Northwestern University Feinberg School of Medicine

Ozdinler Lab

About Our Lab

The overall goal of the Ozdinler Lab is to understand the cellular and molecular basis of selective neuronal vulnerability. The lab primarily focuses on the corticospinal motor neurons (CSMN), the neurons that are important for the initiation and modulation of voluntary movement. CSMN degeneration is a key feature in many motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS). 

Selected Publications

Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology. Gautam M, Jara JH, Kocak N, Rylaarsdam LE, Kim KD, Bigio EH, Hande Özdinler P. Acta Neuropathol. 2019 Jan PMID: 30450515 

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS. Dervishi I, Gozutok O, Murnan K, Gautam M, Heller D, Bigio E, Ozdinler PH. Sci Rep 2018 Oct 03 PMID: 30283000 

Incorporating upper motor neuron health in ALS drug discovery. Dervishi I, Ozdinler PH. Drug Discov Today  2018 Mar 23 PMID: 29331501

Evidence for an early innate immune response in the motor cortex of ALS. Jara JH, Genç B, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Özdinler PH.  J Neuroinflammation 2017 Jun 26 PMID: 28651542

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS.  Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH. Sci Rep.  2017 Feb 06. PMID:28165465

Pathophysiological and diagnostic implications of cortical dysfunction in ALS. Geevasinga N, Menon P, Ozdinler PH, Kiernan MC, Vucic S. Nat Rev Neurol. 2016 September 23. PMID:27658852

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH. Hum Mol Genet. 2016 Jan 10. PMID: 26755825

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P. Hande Ozdinler, PhD

P. Hande Ozdinler, PhD
Associate Professor of Neurology - Ken and Ruth Davee Department

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