Northwestern University Feinberg School of Medicine

Shi-Yuan Cheng Lab


  1. Lv D, Li Y, Zhang W, Alvarez AA, Song L, Tang J, Gao WQ, Hu B, Cheng SY, Feng H  TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.  Nat Commun  2017 Nov 13;8(1):1454. doi:10.1038/s41467-017-01731-w
  2. Bell JB, Eckerdt F, Dhruv H, Finlay D, Peng S, Kim S, Kroczynska B, Beauchamp E, Alley K, Clymer J, Goldman S, Cheng SY, James CD, Nakano I, Horbinski C, Mazar AP, Vuori K, Kumthekar P, Raizer J, Berens ME, Platanias LC  Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy is Regulated by MNK1 and mRNA Translation.  Mol Cancer Res  2017 Oct 17;. pii:molcanres.0397.2017
  3. Lv D, Jia F, Hou Y, Sang Y, Alvarez AA, Zhang W, Gao WQ, Hu B, Cheng SY, Ge J, Li Y, Feng H  Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.  Cancer Res  2017 Nov 15;77(22):6190-6201. doi:10.1158/0008-5472.CAN-17-1388
  4. Wang W, Zhang H, Liu S, Kim CK, Xu Y, Hurley LA, Nishikawa R, Nagane M, Hu B, Stegh AH, Cheng SY, Cheng C  Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A.  Proc Natl Acad Sci U S A  2017 Aug 01;114(31):8366-8371. doi:10.1073/pnas.1701289114
  5. Zhang W, Yan L, Zhang W, Tong Y, Cheng SY  The US Chinese Anti-Cancer Association and the Asian Fund for Cancer Research Recognize Young Chinese Cancer Researchers with the 2016 USCACA-AFCR scholar awards.  Chin J Cancer  2017 Mar 17;36(1):30. doi:10.1186/s40880-017-0197-4
  6. Zhang L, Zhang W, Li Y, Alvarez A, Li Z, Wang Y, Song L, Lv D, Nakano I, Hu B, Cheng SY, Feng H  SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.  Oncogene  2016 Oct 27;35(43):5641-5652. doi:10.1038/onc.2016.100
  7. Huang T, Alvarez AA, Pangeni RP, Horbinski CM, Lu S, Kim SH, James CD, J Raizer J, A Kessler J, Brenann CW, Sulman EP, Finocchiaro G, Tan M, Nishikawa R, Lu X, Nakano I, Hu B, Cheng SY  A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.  Nat Commun  2016 10 04;7:12885. doi:10.1038/ncomms12885
  8. Hashizume R, Zhang A, Mueller S, Prados MD, Lulla RR, Goldman S, Saratsis AM, Mazar AP, Stegh AH, Cheng SY, Horbinski C, Haas-Kogan DA, Sarkaria JN, Waldman T, James CD  Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth.  Neuro Oncol  2016 Nov;18(11):1519-1528
  9. Bell JB, Eckerdt FD, Alley K, Magnusson LP, Hussain H, Bi Y, Arslan AD, Clymer J, Alvarez AA, Goldman S, Cheng SY, Nakano I, Horbinski C, Davuluri RV, James CD, Platanias LC  MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.  Mol Cancer Res  2016 Oct;14(10):984-993
  10. Zhang H, Lin Y, Li K, Liang J, Xiao X, Cai J, Tan Y, Xing F, Mai J, Li Y, Chen W, Sheng L, Gu J, Zhu W, Yin W, Qiu P, Su X, Lu B, Tian X, Liu J, Lu W, Dou Y, Huang Y, Hu B, Kang Z, Gao G, Mao Z, Cheng SY, Lu L, Bai XT, Gong S, Yan G, Hu J  Naturally Existing Oncolytic Virus M1 Is Nonpathogenic for the Nonhuman Primates After Multiple Rounds of Repeated Intravenous Injections.  Hum Gene Ther  2016 Sep;27(9):700-11. doi:10.1089/hum.2016.038
  11. Iqbal A, Eckerdt F, Bell J, Nakano I, Giles FJ, Cheng SY, Lulla RR, Goldman S, Platanias LC  Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.  Oncotarget  2016 May 31;7(22):33192-201. doi:10.18632/oncotarget.8899
  12. Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I  Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.  Cancer Cell  2016 Feb 08;29(2):201-13. doi:10.1016/j.ccell.2016.01.005
  13. Eckerdt F, Alvarez A, Bell J, Arvanitis C, Iqbal A, Arslan AD, Hu B, Cheng SY, Goldman S, Platanias LC  A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids.  Biotechniques  2016 Jan;60(1):43-6. doi:10.2144/000114372
  14. Li Y, Zhou QL, Sun W, Chandrasekharan P, Cheng HS, Ying Z, Lakshmanan M, Raju A, Tenen DG, Cheng SY, Chuang KH, Li J, Prabhakar S, Li M, Tergaonkar V  Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.  Nat Cell Biol  2015 Oct;17(10):1327-38. doi:10.1038/ncb3240
  15. Lu S, Lu KN, Cheng SY, Hu B, Ma X, Nystrom N, Lu X  Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets.  PLoS Comput Biol  2015 Aug;11(8):e1004257. doi:10.1371/journal.pcbi.1004257
  16. Chandran UR, Luthra S, Santana-Santos L, Mao P, Kim SH, Minata M, Li J, Benos PV, DeWang M, Hu B, Cheng SY, Nakano I, Sobol RW  Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells.  Genom Data  2015 Sep 01;5:333-336
  17. Feng H, Li Y, Yin Y, Zhang W, Hou Y, Zhang L, Li Z, Xie B, Gao WQ, Sarkaria JN, Raizer JJ, James CD, Parsa AT, Hu B, Cheng SY  Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α.  Neuro Oncol  2015 Jun;17(6):832-42. doi:10.1093/neuonc/nou323
  18. Yoshida Y, Ozawa T, Yao TW, Shen W, Brown D, Parsa AT, Raizer JJ, Cheng SY, Stegh AH, Mazar AP, Giles FJ, Sarkaria JN, Butowski N, Nicolaides T, James CD  NT113, a pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification.  Mol Cancer Ther  2014 Dec;13(12):2919-29. doi:10.1158/1535-7163.MCT-14-0306
  19. Ma HI, Hueng DY, Shui HA, Han JM, Wang CH, Lai YH, Cheng SY, Xiao X, Chen MT, Yang YP  Intratumoral decorin gene delivery by AAV vector inhibits brain glioblastomas and prolongs survival of animals by inducing cell differentiation.  Int J Mol Sci  2014 Mar 12;15(3):4393-414. doi:10.3390/ijms15034393
  20. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng SY  EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.  Oncogene  2014 May 08;33(19):2504-12. doi:10.1038/onc.2013.198
For a full list of our publication record, please visit PubMed.