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We investigate the type 3 intermediate filament protein vimentin and its role in pulmonary health and disease. Vimentin is expressed in macrophages, where it plays a critical role in innate immune signaling. In the absence of vimentin, inflammation and its associated tissue injury are greatly reduced. This raises intriguing clinical implications for the treatment of inflammatory diseases. 

Vimentin is a key protein in the distal pole complex of regulatory T cells (Tregs). Infection by influenza A virus induces robust Treg proliferation and activation to facilitate tissue repair. We investigate whether loss of vimentin in Tregs augments their function, promoting lung recovery following influenza. 

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See also T32 Training Program in Lung Science.