Northwestern University Feinberg School of Medicine

Alan Hauser Laboratory


Learn more about the work that we do in the Alan Hauser Laboratory through our recent publications.
  1. Walter JM, Ren Z, Yacoub T, Reyfman PA, Shah RD, Abdala-Valencia H, Nam K, Morgan VK, Anekalla KR, Joshi N, McQuattie-Pimentel AC, Chen CI, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Aillon RP, Watanabe S, Williams KJN, Lu Z, Paonessa J, Hountras P, Breganio M, Borkowski N, Donnelly HK, Allen JP, Amaral LA, Bharat A, Misharin AV, Bagheri N, Hauser AR, Budinger GRS, Wunderink RG  Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia.  Am J Respir Crit Care Med  2018 Nov 06;. doi:10.1164/rccm.201804-0650OC
  2. Hughes AJ, Knoten CA, Morris AR, Hauser AR  ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa.  J Med Microbiol  2018 Aug;67(8):1168-1180. doi:10.1099/jmm.0.000782
  3. Krapp F, Ozer EA, Qi C, Hauser AR  Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States.  Open Forum Infect Dis  2018 May;5(5):ofy074. doi:10.1093/ofid/ofy074
  4. Rutherford V, Yom K, Ozer EA, Pura O, Hughes A, Murphy KR, Cudzilo L, Mitchell D, Hauser AR  Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa.  Environ Microbiol Rep  2018 08;10(4):485-492. doi:10.1111/1758-2229.12653
  5. Rhodes NJ, Cruce CE, O'Donnell JN, Wunderink RG, Hauser AR  Resistance Trends and Treatment Options in Gram-Negative Ventilator-Associated Pneumonia.  Curr Infect Dis Rep  2018 Mar 06;20(2):3. doi:10.1007/s11908-018-0609-x
  6. Kociolek LK, Ozer EA, Gerding DN, Hecht DW, Patel SJ, Hauser AR  Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.  J Antimicrob Chemother  2018 May 01;73(5):1222-1229. doi:10.1093/jac/dkx523
  7. Krapp F, Morris AR, Ozer EA, Hauser AR  Virulence Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains from Patients with Necrotizing Skin and Soft Tissue Infections.  Sci Rep  2017 Oct 19;7(1):13533. doi:10.1038/s41598-017-13524-8
  8. Zhang A, Veesenmeyer JL, Hauser AR  Phosphatidylinositol 4,5-Bisphosphate-Dependent Oligomerization of the Pseudomonas aeruginosa Cytotoxin ExoU.  Infect Immun  2018 01;86(1). pii:e00402-17
  9. Ozer EA, Hauser AR, Gerding DN, Espinosa RO, Hecht DW, Kociolek LK  Complete Genome Sequence of Clostridioides difficile Epidemic Strain DH/NAP11/106/ST-42, Isolated from Stool from a Pediatric Patient with Diarrhea.  Genome Announc  2017 Sep 21;5(38). pii:e00923-17
  10. Berube BJ, Murphy KR, Torhan MC, Bowlin NO, Williams JD, Bowlin TL, Moir DT, Hauser AR  Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection.  Antimicrob Agents Chemother  2017 11;61(11). pii:e01202-17
  11. Henry CS, Rotman E, Lathem WW, Tyo KE, Hauser AR, Mandel MJ  Generation and Validation of the iKp1289 Metabolic Model for Klebsiella pneumoniae KPPR1.  J Infect Dis  2017 Feb 15;215(suppl_1):S37-S43. doi:10.1093/infdis/jiw465
  12. Prickett MH, Hauser AR, McColley SA, Cullina J, Potter E, Powers C, Jain M  Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene.  Thorax  2017 01;72(1):40-47. doi:10.1136/thoraxjnl-2015-208027
  13. Ozer EA, Morris AR, Krapp F, Henry CS, Tyo KE, Lathem WW, Hauser AR  Draft Genome Sequence of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Isolate from a Clinical Source.  Genome Announc  2016 May 26;4(3). doi:10.1128/genomeA.00422-16
  14. Hauser AR, Mecsas J, Moir DT  Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.  Clin Infect Dis  2016 07 01;63(1):89-95. doi:10.1093/cid/ciw200
  15. Fitzpatrick MA, Ozer EA, Hauser AR  Utility of Whole-Genome Sequencing in Characterizing Acinetobacter Epidemiology and Analyzing Hospital Outbreaks.  J Clin Microbiol  2016 Mar;54(3):593-612. doi:10.1128/JCM.01818-15
  16. Berube BJ, Rangel SM, Hauser AR  Pseudomonas aeruginosa: breaking down barriers.  Curr Genet  2016 Feb;62(1):109-13. doi:10.1007/s00294-015-0522-x
  17. Rangel SM, Diaz MH, Knoten CA, Zhang A, Hauser AR  The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.  PLoS Pathog  2015 Jun;11(6):e1004945. doi:10.1371/journal.ppat.1004945
  18. Zhang A, Rangel SM, Hauser AR  The great escape: Pseudomonas breaks out of the lung.  Microb Cell  ;2(10):409-411
  19. Tyson GH, Halavaty AS, Kim H, Geissler B, Agard M, Satchell KJ, Cho W, Anderson WF, Hauser AR  A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases.  J Biol Chem  2015 Jan 30;290(5):2919-37. doi:10.1074/jbc.M114.611251
  20. Tran CS, Rangel SM, Almblad H, Kierbel A, Givskov M, Tolker-Nielsen T, Hauser AR, Engel JN  The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier.  PLoS Pathog  2014 Nov;10(11):e1004479. doi:10.1371/journal.ppat.1004479
  21. Fitzpatrick MA, Ozer E, Bolon MK, Hauser AR  Influence of ACB complex genospecies on clinical outcomes in a U.S. hospital with high rates of multidrug resistance.  J Infect  2015 Feb;70(2):144-52. doi:10.1016/j.jinf.2014.09.004
  22. Ozer EA, Fitzpatrick MA, Hauser AR  Draft Genome Sequence of Acinetobacter baumannii Strain ABBL099, a Multidrug-Resistant Clinical Outbreak Isolate with a Novel Multilocus Sequence Type.  Genome Announc  2014 Sep 11;2(5). doi:10.1128/genomeA.00738-14
  23. Ozer EA, Allen JP, Hauser AR  Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt.  BMC Genomics  2014 Aug 29;15:737. doi:10.1186/1471-2164-15-737
  24. Rangel SM, Logan LK, Hauser AR  The ADP-ribosyltransferase domain of the effector protein ExoS inhibits phagocytosis of Pseudomonas aeruginosa during pneumonia.  MBio  2014 Jun 10;5(3):e01080-14. doi:10.1128/mBio.01080-14
  25. Wang N, Ozer EA, Mandel MJ, Hauser AR  Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung.  MBio  2014 Jun 03;5(3):e01163-14. doi:10.1128/mBio.01163-14
  26. Allen JP, Ozer EA, Hauser AR  Different paths to pathogenesis.  Trends Microbiol  2014 Apr;22(4):168-9. doi:10.1016/j.tim.2014.02.013
  27. Hauser AR  Pseudomonas aeruginosa virulence and antimicrobial resistance: two sides of the same coin?  Crit Care Med  2014 Jan;42(1):201-2. doi:10.1097/CCM.0b013e3182a120cd