News
12.17.19
Dr. Ozdinler was interviewed by BBC World News
11.7.19
Ozdinler Lab identified Mitoautophagy, a novel self-destructive path for mitochondria
1.22.19
Dr. Gautam is named the inaugural Ellen McConnell Blakeman fellow
11.6.18
Going from Mutations to Protein Networks in ALS
7.12.18
Appreciating the Importance of Upper Motor Neurons
7.12.17
Dr. Jara has been interviewed by ALSA
5.31.17
Effective September 2017 Dr. Ozdinler will be an Associate Professor with tenure
2.17.17
Upper Motor Neurons Contribute to ALS in Human Brain Tissue
2.7.17
Investigating a Novel Pathology of ALS
9.4.16
Nobel Forum at the Karolinska Institutet
3.14.16
The 30 Most Influential Turkish-American Women
3.1.16
Search for ALS a Richly Collaborative Venture
2.24.16
Gene Therapy Vector Reaches Most of Brain’s Upper Motor Neurons
About Our Lab
The overall goal of the Ozdinler Lab is to understand the cellular and molecular basis of selective neuronal vulnerability. The lab primarily focuses on the corticospinal motor neurons (CSMN), the neurons that are important for the initiation and modulation of voluntary movement. CSMN degeneration is a key feature in many motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS).
Selected Publications
Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology. Gautam M, Jara JH, Kocak N, Rylaarsdam LE, Kim KD, Bigio EH, Hande Özdinler P. Acta Neuropathol. 2019 Jan PMID: 30450515
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS. Dervishi I, Gozutok O, Murnan K, Gautam M, Heller D, Bigio E, Ozdinler PH. Sci Rep 2018 Oct 03 PMID: 30283000
Incorporating upper motor neuron health in ALS drug discovery. Dervishi I, Ozdinler PH. Drug Discov Today 2018 Mar 23 PMID: 29331501
Evidence for an early innate immune response in the motor cortex of ALS. Jara JH, Genç B, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Özdinler PH. J Neuroinflammation 2017 Jun 26 PMID: 28651542
Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH. Sci Rep. 2017 Feb 06. PMID:28165465
Pathophysiological and diagnostic implications of cortical dysfunction in ALS. Geevasinga N, Menon P, Ozdinler PH, Kiernan MC, Vucic S. Nat Rev Neurol. 2016 September 23. PMID:27658852
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH. Hum Mol Genet. 2016 Jan 10. PMID: 26755825
