Northwestern University Feinberg School of Medicine

Shi-Yuan Cheng Lab


  1. Goenka A, Tiek DM, Song X, Iglesia RP, Lu M, Hu B, Cheng SY  The Role of Non-Coding RNAs in Glioma.  Biomedicines  2022 Aug 20;10(8). pii:2031
  2. Tiek D, Cheng SY  DNA damage and metabolic mechanisms of cancer drug resistance.  Cancer Drug Resist  2022;5(2):368-379. doi:10.20517/cdr.2021.148
  3. Iglesia RP, Prado MB, Alves RN, Escobar MIM, Fernandes CFL, Fortes ACDS, Souza MCDS, Boccacino JM, Cangiano G, Soares SR  et al.  Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression.  Front Cell Dev Biol  2022;10:907423. doi:10.3389/fcell.2022.907423
  4. Goenka A, Cheng SY  Targeting Neddylation in Cancer.  Neuro Oncol  2022 Jun 24;. pii:noac159
  5. Tiek DM, Erdogdu B, Razaghi R, Jin L, Sadowski N, Alamillo-Ferrer C, Hogg JR, Haddad BR, Drewry DH, Wells CI  et al.  Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas.  Sci Adv  2022 06 24;8(25):eabn3471. doi:10.1126/sciadv.abn3471
  6. Tiek DM, Cheng SY  New life for an old therapy: ELTD1 as a downstream target of angiogenesis.  Neuro Oncol  2022 03 12;24(3):412-413. doi:10.1093/neuonc/noab286
  7. Yu B, Luo F, Sun B, Liu W, Shi Q, Cheng SY, Chen C, Chen G, Li Y, Feng H  KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.  Adv Sci (Weinh)  2021 10;8(20):e2100014. doi:10.1002/advs.202100014
  8. Song L, Lin C, Gong H, Wang C, Liu L, Wu J, Tao S, Hu B, Cheng SY, Li M  et al.  Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops.  Cell Res  2021 Oct;31(10):1138. doi:10.1038/s41422-021-00549-y
  9. Cai J, Zeng C, Hua W, Qi Z, Song Y, Lu X, Li D, Zhang Z, Cui X, Zhang X  et al.  An integrative analysis of genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA detects noninvasive diagnostic markers for gliomas.  Neurooncol Adv  ;3(1):vdab049. doi:10.1093/noajnl/vdab049
  10. Goenka A, Tiek D, Song X, Huang T, Hu B, Cheng SY  The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma.  Cells  2021 02 24;10(3). pii:484
  11. Gao X, Xia X, Li F, Zhang M, Zhou H, Wu X, Zhong J, Zhao Z, Zhao K, Liu D  et al.  Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.  Nat Cell Biol  2021 03;23(3):278-291. doi:10.1038/s41556-021-00639-4
  12. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A  et al.  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.  Autophagy  2021 Jan;17(1):1-382. doi:10.1080/15548627.2020.1797280
  13. Huang T, Cheng SY  Targeting phospholipid metabolism for glioblastoma therapy.  Neuro Oncol  2021 03 25;23(3):343-344. doi:10.1093/neuonc/noaa309
  14. Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A  et al.  PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.  Mol Cell  2021 03 18;81(6):1276-1291.e9. pii:S1097-2765(21)00015-0
  15. Luo JH, Liu S, Tao J, Ren BG, Luo K, Chen ZH, Nalesnik M, Cieply K, Ma T, Cheng SY  et al.  Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.  Oncogene  2021 02;40(6):1064-1076. doi:10.1038/s41388-020-01582-8
  16. Huang T, Song X, Xu D, Tiek D, Goenka A, Wu B, Sastry N, Hu B, Cheng SY  Stem cell programs in cancer initiation, progression, and therapy resistance.  Theranostics  2020;10(19):8721-8743. doi:10.7150/thno.41648
  17. Nayak S, Mahenthiran A, Yang Y, McClendon M, Mania-Farnell B, James CD, Kessler JA, Tomita T, Cheng SY, Stupp SI  et al.  Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application.  Cancers (Basel)  2020 Feb 24;12(2). pii:E516
  18. Sastry NG, Wan X, Huang T, Alvarez AA, Pangeni RP, Song X, James CD, Horbinski CM, Brennan CW, Nakano I  et al.  LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement.  Neuro Oncol  2020 09 29;22(9):1315-1326. doi:10.1093/neuonc/noaa032
  19. Tang J, Yu B, Li Y, Zhang W, Alvarez AA, Hu B, Cheng SY, Feng H  TGF-β-activated lncRNA LINC00115 is a critical regulator of glioma stem-like cell tumorigenicity.  EMBO Rep  2019 12 05;20(12):e48170. doi:10.15252/embr.201948170
  20. Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H  CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.  Nat Commun  2019 09 05;10(1):4013. doi:10.1038/s41467-019-12001-2
  21. Song X, Wan X, Huang T, Zeng C, Sastry N, Wu B, James CD, Horbinski C, Nakano I, Zhang W  et al.  SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes.  Cancer Res  2019 10 15;79(20):5288-5301. doi:10.1158/0008-5472.CAN-19-1504
  22. Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H  Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.  J Exp Clin Cancer Res  2019 Jul 29;38(1):331. doi:10.1186/s13046-019-1335-4
  23. Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H  Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.  J Orthop Surg Res  2019 07 16;14(1):215. doi:10.1186/s13018-019-1274-y
  24. Sang Y, Hou Y, Cheng R, Zheng L, Alvarez AA, Hu B, Cheng SY, Zhang W, Li Y, Feng H  Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2-mediated signaling.  Neuro Oncol  2019 11 04;21(11):1423-1435. doi:10.1093/neuonc/noz107
  25. Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H  Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.  J Exp Clin Cancer Res  2019 04 05;38(1):147. doi:10.1186/s13046-019-1151-x
  26. Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y  et al.  Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation.  Cell Rep  2019 02 12;26(7):1893-1905.e7. pii:S2211-1247(19)30105-6
  27. Huang T, Wan X, Alvarez AA, James CD, Song X, Yang Y, Sastry N, Nakano I, Sulman EP, Hu B  et al.  MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy.  Autophagy  2019 06;15(6):1100-1111. doi:10.1080/15548627.2019.1569947
For a full list of our publication record, please visit PubMed.