Join Us
Northwestern University is ranked as the 9th best university in the country by U.S. News & World Report 2022. Dr. Ruli Gao's laboratory at Feinberg School of Medicine at Northwestern pioneers the development of single-cell long reads sequencing technologies and computational methodologies as well as their applications in dissecting human diseases. Dr. Gao has made significant contributions in understanding tumor evolution models by developing and applying single-cell sequencing technologies and bioinformatic algorithms. These include development of the paradigm shift punctuated copy number evolution (PCNE) model that challenged Darwinian gradualism in tumor evolution (Nature Genetics, 2016), the bi-mode chemo-resistance evolution model where adaptive selection of genotypes and acquired reprogramming of phenotypes are activated in parallel (Cell, 2018), the high throughput nanogrid single nuclear RNA sequencing technology that opened the avenue of analyzing single-cell transcriptomes from archival frozen tissue samples (Nature Communications, 2017), the CopyKat, an integrative Bayesian algorithm to infer single-cell genetic architecture from scRNA-seq data (Nature Biotechnology, 2021), the scNanoGPS, a robust toolkit for analyzing single cell nanopore sequencing data (Shiau et al., 2023), the anaplastic transformation model of thyroid cancer (Lu et al., 2023) and mosaic mutation atlas of human hearts.
Multiple positions are available with detailed requirements as follows:
Postdoctoral Fellow in Bioinformatics
- Strongly interested in developing bioinformatic tools for analyzing single-cell third-generation sequencing data to dissect human diseases including cancer evolution, can therapeutic responses, heart diseases and transplantation rejection.
- Recent graduate with PhD or MD/PhD in Bioinformatics, Genomics, Computational Biology, or equivalent areas.
Postdoctoral Fellow in Genomics
- Strongly interested in studying human disease genomics by developing and applying single-cell third-generation sequencing technologies to obtain same cell mega-omics including but not limited to single cell isoforms, mutations, structure variations, copy numbers and methylations.
- Recent graduate with PhD or MD/PhD in Molecular Genetics, Genomics, Molecular Biology, Biochemistry, Cell Biology, or equivalent areas.
Lab Manager
- Strongly interested in single cell sequencing, next generation and third generation sequencing technologies.
- Strongly interested in developing standard protocols.
- Experience in human tissue processing and cell culture.
- Detail-oriented, with excellent managing skills and leadership.
- Master Degree in Molecular Genetics, Genomics, Molecular Biology, Cell Biology, or equivalent areas. Candidate with PhD in these areas are highly encouraged to apply.
All applicant should send a CV and cover letter to Dr. Ruli Gao (ruli.gao@northwestern.edu). Postdoctoral applicants are expect to include the contact information of three references.