The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.
News and Events
- Welcome to Dr. Xuechao Wan, who joined the Cheng lab in February 2017!
- Congratulations to Dr. Tianzhi Huang and the Cheng lab for their recently published manuscript in Nature Communications!
- Congratulations to Dr. Angel Alvarez for receiving the NIH/NCI T32 Training Grant (T32 CA070085)!
- Congratulations to Dr. Angel Alvarez for receiving the H Foundation research grant to study proteomic analysis of glioma stem cells!
- Congratulations to Ms. Namratha Sastry for receiving the Fishel Fellowship from the Lurie Cancer Center!
- Huang, T., et al. (2016) “A Regulatory Circuit of miR-125b/miR-20b and Wnt Signaling Controls GBM Phenotypes through FZD6-Mediated Pathways.” Nat. Comm. 7:12885
- Feng, H., et al. (2012) “Phosphorylation of Dock180Y722 by Src Family Kinases Mediates EGFRvIII-driven Glioma Tumorigenesis.” PNAS, 109(8):3018-23
- Feng, H., et al. (2014) “EGFR Phosphorylation of DCBLD2 Recruits TRAF6 and Stimulates Akt-promoted Tumorigenesis.” J Clin. Invest. 124(9):3741-56