Investigating the cellular and molecular basis of selective neuronal vulnerability.

The Ozdinler Lab

The overall goal of the Ozdinler Lab is to understand the cellular and molecular basis of selective neuronal vulnerability. The lab primarily focuses on the corticospinal motor neurons (CSMN), the neurons that are important for the initiation and modulation of voluntary movement. CSMN degeneration is a key feature in many motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS).

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Lab Leadership

Hande Ozdinler, PhD
Associate Professor of Neuromuscular Disease in the Ken & Ruth Davee Department of Neurology

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The Latest From the Lab

Calming the Destructive Cells of ALS by Two Independent Approaches

Northwestern Medicine scientists have discovered two ways to preserve diseased upper motor neurons that would normally be destroyed in ALS.

Selected Publication

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathologyBarış Genç , Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, Gashaw M Goshu, Nuran Koçak, Edward Xie, Richard B Silverman, P Hande Özdinler.
Clin Transl Med. 2021 Feb;11(2):e336.
doi: 10.1002/ctm2.336.
PMID: 33634973