Northwestern University Feinberg School of Medicine

Ronen Sumagin Lab

Our Lab

Our laboratory is utilizing state-of-the-art intravital imaging techniques, including multi-photon and spinning disc microscopy, as well as multiple animal models of intestinal inflammation and disease, supplemented by in-vitro biochemical and molecular approaches to study leukocyte (neutrophil, monocyte/macrophage) trafficking in mucosal tissues. We are particularly interested in exploring the roles of innate immune cells in regulating intestinal homeostasis, wound healing, host pathogen interactions and cancer development.

Ronen Sumagin, PhD

Ronen Sumagin, PhD
Assistant Professor in Pathology


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Selected Publications

Butin-Israeli V, Bui TM, Wiesolek HL, Mascarenhas L, Lee JJ, Mehl LC, Knutson KR, Adam SA, Goldman RD, Beyder A, Wiesmuller L, Hanauer SB, Sumagin R  Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing.  J Clin Invest 2019 Feb 1;129(2):712-726 PMID: 30640176, PMCID: PMC6355304

Sullivan DP, Bui T, Muller WA, Butin-Israeli V, Sumagin R  In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines. Mucosal Immunol 2018 Nov;11(6):1571-1581 PMID: 30104624, PMCID: PMC6279495

Butin-Israeli V, Houser MC, Feng M, Thorp EB, Nusrat A, Parkos CA, Sumagin R  Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration.  FASEB J 2016 Dec;30(12):4007-4020 PMID: 27553226, PMCID: PMC5102120

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