Figure 5. Development of the lymphatic vasculature is arrested in Prox1 null mice. A) At E14.5, most of the heterozygous and all of the homozygous Prox1 embryos developed severe edema (arrow). B) At the same stage, normal development of the lymphatic capillary network of the dermis was observed in Prox1 heterozygous embryos. In contrast, no lymphatic vessels and capillaries were seen in the homozygous littermates (C). Formation of the vascular system seemed to be unaffected in these mutant mice (arrow).
Figure 6. Prox1 expression (green) in dermal lymphatic capillaries.
Figure 7. Prox1 heterozygous mice become obese with age.