Publications
Learn more about the work that we do in the Laimonis Laimins Laboratory through our recent publications.
- Gusho E, Laimins LA Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS. PLoS Pathog 2022 Jul;18(7):e1010725. pii:e1010725
- Hong S, Li Y, Kaminski PJ, Andrade J, Laimins LA Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway. mBio 2020 Aug 12;11(4). pii:e01628-20
- Kono T, Hoover P, Poropatich K, Paunesku T, Mittal BB, Samant S, Laimins LA Activation of DNA damage repair factors in HPV positive oropharyngeal cancers. Virology 2020 Aug;547:27-34. doi:10.1016/j.virol.2020.05.003
- Hong S, Xu J, Li Y, Andrade J, Hoover P, Kaminski PJ, Laimins LA Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation. Oncogene 2019 Apr;38(17):3274-3287. doi:10.1038/s41388-018-0633-1
- Spriggs CC, Blanco LZ, Maniar KP, Laimins LA Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression. Int J Gynecol Pathol 2019 Jan;38(1):1-10. doi:10.1097/PGP.0000000000000477
- Hong S, Cheng S, Songock W, Bodily J, Laimins LA Suppression of MicroRNA 424 Levels by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification. J Virol 2017 Dec 15;91(24). pii:e01712-17
- Spriggs CC, Laimins LA Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication. Viruses 2017 Aug 18;9(8). pii:232
- Hong S, Laimins LA Manipulation of the innate immune response by human papillomaviruses. Virus Res 2017 Mar 02;231:34-40. doi:10.1016/j.virusres.2016.11.004
- Spriggs CC, Laimins LA FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. mBio 2017 Feb 14;8(1). pii:e02340-16
- Gunasekharan VK, Li Y, Andrade J, Laimins LA Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle. PLoS Pathog 2016 Jul;12(7):e1005747. pii:e1005747
- Langsfeld E, Laimins LA Human papillomaviruses: research priorities for the next decade. Trends Cancer 2016 May;2(5):234-240
- Hong S, Cheng S, Iovane A, Laimins LA STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication. mBio 2015 Dec 22;6(6):e02006-15. pii:e02006-15
- Galloway DA, Laimins LA Human papillomaviruses: shared and distinct pathways for pathogenesis. Curr Opin Virol 2015 Oct;14:87-92. doi:10.1016/j.coviro.2015.09.001
- Langsfeld ES, Bodily JM, Laimins LA The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes. PLoS Pathog 2015 Sep;11(9):e1005181. pii:e1005181
- Mehta K, Gunasekharan V, Satsuka A, Laimins LA Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators. PLoS Pathog 2015 Apr;11(4):e1004763. pii:e1004763
- Hong S, Dutta A, Laimins LA The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses. J Virol 2015 Apr;89(8):4668-75. doi:10.1128/JVI.03455-14
- Pattabiraman C, Hong S, Gunasekharan VK, Pranatharthi A, Bajaj J, Srivastava S, Krishnamurthy H, Ammothumkandy A, Giri VG, Laimins LA et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res 2014 Nov 15;74(22):6682-92. doi:10.1158/0008-5472.CAN-14-1032
- Mighty KK, Laimins LA The role of human papillomaviruses in oncogenesis. Recent Results Cancer Res 2014;193:135-48. doi:10.1007/978-3-642-38965-8_8
- Hong S, Laimins LA Regulation of the life cycle of HPVs by differentiation and the DNA damage response. Future Microbiol 2013 Dec;8(12):1547-57. doi:10.2217/fmb.13.127
- Gunasekharan V, Laimins LA Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification. J Virol 2013 May;87(10):6037-43. doi:10.1128/JVI.00153-13
- Hong S, Laimins LA The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation. PLoS Pathog 2013;9(4):e1003295. pii:e1003295
- Regan JA, Laimins LA Viral transformation of epithelial cells. Methods Mol Biol 2013;945:449-65. doi:10.1007/978-1-62703-125-7_26