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Learn more about the work that we do in the Laimonis Laimins Lab through our recent publications.

  1. Templeton CW, Laimins LA  p53-dependent R-loop formation and HPV pathogenesis.  Proc Natl Acad Sci U S A  2023 Aug 29;120(35):e2305907120. pii:e2305907120
  2. Gusho E, Laimins LA  Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS.  PLoS Pathog  2022 Jul;18(7):e1010725. pii:e1010725
  3. Hong S, Li Y, Kaminski PJ, Andrade J, Laimins LA  Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway.  mBio  2020 Aug 12;11(4). pii:e01628-20
  4. Kono T, Hoover P, Poropatich K, Paunesku T, Mittal BB, Samant S, Laimins LA  Activation of DNA damage repair factors in HPV positive oropharyngeal cancers.  Virology  2020 Aug;547:27-34. doi:10.1016/j.virol.2020.05.003
  5. Hong S, Xu J, Li Y, Andrade J, Hoover P, Kaminski PJ, Laimins LA  Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.  Oncogene  2019 Apr;38(17):3274-3287. doi:10.1038/s41388-018-0633-1
  6. Spriggs CC, Blanco LZ, Maniar KP, Laimins LA  Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression.  Int J Gynecol Pathol  2019 Jan;38(1):1-10. doi:10.1097/PGP.0000000000000477
  7. Hong S, Cheng S, Songock W, Bodily J, Laimins LA  Suppression of MicroRNA 424 Levels by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification.  J Virol  2017 Dec 15;91(24). pii:e01712-17
  8. Spriggs CC, Laimins LA  Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication.  Viruses  2017 Aug 18;9(8). pii:232
  9. Hong S, Laimins LA  Manipulation of the innate immune response by human papillomaviruses.  Virus Res  2017 Mar 02;231:34-40. doi:10.1016/j.virusres.2016.11.004
  10. Spriggs CC, Laimins LA  FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication.  mBio  2017 Feb 14;8(1). pii:e02340-16
  11. Gunasekharan VK, Li Y, Andrade J, Laimins LA  Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle.  PLoS Pathog  2016 Jul;12(7):e1005747. pii:e1005747
  12. Langsfeld E, Laimins LA  Human papillomaviruses: research priorities for the next decade.  Trends Cancer  2016 May;2(5):234-240
  13. Hong S, Cheng S, Iovane A, Laimins LA  STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication.  mBio  2015 Dec 22;6(6):e02006-15. pii:e02006-15
  14. Galloway DA, Laimins LA  Human papillomaviruses: shared and distinct pathways for pathogenesis.  Curr Opin Virol  2015 Oct;14:87-92. doi:10.1016/j.coviro.2015.09.001
  15. Langsfeld ES, Bodily JM, Laimins LA  The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.  PLoS Pathog  2015 Sep;11(9):e1005181. pii:e1005181
  16. Mehta K, Gunasekharan V, Satsuka A, Laimins LA  Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.  PLoS Pathog  2015 Apr;11(4):e1004763. pii:e1004763
  17. Hong S, Dutta A, Laimins LA  The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses.  J Virol  2015 Apr;89(8):4668-75. doi:10.1128/JVI.03455-14
  18. Pattabiraman C, Hong S, Gunasekharan VK, Pranatharthi A, Bajaj J, Srivastava S, Krishnamurthy H, Ammothumkandy A, Giri VG, Laimins LA  et al.  CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits.  Cancer Res  2014 Nov 15;74(22):6682-92. doi:10.1158/0008-5472.CAN-14-1032
  19. Mighty KK, Laimins LA  The role of human papillomaviruses in oncogenesis.  Recent Results Cancer Res  2014;193:135-48. doi:10.1007/978-3-642-38965-8_8
  20. Hong S, Laimins LA  Regulation of the life cycle of HPVs by differentiation and the DNA damage response.  Future Microbiol  2013 Dec;8(12):1547-57. doi:10.2217/fmb.13.127
  21. Gunasekharan V, Laimins LA  Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification.  J Virol  2013 May;87(10):6037-43. doi:10.1128/JVI.00153-13
  22. Hong S, Laimins LA  The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation.  PLoS Pathog  2013;9(4):e1003295. pii:e1003295
  23. Regan JA, Laimins LA  Viral transformation of epithelial cells.  Methods Mol Biol  2013;945:449-65. doi:10.1007/978-1-62703-125-7_26