Leukocyte trafficking
A scanning electron microscopy image shows a cross section of a skeletal muscle with a blood vessel (post-capillary venule) in the middle and the circulating leukocytes adherent to the vessel wall.
Leukocyte trafficking
A scanning electron microscopy image shows a cross section of a skeletal muscle with a blood vessel (post-capillary venule) in the middle and the circulating leukocytes adherent to the vessel wall.
Roles for innate immune cells in mucosal injury and wound healing
The image shows re-epithelialization and closure of a mucosal wound that was superficially introduced into a mouse colon using a colonoscopic-biopsy-based technique. Eight-micrometer sections of extracted, OCT-frozen, wounded tissue were stained for E-cadherin (green) and Ki67 (red) to visualize total and proliferating epithelial cells in the wounded regions (cell nuclei in blue).
Roles for innate immune cells in mucosal injury and wound healing
The image shows re-epithelialization and closure of a mucosal wound that was superficially introduced into a mouse colon using a colonoscopic-biopsy-based technique. Eight-micrometer sections of extracted, OCT-frozen, wounded tissue were stained for E-cadherin (green) and Ki67 (red) to visualize total and proliferating epithelial cells in the wounded regions (cell nuclei in blue).
Roles for innate immunity in development of colorectal cancer
In vivo studies of metastatic colorectal cancer cells (red) and neutrophil (green) interactions in mouse liver (primary metastatic organ for colorectal cancer).
Roles for innate immunity in development of colorectal cancer
In vivo studies of metastatic colorectal cancer cells (red) and neutrophil (green) interactions in mouse liver (primary metastatic organ for colorectal cancer).

Our Lab

Our laboratory is utilizing state-of-the-art intravital imaging techniques, including multi-photon and spinning disc microscopy, as well as multiple animal models of intestinal inflammation and disease, supplemented by in-vitro biochemical and molecular approaches to study leukocyte (neutrophil, monocyte/macrophage) trafficking in mucosal tissues. We are particularly interested in exploring the roles of innate immune cells in regulating intestinal homeostasis, wound healing, host pathogen interactions and cancer development.

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Ronen Sumagin, PhD

Ronen Sumagin, PhD
Assistant Professor in Pathology

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Selected Publications

Butin-Israeli V, Bui TM, Wiesolek HL, Mascarenhas L, Lee JJ, Mehl LC, Knutson KR, Adam SA, Goldman RD, Beyder A, Wiesmuller L, Hanauer SB, Sumagin R Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing. J Clin Invest 2019 Feb 1;129(2):712-726 PMID: 30640176, PMCID: PMC6355304

Slater TW, Finkielsztein A, Mascarenhas LA, Mehl LC, Butin-Israeli V, Sumagin R Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing. J Immunol 2017 Apr 1;198(7):2886-2897 PMID: 28242649, PMCID: PMC5360559

Butin-Israeli V, Houser MC, Feng M, Thorp EB, Nusrat A, Parkos CA, Sumagin R Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration. FASEB J 2016 Dec;30(12):4007-4020 PMID: 27553226, PMCID: PMC5102120

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Ronen Sumagin Lab

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