Human Glioblastoma (GBM)Dissecting the mechanisms causing the most malignant of human brain tumorsHuman Glioblastoma (GBM)Dissecting the mechanisms causing the most malignant of human brain tumors
Glioma Stem CellsDefining distinct phenotypes in clinically relevant subtypes of GBM cell linesGlioma Stem CellsDefining distinct phenotypes in clinically relevant subtypes of GBM cell lines
Molecular profilingCharacterizing the differential expression profiles in proneural vs mesenchymal GBM stem cellsMolecular profilingCharacterizing the differential expression profiles in proneural vs mesenchymal GBM stem cells
Our lab
The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.
News and Events
- Congratulations to Dr. Cheng and the Cheng lab for their feature in the Feinberg School of Medicine News Center! (Dec 2017)
- Congratulations to Dr. Tianzhi Huang and the Cheng lab for their new publication in Cancer Cell! (Dec 2017)
- Congratulations to Dr. Tianzhi Huang for receiving the Katten Muchin Rosenman Travel Scholarship Award from Lurie Cancer Center! (July 2017)
- Congratulations and best wishes to Dr. Rajendra Pangeni for starting a new position at City of Hope! (July 2017)
- Congratulations to Ms. Namratha Sastry for receiving the Fishel Fellowship from the Lurie Cancer Center! (July 2017)
- Welcome to Dr. Xuechao Wan, who joined the Cheng lab as a post-doctoral fellow! (Feb 2017)
- Congratulations to Dr. Tianzhi Huang and the Cheng lab for their recently published manuscript in Nature Communications! (Oct 2017)
Select Publications
- Huang, T., et al. (2016) “A Regulatory Circuit of miR-125b/miR-20b and Wnt Signaling Controls GBM Phenotypes through FZD6-Mediated Pathways.” Nat. Comm. 7:12885
- Feng, H., et al. (2012) “Phosphorylation of Dock180Y722 by Src Family Kinases Mediates EGFRvIII-driven Glioma Tumorigenesis.” PNAS, 109(8):3018-23
- Feng, H., et al. (2014) “EGFR Phosphorylation of DCBLD2 Recruits TRAF6 and Stimulates Akt-promoted Tumorigenesis.” J Clin. Invest. 124(9):3741-56
