Research

What We Do

Dissecting cellular and molecular mechanisms of human diseases by single cell long read sequencing and bioinformatics

Projects

photo of single-cell nanopore sequencing technology

Single-cell nanopore sequencing technologies

Developing single cell third generation sequencing technologies and computational methodologies to study genotypes and phenotypes of same cells.

image of chronic reprogramming of single cells; donor transplant to normal in one month to hypertrophy in one year to vasculopathy in five years to graft failure in 10 years

Delineating cellular mechanism of chronic heart transplant failure

Studying the roles of donor and host cells in human transplanted heart failure using single cell long read sequencing technologies and bioinformatics.

image of adaptive evolution of brain metastasis; primary tumor to CNS to metastatic tumor; from polyclones to invasion to adaptation

Tracking brain metastasis evolution

Applying novel single-cell DNA and RNA sequencing technologies to deconvolute tumor evolution models during brain metastasis.

image of an intratumor transformation model; single cell RNAseq and single cell CNVs; bulk RNAseq with target SNVs to cell lineages tumor progression

Primary cancer clonal dynamics

Using high throughput single-cell multi-omics to analyze tumor cell populations and their interactions with stromal and immune cell subpopulations.