Studying immune cell trafficking and function in mucosal inflammation and cancer.
The Sumagin Lab
Our laboratory is utilizing state-of-the-art intravital imaging techniques, including multi-photon and spinning disc microscopy, as well as multiple animal models of intestinal inflammation and disease, supplemented by in-vitro biochemical and molecular approaches to study leukocyte (neutrophil, monocyte/macrophage) trafficking in mucosal tissues. We are particularly interested in exploring the roles of innate immune cells in regulating intestinal homeostasis, wound healing, host pathogen interactions and cancer development.
Meet Our Team
Mei Y, Han X, Liu Y, Yang J, Sumagin R, Ji P Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment. Nat Commun 2020 Jun 23;11(1):3172 PMID: 32576838, PMCID: PMC7311390
Bui TM, Wiesolek HL, Sumagin R ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. J Leukoc Biol 2020 Mar 17; PMID: 32182390, PMCID:
Wiesolek HL, Bui TM, Lee JJ, Dalal P, Finkielsztein A, Batra A, Thorp EB, Sumagin R Intercellular Adhesion Molecule 1 Functions as an Efferocytosis Receptor in Inflammatory Macrophages. Am J Pathol 2020 Apr;190(4):874-885 PMID: 32035057, PMCID: PMC7180595