The primary goals of research projects in Cheng laboratory is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas) and breast cancers.
News and Events
- Congratulations to Dr. Tianzhi Huang for receiving the Stone Award for the Lurie Cancer Center Poster Session!
- "A regulatory circuit of miR-125b/miR-20b and Wnt signaling controls GBM phenotypes through FZD6 mediated pathways."
- Congratulations to Dr. Shi-Yuan Cheng for being awarded an R01 from NIH/NINDS titled "Glioblastoma Phenotype Modulation Through miRNA Control of Wnt Signaling"!!!
Feng, H., Hu, B., Jarzynka, M.J., Liu, K.-W., Hamilton, R. L., Vuori, K., Furnari, F.B., Johns, T.G., Tang, C., Nishikawa, R., Cavenee, W.K. and Cheng, S.-Y. (2012) “Phosphorylation of Dock180Y722 by Src Family Kinases Mediates EGFRvIII-driven Glioma Tumorigenesis.” Proc. Natl. Acad. Sci., USA, 109(8):3018-23 PMCID: PMC: 3286964
Feng, H., Lopes, G., Kim, C., Duncan, C. G., Alvarez, A., Nishikawa, N., Nagane, M., Su, A.-J., Auron, P. E., Hedberg, M.L., Wang, L., Raizer, J.J., Kessler, J.A., Parsa, A.T., Gao, W.-Q., Kim, S., M. Mutsuko, Nakano, I., Grandis, J.R., McLendon, R.E., Bigner, D.D., Lin, H.-K., Furnari, F.B., Cavenee, W.K., Hu, B., Yan, H. and Cheng, S.-Y. (2014) “EGFR Phosphorylation of DCBLD2 Recruits TRAF6 and Stimulates Akt-promoted Tumorigenesis.” J Clin. Invest. 124(9):3741-56; PMCID: PMC4151226View all publications