Lymphatic Vessels in Pancreatitis

The lymphatic vasculature is increasingly recognized as a key regulator of inflammation, immune
surveillance, and tissue repair. Lymphatic vessels help restore tissue homeostasis by draining
excess fluid, transporting immune cells, and promoting resolution of inflammation. Enhancing
lymphatic function may therefore represent a promising therapeutic strategy to reduce tissue
injury and improving recovery following pancreatitis.

Although lymphatic vessels play important roles in many organs, their contribution to pancreatic
injury and repair in pancreatitis remain poorly understood. Our research addresses this important
knowledge gap using genetic mouse models, pharmacologic approaches, three-dimensional
imaging, and single-cell transcriptomics. By defining how lymphatic vessels regulate inflammation
and tissue repair in the pancreas, we aim to uncover novel mechanisms and identify new
therapeutic opportunities for pancreatitis.