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Northwestern University Feinberg School of Medicine
Guillermo Oliver Lab

Publications

For a full list of our publication record, please visit Guillermo Oliver's faculty profile.

  1. Takata, N., Miska, J.M., Morgan, M.A. et al. Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis. Nat Commun 14, 4129 (2023). https://doi.org/10.1038/s41467-023-39672-2
  2. Ma, W., Gil, H.J., Escobedo, N., Benito-Martín, A., Ximénez-Embún, P., Muñoz, J., Peinado, H., Rockson, S.G., and Oliver, G. (2020). Platelet factor 4 is a biomarker for lymphatic-promoted disorders. JCI Insight.
  3. Fiore, L., Takata, N., Acosta, S., Ma, W., Pandit, T., Oxendine, M., & Oliver, G. (2020). Optic vesicle morphogenesis requires primary cilia. Developmental biology.
  4. Liu, X., Gu, X., Ma, W., Oxendine, M., Gil, H. J., Davis, G. E., ... & Oliver, G. (2018). Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions. Development, 145(17), dev165092.
  5. Gil, H. J., Ma, W., & Oliver, G. (2018). A novel podoplanin‐GFPCre mouse strain for gene deletion in lymphatic endothelial cells. genesis, 56(4), e23102.
  6. Takata, N., Abbey, D., Fiore, L., Acosta, S., Feng, R., Gil, H. J., ... & Eiraku, M. (2017). An eye organoid approach identifies Six3 suppression of R-spondin 2 as a critical step in mouse neuroretina differentiation. Cell reports, 21(6), 1534-1549.
  7. Geng, X., Acosta, S., Lagutin, O., Gil, H. J., & Oliver, G. (2016). Six3 dosage mediates the pathogenesis of holoprosencephaly. Development, 143(23), 4462-4473.
  8. Escobedo, N., Proulx, S. T., Karaman, S., Dillard, M. E., Johnson, N., Detmar, M., & Oliver, G. (2016). Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice. JCI Insight, 1(2):e85096. doi:10.1172/jci.insight.85096.
  9. Srinivasan, S., Escobedo, N., Yang, Y., Interiano, A., Dillard, M.E., Finkelstein, D., Mukatira, S., Gil, HJ., Nurmi, H., Alitalo, K., and Oliver, G. (2014). Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors (Genes & Dev, 28, 2175-2187).
  10. Wiener, Z., Hogstrom, J., Hyvonen, V., Band, A., Kallio, P., Holopainen, T., Dufva, O., Haglund, C., Kruuna, O., Oliver, G., Neriah, YB., and Alitalo, K (2014). Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance (Cell Reports 8, 1-14).
  11. Lavado, A., and Oliver, G. (2014). Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrus. Developmental Biology 388, 11-21.
  12. Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. (2013). Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest. doi: 10.1172/JCI70422, PMCID: PMC3871239
  13. Yang, Y., Garcia-Verdugo, J.M., Soriano, M., Srinivasan, S., Scallan, J., Singh, M.K, Epstein, J.A., and Oliver, G. (2012). Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood 120, 2340-8.
  14. Chen, C-Y., Bertozzi, C., Zou, Z., Yuan, L., L, MM., Stachelek, S.J., Srinivasan, S., Guo, L., Vincente, A., Mericko, P., Levy, R.J., Makinen, T., Oliver, G. and Kahn, M.L. (2012). Blood flow reprograms lymphatic vessels to blood vessels through shear-mediated loss of endothelial Prox1. J Clin Investigation 122, 2006–2017.
  15. Yao, L-C., Baluk, P., Srinivasan, S., Oliver, G and McDonald, D.M. (2012). Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol, 180, 2561–2575.
  16. Srinivasan, S. and Oliver, G. (2011). Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lympho-venous valves. Genes & Dev 25, 2187-97.
  17. Lavado, A. and Oliver, G. (2011). Six3 is required for ependymal cell maturation. Development 138, 5291-5300.
  18. Karner, C.M., Das, A., Ma, Z., Self, M., Chen, C., Lum, L. Oliver, G and Carroll, T.J. (2011). Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 138, 1247-1257.
  19. He, G., Tavella, S., Hanley, K.P., Self, M., Oliver, G., Grifone, R., Hanley, N., Ward, C., and Bobola, N. (2010). Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base. Dev Biol 344, 720-730.
  20. McGovern, S., Pan, J., Oliver, G., Cutz, E., and Yeger, H. (2010). The role of hypoxia and neurogenic genes (Mash-1 and Prox-1) in the developmental maturation of pulmonary neuroendocrine cells in fetal mouse lung. Lab Invest, 90, 180-195.
  21. Liu, W., Lagutin, O., Swindell, E., Jamrich, M., and Oliver, G. (2010). Neuroretina specification in mammals requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Investigation, 120, 3568-3577.
  22. Srinivasan, S., Geng, X., Yang, Y., Wang, Y., Mukatira, S., Studer, M., Porto, M., Lagutin, O., and Oliver, G. (2010). The nuclear hormone receptor Coup-TFII is required for the initiation and maintenance of Prox1 expression in lymphatic endothelial cells. Genes & Dev 24, 696-707.
  23. Lavado, A., Chow, L.M.L., Baker, S.J., and Oliver, G. (2010). Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis. PLoS Biol 8(8): e1000460. doi:10.1371/journal.pbio.1000460.
  24. Self, M., Geng, X., and Oliver, G. (2009). Six2 activity is required for the formation of the mammalian pyloric sphincter. Dev Biology, 334, 409-417. PMCID: PMC2792912
  25. Risebro, C.A., Searles, R.G., Melville, A.A., Ehler, E., Dyal, S., Jina, N., Shah, S., Hubank, M., Dillar, M.E., Harvey, N.L., Schwartz, R.J., Chien, K.R., Oliver, G., & Riley, P.R. (2009). Prox1 maintains muscle structure and growth in the developing heart. Development, 136, 495-505.
  26. Vondenhoff, M.F.R., van del Pavert, S., Dillard, M.E., Greuter, M., Krall, G., Oliver, G*., & Mebius, R.E*. (2009). Lymph sacs are not required for the initiation of lymph node formation. Development 136, 29-34.
  27. Johnson, N., Dillard, M., Baluk, P., McDonald, D.M., Harvey, N.L., Frase, S.L. and Oliver, G. (2008). Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity Genes & Dev 22, 3282-3291.
  28. Accompanying Perspective “Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells” (by Bixel, M.G., and Adams, R.H). Highlighted by Science’s Editor’s Choice (Science 322, 1610).
  29. Jeong, Y., Coluccio Leskow, F., El-Jaick K., Roessler, E., Muenke, M., Yocum, A., David, V., Li, X., Geng, X., Oliver, G., and Epstein, D.J. (2008). Regulation of a remote Sonic hedgehog forebrain enhancer by the Six3 homeoprotein. Nat Genet. 40, 1348-1353. PMCID: PMC2648611
  30. Geng, X., Speirs, C., Lagutin, O., Inbal, A., Liu, W., Solnica-Krezel, L., Jeong, Y., Epstein, D., and Oliver, G. (2008). Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoproscencephaly. Dev Cell 15, 236-247. PMCID: PMC2597207
  31. Petrova, T.V., Nykanen, A., Normen, C., Ivanov, K.I., Andersson, L.C., Haglund, C., Puolakkainen, P., Wempe, F., von Melchner, H., Gradwhol, G., Vanharanta, S., Aaltonen, L.A., Saharinen, J.., Gentile, M., Clarke, A., Taipale, J., Oliver, G. and Alitalo, K. (2008). Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype. Cancer Cell. 13, 407-19.
  32. Kobayashi1, A., Valerius, M.T., Mugford, J.W., Carroll, T.J., Self, M., Oliver, G., & McMahon, A.P. (2008). Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell, 3, 169-181. PMCID: PMC2561900
  33. Kutejova, E., Engist, B., Self, M., Oliver, G., & Bobola, N. (2008). Six2 functions redundantly immediately downstream of Hoxa2. Development, 135, 1463-1470.