Exploring DNA virus biology.

The Walsh Lab

Poxvirus Research

One area of research in our lab is focused on how poxviruses control translation by targeting ribosomes and innate immune responses by targeting mTOR.

Herpesvirus Research

Our group is also interested in how herpesviruses, such as human cytomegalovirus, use microtubules to control cellular architecture and behavior to promote infection.

Explore Our Research Access Resources

Lab Leadership

Derek F. Walsh, PhD
Professor of Microbiology-Immunology

Meet the full lab team Contact Us

Selected Publications

Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D. The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses. Nature Communications. 2023. https://doi.org/10.1038/s41467-023-43635-y

Pegg CE, et al. Herpesviruses assimilate kinesin to produce motorized viral particles. Nature. 2021. https://doi.org/10.1038/s41586-021-04106-w

Procter D, Furey C, Garza-Gongora AG, Kosak T, Walsh D. Cytoplasmic Control of Intranuclear Polarity by Human Cytomegalovirus. Nature. 2020. https://doi.org/10.1038/s41586-020-2714-x

Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D. Poxviruses evade cytosolic sensing through disruption of an mTORC1-mTORC2 regulatory circuit. Cell. 2018. https://doi.org/10.1016/j.cell.2018.06.053

Jha S, Rollins MG, Fuchs G, Procter DJ, Hall EA, Cozzolino K, Sarnow P, Savas JN, Walsh D. Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase. Nature. 2017. https://doi.org/10.1038/nature22814