Northwestern University Feinberg School of Medicine

Derek Walsh Lab


Learn more about the work that we do in the Derek Walsh Laboratory through our recent publications.
  1. Park C, Walsh D  RACK1 Regulates Poxvirus Protein Synthesis Independently of Its Role in Ribosome-Based Stress Signaling.  J Virol  2022 Sep 28;96(18):e0109322. doi:10.1128/jvi.01093-22
  2. Pegg CE, Zaichick SV, Bomba-Warczak E, Jovasevic V, Kim D, Kharkwal H, Wilson DW, Walsh D, Sollars PJ, Pickard GE  et al.  Herpesviruses assimilate kinesin to produce motorized viral particles.  Nature  2021 11;599(7886):662-666. doi:10.1038/s41586-021-04106-w
  3. Furey C, Astar H, Walsh D  Human Cytomegalovirus Exploits TACC3 To Control Microtubule Dynamics and Late Stages of Infection.  J Virol  2021 08 25;95(18):e0082121. doi:10.1128/JVI.00821-21
  4. Procter DJ, Furey C, Garza-Gongora AG, Kosak ST, Walsh D  Cytoplasmic control of intranuclear polarity by human cytomegalovirus.  Nature  2020 11;587(7832):109-114. doi:10.1038/s41586-020-2714-x
  5. DiGiuseppe S, Rollins MG, Astar H, Khalatyan N, Savas JN, Walsh D  Proteomic and mechanistic dissection of the poxvirus-customized ribosome.  J Cell Sci  2020 07 09;134(5). pii:jcs246603
  6. Furey C, Jovasevic V, Walsh D  TACC3 Regulates Microtubule Plus-End Dynamics and Cargo Transport in Interphase Cells.  Cell Rep  2020 01 07;30(1):269-283.e6. pii:S2211-1247(19)31675-4
  7. Meade N, King M, Munger J, Walsh D  mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.  J Virol  2019 08 01;93(15). pii:e00784-19
  8. Meade N, DiGiuseppe S, Walsh D  Translational control during poxvirus infection.  Wiley Interdiscip Rev RNA  2019 03;10(2):e1515. doi:10.1002/wrna.1515
  9. Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D  Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.  Cell  2018 08 23;174(5):1143-1157.e17. pii:S0092-8674(18)30856-0
  10. Walsh D, Naghavi MH  Exploitation of Cytoskeletal Networks during Early Viral Infection.  Trends Microbiol  2019 01;27(1):39-50. pii:S0966-842X(18)30156-2
  11. Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH  Author Correction: HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration.  Nat Commun  2018 06 05;9(1):2257. doi:10.1038/s41467-018-04750-3
  12. DiGiuseppe S, Rollins MG, Bartom ET, Walsh D  ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis.  Cell Rep  2018 05 01;23(5):1249-1258. pii:S2211-1247(18)30520-5
  13. Procter DJ, Banerjee A, Nukui M, Kruse K, Gaponenko V, Murphy EA, Komarova Y, Walsh D  The HCMV Assembly Compartment Is a Dynamic Golgi-Derived MTOC that Controls Nuclear Rotation and Virus Spread.  Dev Cell  2018 04 09;45(1):83-100.e7. pii:S1534-5807(18)30197-7
  14. Walsh D  Poxviruses: Slipping and sliding through transcription and translation.  PLoS Pathog  2017 11;13(11):e1006634. doi:10.1371/journal.ppat.1006634
  15. Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH  HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration.  Nat Commun  2017 11 15;8(1):1522. doi:10.1038/s41467-017-01795-8
  16. Jha S, Rollins MG, Fuchs G, Procter DJ, Hall EA, Cozzolino K, Sarnow P, Savas JN, Walsh D  Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.  Nature  2017 06 29;546(7660):651-655. doi:10.1038/nature22814
  17. Naghavi MH, Walsh D  Microtubule Regulation and Function during Virus Infection.  J Virol  2017 08 15;91(16). pii:e00538-17
  18. Jan E, Mohr I, Walsh D  A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells.  Annu Rev Virol  2016 09 29;3(1):283-307
  19. Jovasevic V, Naghavi MH, Walsh D  Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells.  J Cell Biol  2015 Oct 26;211(2):323-37. doi:10.1083/jcb.201505123
  20. Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA, Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH  HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.  Nat Commun  2015 Mar 30;6:6660. doi:10.1038/ncomms7660
  21. Walsh D, Mohr I  Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.  Genes Dev  2014 Apr 15;28(8):835-40. doi:10.1101/gad.236752.113
  22. Sabo Y, Walsh D, Barry DS, Tinaztepe S, de Los Santos K, Goff SP, Gundersen GG, Naghavi MH  HIV-1 induces the formation of stable microtubules to enhance early infection.  Cell Host Microbe  2013 Nov 13;14(5):535-46. doi:10.1016/j.chom.2013.10.012
  23. Naghavi MH, Gundersen GG, Walsh D  Plus-end tracking proteins, CLASPs, and a viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus spread.  Proc Natl Acad Sci U S A  2013 Nov 05;110(45):18268-73. doi:10.1073/pnas.1310760110
  24. Walsh D, Mathews MB, Mohr I  Tinkering with translation: protein synthesis in virus-infected cells.  Cold Spring Harb Perspect Biol  2013 Jan 01;5(1):a012351. doi:10.1101/cshperspect.a012351
  25. Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I  et al.  Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.  Nat Immunol  2012 Apr 29;13(6):543-550. doi:10.1038/ni.2291
  26. Zaborowska I, Kellner K, Henry M, Meleady P, Walsh D  Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3.  Virology  2012 Mar 30;425(1):11-22. doi:10.1016/j.virol.2011.12.022
  27. Walsh D, Mohr I  Viral subversion of the host protein synthesis machinery.  Nat Rev Microbiol  2011 Oct 17;9(12):860-75. doi:10.1038/nrmicro2655
  28. Naghavi M, Walsh D  Research funding: Learn from Ireland's knowledge economy.  Nature  2011 Aug 24;476(7361):399. doi:10.1038/476399b
  29. Brown C, Morham SG, Walsh D, Naghavi MH  Focal adhesion proteins talin-1 and vinculin negatively affect paxillin phosphorylation and limit retroviral infection.  J Mol Biol  2011 Jul 29;410(5):761-77. doi:10.1016/j.jmb.2011.03.076
  30. Henning MS, Stiedl P, Barry DS, McMahon R, Morham SG, Walsh D, Naghavi MH  PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1.  Virology  2011 Jul 05;415(2):114-21. doi:10.1016/j.virol.2011.04.006
  31. Walsh D  Manipulation of the host translation initiation complex eIF4F by DNA viruses.  Biochem Soc Trans  2010 Dec;38(6):1511-6. doi:10.1042/BST0381511
  32. McMahon R, Zaborowska I, Walsh D  Noncytotoxic inhibition of viral infection through eIF4F-independent suppression of translation by 4EGi-1.  J Virol  2011 Jan;85(2):853-64. doi:10.1128/JVI.01873-10
  33. Arias C, Walsh D, Harbell J, Wilson AC, Mohr I  Activation of host translational control pathways by a viral developmental switch.  PLoS Pathog  2009 Mar;5(3):e1000334. doi:10.1371/journal.ppat.1000334
  34. Zaborowska I, Walsh D  PI3K signaling regulates rapamycin-insensitive translation initiation complex formation in vaccinia virus-infected cells.  J Virol  2009 Apr;83(8):3988-92. doi:10.1128/JVI.02284-08
  35. McMahon R, Walsh D  Efficient quiescent infection of normal human diploid fibroblasts with wild-type herpes simplex virus type 1.  J Virol  2008 Oct;82(20):10218-30. doi:10.1128/JVI.00859-08
  36. Walsh D, Arias C, Perez C, Halladin D, Escandon M, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Mohr I  Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.  Mol Cell Biol  2008 Apr;28(8):2648-58. doi:10.1128/MCB.01631-07
  37. Walsh D, Mohr I  Assembly of an active translation initiation factor complex by a viral protein.  Genes Dev  2006 Feb 15;20(4):461-72
  38. Walsh D, Perez C, Notary J, Mohr I  Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells.  J Virol  2005 Jul;79(13):8057-64
  39. Walsh D, Mohr I  Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells.  Genes Dev  2004 Mar 15;18(6):660-72
  40. Walsh D, Meleady P, Power B, Morley SJ, Clynes M  Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines.  Differentiation  2003 Mar;71(2):126-34