Our lab

The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.

News and Events

  • ANNOUCEMENT: The Cheng lab has a postdoctoral position open. Interested candidates should contact Dr. Cheng at shiyuan.cheng@northwestern.edu
  • Welcome to Dr. Rajendra Pangeni (postdoctoral fellow), who completed his PhD from the University of Wolverhampton!
  • Welcome to Namratha Sastry, a rising 2nd year graduate student in NUIN!
  • Welcome to Jae Oh for joining us for the 2015-2016 school year through IMSA!
  • Congratulations to Dr. Shi-Yuan Cheng for being awarded an R01 from NIH/NINDS titled "Glioblastoma Phenotype Modulation Through miRNA Control of Wnt Signaling"!!!

    Select Publications

    Feng, H., Hu, B., Jarzynka, M.J., Liu, K.-W., Hamilton, R. L., Vuori, K., Furnari, F.B., Johns, T.G., Tang, C., Nishikawa, R., Cavenee, W.K. and Cheng, S.-Y. (2012) “Phosphorylation of Dock180Y722 by Src Family Kinases Mediates EGFRvIII-driven Glioma Tumorigenesis.” Proc. Natl. Acad. Sci., USA, 109(8):3018-23 PMCID: PMC: 3286964 

    Feng, H., Lopes, G., Kim, C., Duncan, C. G., Alvarez, A., Nishikawa, N., Nagane, M., Su, A.-J., Auron, P. E., Hedberg, M.L., Wang, L., Raizer, J.J., Kessler, J.A., Parsa, A.T., Gao, W.-Q., Kim, S., M. Mutsuko, Nakano, I., Grandis, J.R., McLendon, R.E., Bigner, D.D., Lin, H.-K., Furnari, F.B., Cavenee, W.K., Hu, B., Yan, H. and Cheng, S.-Y. (2014) “EGFR Phosphorylation of DCBLD2 Recruits TRAF6 and Stimulates Akt-promoted Tumorigenesis.” J Clin. Invest. 124(9):3741-56; PMCID: PMC4151226

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    Shi-Yuan Cheng, PhD

    Shi-Yuan Cheng, PhD
    Professor in Neurology - Ken and Ruth Davee Department

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