Northwestern University Feinberg School of Medicine

Derek Walsh Lab

Our Lab

Research in our laboratory focuses on two aspects of DNA virus biology: 1) The role of the host translation system during infection by poxviruses. 2) Microtubule regulation and function during herpes simplex virus infection.

Selected Publications

Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D  Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.  Cell  2018. pii:S0092-8674(18)30856-0

DiGiuseppe S, Rollins MG, Bartom ET, Walsh D  ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis.  Cell Rep  2018. pii:S2211-1247(18)30520-5

Procter DJ, Banerjee A, Nukui M, Kruse K, Gaponenko V, Murphy EA, Komarova Y, Walsh D  The HCMV Assembly Compartment Is a Dynamic Golgi-Derived MTOC that Controls Nuclear Rotation and Virus Spread.  Dev Cell  2018. pii:S1534-5807(18)30197-7

Jha S, Rollins MG, Fuchs G, Procter DJ, Hall EA, Cozzolino K, Sarnow P, Savas JN, Walsh D  Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.  Nature  2017. doi:10.1038/nature22814

Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH  HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration.  Nat Commun  2017. doi:10.1038/s41467-017-01795-8

Derek Walsh, PhD

Derek Walsh, PhD
Associate Professor in Microbiology-Immunology

For more information, click here to visit our department page.