Exploring molecular regulation of angiogenesis and vascular homeostasis
What We Do
The laboratory investigates the mechanisms behind the formation of vascular tumors and anomalies. Its additional focus is understanding vascular resilience and dissecting the molecular mechanisms behind response to stressors, including aging. Scroll through to learn about our most recently published discoveries in vascular biology.
Romay Nat Cardiovasc Res 2025
In this study we analyzed gene expression in key large vessel regions, revealing spatial and sex-based differences linked to vascular disease. They identified candidate genes, including CPNE8 and SORBS2, and uncovered how regional origin and sex influence variations in vascular cell populations and disease risk.
Pi Cell Syst 2025
Aortic growth after birth follows specific, blood flow-aligned proliferation waves, balanced by cell extrusion to maintain size. Combining experiments and modeling, this study uncovers how differentiated cell proliferation and metabolic changes orchestrate organ scaling and homeostasis.
Moise Front Physiol 2024
The vessel wall's inner layer endures relentless mechanical forces from blood flow, prompting cytoskeletal changes. This research uncovers microtubules as essential mediators of endothelial responses to shear stress, highlighting their role in cell shape adaptation and vascular function through targeted acetylation regulation.
Romay JCI 2024
A concrete understanding of how aging affects the brain vasculature remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels. To clarify the consequences of Notch3 loss in the brain vasculature …read more
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