Investigating mechanisms driving repair and recovery from viral pneumonia.
The Ridge Lab
Our research focuses on mechanisms that drive repair and recovery from viral pneumonia. We aim to identify the molecular signaling that modulates the transition from the initial phases of acute lung injury to the later phases of resolution and repair. We are particularly interested in the role played by the intermediate filament protein vimentin in activation of inflammasome, cGAS-STING, and other signaling pathways in macrophages and regulatory T cells (Tregs).
Explore our Research View Publications Ridge Lab in the News
Lab Leadership
Karen M. Ridge, PhD
Ernest S. Bazley Professor of Pulmonary Sciences
Professor of Medicine (Pulmonary and Critical Care) and Cell & Developmental Biology
Alveolar Epithelial Cells
Type 1 (T1-alpha, red) and 2 (pro-SP-C, green) alveolar epithelial cells in a mouse lung
Vimentin and NLRP3
Proximity ligation assay between vimentin and NLRP3 in mouse macrophage
Mouse Lung with Influenza
Influenza A virus NS1 protein (brown) in influenza-infected mouse lung
Vimentin in Regulatory T Cells
Vimentin intermediate filaments (green) in induced regulatory T cells
Internal Collaborators
External Collaborators
- John Eriksson, PhD, Åbo Akademi University
- Paul A. Janmey, PhD, University of Pennsylvania
- Diana Toivola, PhD, Åbo Akademi University
- Rachel L. Zemans, MD, University of Michigan