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Research

What We Do

Dissecting cellular and molecular mechanisms of human diseases by single cell long read sequencing and bioinformatics

Projects

photo of single-cell nanopore sequencing technology

Single-cell nanopore sequencing technologies

Developing single cell third generation sequencing technologies and computational methodologies to study genotypes and phenotypes of same cells.

image of adaptive evolution of brain metastasis; primary tumor to CNS to metastatic tumor; from polyclones to invasion to adaptation

Tracking brain metastasis evolution

Applying novel single-cell DNA and RNA sequencing technologies to deconvolute tumor evolution models during brain metastasis.

image of an intratumor transformation model; single cell RNAseq and single cell CNVs; bulk RNAseq with target SNVs to cell lineages tumor progression

Primary cancer clonal dynamics

Using high throughput single-cell multi-omics to analyze tumor cell populations and their interactions with stromal and immune cell subpopulations.

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