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Northwestern University Feinberg School of Medicine
Shi-Yuan Cheng Lab

Publications

For a full list of our publications, please visit PubMed.

  1. Luo M, Wu S, Huang C, Zheng Z, Xia Q, Li Y, Zhou X, Hong S, Zhong R, Li W  et al.  Inhibition of PRMT5-dependent YAP methylation attenuates tumorigenicity and radioresistance in glioblastoma.  Cancer Lett  2026 Apr 28;644:218308. doi:10.1016/j.canlet.2026.218308
  2. Yu X, Song X, Schäfer RA, Meng Q, Tiek D, Wu R, He Q, Walker M, Cao Q, Yang R  et al.  An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs.  Nat Cell Biol  2026 Mar 27;. doi:10.1038/s41556-026-01924-w
  3. Wu R, Yu X, Song X, He Q, Walker M, Sisbarro D, Horbinski C, Tiek D, Hu B, Zhang N  et al.  Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced Quaking (QKI) isoforms.  Neuro Oncol  2026 Feb 17;. pii:noag030
  4. Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S  et al.  Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.  Nat Commun  2025 Dec 13;17(1):440. pii:440
  5. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem.  Genome Biol  2025 Dec 12;26(1):426. pii:426
  6. Tiek D, Song X, Wu R, Yu X, Walker M, Mao Y, Sisbarro D, He Q, Magassa A, Singh A  et al.  Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds.  Neuro Oncol  2025 Nov 10;. pii:noaf265
  7. Yu X, Song X, Tiek D, Wu R, Walker M, Horbinski C, Hu B, Cheng SY  Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma.  Neuro Oncol  2025 Sep 17;27(8):2023-2034. doi:10.1093/neuonc/noaf086
  8. Núñez FJ, Banerjee K, Mujeeb AA, Mauser A, Tronrud CE, Zhu Z, Raghuram S, Sheth MR, Agudelo JAP, Zelaya J  et al.  Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target.  Res Sq  2025 Sep 11;. pii:rs.3.rs-7483444
  9. Wang C, Zhou J, Li T, Du S, Urushidani T, Wang D, Chen Y, Mullen M, Cao X, Cheng SY  et al.  Akt-elicited phosphorylation of Acapin steers cell migration.  J Mol Cell Biol  2025 Sep 10;17(3). pii:mjaf010
  10. Wu R, Yu S, Bi A, Li Y, Tiek D, Yu K, Xiong H, Shi Q, Mo Z, Yu X  et al.  Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer.  Cancer Lett  2025 Sep 01;627:217823. doi:10.1016/j.canlet.2025.217823
  11. Cheng SY, Yu X, Song X, Schäfer R, Meng Q, Tiek D, Wu R, He Q, Walker M, Yang R  et al.  An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs.  Res Sq  2025 Jun 24;. pii:rs.3.rs-6456987
  12. Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY  A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem.  bioRxiv  2025 Mar 30;. pii:2025.03.26.645511
  13. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng S-  Correction: EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.  Oncogene  2025 Mar;44(10):710-711. doi:10.1038/s41388-025-03290-7
  14. Tiek D, Song X, Yu X, Wu R, Iglesia R, Catezone A, McCortney K, Walshon J, Horbinski C, Jamshidi P  et al.  Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma.  iScience  2025 Feb 21;28(2):111769. pii:111769
  15. Zhou X, Xia Q, Wang B, Li J, Liu B, Wang S, Huang M, Zhong R, Cheng SY, Wang X  et al.  USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5.  Theranostics  2025;15(6):2293-2314. doi:10.7150/thno.103629
  16. Xu C, Chen G, Yu B, Sun B, Zhang Y, Zhang M, Yang Y, Xiao Y, Cheng SY, Li Y  et al.  TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.  Adv Sci (Weinh)  2024 Aug;11(29):e2400023. pii:2400023
  17. Song X, Tiek D, Miki S, Huang T, Lu M, Goenka A, Iglesia R, Yu X, Wu R, Walker M  et al.  RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.  J Clin Invest  2024 Apr 25;134(11). pii:e173789
  18. Kim DR, Orr MJ, Yu X, Munshi HH, Wang A, Trudeau C, Kwong AJ, Cheng SY, Scheidt KA  Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma.  ACS Med Chem Lett  2024 Feb 08;15(2):258-264. doi:10.1021/acsmedchemlett.3c00505
  19. Bhutada I, Khambati F, Cheng SY, Tiek DM, Duckett D, Lawrence H, Vogelbaum MA, Mo Q, Chellappan SP, Padmanabhan J  CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.  Neuro Oncol  2024 Jan 05;26(1):70-84. doi:10.1093/neuonc/noad143
  20. Sun MA, Yang R, Liu H, Wang W, Song X, Hu B, Reynolds N, Roso K, Chen LH, Greer PK  et al.  Repurposing Clemastine to Target Glioblastoma Cell Stemness.  Cancers (Basel)  2023 Sep 18;15(18). pii:4619
  21. Goenka A, Song X, Tiek D, Iglesia RP, Lu M, Zeng C, Horbinski C, Zhang W, Hu B, Cheng SY  Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis.  Neuro Oncol  2023 Sep 05;25(9):1592-1604. doi:10.1093/neuonc/noad065
  22. Zeng C, Song X, Zhang Z, Cai Q, Cai J, Horbinski C, Hu B, Cheng SY, Zhang W  Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis.  Acta Neuropathol Commun  2023 Aug 14;11(1):133. pii:133
  23. Cai Q, Zhang Z, Cui X, Zeng C, Cai J, Cai J, Wu K, Zhang X, Shi Y, Arvanitakis Z  et al.  PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.  Database (Oxford)  2023 Jun 10;2023. pii:baad042
  24. Getu AA, Zhou M, Cheng SY, Tan M  The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.  Cancer Lett  2023 Jun 01;563:216183. doi:10.1016/j.canlet.2023.216183
  25. Tiek D, Wells CI, Schröder M, Song X, Alamillo-Ferrer C, Goenka A, Iglesia R, Lu M, Hu B, Kwarcinski F  et al.  SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4.  Curr Res Chem Biol  2023;3. pii:100045