Northwestern University Feinberg School of Medicine

Shi-Yuan Cheng Lab


  1. Pangeni RP, Zhang Z, Alvarez AA, Wan X, Sastry N, Lu S, Shi T, Huang T, Lei CX, James CD, Kessler JA, Brennan CW, Nakano I, Lu X, Hu B, Zhang W, Cheng SY  Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma.  Epigenetics  2018;13(4):432-448. doi:10.1080/15592294.2018.1469892
  2. Sang Y, Li Y, Song L, Alvarez AA, Zhang W, Lv D, Tang J, Liu F, Chang Z, Hatakeyama S, Hu B, Cheng SY, Feng H  TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.  Cancer Res  2018 Apr 01;78(7):1792-1804. doi:10.1158/0008-5472.CAN-17-2774
  3. Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY  MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.  Cancer Cell  2017 Dec 11;32(6):840-855.e8. pii:S1535-6108(17)30508-1
  4. Lv D, Li Y, Zhang W, Alvarez AA, Song L, Tang J, Gao WQ, Hu B, Cheng SY, Feng H  TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.  Nat Commun  2017 11 13;8(1):1454. doi:10.1038/s41467-017-01731-w
  5. Bell JB, Eckerdt F, Dhruv HD, Finlay D, Peng S, Kim S, Kroczynska B, Beauchamp EM, Alley K, Clymer J, Goldman S, Cheng SY, James CD, Nakano I, Horbinski C, Mazar AP, Vuori K, Kumthekar P, Raizer J, Berens ME, Platanias LC  Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation.  Mol Cancer Res  2018 Jan;16(1):32-46. doi:10.1158/1541-7786.MCR-17-0397
  6. Lv D, Jia F, Hou Y, Sang Y, Alvarez AA, Zhang W, Gao WQ, Hu B, Cheng SY, Ge J, Li Y, Feng H  Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.  Cancer Res  2017 11 15;77(22):6190-6201. doi:10.1158/0008-5472.CAN-17-1388
  7. Wang W, Zhang H, Liu S, Kim CK, Xu Y, Hurley LA, Nishikawa R, Nagane M, Hu B, Stegh AH, Cheng SY, Cheng C  Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A.  Proc Natl Acad Sci U S A  2017 08 01;114(31):8366-8371. doi:10.1073/pnas.1701289114
  8. Zhang W, Yan L, Zhang W, Tong Y, Cheng SY  The US Chinese Anti-Cancer Association and the Asian Fund for Cancer Research Recognize Young Chinese Cancer Researchers with the 2016 USCACA-AFCR scholar awards.  Chin J Cancer  2017 Mar 17;36(1):30. doi:10.1186/s40880-017-0197-4
  9. Zhang L, Zhang W, Li Y, Alvarez A, Li Z, Wang Y, Song L, Lv D, Nakano I, Hu B, Cheng SY, Feng H  SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.  Oncogene  2016 10 27;35(43):5641-5652. doi:10.1038/onc.2016.100
  10. Huang T, Alvarez AA, Pangeni RP, Horbinski CM, Lu S, Kim SH, James CD, J Raizer J, A Kessler J, Brenann CW, Sulman EP, Finocchiaro G, Tan M, Nishikawa R, Lu X, Nakano I, Hu B, Cheng SY  A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.  Nat Commun  2016 10 04;7:12885. doi:10.1038/ncomms12885
  11. Hashizume R, Zhang A, Mueller S, Prados MD, Lulla RR, Goldman S, Saratsis AM, Mazar AP, Stegh AH, Cheng SY, Horbinski C, Haas-Kogan DA, Sarkaria JN, Waldman T, James CD  Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth.  Neuro Oncol  2016 11;18(11):1519-1528
  12. Bell JB, Eckerdt FD, Alley K, Magnusson LP, Hussain H, Bi Y, Arslan AD, Clymer J, Alvarez AA, Goldman S, Cheng SY, Nakano I, Horbinski C, Davuluri RV, James CD, Platanias LC  MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.  Mol Cancer Res  2016 10;14(10):984-993
  13. Zhang H, Lin Y, Li K, Liang J, Xiao X, Cai J, Tan Y, Xing F, Mai J, Li Y, Chen W, Sheng L, Gu J, Zhu W, Yin W, Qiu P, Su X, Lu B, Tian X, Liu J, Lu W, Dou Y, Huang Y, Hu B, Kang Z, Gao G, Mao Z, Cheng SY, Lu L, Bai XT, Gong S, Yan G, Hu J  Naturally Existing Oncolytic Virus M1 Is Nonpathogenic for the Nonhuman Primates After Multiple Rounds of Repeated Intravenous Injections.  Hum Gene Ther  2016 09;27(9):700-11. doi:10.1089/hum.2016.038
  14. Iqbal A, Eckerdt F, Bell J, Nakano I, Giles FJ, Cheng SY, Lulla RR, Goldman S, Platanias LC  Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.  Oncotarget  2016 May 31;7(22):33192-201. doi:10.18632/oncotarget.8899
  15. Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I  Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.  Cancer Cell  2016 Feb 08;29(2):201-13. doi:10.1016/j.ccell.2016.01.005
  16. Eckerdt F, Alvarez A, Bell J, Arvanitis C, Iqbal A, Arslan AD, Hu B, Cheng SY, Goldman S, Platanias LC  A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids.  Biotechniques  2016 Jan;60(1):43-6. doi:10.2144/000114372
  17. Li Y, Zhou QL, Sun W, Chandrasekharan P, Cheng HS, Ying Z, Lakshmanan M, Raju A, Tenen DG, Cheng SY, Chuang KH, Li J, Prabhakar S, Li M, Tergaonkar V  Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.  Nat Cell Biol  2015 Oct;17(10):1327-38. doi:10.1038/ncb3240
  18. Lu S, Lu KN, Cheng SY, Hu B, Ma X, Nystrom N, Lu X  Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets.  PLoS Comput Biol  2015 Aug;11(8):e1004257. doi:10.1371/journal.pcbi.1004257
  19. Chandran UR, Luthra S, Santana-Santos L, Mao P, Kim SH, Minata M, Li J, Benos PV, DeWang M, Hu B, Cheng SY, Nakano I, Sobol RW  Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells.  Genom Data  2015 Sep 01;5:333-336
  20. Feng H, Li Y, Yin Y, Zhang W, Hou Y, Zhang L, Li Z, Xie B, Gao WQ, Sarkaria JN, Raizer JJ, James CD, Parsa AT, Hu B, Cheng SY  Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α.  Neuro Oncol  2015 Jun;17(6):832-42. doi:10.1093/neuonc/nou323
For a full list of our publication record, please visit PubMed.