minasov G, Shuvalova LA, Lebrun-Corbin M, Satchell KJF, Ozer EA et al. Functional and Structural Characterization of OXA-935, a Novel OXA-10-Family β-Lactamase from Pseudomonas aeruginosa. Antimicrob Agents Chemother 2022 Oct 18;66(10):e0098522. pii:e00985-22
- Kochan TJ, Nozick SH, Medernach RL, Cheung BH, Gatesy SWM, Lebrun-Corbin M, Mitra SD, Khalatyan N, Krapp F, Qi C et al. Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates. BMC Infect Dis 2022 Jul 07;22(1):603. pii:603
- Locci E, Liu J, Pais GM, Chighine A, Kahnamoei DA, Xanthos T, Chalkias A, Lee A, Hauser AR, Chang J et al. Urinary Metabolomics From a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury. Int J Antimicrob Agents 2022 Jul;60(1):106593. doi:10.1016/j.ijantimicag.2022.106593
- Cherny KE, Balaji A, Mukherjee J, Goo YA, Hauser AR, Ozer E, Satchell KJF, Bachta KER, Kochan TJ, Mitra SD et al. Identification of Clostridium innocuum hypothetical protein that is cross-reactive with C. difficile anti-toxin antibodies. Anaerobe 2022 Jun;75:102555. doi:10.1016/j.anaerobe.2022.102555
- Huang Y, Rana AP, Wenzler E, Ozer EA, Krapp F, Bulitta JB, Hauser AR, Bulman ZP Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae. J Antimicrob Chemother 2022 Feb 02;77(2):356-363. doi:10.1093/jac/dkab381
- Bulman ZP, Krapp F, Pincus NB, Wenzler E, Murphy KR, Qi C, Ozer EA, Hauser AR Genomic Features Associated with the Degree of Phenotypic Resistance to Carbapenems in Carbapenem-Resistant Klebsiella pneumoniae. mSystems 2021 Oct 26;6(5):e0019421. pii:e00194-21
- Huang Y, Sokolowski K, Rana A, Singh N, Wang J, Chen K, Lang Y, Zhou J, Kadiyala N, Krapp F et al. Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2021 Aug 17;65(9):e0069221. pii:e00692-21
- Allen JP, Snitkin E, Pincus NB, Hauser AR Forest and Trees: Exploring Bacterial Virulence with Genome-wide Association Studies and Machine Learning. Trends Microbiol 2021 Jul;29(7):621-633. doi:10.1016/j.tim.2020.12.002
- Pincus NB, Ozer EA, Allen JP, Nguyen M, Davis JJ, Winter DR, Chuang CH, Chiu CH, Zamorano L, Oliver A et al. Erratum for Pincus et al., "A Genome-Based Model to Predict the Virulence of Pseudomonas aeruginosa Isolates". mBio 2021 Feb 23;12(1). pii:e00037-21
- Butler DA, Rana AP, Krapp F, Patel SR, Huang Y, Ozer EA, Hauser AR, Bulman ZP Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib. J Antimicrob Chemother 2021 Feb 11;76(3):671-679. doi:10.1093/jac/dkaa480
- Hreha TN, Foreman S, Duran-Pinedo A, Morris AR, Diaz-Rodriguez P, Jones JA, Ferrara K, Bourges A, Rodriguez L, Koffas MAG et al. The three NADH dehydrogenases of Pseudomonas aeruginosa: Their roles in energy metabolism and links to virulence. PLoS One 2021;16(2):e0244142. pii:e0244142
- Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF et al. A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways. EBioMedicine 2020 Dec;62:103112. pii:103112
- Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ et al. Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. Clin Infect Dis 2020 Sep 12;71(6):1524-1531. doi:10.1093/cid/ciz973
- Pincus NB, Ozer EA, Allen JP, Nguyen M, Davis JJ, Winter DR, Chuang CH, Chiu CH, Zamorano L, Oliver A et al. A Genome-Based Model to Predict the Virulence of Pseudomonas aeruginosa Isolates. mBio 2020 Aug 25;11(4). pii:e01527-20
- Moir DT, Bowlin NO, Berube BJ, Yabut J, Mills DM, Nguyen GT, Aron ZD, Williams JD, Mecsas J, Hauser AR et al. A Structure-Function-Inhibition Analysis of the Pseudomonas aeruginosa Type III Secretion Needle Protein PscF. J Bacteriol 2020 Aug 25;202(18). pii:e00055-20
- Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF et al. A Unique Clade of SARS-CoV-2 Viruses is Associated with Lower Viral Loads in Patient Upper Airways. medRxiv 2020 Jun 21;. pii:2020.05.19.20107144
- Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N et al. Natural Clostridioides difficile Toxin Immunization in Colonized Infants. Clin Infect Dis 2020 May 06;70(10):2095-2102. doi:10.1093/cid/ciz582
- Liu J, Pais GM, Avedissian SN, Gilchrist A, Lee A, Rhodes NJ, Hauser AR, Scheetz MH Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational In Vivo Rat Model. Antimicrob Agents Chemother 2020 Apr 21;64(5). pii:e02300-19
- Allen JP, Ozer EA, Minasov G, Shuvalova L, Kiryukhina O, Satchell KJF, Hauser AR A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant. Proc Natl Acad Sci U S A 2020 Mar 24;117(12):6811-6821. doi:10.1073/pnas.1919198117
- Bachta KER, Allen JP, Cheung BH, Chiu CH, Hauser AR Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice. Nat Commun 2020 Jan 28;11(1):543. pii:543
- Kochan TJ, Ozer EA, Pincus NB, Fitzpatrick MA, Hauser AR Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate. Microbiol Resour Announc 2020 Jan 16;9(3). pii:e01408-19
- Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance. Microbiol Resour Announc 2019 Jul 18;8(29). pii:e00623-19
- Allen JP, Hauser AR Diversity of Contact-Dependent Growth Inhibition Systems of Pseudomonas aeruginosa. J Bacteriol 2019 Jul 15;201(14). pii:e00776-18
- Ozer EA, Nnah E, Didelot X, Whitaker RJ, Hauser AR The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages. Genome Biol Evol 2019 Jul 01;11(1):1780-1796. doi:10.1093/gbe/evz119
- Agard MJ, Ozer EA, Morris AR, Piseaux R, Hauser AR A Genomic Approach To Identify Klebsiella pneumoniae and Acinetobacter baumannii Strains with Enhanced Competitive Fitness in the Lungs during Multistrain Pneumonia. Infect Immun 2019 Jun;87(6). pii:e00871-18
- Walter JM, Ren Z, Yacoub T, Reyfman PA, Shah RD, Abdala-Valencia H, Nam K, Morgan VK, Anekalla KR, Joshi N et al. Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia. Am J Respir Crit Care Med 2019 May 15;199(10):1225-1237. doi:10.1164/rccm.201804-0650OC
- Avedissian SN, Liu J, Rhodes NJ, Lee A, Pais GM, Hauser AR, Scheetz MH A Review of the Clinical Pharmacokinetics of Polymyxin B. Antibiotics (Basel) 2019 Mar 22;8(1). pii:31
- Hughes AJ, Knoten CA, Morris AR, Hauser AR ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa. J Med Microbiol 2018 Aug;67(8):1168-1180. doi:10.1099/jmm.0.000782
- Rutherford V, Yom K, Ozer EA, Pura O, Hughes A, Murphy KR, Cudzilo L, Mitchell D, Hauser AR Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa. Environ Microbiol Rep 2018 Aug;10(4):485-492. doi:10.1111/1758-2229.12653
- Krapp F, Ozer EA, Qi C, Hauser AR Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States. Open Forum Infect Dis 2018 May;5(5):ofy074. pii:ofy074
- Kociolek LK, Ozer EA, Gerding DN, Hecht DW, Patel SJ, Hauser AR Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital. J Antimicrob Chemother 2018 May 01;73(5):1222-1229. doi:10.1093/jac/dkx523
- Rhodes NJ, Cruce CE, O'Donnell JN, Wunderink RG, Hauser AR Resistance Trends and Treatment Options in Gram-Negative Ventilator-Associated Pneumonia. Curr Infect Dis Rep 2018 Mar 06;20(2):3. doi:10.1007/s11908-018-0609-x
- Zhang A, Veesenmeyer JL, Hauser AR Phosphatidylinositol 4,5-Bisphosphate-Dependent Oligomerization of the Pseudomonas aeruginosa Cytotoxin ExoU. Infect Immun 2018 Jan;86(1). pii:e00402-17