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Developing novel approaches for anti-cancer therapies.

The primary goal of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and therapy resistance, and to develop novel approaches for anti-cancer therapies. Our approaches include computational methods, molecular and cellular biology, tumor xenograft model in animal, human iPSC-derived glioma model, and 3D tumor organoid model.

The Latest From the Lab


Congratulations to Dr. Xiao Song for receiving the DoD PRCRP Career Development Award! (February 2024)

Congratulations to Dr. Xiao Song for receiving the 2023 Illumina Pilot Project Award! (December 2023)

Congratulations to Dr. Deanna Tiek for receiving the NIH K99 Scholar Award! (June 2023)

Celebraing Lnar New Year 2024!

Celebrating Lunar New Year 2024!

Selected Publication

Goenka A., et al. Oncogenic Long Non-coding RNA LINC02283 Enhances PDGF Receptor A mediated Signaling and Drives Glioblastoma Tumorigenesis. Neuro Oncol, 2023 Sep 5;25(9):1592-1604.

Tiek D., et al. Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas. Sci Adv, 2022 Jun 24;8(25):eabn3471.

Huang T., et al. PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Mol Cell. 2021 Mar 18;81(6):1276-1291.e9.

Song X., et al. SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes. Cancer Res, 2019 Oct 15;79(20):5288-5301.

Huang T., et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell, 2017 Dec 11;32(6):840-855.e8. 


Dr. Cheng in his lab

Lab Leadership

Shi-Yuan Cheng, PhD
Professor of Neurology (Neuro-oncology)

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