2019                                                               

The role of neurofilament aggregation in neurodegeneration: lessons from rareinheritedneurological disorders. Didonna A, Opal P. Mol Neurodegener. 2019 May 16;14(1):19. doi: 10.1186/s13024-019-0318-4. Review. PMID:31097008

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1. Hu YS, Do J, Edamakanti CR, Kini AR, Martina M, Stupp SI, Opal P. Brain. 2019 Feb 1;142(2):312-321. doi: 10.1093/brain/awy328.PMID:30649233

Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P.Hum Mol Genet. 2019 Apr 15;28(8):1343-1356. doi: 10.1093/hmg/ddy433.PMID:30590536

2018

Mutant ataxin-1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 June 1;128(6):2252-2265. Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923

2017

Mutant ataxin-1 inhibits neural progenitor cell proliferation in SCA1. Cerebellum. 2017 Apr;16(2):340-347. Cvetanovic M, Hu YS, Opal P. PMID: 27306906

2016

The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Mol Biol Cell. 2016 Dec 15;27(25):3980-3990. Lin NH, Huang YS, Opal P, Goldman RD, Messing A, Perng MD. PMID: 27798231

Advances in sequencing technologies for understanding hereditary ataxias: a review. JAMA Neurol. 2016 Dec 1;73(12):1485-1490. Didonna A, Opal P. PMID: 27749953

Paraneoplastic cerebellar degeneration with anti-Yo antibodies - a review. Ann Clin Transl Neurol. 2016 Jun 30;3(8):655-63. Venkatraman A, Opal P. PMID: 27606347

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy. Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. PMID: 27000625

2015

Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability. J Neurosci. 2015 Aug 12;35(32):11292-307. Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. PMID: 26269637

The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurosci. 2015 Jan;2(1):79-101. Didonna A, Opal P. PMID: 25642438

2014

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.Neuroscience. Epub January 2015. Cvetanovic M., Ingram M., Orr, H., and Opal P. PMID: 25595967

An investigation of diffusion imaging techniques in the evaluation of spinocerebellar ataxia and multisystem atrophy. J Clin Neurosci. 2015 Jan;22(1):166-72. doi: 10.1016/j.jocn.2014.08.006. Epub 2014 Nov 26. Rozenfeld MN, Nemeth AJ, Walker MT, Mohan P, Wang X, Parrish TB, Opal P. PMID: 25439745

The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15;23(14):3733-45. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842

2013

Explaining intermediate filament accumulation in giant axonal neuropathy. Rare Dis. 2013 Jun 17;1:e25378. Opal P, Goldman RD. PMID: 25003002

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May 1;123(5):1964-75. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478

2012

LANP mediates neuritic pathology in Spinocerebellar ataxia type 1. Neurobiol Dis. 2012 Dec;48(3):526-32. Cvetanovic M, Kular RK, Opal P. PMID: 22884877

2011

Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1. Nat Med. 2011 Oct 16;17(11):1445-7. Cvetanovic M, Patel JM, Marti HH, Kini AR, Opal P. PMID: 22001907

2010

Cpd-1 null mice display a subtle neurological phenotype. PLoS One. 2010 Sep 9;5(9). pii: e12649. Kular RK, Gogliotti RG, Opal P. PMID: 20844742

2009

Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex. J Biol Chem. 2009 Mar 20;284(12):7783-92. Kular RK, Cvetanovic M, Siferd S, Kini AR, Opal P. PMID: 19136565

2008

Association of spinocerebellar ataxia type 3 and spinocerebellar ataxia type 8 microsatellite expansions: genetic counseling implications. Mov Disord. 2008 Jan;23(1):154-5. Paganoni S, Seelaus CA, Ormond KE, Opal P. PMID: 17987652

2007

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep. 2007 Jul;8(7):671-7. Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P. PMC: 1905893

Huntington's disease presenting as postsurgical psychosis. Mov Disord. 2007 Jun 15;22(8):1209-10. Paganoni S, Naidech AM, Opal P. PMID: 17443707