Northwestern University Feinberg School of Medicine

Opal Laboratory




The role of neurofilament aggregation in neurodegeneration: lessons from rareinheritedneurological disorders. Didonna A, Opal P. Mol Neurodegener. 2019 May 16;14(1):19. doi: 10.1186/s13024-019-0318-4. Review. PMID:31097008

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1. Hu YS, Do J, Edamakanti CR, Kini AR, Martina M, Stupp SI, Opal P. Brain. 2019 Feb 1;142(2):312-321. doi: 10.1093/brain/awy328.PMID:30649233

Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P.Hum Mol Genet. 2019 Apr 15;28(8):1343-1356. doi: 10.1093/hmg/ddy433.PMID:30590536


Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer.
Murmann AE, Yu J, Opal P, Peter ME.Trends Cancer. 2018 Oct;4(10):684-700. doi: 10.1016/j.trecan.2018.08.004. Epub 2018 Sep 26. Review.

Mutant ataxin-1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 June 1;128(6):2252-2265. Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923


Mutant ataxin-1 inhibits neural progenitor cell proliferation in SCA1. Cerebellum. 2017 Apr;16(2):340-347. Cvetanovic M, Hu YS, Opal P. PMID: 27306906


The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Mol Biol Cell. 2016 Dec 15;27(25):3980-3990. Lin NH, Huang YS, Opal P, Goldman RD, Messing A, Perng MD. PMID: 27798231

Advances in sequencing technologies for understanding hereditary ataxias: a review. JAMA Neurol. 2016 Dec 1;73(12):1485-1490. Didonna A, Opal P. PMID: 27749953

Paraneoplastic cerebellar degeneration with anti-Yo antibodies - a review. Ann Clin Transl Neurol. 2016 Jun 30;3(8):655-63. Venkatraman A, Opal P. PMID: 27606347

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy. Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. PMID: 27000625


Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability. J Neurosci. 2015 Aug 12;35(32):11292-307. Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. PMID: 26269637

The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurosci. 2015 Jan;2(1):79-101. Didonna A, Opal P. PMID: 25642438


Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.Neuroscience. Epub January 2015Cvetanovic M., Ingram M., Orr, H., and Opal P. PMID: 25595967

An investigation of diffusion imaging techniques in the evaluation of spinocerebellar ataxia and multisystem atrophyJ Clin Neurosci. 2015 Jan;22(1):166-72. doi: 10.1016/j.jocn.2014.08.006. Epub 2014 Nov 26. Rozenfeld MN, Nemeth AJ, Walker MT, Mohan P, Wang X, Parrish TB, Opal P. PMID: 25439745

The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15;23(14):3733-45. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842


Explaining intermediate filament accumulation in giant axonal neuropathy. Rare Dis. 2013 Jun 17;1:e25378. Opal P, Goldman RD. PMID: 25003002

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May 1;123(5):1964-75. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478


LANP mediates neuritic pathology in Spinocerebellar ataxia type 1. Neurobiol Dis. 2012 Dec;48(3):526-32. Cvetanovic M, Kular RK, Opal P. PMID: 22884877


Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1. Nat Med. 2011 Oct 16;17(11):1445-7. Cvetanovic M, Patel JM, Marti HH, Kini AR, Opal P. PMID: 22001907


Cpd-1 null mice display a subtle neurological phenotype. PLoS One. 2010 Sep 9;5(9). pii: e12649. Kular RK, Gogliotti RG, Opal P. PMID: 20844742


Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex. J Biol Chem. 2009 Mar 20;284(12):7783-92. Kular RK, Cvetanovic M, Siferd S, Kini AR, Opal P. PMID: 19136565


Association of spinocerebellar ataxia type 3 and spinocerebellar ataxia type 8 microsatellite expansions: genetic counseling implications. Mov Disord. 2008 Jan;23(1):154-5. Paganoni S, Seelaus CA, Ormond KE, Opal P. PMID: 17987652


The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep. 2007 Jul;8(7):671-7. Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P. PMC: 1905893

Huntington's disease presenting as postsurgical psychosis. Mov Disord. 2007 Jun 15;22(8):1209-10. Paganoni S, Naidech AM, Opal P. PMID: 17443707



View the Opal Laboratory's publications in PubMed