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Learn more about the work that we do in the Beatriz Sosa-Pineda Laboratory through our recent publications.

  1. Ma R, Martinez-Ramirez AS, Borders TL, Gao F and Sosa-Pineda B. Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts. Elife. 2020 Mar 10;9. pii: e46206. doi: 10.7554/eLife.46206. PMID: 32154783.
  2. Lewis PL, Su J, Yan M, Meng F, Glaser SS, Alpini GD, Green RM, Sosa-Pineda B, Shah RN. Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Sci Rep. 8(1):12220, 2018. PMCID: PMC6093899.
  3. Drosos Y, Escobar D, Chiang M-Y, Roys K, Valentine V, Valentine MB, Rehg JE, Sahai V, Begley LA, Ye J, Paul L, McKinnon PJ, Sosa-Pineda B. ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer. Sci. Rep. 7(1):11144, 2017. PMCID: PMC5593966.
  4. Drosos Y, Neale G, Ye J, Paul L, Kuliyev E, Maitra A, Means AL, Washington MK, Rehg J, Finkelstein DB, and Sosa-Pineda B.Prox1-heterozygosis sensitizes the pancreas to oncogenic Kras-induced neoplastic transformation. Neoplasia 18(3):172-84, 2016. PMCID: PMC4796801.
  5. Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B. Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-cells. Diabetes. 65(3):687-98, 2016. PMCID: PMC4764148.
  6. Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest. 94(4):409-21, 2014. PMCID: PMC3992484.
  7. Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, and Sosa-Pineda B. Prox1 ablation in hepatic precursors causes defective hepatocyte specification and increases biliary cell commitment. Development. 141(3):538-47, 2014. PMCID: PMC3899812
  8. Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, Asheri R, Wells JM, Heller S, Dor Y, and Glaser B. Gastrin: a distinct fate of Neurogenin3+ progenitor cells in the embryonic pancreas. PLoS One. 8(8):e70397, 2013 PMCID: PMC3734289
  9. Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M,  Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG. The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ. 2013; 20(11):1485-97. doi: 10.1038/cdd.2013.76. PMCID: PMC3792440
  10. Westmoreland JJ, Drosos Y, Kelly J, Ye J, Means AL, Washington MK and Sosa-Pineda B. Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev. Dyn. 241:583-94, 2012. PMCID: PMC3288608.
  11. Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B. Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology. 142(4):999-1009, 2012. PMCID: PMC3398795.
  12. Magenheim J, Klein AM, Stanger BZ, Ashery-Padan R, Sosa-Pineda B, Gu G, Dor Y. Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev. Biol. 359(1):26-36, 2011. PMCID: PMC3746519
  13. Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R. Islet b-cell-specific MafA transcription requires the 5'-flanking conserved Region 3 control domain. Mol Cell Biol. 30(17):4234-44, 2010. PMCID: PMC2937551
  14. Kang HS, Kim YS, Zeruth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Pierreux, C.E., Lemaigre, F., Foley J, and Jetten AM. Transcription factor Glis3: a novel critical player in the regulation of pancreatic b-cell development and insulin gene expression. Mol. Cell. Biol. 29:24, 6366-6379, 2009. PMCID: PMC2786880
  15. Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell. 138(3):449-62, 2009. PMCID: PMC2792203.
  16. Westmoreland JJ, Wang Q, Bouzaffour M, Baker SJ, Sosa-Pineda B.  Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev. Biol. 334(1):285-98, 2009. PMCID: PMC2744847.
  17. Wang, Q, Elghazi, L, Martin, S, Martins, I, Srinivasan, S, Geng, X, Sleeman, M, Collombat, P, Houghton, J and Sosa-Pineda, B. Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. Dev Dyn 237:51-61, 2008. Accepted before April 7, 2008.
  18. Krishnamurthy, P.C., Du, G., Fukuda, Y., Sun, D., Sampath, J., Mercer, K.E., Wang, J., Sosa-Pineda, B., Murti, G.K. and Schuetz, J.D. Identification of a mammalian mitochondrial porphyrin transporter. Nature 443: 586-589, 2006.
  19. Kilic G, Wang J, Sosa-Pineda, B. Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice. Dev Dyn. 235:1659-67, 2006.
  20. Artner, I., Lelay, J., Hang, Y., Elgazhi, L., Schisler, J. C., Henderson, E., Sosa-Pineda, B., and Stein, R. MafB: A Transcription Factor of the Glucagon Gene in Islet a Cells is also Expressed in b Cell Progenitors. Diabetes 55:297-304, 2005. 
  21. Wang J, Kilic G, Ayden M, Burke Z, Oliver G, Sosa-Pineda, B. Prox1 activity controls pancreas morphogenesis and participates in the production of “secondary transition” pancreatic endocrine cells. Dev Biol. 286(1):182-94, 2005.
  22. Prado, C.L., Pugh-Bernard, A.E., Elghazi, L., Sosa-Pineda, B. and Sussel, L. Ghrelin cells replace insulin-producing β-cells in two mouse models of pancreas development. PNAS.101: 4679-4684, 2004.
  23. Wang. J., Elghazi, L., Parker, S., Kizilocak, H., Asano, M., Sussel, L. and Sosa-Pineda, B. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation. Developmental Biology. 266(1): 178-189, 2004.
  24. Krakowski, M., Yeung, B., Abdelmalik, R., Good, A., Mocnik, L. Sosa-Pineda, B., St-Onge, L., Gruss, P. and Sarvetnick, N. IFN-g overexpression within the pancreas was not sufficient to rescue Pax4, Pax6 and Pdx-1 mutant mice from death. Pancreas 21: 399-406, 2000.
  25. Sosa-Pineda, B., Wigle, J. T. and Oliver, G. Hepatocyte migration during liver development requires Prox1. Nat. Gen. 25:254-255, 2000.
  26. Larsson L, St-Onge L, Hougaard, DM, Sosa-Pineda B, Gruss P. Pax4 and Pax6 regulate gastrointestinal endocrine cell development. Mech. Dev 79: 153-159, 1998.
  27. St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P. Pax6 is required for differentiation of glucagon-producing a-cells in mouse pancreas. Nature. 387:406-409, 1997.
  28. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G and Gruss, P. The Pax4 gene is essential for differentiation of insulin producing cells in the mammalian pancreas.  Nature 386:399-402, 1997.
  29. Oliver G, Sosa-Pineda B, Geisendorf S, Spana EP, Doe CQ and Gruss P.  Prox 1, a prospero-related homeobox gene expressed during mouse development.  Mech.Dev  44:3-16, 1993.