Northwestern University Feinberg School of Medicine

Shi-Yuan Cheng Lab


  1. Yu B, Luo F, Sun B, Liu W, Shi Q, Cheng SY, Chen C, Chen G, Li Y, Feng H  KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.  Adv Sci (Weinh)  2021 10;8(20):e2100014. doi:10.1002/advs.202100014
  2. Song L, Lin C, Gong H, Wang C, Liu L, Wu J, Tao S, Hu B, Cheng SY, Li M  et al.  Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops.  Cell Res  2021 Oct;31(10):1138. doi:10.1038/s41422-021-00549-y
  3. Cai J, Zeng C, Hua W, Qi Z, Song Y, Lu X, Li D, Zhang Z, Cui X, Zhang X  et al.  An integrative analysis of genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA detects noninvasive diagnostic markers for gliomas.  Neurooncol Adv  ;3(1):vdab049. doi:10.1093/noajnl/vdab049
  4. Goenka A, Tiek D, Song X, Huang T, Hu B, Cheng SY  The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma.  Cells  2021 02 24;10(3). pii:484
  5. Gao X, Xia X, Li F, Zhang M, Zhou H, Wu X, Zhong J, Zhao Z, Zhao K, Liu D  et al.  Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.  Nat Cell Biol  2021 03;23(3):278-291. doi:10.1038/s41556-021-00639-4
  6. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A  et al.  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.  Autophagy  2021 Jan;17(1):1-382. doi:10.1080/15548627.2020.1797280
  7. Huang T, Cheng SY  Targeting phospholipid metabolism for glioblastoma therapy.  Neuro Oncol  2021 03 25;23(3):343-344. doi:10.1093/neuonc/noaa309
  8. Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A  et al.  PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.  Mol Cell  2021 03 18;81(6):1276-1291.e9. pii:S1097-2765(21)00015-0
  9. Luo JH, Liu S, Tao J, Ren BG, Luo K, Chen ZH, Nalesnik M, Cieply K, Ma T, Cheng SY  et al.  Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.  Oncogene  2021 02;40(6):1064-1076. doi:10.1038/s41388-020-01582-8
  10. Huang T, Song X, Xu D, Tiek D, Goenka A, Wu B, Sastry N, Hu B, Cheng SY  Stem cell programs in cancer initiation, progression, and therapy resistance.  Theranostics  2020;10(19):8721-8743. doi:10.7150/thno.41648
  11. Nayak S, Mahenthiran A, Yang Y, McClendon M, Mania-Farnell B, James CD, Kessler JA, Tomita T, Cheng SY, Stupp SI  et al.  Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application.  Cancers (Basel)  2020 Feb 24;12(2). pii:E516
  12. Sastry NG, Wan X, Huang T, Alvarez AA, Pangeni RP, Song X, James CD, Horbinski CM, Brennan CW, Nakano I  et al.  LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement.  Neuro Oncol  2020 09 29;22(9):1315-1326. doi:10.1093/neuonc/noaa032
  13. Tang J, Yu B, Li Y, Zhang W, Alvarez AA, Hu B, Cheng SY, Feng H  TGF-β-activated lncRNA LINC00115 is a critical regulator of glioma stem-like cell tumorigenicity.  EMBO Rep  2019 12 05;20(12):e48170. doi:10.15252/embr.201948170
  14. Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H  CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.  Nat Commun  2019 09 05;10(1):4013. doi:10.1038/s41467-019-12001-2
  15. Song X, Wan X, Huang T, Zeng C, Sastry N, Wu B, James CD, Horbinski C, Nakano I, Zhang W  et al.  SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes.  Cancer Res  2019 10 15;79(20):5288-5301. doi:10.1158/0008-5472.CAN-19-1504
  16. Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H  Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.  J Exp Clin Cancer Res  2019 Jul 29;38(1):331. doi:10.1186/s13046-019-1335-4
  17. Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H  Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.  J Orthop Surg Res  2019 07 16;14(1):215. doi:10.1186/s13018-019-1274-y
  18. Sang Y, Hou Y, Cheng R, Zheng L, Alvarez AA, Hu B, Cheng SY, Zhang W, Li Y, Feng H  Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2-mediated signaling.  Neuro Oncol  2019 11 04;21(11):1423-1435. doi:10.1093/neuonc/noz107
  19. Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H  Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.  J Exp Clin Cancer Res  2019 04 05;38(1):147. doi:10.1186/s13046-019-1151-x
  20. Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y  et al.  Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation.  Cell Rep  2019 02 12;26(7):1893-1905.e7. pii:S2211-1247(19)30105-6
  21. Huang T, Wan X, Alvarez AA, James CD, Song X, Yang Y, Sastry N, Nakano I, Sulman EP, Hu B  et al.  MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy.  Autophagy  2019 06;15(6):1100-1111. doi:10.1080/15548627.2019.1569947
  22. Huang T, Song X, Yang Y, Wan X, Alvarez AA, Sastry N, Feng H, Hu B, Cheng SY  Autophagy and Hallmarks of Cancer.  Crit Rev Oncog  2018;23(5-6):247-267. doi:10.1615/CritRevOncog.2018027913
  23. Pangeni RP, Zhang Z, Alvarez AA, Wan X, Sastry N, Lu S, Shi T, Huang T, Lei CX, James CD  et al.  Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma.  Epigenetics  2018;13(4):432-448. doi:10.1080/15592294.2018.1469892
  24. Sang Y, Li Y, Song L, Alvarez AA, Zhang W, Lv D, Tang J, Liu F, Chang Z, Hatakeyama S  et al.  TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.  Cancer Res  2018 04 01;78(7):1792-1804. doi:10.1158/0008-5472.CAN-17-2774
  25. Bell JB, Eckerdt F, Dhruv HD, Finlay D, Peng S, Kim S, Kroczynska B, Beauchamp EM, Alley K, Clymer J  et al.  Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation.  Mol Cancer Res  2018 01;16(1):32-46. doi:10.1158/1541-7786.MCR-17-0397
For a full list of our publication record, please visit PubMed.