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Northwestern University Feinberg School of Medicine
Parvez Lab

Publications

Learn more about the work that we do in the Parvez Lab through our recent publications.

As a Postdoctoral Fellow

(* equal contribution ‡ co-corresponding author)

  • (22) Nwagbo, U., Parvez, S., Maschek, J. A., and Bernstein, P. S. (2024) Elovl4b Knockout Zebrafish as a Model for Ocular Very-Long-Chain Polyunsaturated Fatty Acid Deficiency. Journal of Lipid Research, 100518
  • (21) Parvez, S., Zhang, T., and Peterson R. T. (2023) Scalable CRISPR Screens in Zebrafish Using MIC-Drop. Zebrafish: Methods and Protocols, 319-334
  • (20) Parvez, S., Brandt, Z. J., and Peterson R. T. (2023) Large-scale F0 CRISPR screens in vivo using MIC-Drop. Nature Protocols, 18(6), 1841-1865
  • (19) Ma, J., Zhang, W., Sun, Z., Parvez, S., Peterson R. T., and Yeh J. R. (2022) Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase. bioRxiv, 2022.10. 30.514454
  • (18) Parvez, S., Herdman, C., Beerens, M. Chakrabarti, K., Harmer, Z., Yeh, J. J., MacRae, C. A., Yost, H. J., and Peterson, R. T. (2021) MIC-Drop: a platform for large-scale in vivo CRISPR screens. Science, 373(6559), 1146-1151.
  • (17) Tu, J., Svatunek, D., Parvez, S., Eckvahl, H.,Xu, M., Peterson, R. T., Houk, K., & Franzini, R. M. (2020) Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. Chem. Sci., 11, 169-79.
  • (16) Tu, J., Svatunek, D., Parvez, S., Liu, A., Levandowski, B., Eckvahl, H., Peterson, R. T., Houk, K., & Franzini, R. (2019). Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles. Angew. Chem., 131(27), 9141–9146.
  • (15) Tu, J., Xu, M., Parvez, S., Peterson, R. T., & Franzini, R. (2018). Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. JACS, 140(27), 8410–8414

During PhD and Undergraduate

(* equal contribution ‡ co-corresponding author)

  • (14) Huang, K-T, Ly, P. Poganik, J. R., Parvez, S., Long, M. J. C., and Aye, Y. (2023) Monitoring On-Target Signaling Responses in Larval Zebrafish-Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites. JoVE (Journal of Visualized Experiments), e64846.
  • (13) van Hall-Beauvais, A., Poganik, J., Huang, K-T., Parvez, S., Zhao, Y., Lin, H-Y., Liu, X., Long, M. J. C.‡, and Aye, Y.‡ (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLife, 11, e83373.
  • (12) Huang, K-T*, Poganik, J.*, Parvez, S., Raja, S., Miller, B., Long, M. J. C., Fetcho, J. R., and Aye, Y. (2023) Z-REX: Shepherding Reactive Electrophiles to Specific Proteins Expressed either Tissue-Specifically or Ubiquitously and Recording the Resultant Functional Electrophile-Induced Redox Responses in Larval Fish. Nature Protocol, 18 (5), 1379-1415.
  • (11) Poganik, J., Huang, K-T, Parvez, S., Zhao, Y., Raja, S., Long, M. J. C. ‡, and Aye, Y. ‡ (2021) Wdr1 and Cofilin are Necessary Mediators of Immune-Cell-Specific Apoptosis Triggered by Tecfidera. Nature Communications, 12(1), 1-15.
  • (9) Parvez, S.*, Long, M. J. C.*, Poganik, J., & Aye, Y. (2018). Redox Signaling by Reactive Electrophiles and Oxidants. Chem. Rev., 118(18), 8798–8888.
  • (8) Li, S., Zhang, A., Zatopek, K., Parvez, S., Gardner, A., Corrêa, I., Noren, C., & Xu, M. (2018). Enhancing Multistep DNA Processing by Solid-Phase Enzyme Catalysis on Polyethylene Glycol Coated Beads. Bioconj. Chem., 29(7), 2316–2324.
  • (7) Long, M. J. C.*, Parvez, S.*, Zhao, Y., Surya, S., Wang, Y., Zhang, S., & Aye, Y. (2017). Akt3 is a privileged first responder in isozyme-specific electrophile response. Nature Chem. Biol., 13(3), 333–338.
  • (6) Long, M. J. C.*, Lin, H-Y.*, Parvez, S., Zhao, Y., Poganik, J., Huang, P., & Aye, Y. (2017). β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Cell Chem. Biol., 24(8), 944–957.e7.
  • (5) Parvez, S.*, Long, M. J. C.*, Lin, H-Y., Zhao, Y., Haegele, J., Pham, V., Lee, D., & Aye, Y. (2016). T-REX on-demand redox targeting in live cells. Nature Prot., 11(12), 2328–2356.
  • (4) Parvez, S.*, Fu, Y.*, Li, J., Long, M. J. C., Lin, H-Y., Lee, D., Hu, G., & Aye, Y. (2015). Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response. JACS, 137(1), 10–13.
  • (3) Fang, X.*, Fu, Y.*, Long, M. J. C., Haegele, J., Ge, E., Parvez, S., & Aye, Y. (2013). Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells. JACS, 135(39), 14496–14499.
  • (2) Fu, Y.*, Long, M.*, Rigney, M., Parvez, S., Blessing, W., & Aye, Y. (2013). Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase. Biochemistry, 52(40), 7050–7059.
  • (1) Naing, S-H.*, Parvez, S.*, Pender-Cudlip*, M., Groves, J., & Austin, R. (2013). Substrate specificity and reaction mechanism of purified alkane hydroxylase from the hydrocarbonoclastic bacterium Alcanivorax borkumensis (AbAlkB). J. Inorg. Biochem., 121, 46–52