Research
What We Do
Dissecting cellular and molecular mechanisms of human diseases by single cell long read sequencing and bioinformatics
Projects
![photo of single-cell nanopore sequencing technology](../images/project1_scnanornaseq1.jpg)
Single-cell nanopore sequencing technologies
Developing single cell third generation sequencing technologies and computational methodologies to study genotypes and phenotypes of same cells.
![image of chronic reprogramming of single cells; donor transplant to normal in one month to hypertrophy in one year to vasculopathy in five years to graft failure in 10 years](../images/project2_transplant_copy.jpg)
Delineating cellular mechanism of chronic heart transplant failure
Studying the roles of donor and host cells in human transplanted heart failure using single cell long read sequencing technologies and bioinformatics.
![image of adaptive evolution of brain metastasis; primary tumor to CNS to metastatic tumor; from polyclones to invasion to adaptation](../images/project3_brain-metastasis_copy.jpg)
Tracking brain metastasis evolution
Applying novel single-cell DNA and RNA sequencing technologies to deconvolute tumor evolution models during brain metastasis.
![image of an intratumor transformation model; single cell RNAseq and single cell CNVs; bulk RNAseq with target SNVs to cell lineages tumor progression](../images/project4_cancer_cell_atlas-_copy.jpg)
Primary cancer clonal dynamics
Using high throughput single-cell multi-omics to analyze tumor cell populations and their interactions with stromal and immune cell subpopulations.