Human Glioblastoma (GBM)Dissecting the mechanisms causing the most malignant of human brain tumorsHuman Glioblastoma (GBM)Dissecting the mechanisms causing the most malignant of human brain tumors
Aberrant SignalingDissecting the molecular mechanisms that promote GBM tumorigenesisAberrant SignalingDissecting the molecular mechanisms that promote GBM tumorigenesis
RNA Splicing RegulationInvestigating alternative splicing mechanisms that enhance GBM tumorigenesisRNA Splicing RegulationInvestigating alternative splicing mechanisms that enhance GBM tumorigenesis
Role of protein arginine methylation in mitosis of GBM cellsIdentified a CK2a-PRMT6-RCC1signaling axis that is important for mitotic activity, malignancy,and therapy resistance in GBM cells.Role of protein arginine methylation in mitosis of GBM cellsIdentified a CK2a-PRMT6-RCC1signaling axis that is important for mitotic activity, malignancy,and therapy resistance in GBM cells.
Our lab
The primary goal of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and therapy resistance, and to develop novel approaches for anti-cancer therapies. Our approaches include computational methods, molecular and cellular biology, tumor xenograft model in animal, human iPSC-derived glioma model, and 3D tumor organoid model.
News and Events
- Congratulations to Dr. Rebeca Iglesia and the Cheng lab for their new publication in Frontiers Cell and Developmental Biology! (June 2022)
- Congratulations to Dr. Deanna Tiek and the Cheng lab for their new publication in Science Advances! (June 2022)
- Congratulations to Dr. Deanna Tiek for receiving an RCRP-CA grant from DOD! (starting July 2022)
- Congratulations to Dr. Xiao Song for receiving an RCRP-CA grant from DOD! (starting July 2022)
- Congratulations to Dr. Shi-Yuan Cheng and the Cheng lab for receiving an R01 grant from NIH! (starting July 2022)
- Congratulations to Dr. Shi-Yuan Cheng and the Cheng lab for receiving an R21 grant from NINDS! (starting April 2022)
- Congratulations to Dr. Shi-Yuan Cheng and the Cheng lab for receiving a MPI R21 grant from NINDS! (starting April 2022)
- Congratulations to Dr. Tianzhi Huang for his new position as a full professor at Xiamen University School of Life Sciences starting July 1, 2021. Please see his new web page.
- Congratulations to Dr. Tianzhi Huang and the Cheng lab for their new publication in Molecular Cell! (Feb 2021)
- Dr. Namratha Sastry's recent publication was featured in the Northwestern Feinberg School of Medicine News Center! Congrats to the Cheng lab! (April 2020)
- Congratulations to Dr. Shi-Yuan Cheng and the Cheng lab for receiving an R01 grant from NINDS! (April 2020)
- Congratulations to Dr. Namratha Sastry for succesfully completing her PhD Defense and getting her doctorate! (March 2020)
- Congratulations to Dr. Deanna Tiek for receiving the NIH K00 from NCI! (Feb 2020)
- Congratulations to Ms. Namratha Sastry and the Cheng lab for their new publication in Neuro-Oncology! (Feb 2020)
- Congratulations to Dr. Xiao (Lisa) Song and the Cheng lab for their new publication in Cancer Research! (Oct 2019)
- Congratulations to Dr. Tianzhi Huang and the Cheng lab for their new publication in Autophagy! (Jan 2019)
- Congratulations to Ms. Namratha Sastry for receiving the NIH NRSA F31 Grant! (Sept 2018)
Select Publications
- Tiek, D., et al (2022) "Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas." Science Advances 8(25):eabn3471
- Huang, T., et al (2021) "PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells." Mol Cell 81(6):1276-1291
- Gao X., et al (2021) "Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling." Nat Cell Biol 23(3):278-291
- Sastry, N., et al (2020) "LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement." Neuro-Oncology noaa032
- Song, X., et al. (2019) "SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes." Cancer Research 79(20):5288-5301
- Huang, T., et al (2019) "MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy." Autophagy 15(6):1100-1111
- Huang, T., et al. (2017) "MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma." Cancer Cell 32(6):840-855
- Huang, T., et al. (2016) “A Regulatory Circuit of miR-125b/miR-20b and Wnt Signaling Controls GBM Phenotypes through FZD6-Mediated Pathways.” Nat. Comm. 7:12885
- Feng, H., et al. (2012) “Phosphorylation of Dock180Y722 by Src Family Kinases Mediates EGFRvIII-driven Glioma Tumorigenesis.” PNAS 109(8):3018-23
- Feng, H., et al. (2014) “EGFR Phosphorylation of DCBLD2 Recruits TRAF6 and Stimulates Akt-promoted Tumorigenesis.” J Clin. Invest. 124(9):3741-56
