Northwestern University Feinberg School of Medicine

Derek Walsh Lab

Our Lab

Research in our laboratory focuses on two aspects of DNA virus biology: 1) How poxviruses take control of host ribosomes and cell signaling pathways. 2) How herpesviruses, such as human cytomegalovirus, control cellular organization through microtubules, using approaches such as Deep Learning-based image analysis pipelines.

Selected Publications

Procter D, Furey C, Garza-Gongora AG, Kosak T, Walsh D  Cytoplasmic Control of Intranuclear Polarity by Human Cytomegalovirus. Nature 2020. s41586-020-2714-x

Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D  Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.  Cell 2018. pii:S0092-8674(18)30856-0

Procter DJ, Banerjee A, Nukui M, Kruse K, Gaponenko V, Murphy EA, Komarova Y, Walsh D  The HCMV Assembly Compartment Is a Dynamic Golgi-Derived MTOC that Controls Nuclear Rotation and Virus Spread.  Dev Cell  2018. pii:S1534-5807(18)30197-7

Jha S, Rollins MG, Fuchs G, Procter DJ, Hall EA, Cozzolino K, Sarnow P, Savas JN, Walsh D  Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.  Nature 2017. doi:10.1038/nature22814

Derek Walsh, PhD

Derek Walsh, PhD
Professor in Microbiology-Immunology

For more information, click here to visit our department page.