Publications
160 peer-reviewed publications
71 reviews, editorials, and book chapters
2024
Sunshine, H. L., Cicchetto, A. C., Kaczor-Urbanowicz, K. E., Ma, F., Pi, D., Symons, C., Turner, M., Shukla, V., Christofk, H. R., Vallim, T. A., and Iruela-Arispe, M. L. 2024. Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. Cell Rep. 43(1):113627. PMCID: PMC10884959.
Romay, M. C., Knutsen, R. H., Ma, F., Mompeón, A., Hernandez, G. E., Salvador, J., Mirkov, S., Batra, A., Sullivan, D. P., Procissi, D., Buchanan, S., Kronquist, E., Ferrante, E. A., Muller, W. A., Walshon, J., Steffens, A., McCortney, K., Horbinski, C., Tournier-Lasserve, E., Sonabend, A. M., Sorond, F.A., Wang, M.M., Boehm, M., Kozel, B.A., and Iruela-Arispe, M. L. 2024. Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice. J Clin Invest. 134(2): e166134. PMCID: PMC10786701.
2023
Dominguez, A., Iruela-Arispe, M.L. 2023. Integration of Chemo-mechanical signaling in response to fluid shear stress by the endothelium. Curr Opin Cell Biol. 85:102232. doi: 10.1016/j.ceb.2023.102232. PMID: 37703647.
Fernández-Chacón, M., Mühleder, S., Regano, A., Garcia-Ortega, L., Rocha, S.F., Torroja, C., Sanchez-Muñoz, M.S., Lytvyn, M., Casquero-Garcia, V., De Andrés-Laguillo, M., Muhl, L., Orlich, M.M., Gaengel, K., Camafeita, E., Vázquez, J., Benguría, A., Iruela-Arispe, M.L., Dopazo, A., Sánchez-Cabo, F., Carter, H., and Benedito, R. 2022. Incongruence between transcriptional and vascular pathophysiological cell states. Nat Cardiovasc Res. 2: 530-549. DOI: 0.1038/s44161-023-00272-4.
Quijada, P., Park, S., Zhao, P., Kolluri, K.S., Wong, D., Shih, K.D., Fang, K., Pezhouman, A., Wang, L., Daraei, A., Tran, M.D., Rathbun, E.M., Burgos Villar, K.N., Garcia-Hernandez, M.L., Pham, T.T., Lowenstein, C.J., Iruela-Arispe, M.L., Carmichael, S.T., Small, E.M., and Ardehali, R. 2023. Cardiac pericytes mediate the remodeling response to myocardial infarction. J Clin Invest. 133(10): e162188. PMCID: 10178847.
Cicchetto, A.C., Jacobson, E.C., Sunshine, H., Wilde, B.R., Krall, A.S., Jarrett, K.E., Sedgeman, L., Turner, M., Plath, K., Iruela-Arispe, M.L., Vallim, T.Q.D.A., and Christofk, H.R. 2023. ZFP36-mediated mRNA decay regulates metabolism. Cell Rep. 42(5): 112411. PMCID: 10332406.
Iruela-Arispe, M.L. 2023. How to target vascular leakage in retinopathy: could a lipid tighten the pipes? EMBO Mol Med. 15(5): e17520. PMCID: PMC10165356.
Afshar, Y., Ma, F., Quach, A., Jeong, A., Sunshine, H.L., Freitas, V., Jami-Alahmadi, Y., Helaers, R., Li, X., Pellegrini, M., Wohlschlegel, J.A., Romanoski, C.E., Vikkula, M., and Iruela-Arispe, M.L. 2023. Transcriptional drifts associated with environmental changes in endothelial cells. Elife. 12:e81370. PMCID: 10168696.
2022
Taylor, H.A., Finkel, T., Gao, Y., Ballinger, S.W., Campo, R., Chen, R., Chen, S.H., Davidson, K., Iruela-Arispe, M.L., Jaquish, C., LeBrasseur, N.K., Odden, M.C., Papanicolaou, G.J., Picard, M., Srinivas, P., Tjurmina, O., Wolz, M., and Galis, Z.S. 2022. Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop. FASEB J. 36(12):e22639. PMCID: PMC9703084.
Ghochani, Y., Muthukrishnan, S.D., Sohrabi, A., Kawaguchi, R., Condro, M.C., Bastola, S., Gao, F., Qin, Y., Mottahedeh, J., Iruela-Arispe, M.L., Rao, N., Laks, D.R., Liau, L.M., Mathern, G.W., Goldman, S.A., Carmichael, S.T., Nakano, I., Coppola, G., Seidlits, S.K., and Kornblum, H.I. 2022. A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell Rep. 41(3):111511. PMCID: PMC9642966
Salvador, J., Iruela-Arispe, M.L. 2022. Nuclear Mechanosensation and Mechanotransduction in Vascular Cells. Front Cel Dev Biol. 10:905927. PMCID: PMC9247619.
Muratoglu, S.C., Charette, M.F., Galis, Z.S., Greenstein, A.S., Daugherty, A., Joutel, A., Kozel, B.A., Wilcock, D.M., Collins, E.C., Sorond, F.A., Howell, G.R., Hyacinth, H.I., Lloyd, K.K.C., Stenmark, K.R., Boehm, M., Kahn, M.L., Corriveau, R., Wells, S., Bussey, T.J., Sukoff Rizzo, S.J., and Iruela-Arispe, M.L. 2022. Perspectives on cognitive phenotypes and models of vascular disease. ATVB. 42(7): 831-838. PMCID: PMC9233038.
Salvador, J., Hernandez, G.E., Ma, F., Abrahamson, C.W., Pellegrini, M., Goldman, R., Ridge, K.M., and Iruela-Arispe, M.L. 2022. Transcriptional evaluation of the ductus arteriosus at the single-cell level uncovers a requirement for vimentin for complete closure. ATVB. 42(6): 732-742.
Abdelilah-Seyfried, S., Iruela-Arispe, M.L., Penninger, J.M., Tournier-Lasserve, E., Vikkula, M., and Cleaver, O. 2022. Recalibrating vascular malformations and mechanotransduction by pharmacological intervention. J Clin Invest. 132(8):e160227. PMCID: PMC9012280.
Calvanese, V., Capellera-Garcia, S., Ma, F., Fares, I., Liebscher, S., Ng, E.S., Ekstrand, S., Aguadé-Gorgorió, J., Vavilina, A., Lefaudeux, D., Nadel, B., Li, J.Y., Wang, Y., Lee, L.K., Ardehali, R., Iruela-Arispe, M.L., Pellegrini, M., Stanley, E.G., Elefanty, A.G., Schenke-Layland, K., and Mikkola, H.K.A 2022. Mapping human hematopoietic stem cell ontogeny from hemogenic endothelium to birth. Nature. 604: 534-540. PMCID: PMC9645817.
Hernandez, G.E., Ma, F., Martinez, G., Firozabadi, N.B., Salvador, J., Juang, L.J., Zhao, P., Lopez, D.A., Ardehali, R., Beaudin, A.E., Kastrup, C.J., Pellegrini, M., Flick, M.J., Iruela-Arispe, M.L. 2022. Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state. Nat Cardiovasc Res. 1:67–84. PMCID: PMC9121812.
2021
Afshar, Y., Iruela-Arispe, M.L. 2021. Angiogenesis. Chapter in: Fetal and Neonatal Physiology, Sixth Edition. Editors: Polin, R.A., Abman, S.H., Rowitch, D., and Benitz, W.E. Philadelphia, PA: Elsevier. Pp. 54-57.
Iruela-Arispe, M.L. 2021. An inflammatory clock for healthy aging. Nature Aging. 1: 574-575.
Ma, F., Hughes, T.K., Teles, R.M.B., Andrade, P.R., de Andrade Silva, B.J., Plazyo, O., Tsoi, L.C., Do, T., Wadsworth, M.H. 2nd, Oulee, A., Ochoa, M.T., Sarno, E.N., Iruela-Arispe, M.L., Klechevsky, E., Bryson, B., Shalek, A.K., Bloom, B.R., Gudjonsson, J.E., Pellegrini, M., Modlin, R.L. 2021. The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 22(7): 839-850. PMCID: PMC8579511.
Iruela-Arispe, M.L. 2021. New technological developments and their impact in vascular research. Curr Opin Hemat. 28(3): 177-8. PMID: 33714968.
Ma, F., Hernandez, G.E., Romay, M., Iruela-Arispe, M. 2021. Single-cell RNA sequencing to study vascular diversity and function. Curr Opin Hematol. 28(3): 221-229. PMID: 33714967.
Archer, B., Mack, J., Acosta, S., Naksone, R., Dahoud, F., Youssef, K., Goldstein, A., Goldsman, A., Held, M.C., Wiese, M., Bluemich, B., Wessling, M., Emondts, M., Klankermayer, J., Iruela-Arispe, L., Bouchard, L. 2021. Mapping Cell Viability Quantitatively and Independently from Cell Density in 3D Gels Noninvasively. IEE Trans Biomed Eng. 68(110): 2940-47. PMCID:PMC8326301.
Hilfenhaus, G., Mompeón, A., Freshman, J., Prajapati, D., Hernandez, G., Freitas, V.M., Ma, F., Langenbacher, A.D., Mirkov, S., Song, D., Cho, B., Goo, Y.A., Pellegrini, M., Chen, J., Damoiseaux, R., Iruela-Arispe, M.L. 2021. A high-content screen identifies drugs that restrict tumor cell extravasation across the endothelial barrier. Cancer Res. 81(3):619-633. PMCID: PMC7916904.
Evans, C.E., Iruela-Arispe, M.L., Zhao, Y. 2021. Mechanisms of endothelial regeneration and vascular repair and their application to regenerative medicine. Am J Pathol. 191(1):52-65. PMCID: PMC7560161.
2020
Hernandez, G.E., Iruela-Arispe, M.L. 2020. The Many Flavors of Monocyte/Macrophage-Endothelial Cell Interactions. Curr Opin Hematol. 27(3):181-189. PMCID: PMC7717488.
Chen, G., Li, Z., Liu, Y., Chen, D., Beers, J., Cudrici, C., Ferrante, E.A., Schwartzbeck, R., Dmitrieva, N., Yang, D., Zou, J., Iruela-Arispe, M.L., Boehm, M. 2020. Generation of human induced pluripotent stem cells (NIHTVBi004-A, NIHTVBi005-A, NIHTVBi006-A, NIHTVBi007-A, NIHTVBi008-A) from 5 CADASIL patients with NOTCH3 mutation. Stem Cell Res. 45:101821. PMCID: PMC7309701.
2019
Shirali, A.S., Lluri, G., Guihard, P.J., Conrad, M.B., Kim, H., Pawlikowska, L., Boström, K.I., Iruela-Arispe, M.L., and Aboulhosn, J.A. 2019. Angiopoietin-2 predicts morbidity in adults with Fontan physiology. Sci Rep. 9(1): 18328. PMCID: PMC6892891.
Romay, M.C., Toro, C., Iruela-Arispe, M.L. 2019. Emerging molecular mechanisms of vascular dementia. Curr Opin Hematol. 26(3):199-206. PMCID: PMC6986812.
Iruela-Arispe, M.L. 2019. A focus on vascular malformations. Curr Opin Hematol. 26(3): 152-153. PMCID: PMC6986810.
Keklikoglou, I., CIanciaruso, C., Guc, E., Squadrito, M.L., Spring, L.M., Tazzyman, S., Lambien, L., Poissonnier, A., Ferraro, G.B., Baer, C., Cassara, A., Guichard, A., Iruela-Arispe, M.L., Lewis, C.E., Coussens, L.M., Bardia, A., Jain, R.K., Pollard, J.W., De Palma, M. 2019. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biol. 21(2). PMCID: PMC6525097.
Archer, B., Ueberrueck, T., Mack, J.J., Yousef, K., Jarenwattananon, N.N., Rall, D., Wypysek, D., Wiese, M., Bluemich, B., Wessling, M., Iruela-Arispe, M.L., Bouchard, L. 2019. Non-Invasive Quantification of Cell Density in Three-Dimensional Gels by MRI. IEEE Trans Biomed Eng. 66(3):821-830. PMCID: PMC7811270.
2018
Iruela-Arispe, M.L. 2018. Pumping blood with self-reliance and cooperation. JEM. 215(10):2480-2482. PMCID: PMC6170172.
Iruela-Arispe, M.L. 2018. A dual origin for blood vessels. Nature. 562(7726):195-197. PMCID: PMC7010229.
McDonald, A.I., Shirali, A.S., Aragón, R., Ma, F., Hernandez, G., Vaughn, D.A., Mack, J.J., Lim, T.Y., Sunshine, H., Zhao, P., Kalinichenko, V., Pelegrini, M., Ardehali, R., Iruela-Arispe, M.L. 2018. Endothelial Regeneration of Large Vessels is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities. Cell Stem Stell. 23(2):210-225. PMCID: PMC6178982.
Jelinek, D., Flores, A., Uebelhoer, M., Pasque, V., Plath, K., Iruela-Arispe, M.L., Christofk, H.R., Lowry, W.E., Coller, H.A. 2018. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. J Vis Exp. (136): e58860. PMCID: PMC6101961.
Chattopadhyay, A., Yang, X., Mukherjee, P., Sulaiman, D., Fogelman, H.R., Grijalva, V., Dubinnet, S., Wasler, T.C., Paul, M.K., Salehi-Rad, R., Mack, J.J., Iruela-Arispe, M.L., Navab, M., Fogelman, A.M., Reddy, S.T. 2018. Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. Sci Rep. 8(1): 9032. PMCID: PMC5998131.
Hilfenhaus, G., Nguyen, D., Freshman, J., Prajapati, D., Ma, F., Song, D., Ziyad, S., Cuadrado, M., Pellegrini, M., Bustelo, X.R., Iruela-Arispe, M.L. 2018. VAV3-induced Cytoskeletal Dynamics Contribute to Heterotypic Properties of Endothelial Barriers. J Cell Biol. 217(8):2813-2830. PMCID: PMC6080943.
Nowak-Sliwinska, P., Alitalo, K., Allen, A., Anisimov, A., Aplin, A.C., Auerbach, R., Augustin, A.G., Bates, D.O., van Beijnum, J.T., Bender, R.H.,F., Bergers,G., Bikfalvi, A., Bischoff, J., Böck, B.C., Brooks, P.C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A.M., Cleaver, O., Coukos, G., Davis, G.E., De Palma, M., Dimberg, A., Dings, R.P.M., Djonov, V., Dudley, A.C., Dufton, N.P., Fendt, S.M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesuière, B., Gong, Y., Griffin, R.J., Harris, A.L., Hughes, C.C.W., Hultgren, N.W., Iruela-Arispe, M.L., Irving, M., Jain, R.K., Kalluri, R., Kalucka, J., Kerbel, R.S., Kitajewski, J., Klaassen, I., Kleinmann, H.K., Koolwijk, P., Kuczynski, E., Kwak, B.R., K. Marien, J. M. Melero-Martin, L. L. Munn, R. F. Nicosia, A. Noel, J. Nurro, A.-K. Olsson, T. V. Petrova, Pietras, K., Pili, R., Pollard, J.W., Post, M.J., Quax, P.H.A., Rabinovich, G.A., Raica, M., Randi, A.M., Ribatti, D., Ruegg, C., Schlingemann, R.O., Schulte-Merker, S., Smith, L.E.H., Song, J.W., Stacker, S.A., Stalin, J., Stratman, A.N., Van de Velde, M., van Hinsbergh, V.W.M., Vermeulen, P.B., Waltenberger, J., Weinstein, B.M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M.C., Griffioen, A.W. 2018. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 21(3):425-532. PMCID: PMC6237663.
Mack, J.J., Iruela-Arispe, M.L. 2018. NOTCH regulation of the endothelial cell phenotype. Curr Opin Hematol. PMCID: PMC5902133.
Freitas, V.M., Hilfenhaus, G., Iruela-Arispe, M.L. 2018. Metastasis of Circulating Tumor Cells: Speed Matters. Dev Cell. 45(1): 3-5. PMCID: PMC8006089.
Shirali, A.S., Romay, M.C., McDonald, A.I., Su, T., Steel, M.E., Iruela-Arispe, M.L. 2018. A multi-step transcriptional cascade underlies vascular regeneration in vivo. Scientific Reports. 8(1):5430. PMCID: PMC5882937.
Li, L. Zheng, Q. Bhutkar, A., Galván, J., Karamitopoulou, E., Necsulea, A., Noordermeer, D., Piersigilli, A., Peng, M., Perren, A., Ziobec, I., Robinson, H., Iruela-Arispe, M.L., Hanahan, D. 2018. GKAP acts as a genetic modulator of NMDAR signaling to govern invasive tumor growth. Cancer Cell. 33(4)736-751.e5. PMCID: PMC5896248.
Sereti, K.I., Nguyen, N.B., Kamran, P., Zhao, P., Ranjbarvaziri, S., Park, S., Sabri, S., Engel, J.L., Sung, K., Kulkarni, R.P., Ding, Y., Hsiai, T.K., Plath, K., Ernst, J., Sahoo, D., Mikkola, H.K.A., Iruela-Arispe, M.L., Ardehali, R. 2018. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat Commun. 9(1): 754. PMCID: PMC5821855.
Ziyad, S., Riordan, J.D., Cavanaugh, A.C., Su, T., Hernandez, G.E., Hilfenhaus, G., Morselli, M., Huyn, K., Wang, K., Chen, J.N., Dupuy, A.J., Iruela-Arispe, M.L. 2018. A forward genetic screen targeting the endothelium reveals a regulatory role for the lipid kinase Pi4Ka in myelo- and erythropoiesis. Cell Reports. 22(5): 1211-1224. PMCID: PMC5828030.
Duran, I., Tenney, J., Warren, C.M., Sarukhanov, A., Csukasi, F., Skalansky, M., Iruela-Arispe, M.L., Krakow, D. 2018. NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot. Am J Med Genet A. 176(3): 649-656. PMCID: PMC7836020.
Iruela-Arispe, L.M. 2018. VEGF. Chapter in: Encyclopedia of Signaling Molecules, 2nd Edition. Springer. Sangdun Choi, Editor-in-Chief. Pp 5915-5920.
Mundi, S., Massaro, M., Scoditti, E., Carluccio, M.A., van Hunsberg, V.W.M., Iruela-Arispe, M.L., De Caterina, R. 2018. Endothelial permeability, LDL deposition, and cardiovascular risk factors-a review. Cardiovasc Res. 114(1): 35-52. PMCID: PMC5738457.
2017
Mack, J.J., Mosqueiro, T.S., Archer, B.J., Jones, W.M., Sunshine, H., Faas, G.C., Briot, A., Aragón, R., Su, Y.T., Romay, M.C., McDonald, A.I., Kuo, C., Lizama, C.O., Lane, T.F., Zovein, A.C., Fang, Y., Tarling, E.J., de Aguiar Vallim, T.Q., Navab, M., Fogelman, A.M., Bouchard, L.S., Iruela-Arispe., M.L. 2017. NOTCH1 is a mechanosensor in adult arteries. Nature Communications. 8(1): 1620. PMCID: PMC5696341.
Sunshine, H., Iruela-Arispe, M.L. 2017. Membrane lipids and cell signaling. Curr Opin Lipidol. 28(5): 408-413. PMCID: PMC5776726.
Toullec, A., Valerie, B., Rannou, E., Tarlet, G., Guipaud, O., Robine, S., Iruela-Arispe, L.M., Francois, A., Milliat, F. 2017. HIF-1α deletion in the endothelium, but not in the epithelium, protects from radiation-induced enteritis. Cell Mol Gastroenterol Hepatol. 5(1): 15-30. PMCID: PMC5738457.
Zovein, A.C., Iruela-Arispe, M.L. 2017. Angiogenesis. Chapter in: Fetal and Neonatal Physiology, Fifth Edition. Editors: Polin, R.A., Abman, S.H., Rowitch, D.H., Benitz, W.E., and Fox, W.W. Philadelphia, PA: Elsevier. Pp. 85-89.
Mukherjee, P., Hough, G., Chattopadhyay, A., Navab, M., Fogelman, H. R., Meriwether, D., Williams,K., Bensinger,S., Moller, T., Faull, K.F., Lusis, A., Iruela-Arispe, M.L., Bostrom, K., Tontonoz, P., Reddy, S., Fogelman, A. 2017. Transgenic Tomatoes Expressing the 6F Peptide and Ezetimibe Prevent Diet-induced Increases of Interferon-β and Cholesterol 25-hydroxylase in Jejunum. Journal of Lipid Research. J Lipid Res. 58(7):1636-1647. PMCID: PMC5538285.
Rose, B.A., Yokota, T., Chintalgattu, V., Ren, S., Iruela-Arispe, M.L., Khakoo, A.Y., Wang, Y. 2017. Cardiac Myocyte p38α Kinase Regulates Angiogenesis via Myocyte-Endothelial Cell Cross-talk During Stress-Induced Remodeling in Heart. Journal of Biological Chemistry. J Biol Chem. 292(31): 12787-12800. PMCID: PMC5546022.
Mintet, E., Lavigne, J., Paget, V., Tarlet, G., Buard, V., Guipaud, O., Sabourin, J.C., Iruela-Arispe, M.L., Milliat F, Francois A. 2017. Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. Scientific Reports. 7(1)4933. PMCID: PMC5503994.
Jumabay, M., Zhumabai, J., Mansurov, N., Niklason, K.C., Guihard, P.J., Fogelman, A.M., Iruela-Arispe, M.L., Yao, Y., Saparov, A., Bostrom, K.I. 2017. Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells. J Cell Physiol. 233(3):1812-1822. PMCID: PMC5668204.
2016
Guihard, P.J., Yao, J., Blazquez-Medela, A.M., Iruela-Arispe, M.L., Bostrom, K.I., Yao, Y. 2016. Endothelial-Mesenchymal transition in vascular calcification of Ins2 Akita/+ Mice. PLoS One. 11(12):e0167936. PMCID: PMC5148029.
Shirali, A.S., McDonald, A.I., Mack, J.J., Iruela-Arispe, M.L. 2016. Reproducible arterial denudation injury by infrarenal abdominal aortic clamping in a murine model. J Vis Exp. 117:54755. PMCID: PMC5226299.
Inkeles, M.S., Teles, R.M., Pouldar, D., Andrade, P.R., Madigan, C.A., Lopez, D., Ambrose, M., Noursadeghi, M., Sarno, E.N., Rea, T.H., Ochoa, M.T., Iruela-Arispe, M.L., Swindell, W.R., Ottenhoff, T.H., Geluk, A., Bloom, B.R., Pellegrini, M., Modlin, R.L. 2016. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight. 1(15):e88843. PMCID: PMC5033757.
He, H., Mack, J.J., Güc, E., Warren, C.M., Squadrito, M.L., Kilarski, W.W., Baer, C., Freshman, R.D., McDonald, A.I., Ziyad, S., Swartz, M.A., De Palma, M., Iruela-Arispe, M.L. 2016. Perivascular macrophages limit permeability. ATVB. 36(11):2203-2212. PMCID: PMC5083209.
Briot, A., Bouloumie, A., Iruela-Arispe, M.L. 2016. Notch, lipids, and endothelial cells. Curr Opin Lipidol. 27(5):513-20. PMCID: PMC5340259.
Uebelhoer, M., Iruela-Arispe, M.L. 2016. Cross-talk between signaling and metabolism in the vasculature. Vascul Pharmacol. 83:4-9. PMCID: PMC4966612.
Youssef, K., Jarenwattananon, N., Archer, B., Mack, J., Iruela-Arispe, L., Bouchard, L. 2016. 4-D flow control in porous scaffolds: Toward a Next Generation of Bioreactors. IEEE Trans Biomed Eng. 64(1):61-69. PMCID: PMC8006392.
2015
Briot, A., Civelek, M., Seki, A., Hoi, K., Mack, J.J., Lee, S.D., Kim, J., Hong, C., Yu, J., Fishbein, G.A., Vakili, L., Fogelman, A.M., Fishbein M.C., Lusis, A.J., Tontonoz, P., Navab, M., Berliner, J.A., Iruela-Arispe, M.L. 2015. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. J Exp Med. 212(12):2147-63. PMCID: PMC4647265.
Rannou, E., Francois, A., Toullec, A., Guipaud, O., Buard, V., Tarlet, G., Mintet, E., Jaillet, C., Iruela-Arispe, M.L., Benderitter, M., Sabourin, J.C., Milliat, F. 2015. In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury. Sci Rep. 5:15738. PMCID: PMC4625166.
Hernandez-Garcia, R., Iruela-Arispe, M.L., Reyes-Cruz, G., Vazquez-Prado, J. 2015. Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascul Pharmacol. 74:60-72. PMCID: PMC8127077.
Moughon, D., He, H., Schokrpur, S., Jiang, Z.K., David, J., Lin, C., Iruela-Arispe, M.L., Dorigo, O., Wu, L. 2015. Macrophage blockade using CSF1R inhibitors reverses the vascular leakage underlying malignant ascites in late-stage epithelial ovarian cancer. Cancer Res. 75(22):4742-52. PMCID: PMC4675660.
McDonald, A.I., Iruela-Arispe, M.L. 2015. Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury. Vascul Pharmacol. 72:9-15. PMCID: PMC4547868.
Domigan, C.K., Warren, C.M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A., Duan, L., Torres-Collado, A.X., Castellani, L.W., Elashoff, D., Christofk, H.R., van der Bliek, A.M., Potente, M., Iruela-Arispe, M.L. 2015. Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. J Cell Sci. 128(12):2236-48. PMCID: PMC4487014.
Simons, M., Alitalo, K., Annex, B.H., Augustin, H.G., Beam, C., Berk, B.C., Byzova, T., Carmeliet, P., Chilian, W., Cooke, J.P., Davis, G.E., Eichmann, A., Iruela-Arispe, M.L., Keshet, E., Sinusas, A.J., Ruhrberg, C., Woo, Y.J., Dimmeler, S.; American Heart Assoc. Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia. 2015. State-of-the-Art methods for evaluation of Angiogenesis and Tissue Vascularization: A scientific statement from the American Heart Association. Circ Res. 116(11):e99-132.
Rodriguez-Manzaneque, J.C., Fernandez- Rodriguez, R., Rodriguez-Baena, F.J., Iruela-Arispe, M.L. 2015. ADAMTS proteases in vascular biology. Matrix Biol. 44-46:38-45.
Briot, A., Iruela-Arispe, M.L. 2015. Blockade of specific NOTCH ligands: a new promising approach in cancer therapy. Cancer Discov. 5(2): 112-114. PMCID: PMC4342039.
Domigan, C.K., Ziyad, S., Iruela-Arispe, M.L. 2015. Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction. Arterioscler Thromb Vasc Biol. 35(1): 30-39. PMCID: PMC4270848.
2014
Briot, A., Jaroszewicz, A., Warren, C.M., Lu, J., Touma, M., Rudat, C., Hofmann, J.J., Airik, R., Weinmaster, G., Lyons, K., Wang, Y., Kispert, A., Pellegrini, M., Iruela-Arispe, M.L. 2014. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 31(6): 707-721. PMCID: PMC4311887.
Domigan, C.K., Iruela-Arispe, M.L. 2014. Stealing VEGF from thy neighbor. Cell. 159(3): 473-474.
Warren, C.M., Iruela-Arispe, M.L. 2014. Podosome rosettes precede vascular sprouts in tumour angiogenesis. Nat Cell Biol. 16(10): 928-930. PMCID: PMC8128323.
Nowak-Sliwinska, P., Segura, T., Iruela-Arispe, M.L. 2014. The chicken chorioallantoic membrane model in biology, medicine and bioengineering. Angiogenesis. 17(4): 779-804.
Michael, I.P., Westenskow, P.D., Hacibekiroglu, S., Greenwald, A.C., Ballios, B.G., Kurihara, T., Li, Z., Warren, C.M., Zhang, P., Aguilar, E., Donaldson, L., Marchetti, V., Baba, T., Hussein, S.M., Sung, H.K., Iruela-Arispe, M.L., Rini, J.M., van der Kooy, D., Friedlander, M., Nagy, A. 2014. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med. 6:(4) 604-623.
Goddard, L.M., Murphy, T.J., Org, T., Enciso, J.M., Hashimoto-Partyka, M.K., Warren, C.M., Domigan, C.K., McDonald, A.I., He, H., Sanchez, L.A., Allen, N.C., Orsenigo, F., Chao, L.C., Dejana, E., Tontonoz, P., Mikkola, H.K., Iruela-Arispe, M.L. 2014. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell. 156(3): 549-562.
Griffin, D.R., Borrajo, J., Soon, A., Acosta-Velez, G.F., Oshita, V., Darling, N., Mack, J., Barker, T., Iruela-Arispe, M.L., Segura, T. 2014. Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. Chemobiochem. 15(3): 233-242.
Warren, C.M., Ziyad, S., Briot, A., Der, A., Iruela-Arispe, M.L. 2014. A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Science Signaling. 7(307): 233-242.
2013
Milde, F., Lauw, S. Koumoutsakos, P., Iruela-Arispe, M.L. 2013. The mouse retina in 3D: quantification of vascular growth and remodeling Integr Biol. Integr Biol. 5(12): 233-242.
Turlo, K.A., Scapa, J., Bagher, P., Jones, A.W., Feil, R., Korthuis, R.J., Segal, S.S., Iruela-Arispe, M.L. 2013. Beta1-Integrin is essential for vasoregulation and smooth muscle survival In Vivo. Arterioscler Thromb Vasc Biol 33: 2325-2335.
Iruela-Arispe, M.L., Beitel, G.J. 2013. Tubulogenesis. Development. 140: 2851-2855.
Corada, M., Orsenigo, F., Morini, M.F., Pitulescu, M.E., Bhat, G., Nyqvist, D., Breviario F., Conti, V., Briot, A., Iruela-Arispe, M.L., Adams, R.H., Dejana, E. 2013. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat. Commun. 4:2609. PMCID: PMC3826640.
Goddard, L.M., Ton, A.M., Org, T., Mikkola, H.K., Iruela-Arispe, M.L. 2013. Selective suppression of endothelial cytokine production by progesterone receptor. Vascul. Pharmacol 59: 36-43. PMCID: PMC3819224.
Janzen, D.M., Rosales, M.A., Paik, D.Y., Lee, D.S., Smith, D.A., Witte, O.N., Iruela-Arispe, M.L., Memarzadeh, S. 2013. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer Res 73: 4697-4710. PMCID: PMC3752407.
Roodhart, J.M.L., He, H., Daenen, L.G.M., Monvoisin, A., Barber, C., van Amersfoort, M., Hofmann, J.J., Radtke, F., Lane, T.F., Voest, E.E., Iruela-Arispe, M.L. 2013. Notch1 regulates angio-supportive bone-marrow-derived cells in mice: relevance to chemoresistance. Blood 122: 143-153. PMCID: PMC3701902
Baer, C., Squadrito, M.L., Iruela-Arispe, M.L., De Palma, M. 2013. Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches. Exp Cell Res 319: 1626-1634.
Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A.S., Trindade, A., Duarte, A., Zovein, A.C., Iruela-Arispe, M.L., Nih, L.R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z.W., Simons, M., Eichmann, A., le Noble, F. 2013. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development 140: 1720-1729. PMCID: PMC4074271.
Goddard, L.M., Iruela-Arispe, M.L. 2013. Cellular and molecular regulation of vascular permeability. Thromb. Haemost 109: 407-415. PMCID: PMC3786592.
Defalco, T., Saraswathula, A., Briot, A., Iruela-Arispe, M.L., Capel, B. 2013. Testosterone levels influence mouse fetal leydig cell progenitors through Notch signaling. Biol. Reprod 88: 1-12. PMCID: PMC4013875.
Mack, J.J., Youssef, K., Noel, O.D., Lake, M.P., Wu, A., Iruela-Arispe, M.L., Bouchard, L.S. 2013. Real-time maps of fluid flow fields in porous biomaterials. Biomaterials 34: 1980-86. PMCID: PMC3714210.
2012
Domigan, C.K., Iruela-Arispe, M.L. 2012. Recent advances in vascular development. Curr Opin Hematol 19: 176-183. PMCID: PMC3666551.
Howell, M.D., Torres-Collado, A.X., Iruela-Arispe, M.L., Gottschall, P.E. 2012. Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1. PLoS One 7: e47226. PMCID: PMC3469530.
Hofmann, J.J., Briot, A., Enciso, J., Zovein, A.C., Ren, S., Zhang, Z.W., Radtke, F., Simons, M., Wang, Y., Iruela-Arispe, M.L. 2012. Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development 139: 4449-4460. PMCID: PMC3509736.
He, H., Xu, J., Warren, C.M., Duan, D., Wu, L., Iruela-Arispe, M.L. 2012. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood 120: 3152-3162. PMCID: PMC3471522.
Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., Yaniv, K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor-1. Nat. Med 18: 967-973. PMCID: PMC3959651.
Chhabra, A., Lechner, A.J., Ueno, M., Acharya, A., van Handel, B., Wang, Y., Iruela-Arispe, M.L., Tallquist, M.D., Mikkola, H.K. 2012. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev. Cell 13: 651-659. PMCID: PMC3395466.
Hall-Glenn, F., De Young, R.A., Huang, B.L., van Handel, B., Hofmann, J.J., Chen, T.T., Choi, A., Ong, J.R., Benya, P.D., Mikkola, H., Iruela-Arispe, M.L., Lyons, K.M. 2012. CCN2/Connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One 7: e30562. PMCID: PMC3282727.
Turlo, K.A., Noel, O.D., Vora, R., LaRussa, M., Hall-Glenn, F., Iruela-Arispe, M.L. 2012. An essential requirement for Beta-1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev. Biol 365: 23-35. PMCID: PMC3590017.
Cooley, M.A., Fresco, V.M., Dorlon, M.E., Twal, W.O., Lee, N.V., Barth, J.L., Kern, C.B., Iruela-Arispe, M.L., Argraves, W.S. 2012. Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev. Dyn 241: 303-314. PMCID: PMC3489172.
Scheppke, L., Murphy, E., Zarpellon, A., Hofmann, J.J., Merkulova, A., Shields, D., Weis, S., Byzova, T., Ruggeri, Z., Iruela-Arispe, M.L., Cheresh, D. 2012. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood 119: 2149-2158. PMCID: PMC3311249.
Youssef, K., Mack, J.J., Iruela-Arispe, M.L., Bouchard, L.S. 2012. Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor. Biotechnol. Bioeng 109: 1844-1854. PMCID: PMC8103415.
2011
Ziyad, S., Iruela-Arispe, M.L. 2011. Molecular mechanisms of tumor angiogenesis. Genes and Cancer. 2(12): 1085-96. PMCID: PMC3411131.
Iruela-Arispe, M.L. 2011. LUMENating blood vessels. Dev. Cell 20: 412-414. PMCID: PMC3099250.
Anderson, S.M., Shergill, B., Barry, Z.T., Manousiouthakis, E., Chen, T.T., Botvinick, E., Platt, M.O., Iruela-Arispe, M.L., Segura, T. 2011. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integrative Biology 3: 887-896. PMCID: PMC3621282.
2010
Corada, M., Nyqvist, D., Orsenigo, F., Caprini, A., Giampietro, C., Taketo, M.M., Iruela-Arispe, M.L., Adams, R.H., Dejana, E. 2010. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating DII4/Notch signaling. Dev. Cell 18: 938-949. PMCID: PMC8127076.
Hofmann, J.J., Zovein, A.C., Koh, H., Radtke, F., Weinmaster, G., Iruela-Arispe, M.L. 2010. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development 137: 4061-4072. PMCID: PMC2976287.
Turlo, K.A., Gallaher, S.D., Vora, R., Laski, F.A., Iruela-Arispe, M.L. 2010. When Cre-mediated recombination in mice does not result in protein loss. Genetics (highlighted by Journal) 186: 959-967. PMCID: PMC2975293.
Zovein, A.C., Turlo, K.A., Ponec, R.M., Lynch, M.R., Chen, K.C., Hofmann, J.J., Cox, T.C., Gasson, J.C., Iruela-Arispe, M.L. 2010. Vascular remodeling of the vitelline artery initiates extra-vascular emergence of hematopoietic clusters. Blood (Cover) 116: 3435-3444. PMCID: PMC8127023.
Da Silva, R.G., Tavora, B., Robinson, S.D., Reynolds, L.E., Szekeres, C., Lamar, J., Batista, S., Kotourou, V., Germain, M.A., Reynolds, A.R., Jones, D.T., Watson, A.R., Jones, J.L., Harris, A., Hart, I.R., Iruela-Arispe, M.L., Dipersion, C.M., Kreidberg, J.A., Hodivala-Dilke, K.M. 2010. Endothelial alpha 3 beta1 integrin represses pathological angiogenesis and sustains endothelial VEGF. Am. J. Pathol 177: 1534-1548. PMCID: PMC2928983.
Warren, C.M., Iruela-Arispe, M.L. 2010. Signaling circuitry in vascular morphogenesis. Curr Opin Hematol 17: 213-218. PMCID: PMC2921923.
Arroyo, A.G., Iruela-Arispe, M.L. 2010. Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res 86: 226-235. PMCID: PMC2856193.
Chen, T.T., Luque, A., Lee, S., Anderson, S.M., Segura, T., Iruela-Arispe, M.L. 2010. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188: 595-609. PMCID: PMC2828913.
Zovein, A.C., Luque, A., Turlo, K.A., Hofmann, J.J., Yee, K.M., Becker, M.S., Fassler, R., Mellman, I., Lane, T.F., Iruela-Arispe, M.L. 2010. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev. Cell 18: 39-51. PMCID: PMC3178410.
Stockman, C., Kerdiles, Y., Nomaksteinsky, M., Weidemann, A., Takeda, N., Doedens, A., Torres-Collado, A.X., Iruela-Arispe, M.L., Nizet, V., Johnson, R.S. 2010. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA 107: 4329-4334. PMCID: PMC2840078.
Lee, Y.J., Koch, M., Karl, D., Torres-Collado, A.X., Fernando, N.T., Rothrock, C., Kuruppu, D., Ryeom, S., Iruela-Arispe, M.L., Yoon, S.S. 2010. Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. Cancer Res 70: 948-956. PMCID: PMC2934910.
Priceman, S.J., Sung, J.L., Shaposhnik,, Z., Burton, J.B., Torres-Collado, A.X., Moughon, D.L., Johnson, M., Lusis, A.J., Cohen, D.A., Iruela-Arispe, M.L., Wu, L. 2010. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic of anti-angiogenic therapy. Blood 115: 1461-471. PMCID: PMC2826767.
Iruela-Arispe, M.L., Lee, S. 2010. Mechanisms underlying context-dependent VEGF signaling for distinct biological responses. Handbook of Cell Signaling, Second Ed.: 1919-1925.
2009
Torres-Collado, A.X., Iruela-Arispe, M.L. 2009. Contributions of ADAMS and ADAMTSs during Tumor Expansion and Metastasis. Chapter in: Cancer Genome and Tumor Microenvironment. Editor: Thomas-Tikhonenko, A. New York: Springer. Pp. 293-314.
Iruela-Arispe, M.L., and Lee, S. 2009. Mechanisms Underlying Context-Dependent VEGF Signaling for Distinct Biological Responses. Chapter in: Handbook of Cell Signaling, Second Edition. Editors: Brandshaw, R., and Dennis, E. San Diego: Academic Press. Pp. 1919-1925.
Zovein, A.C., Iruela-Arispe, M.L. 2009. Time to cut the cord: placental HSCs grow up. Cell Stem Cell. 5(4): 351-352.
Skuli, N., Liu, L., Runge, A., Wang, T., Yuan, L., Patel, S., Iruela-Arispe, M.L., Simon, M.C., Keith, B. 2009. Endothelial deletion of hypoxia-inducible factor-2alpha(HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 114: 469-477. PMCID: PMC2714217
Anderson, S.M., Chen, T.T., Iruela-Arispe, M.L., Segura, T. 2009. The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. Biomaterials 30: 4618-4628. PMCID: PMC2826152
Speck, N.A., Iruela-Arispe, M.L. 2009. Conditional Cre/LoxP Strategies for the Study of Hematopoietic Stem Cell Formation. Blood Cells Mol. Dis 43: 6-11. PMCID: PMC2723839
Rodriguez-Manzaneque, J.C., Carpizo, D., Plaza-Calonge, M.D., Torres-Collado, A.X., Thai, S.N., Simons, M., Horowitz, A., Iruela-Arispe, M.L. 2008. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int. J. Biochem. Cell Biol. 41:800-810. PMCID: PMC3807939
Iruela-Arispe, M.L., Davis, G.E. 2009. Cellular and molecular mechanisms of vascular lumen formation. Dev Cell. 16(2):222-31. PMCID: PMC8606173
2008
Iruela-Arispe, M.Luisa. 2008. Regulation of Thrombospondin1 by Extracellular Proteases. Current Drug Targets 9: 863-868. PMCID: PMC3010394
Zovein, A.C. Hofmann, J.J., Lynch, M., French, W.J., Turlo, K.A., Yang, Y., Becher, M.S., Zanetta, L., Dejana, E., Gasson, J. Tallquist, M.D., Iruela-Arispe, M.L. 2008. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 3: 625-636. PMCID: PMC2631552
Suarez, Y., Fernandez-Hernando, C., Yu, J., Gerber, S.A., Harrison, K.D., Pober, J.S. Iruela-Arispe, M.L., Merkernschlager, M., Sessa, W.C. 2008. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. PNAS 105: 14082-14087. PMCID: PMC2544582
Guo, W., Lasky, J.L., Chang, C.J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J.E., Chen, J. Y., Iruela-Arispe, M.L., Varella-Garcia, M., Wu, H. 2008. Multi-genetic events collaboratively contribute to Pten-deficient leukemia stem-cell formation. Nature 453:529-533. PMCID:PMC2840044
Stankunas, K. Hang, C.T., Tsun, Z.Y. Chen, H., Lee, N.V., Wu, J.I., Shang, C., Bayle, J.H., Shou, W., Iruela-Arispe, M.L., Chang, C.P. 2008. Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell 14: 298-311. PMCID: PMC2274005
Misra, S., Lee, N. Fu, A.A., Raghavakaimal, S., Mandrekar, J., Bjarnason, H., McKusick, M.A., Iruela-Arispe, L., Mukhopadhyay, D. 2008. Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts. J Vasc Interv Radiol. 19(1): 111-119.
Iruela-Arispe, M.L. 2008.Endothelial Cell Activation. Chapter in: Angiogenesis: An Integrative Approach from Science to Medicine. Springer, Editors: Judah Folkman and J. Figg, 35-43.
2007
Lee, N.V., Iruela-Arispe, M.L. 2007. Thrombospondins and Angiogenesis. Chapter in: Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. Editors: Marme, D., and Fusening, N. Berlin; New York: Springer. Pp. 233-245.
Lundkvist, A., Lee, S., Iruela-Arispe, L., Betsholtz, C., Gerhardt, H. 2007. Growth factor gradients in vascular patterning. Novartis Found. Symp 283: 194-201.
Lee, S., Iruela-Arispe, M.L. 2007. The Extracellular Matrix and VEGF Processing. Chapter in: Antiangiogenic Agents in Cancer Therapy, 2nd Edition. Editors: Ellis, L., and Teicher, B.A. Totawa, NJ: The Humana Press, Inc. Pp. 194-201.
Hofmann, J.J., Iruela-Arispe M.L. 2007. Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expr Patterns. 7: 461-470.
Lee, M., Chen, T.T., Iruela-Arispe, M.L., Wu, B.M., Dunn, J.C. 2007. Modulation of protein delivery from modular polymer scaffolds. Biomaterials. 28: 1862-1870.
Hellstrom, M., Phng, L.K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalen, M., Gerhardt, H., Betsholtz, C. 2007. D114/Notch1 regulates formation of tip cells during angiogenesis. Nature. 445: 776-780.
Hofmann, J.J., Iruela-Arispe, M.L. 2007. Notch signaling in blood vessels: who is talking to whom about what? Circulation Res 100: 1556-1568.
Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P., Iruela-Arispe, M.L. 2007. Autocrine VEGF Signaling Is Required for Vascular Homeostasis. Cell 130: 691-703. PMCID: PMC3010851
2006
Zovein, A.C., Iruela-Arispe, M.L. 2006. My O’Myeloid, a tale of two lineages. PNAS 103: 12959-12960. PMCID: PMC1559733
Iruela-Arispe, M.L. 2006. When it comes to lymphatics, it is all a question of time. Am J Pathol 169: 347-350. PMCID: PMC1698778
Barber, C.L., Iruela-Arispe, M.L. 2006. The Ever-Elusive Endothelial Progenitor Cell: Identities, Functions and Clinical Implications. Pediatr Res. 59: 26-32.
Alva, J.A., Zovein, A.C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N.L., Carmeliet, P., Iruela-Arispe, M.L. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235: 759-767.
Yang, L.V., Radu, C.G., Roy, M., Lee, S., McLaughlin, J., Teitell, M.A., Iruela-Arispe M.L., Witte, O.N. 2006. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol 27: 1334-1347. PMCID: PMC1800706
Kern, C.B., Twal, W.O., Mjaatvedt, C.H., Fairey, S.E., Toole, B.P., Iruela-Arispe, M.L., Argraves, W.S. 2006. Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn 235: 2238-2247. PMCID: PMC1828280
Torres-Collado, A.X., Kisiel, W., Iruela-Arispe, M.L., Rodriguez-Manzaneque, J.C. 2006. ADAMTS1 interacts with, cleaves and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 (TFPI-2). J Biol Chem 281: 17827-17837.
Monvoisin, A., Alva, J.A., Hofmann, J.J., Zovein, A.C., Lane, T.F., Iruela-Arispe, M.L. 2006. VE-cadherin-CreER(T2) transgenic mice: A model for inducible recombination in the endothelium. Dev Dyn 235: 3413-3422.
Lee, N.V., Sato, M., Annis, D.S., Loo, J.A., Wu, L., Mosher, D.F., Iruela-Arispe, M.L. 2006. ADAMTS1 mediates the release of anti-angiogenic polypeptides from TSP1 and TSP2. The EMBO J 25: 5270-5283. PMCID: PMC1636613
Hashimoto-Partyka, M., Lydon, J., Iruela-Arispe, M.L. 2006. Generation of a mouse for conditional excision of progesterone receptor (PRCE). Genesis 44: 391-395.
Lee, N.V., Rodriguez-Manzaneque, J.C., Thai, S.N., Twal, W.O., Luque, A., Lyons, K.M., Argraves, W.S., Iruela-Arispe, M.L. 2005. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem 280: 34796-34804.
Cho, H.M., Rosenblatt, J.D., Kang, Y.S., Iruela-Arispe, M.L., Morrison, S.L., Penichet, M.L., Kwon, Y.G., Kim, T.W., Webster, K.A., Nechustan, H. and Shin, S.U. 2005. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein. Mol Cancer Ther 4: 956-967.
2005
Iruela-Arispe, M.L. 2005. Vascular Development and Angiogenesis. Chapter in: Encyclopedia of Molecular Cell Biology and Molecular Medicine. Editor: Meyers, R. Weinheim: Wiley-VCH Verlag. Pp. 201-232.
Lee, S., Jilani, S.M. Nikolova, G.V., Carpizo, D., Iruela-Arispe, M.L.. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 169:681-691. PMCID: PMC2171712
Krampert, M., Kuenzle, S., Thai, S.N., Lee, N., Iruela-Arispe, M.L., Werner, S. 2005. ADAMTS1 proteinase is upregulated in wounded skin and regulates migration of fibroblasts and endothelial cells. J Biol Chem 280: 23844-23852.
2004
Thomas-Tikkonenko, A., Iruela-Arispe, M.L. 2004. Whence Thrombospondin? Cancer Biology and Therapy 3: 406-7.
Alva, J.A., Iruela-Arispe, M.L. 2004. Notch Signaling in Vascular Morphogenesis. Current Opinion in Hematology 11: 278-283.
Iruela-Arispe, M.L., Luque, A., Lee, N. 2004. Thrombospondin modules in Angiogenesis. Int. Journal of Biochemistry and Cell Biol 36: 1070-1078.
Iruela-Arispe, M.L. 2004. Angiogenesis: novel and basic science insights and human therapy. Keystone Symposium – IDrugs 7: 111-113.
Fiala, M., Murphy, T., MacDougall, J., Yang, W., Luque, A., Iruela-Arispe, L.., Cashman, J., Buga, G., Byrns, R.E., Barbaro, G., Arthos, J. 2004. HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis. Cardiovasc Toxicol 4: 327-337.
Calzada, M.J., Zhou, L., Sipes, J.M., Zhang, J., Krutzsch, H.C., Iruela-Arispe M.L.., Annis, D.S., Mosher, D.F., Roberts, D.D. 2004. Alpha4 Beta1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo. Circ Res 94: 462-470.
2003
Ellwood-Yen, K., Graeber, T.G., Wongvipat, J., Iruela-Arispe, M.L., Zhang, J., Matusik, R., Thomas, G.V., Sawyers, C.L. 2003. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 4: 223-238.
Iruela-Arispe, M.L., Carpizo, D., Luque, A. 2003. ADAMTS1: a matrix metalloprotease with angioinhibitory properties. Ann N Y Acad Sci 995: 183-190.
Jilani, S.M., Murphy, T.J., Thai, S.N., Eichmann, A., Alva, J.A., Iruela-Arispe, M.L. 2003. Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem 51: 597-604.
Luque, A., Carpizo, D.R., Iruela-Arispe, M.L. 2003. ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem. 278:23656-665.
2002
Park H.J., Kong D., Iruela-Arispe M.L., Begley U, Tang D, Galper J.B. 2002. 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circ Res. 91: 143-150.
Gaspar, J., Thai, S., Voland, C., Dube, A., Libermann, T.A., Iruela-Arispe, M.L., Oettgen, P. 2002. Opposing functions of the Ets factors NERF and ELF-1 in the regulation of the Tie genes during chicken blood vessel development. Art Throm and Vasc Biol. 22: 1106-1112.
Adams, J.Y., Johnson, M., Sato, M., Berger, F., Gambhir, S.S., Carey, M., Iruela-Arispe, M.L.. and Lily, Wu. 2002. Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nature Med 8: 891-897.
Thai, S.N.M., Iruela-Arispe, M.L. 2002. Expression of ADAMTS1 during murine development. Mechanisms of Development. 115(1-2): 181-185.
Rodriguez-Manzaneque, J.C., Westling, J., Thai, S.N., Luque, A., Knauper, V., Murphy, G., Sandy, J.D., Iruela-Arispe, M.L. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem. and Biophys. Res. Comm 293: 501-508.
Murayama, Y., Vinuela, F., Tateshima, S., Gonzalez, N.R., Song, J.K., Mahdavieh, H., Iruela-Arispe, M.L. 2002. Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms. Stroke 33: 1120-1128.
2001
Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J., Iruela-Arispe, M.L. 2001. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. PNAS 98: 12485-12490. PMCID: PMC60080
Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M.L., Weinmaster, G. 2001. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mechanisms of Development 108: 161-164.
Augustin, H.G., Iruela-Arispe, M.L., Rogers, P., Smith, S. 2001. Vascular Morphogenesis in the Female Reproductive System. Springer-Birkhaeuser, New York: 161-164.
Saaristo, A., Karkkainen, M.J., Alitalo, K., Montesano, R., Iruela-Arispe, M.L., Pepper, M.S. 2001. Growth factor regulation of physiological angiogenesis in the mammary gland. Chapter in: Vascular Morphogenesis in the Female Reproductive System. Editors: Augustin, H.G., Iruela-Arispe, M.L., Rogers, P., and Smith, S. Boston: Birkhaeuser. Pp. 25-40.
Iruela-Arispe, M.L., Ortega, M.A., Oikemus, S., Pepper, M.S. 2001. Vascular morphogenesis in the mammary gland – introduction and overview. Chapter in: Vascular Morphogenesis in the Female Reproductive System. Editors: Augustin, H.G., Iruela-Arispe, M.L., Rogers, P., and Smith, S. Boston: Birkhaeuser. Pp. 3-24.
Sandy, J.D., Westling, J., Kenagy, R.D., Iruela-Arispe, M.L., Verscharen, C., Rodriguez-Manzaneque, J.C., Zimmerman, D., Lemire, J.M., Fischer, J.W., Wight, T.N., Clowes, A.W. 2001. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site which is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J. Biol. Chem 276: 13372-13378.
Dube, A., Thai, S., Gaspar, J., Rudders, S., Libermann, T.A., Iruela-Arispe, M.L., Oettgen, P. 2001. ELF-1 is a transcriptional regulator of the Tie-2 gene during vascular development. Circ Res. 88: 237-244.
Graubert, M.D., Ortega, M.A., Kessel, B., Mortola, J.F., Iruela-Arispe, M.L. 2001. Vascular repair after menstruation involves regulation of vascular endothelial growth factor-receptor phosphorylation by sFLT-1. Am. J. Pathol 158: 1399-1410. PMCID: PMC1891924
2000
Carpizo, D., Iruela-Arispe, M.L. 2000. Endogenous regulators of angiogenesis – Emphasis on proteins with thrombospondin – type I motifs. Cancer and Metastasis Reviews 19: 159-165.
Pal, S., Iruela-Arispe, M.L.., Harvey, V.S., Zeng, H., Nagy, J.A., Dvorak, H.F., Mukhopadhyay, D. 2000. Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade. Microvasc. Res 60: 112-120.
Rodriguez-Manzaneque, J.C., Milchanowski, A.B., Dufour, E.K., Leduc, R., Iruela-Arispe, M.L. 2000. Characterization of Meth-1/Adamts-1 processing reveals two distinct active forms. J. Biol. Chem 275: 33471-33479.
Streit, M., Valesco, P., Riccardi, L., Spencer, L., Brown, L.F., Janes, L., Lange-Asschenfeldt, B., Yano, K., Hawighorst, T., Iruela-Arispe, M.L., Detmar, M. 2000. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. The EMBO Journal 19: 3272-3282.
Pepper, M.S., Baetens, D., Mandroita, S.J., Di Sanza, C., Oikemus, S., Lane, T.F., Soriano, J.V., Orci, L., Montesano, R., Iruela-Arispe, M.L. 2000. Regulation of VEGF and VEGF receptor expression in rodent mammary gland during pregnancy, lactation and involution. Dev. Dynamics 218: 507-524.
Lee S.W., Reimer, C.L., Fang, L., Iruela-Arispe, M.L., Aaronson, S.A. 2000. Overexpression of kinase-associated phosphatase (KAP) in Breast and Prostate Cancer Inhibition of the transformed phenotype by antisense KAP Expression. Molec. & Cell. Biol 20: 1723-1732. PMCID: PMC85355
Chandrasekaran, L., He, Z.C., Al-Barazi, H., Krutzch, H.C., Iruela-Arispe, M.L., Roberts, D.D. 2000. Cell contact-dependent activation of a 3b1 integrin modulates endothelial cell responses to thrombospondin-1. Mol. Biol. Cell 11: 2885-2900. PMCID: PMC14963
Rodriguez-Manzaneque, J.C., Graubert, M., Iruela-Arispe, M.L. 2000. Endothelial cell dysfunction following prolonged activation of progesterone receptor. Human Reproduction 15: 39-47.
1999
Iruela-Arispe, M.L.., Ortega, M.A., Vazquez, F. 1999. Antiangiogenic Function of Thrombospondin-1. Chapter in: Angiogenesis in Health and Disease: Basic Mechanisms and Clinical Applications. Editor: Rubanyi, G.M. New York: CRC Press. Pp.349-357.
Iruela-Arispe, M.L.., Vazquez, F., and Ortega, M.A. 1999. Anti-angiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors. Ann. N.Y. Acad. Sci 886: 58-66.
Iruela-Arispe, M.L., Lombardo, M., Krutzsch, H.C., Lawler, J., Roberts, D.D. 1999. Inhibition of angiogenesis by thrombospondin-1 is mediated by two independent regions within the type1 repeats. Circulation 100: 1423-1431.
Wu. H., Lee, S.H., Jing Gao, Xin Liu, Iruela-Arispe, M.L. 1999. Inactivation of erythropoetin leads to defects in cardiac morphogenesis. Development 126: 3597-3605.
Vazquez, F., Hasting, G., Ortega, M.A., Lane, T.F., Oikemus, S., Lombardo, M., Iruela-Arispe, M.L. 1999. METH1 a human ortholog of ADAMTS, and METH2 are members of a new family of proteins with angio-inhibitory activity. J Bio Chem. 274: 23349-23357.
Zhai, Y., Yu, L., Iruela- Arispe, L., Huang, W.Q., Wang, Z., Hayes, A.J., Lu, J., Jaing, G., Rojas, L., Lippman, M.E., Ni, J., Yu, G.L., Li, L.Y. 1999. Inhibition of angiogenesis and breast cancer xenograft tumor by VEGI, a novel cytokine of the TNF superfamily. Int. J. Cancer 82: 131-136.
Brown, L.F., Guidi, A.J., Schnitt, S.J., Van De Water, L., Iruela- Arispe, M.L., Yeu, T.K., Tognassi, K., Dvorak, H.F. 1999. Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin. Cancer Res 5: 1041-1056.
Iruela-Arispe, M.L., Rodriguez- Manzaneque, Abu-Jawdeh, G. 1999. Endometrical endothelial cells express estrogen and progesterone receptors and exhibit a tissue specific response to angiogenic growth factors. Microcirculation 6: 127-140.
Dhanabal, M., Ramchandran, R., Volk, R., Stillman, I.E., Lombardo, M., Iruela-Arispe, M.L., Simons, M., Sukhatme, V.P. 1999. Endostatin: yeast production, mutants, and anti-tumor effect in renal cell carcinoma. Cancer Res 59: 189-197.
Vazquez, F., Rodriguez-Manzaneque, J.C., Lydon, J.P., Edwards, D.P., O’Malley B.W., Iruela-Arispe, M.L. 1999. Progesterone regulates proliferation of endothelial cells. J. Biol. Chem 274: 2185-2192.
1997
Lee, S.H., Hungerford, J.E., Little, C.D., Iruela-Arispe, M.L. 1997. Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall. Dev. Dyn 209: 342-352.
Iruela-Arispe, M.L., Dvorak, H.F. 1997. Angiogenesis: A dynamic balance of stimulator and inhibitors. Thromb Haem 78: 672-677.
Iruela-Arispe, M.L. 1997. Normal placentation: A tale that requires an epithelial-to-endothelial conversion. J Clin Invest 99: 2057-2058.
Brown, L.F., Demar, M., Tognazzi, K., Abu-Jawdeh., G., Iruela-Arispe, M.L. 1997. Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor (vascular endothelial growth factor). Lab Invest 76: 245-255.
1996
Luther, T., Flossel, C., Mackman, N., Bierhaus, A., Kasper, M., Albrecht, S., Sage, E.H., Iruela-Arispe, L., Grossmann, H., Strohlein, A., Zhang, Y., Nawroth, P.P., Carmeliet, P., Loskutoff, D.J., Mueller, M. 1996. Tissue factor expression during human and mouse development. Am J Pathol. 149: 101-113.
Iruela-Arispe, M.L., Vernon, R.B., Wu, H., Jaenish, R., Sage, E.H. 1996. Type I collagen-deficient mov 13 mice do not retain SPARC in the extracellular matrix: Implications for fibroblast function. Dev. Dyn 207: 171-183.
Gariano, R.F., Iruela-Arispe M.L., Sage, E. H., Hendrickson, A.E. 1996. Immunohistochemical characterization of developing and mature primate retinal blood vessels. Invest. Ophthalmol. & Visual Science 37: 93-103.
Iruela-Arispe, M.L., Porter, P., Bornstein, P., Sage E.H. 1996. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in human endometrium. J. Clin. Invest 97: 403-412. PMCID: PMC507031
1995
Iruela-Arispe, L., Gordon, K., Hugo, C., Duijvestijn, A. M. Claffey, K.P., Reilly, M., Couser, W. G., Alpers, C.E., Johnson, R.J. 1995. Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis. Am. J. Pathol 147: 1715-1728. PMCID: PMC1869935
Reed, M.J., Iruela-Arispe, M.L., O’ Brein, E.R., Truong, T., LaBell, T., Bornstein, P., Sage E.H. 1995. Expression of thrombospondins by endothelial cells: injury is correlated with TSP1. Am. J. Pathol 147: 1068-1080. PMCID: PMC1870996
Seiffert, D., Iruela-Arispe, M.L., Sage, E.H., Loskutoff, D.J. 1995. Distribution of vitronectin mRNA during murine development. Dev. Dyn 203: 71-79.
Vernon, R.B., Lara, S.L., Drake, C.J., Iruela-Arispe, M.L., Angello J.C., Little, C.D., Wight, T.N., Sage, E.H. 1995. Organized Type I collagen influences endothelial patterns during “spontaneous angiogenesis in vitro”: planar cultures as models of vascular development. Cell Dev Biol. 31: 120-131.
Iruela-Arispe, M.L., Lane, T.F., Redmond, D., Reilly, M., Bolender, R., Kavanaugh, T.J., Sage E.H. 1995. Expression of SPARC during the development of the chorioallantoic membrane: evidence for regulated proteolysis in vivo. Mol Biol Cell. 6: 327-343. PMCID: PMC301191
1994
Gariano, R.F., Iruela-Arispe, M.L., Hendrickson, A.E. 1994. Vascular Development in the primate retina: Comparison of laminar plexus formation in monkey and human. Invest Ophtal Vis Sci. 35: 3442-3455.
Lane, T.F., Iruela-Arispe, M.L., Johnson, R.S., Sage, E.H. 1994. SPARC is a source of copper-binding peptides that stimulate angiogenesis. J Cell Biol. 125: 929-943. PMCID: PMC2120067
Battegay, E. J., Rupp, J., Iruela-Arispe, M.L., Sage, E.H., Pech, M. 1994. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGFB-receptors. J Cell Biol. 125: 917-928. PMCID: PMC2120083
Iruela-Arispe, M.L., Liska, D.A., Sage, E.H., Borenstein, P. 1994. Differential of Expression of Thrombospondin 1, 2, and 3 during Murine Development. Dev Dyn. 197: 40-56.
1993
Bassuk, J.A., Iruela-Arispe, M.L., Lane, T.F., Benson, J. M., Berg, R.A., Sage, E.H. 1993. Molecular analysis of chicken embryo SPARC. Europ J Biochem. 218: 117-127.
Iruela-Arispe, M.L., Sage, E.H. 1993. Endothelial Cells Exhibiting Angiogenesis In vitro Proliferate in Response to TGF-B1. J Cell Biochem. 52: 414-430.
1992
Floege, J., Johnson, R.J., Gordon, K., Yoshimura, A., Campell, C., Iruela-Arispe, M.L., Alpers, C.E., Couser, W.G. 1992. Altered Glomerular Extracellular Matrix Synthesis in Experimental Membranous Nephropathy. Kidney Int. 42: 573-585.
Javelainen, H.T., Iruela-Arispe, M.L., Kinsella, M.G. Sandell, L.J., Sage, E.H., Wight, T.N. 1992. Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in Vitro. Exp Cell Res. 203: 395-401.
Sage, E.H., Lane, T.F., Iruela-Arispe, M.L., Funk, S.E. 1992. A Protein that Modulates Cell Cycle and Cell-matrix Interactions. Chapter in: Proc. Forth Int'l Conf. Chem. Biol. Editors: Tiss, M., Slavkin, H., and Price, P. Amsterdam: Elsevier. Pp. 235-242.
Lane, T., Iruela-Arispe, M.L., Sage, E.H. 1992. Regulation of Gene Expression by SPARC during Angiogenesis in vitro: Changes in Fibronectin, Thrombospondin- 1, and Plasminogen Activator Inhibitor- 1. J Bio Chem. 267: 16736-16745.
Vernon R.B., Angello, J.C., Iruela-Arispe, M.L., Lane, T.F., Sage E.H. 1992. Reorganization of Basement Membrane Matrices by Cellular Traction Promotes the Formation of Cellular Networks in vitro. Lab Invest. 66: 536-547.
Iruela-Arispe, M.L., Chun, L., Sage, E. H. 1992. Structure and Biology of Type VIII Collagen. Trends Glycosci. Glycotechnol 4: 188-199.
Raines, E.W., Lane, T., Iruela-Arispe, M.L., Ross, R., and Sage, E.H. 1992. The Extracellular Glycoprotein SPARC Interacts with Platelet-derived Growth Factor (PDGF)-AB and BB and Inhibits Binding of PDGF to its Receptors. Proc. Natl.Acad. Sci 89: 1281-1285. PMCID: PMC48433
1991
Iruela-Arispe, M.L.., Diglio, C.A., Sage, E.H. 1991. Modulation of Extracellular Matrix Proteins by Endothelial Cells undergoing Angiogenesis in vitro. Arterioscler. Thromb 11: 805-815.
Fouser, L., Iruela-Arispe, M.L., Borstein, P., Sage, E.H. 1991. Transcriptional Activity of the alpha 1(I)-Collagen Promoter in Endothelial Cells is Correlated with the Formation of Capillary-like Structures by Endothelial Cells in Vitro. J. Biol. Chem 266: 18345-18351.
Iruela-Arispe, M.L., Bornstein, P., Sage, H. 1991. Thrombospondin Exerts an Antiangiogenic Effect on Tube Formation by Endothelial Cells in vitro. Proc Natl Acad Sci. 88: 5026-5030. PMCID: PMC51800
Iruela-Arispe, M.L., Sage, H. 1991. Expression of Type VIII Collagen during Morphogenesis of the Chicken and Mouse Heart. Dev Biol. 144: 107-118.
Paulus, W., Sage, H., Liszka, U., Iruela-Arispe, M.L., Jellinger, K. 1991. Increased levels of type VIII collagen in human brain tumours compared to normal brain tissue and non-neoplastic cerebral disorders. Brit J Cancer. 63: 367-371. PMCID: PMC1971869
1990
Iruela-Arispe, M.L., Hasselaar, P., Sage, H. 1990. Differential Expression of Extracellular Proteins is correlated with Angiogenesis In vitro. Lab Invest. 64: 174-186.
Sage, H., Iruela-Arispe, M.L. 1990. Type VIII Collagen in Murine Development. Association with Capillary Formation in vitro. Chapter in: Structure, Molecular Biology and Pathology of Collagen. Editors: Fleishmajer, R., Olsen, B.R., and Kühn, K.A. New York: New York Academy of Sciences. Vol. 580. Pp 17-31.
Sage, H., Vernon, R.D., Decker, J., Funk, S., Iruela-Arispe, M.L. 1989. Distribution of the Calcium-binding Protein SPARC in Tissues of Embryonic and Adult Mice. J Histochem Cytochem 37(6): 819-829.
Chow, M., Boyd, C.D., Iruela-Arispe, M.L., Wrenn, D.S., Mecham, R., Sage, H. 1989. Characterization of Elastin Protein and mRNA from Salmonid Fish (Oncorhynchus kisutch). Comp Biochem Physiol 93B(4): 835-845.
Cotta-Pereira, G., Iruela-Arispe, M.L. 1989. Extracellular matrix: Functional significance of oxytalan, elaunin and elastic fibers. Chapter in: Cells and Tissues: A Three Dimensional Approach by Modern Techniques in Microscopy. Editor: Motta, P. New York: Alan R. Liss, Inc. Pp. 61-67.