Publications
Learn more about the work that we do in the Mojgan Naghavi Laboratory through our recent publications.
- Stephens C, Naghavi MH The host cytoskeleton: a key regulator of early HIV-1 infection. FEBS J 2024 May;291(9):1835-1848. doi:10.1111/febs.16706
- Gu F, Boisjoli M, Naghavi MH HIV-1 promotes ubiquitination of the amyloidogenic C-terminal fragment of APP to support viral replication. Nat Commun 2023 Jul 15;14(1):4227. pii:4227
- Malikov V, Naghavi MH FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression. J Virol 2023 Jun 29;97(6):e0049923. pii:e00499-23
- Naghavi MH Virus update for the M2 "mac-in-touch". J Cell Biol 2023 May 01;222(5). pii:e202303016
- Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B et al. Virology under the Microscope-a Call for Rational Discourse. mSphere 2023 Apr 20;8(2):e0003423. pii:e00034-23
- Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B et al. Virology under the Microscope-a Call for Rational Discourse. mBio 2023 Feb 28;14(1):e0018823. pii:e00188-23
- Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B et al. Virology under the Microscope-a Call for Rational Discourse. J Virol 2023 Feb 28;97(2):e0008923. pii:e00089-23
- da Silva ES, Naghavi MH Microtubules and viral infection. Adv Virus Res 2023;115:87-134. doi:10.1016/bs.aivir.2023.02.003
- Malikov V, Meade N, Simons LM, Hultquist JF, Naghavi MH FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression. Cell Rep 2022 Feb 15;38(7):110396. doi:10.1016/j.celrep.2022.110396
- Shanmugapriya S, Santos da Silva E, Campbell JA, Boisjoli MP, Naghavi MH Dynactin 1 negatively regulates HIV-1 infection by sequestering the host cofactor CLIP170. Proc Natl Acad Sci U S A 2021 Oct 26;118(43). pii:e2102884118
- Naghavi MH HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection. Retrovirology 2021 Jul 06;18(1):19. pii:19
- Santos da Silva E, Shanmugapriya S, Malikov V, Gu F, Delaney MK, Naghavi MH HIV-1 capsids mimic a microtubule regulator to coordinate early stages of infection. EMBO J 2020 Oct 15;39(20):e104870. pii:e104870
- Mitra S, Shanmugapriya S, Santos da Silva E, Naghavi MH HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus. J Virol 2020 Jul 01;94(14). pii:e00404-20
- Huang PT, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH, Xiong Y FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking. Cell Rep 2019 Aug 27;28(9):2373-2385.e7. doi:10.1016/j.celrep.2019.07.079
- Walsh D, Naghavi MH Exploitation of Cytoskeletal Networks during Early Viral Infection. Trends Microbiol 2019 Jan;27(1):39-50. doi:10.1016/j.tim.2018.06.008
- Naghavi MH "APP"reciating the complexity of HIV-induced neurodegenerative diseases. PLoS Pathog 2018 Oct;14(10):e1007309. pii:e1007309
- Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit. Cell 2018 Aug 23;174(5):1143-1157.e17. doi:10.1016/j.cell.2018.06.053
- Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH Author Correction: HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun 2018 Jun 05;9(1):2257. pii:2257
- Chai Q, Jovasevic V, Malikov V, Sabo Y, Morham S, Walsh D, Naghavi MH HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun 2017 Nov 15;8(1):1522. pii:1522
- Malikov V, Naghavi MH Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating. Cell Rep 2017 Sep 19;20(12):2792-2799. doi:10.1016/j.celrep.2017.08.076
- Delaney MK, Malikov V, Chai Q, Zhao G, Naghavi MH Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport. Proc Natl Acad Sci U S A 2017 Aug 15;114(33):E6932-E6941. doi:10.1073/pnas.1700247114
- Naghavi MH, Walsh D Microtubule Regulation and Function during Virus Infection. J Virol 2017 Aug 15;91(16). pii:e00538-17
- Jovasevic V, Naghavi MH, Walsh D Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells. J Cell Biol 2015 Oct 26;211(2):323-37. doi:10.1083/jcb.201505123
- Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA, Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun 2015 Mar 30;6:6660. doi:10.1038/ncomms7660
- Naghavi MH Stable microtubule subsets facilitate early HIV-1 infection. AIDS Res Hum Retroviruses 2014 Mar;30(3):211-2. doi:10.1089/aid.2014.0026
- Sabo Y, Walsh D, Barry DS, Tinaztepe S, de Los Santos K, Goff SP, Gundersen GG, Naghavi MH HIV-1 induces the formation of stable microtubules to enhance early infection. Cell Host Microbe 2013 Nov 13;14(5):535-46. doi:10.1016/j.chom.2013.10.012
- Naghavi MH, Gundersen GG, Walsh D Plus-end tracking proteins, CLASPs, and a viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus spread. Proc Natl Acad Sci U S A 2013 Nov 05;110(45):18268-73. doi:10.1073/pnas.1310760110
- Naghavi M, Walsh D Research funding: Learn from Ireland's knowledge economy. Nature 2011 Aug 24;476(7361):399. doi:10.1038/476399b
- Brown C, Morham SG, Walsh D, Naghavi MH Focal adhesion proteins talin-1 and vinculin negatively affect paxillin phosphorylation and limit retroviral infection. J Mol Biol 2011 Jul 29;410(5):761-77. doi:10.1016/j.jmb.2011.03.076
- Henning MS, Stiedl P, Barry DS, McMahon R, Morham SG, Walsh D, Naghavi MH PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1. Virology 2011 Jul 05;415(2):114-21. doi:10.1016/j.virol.2011.04.006
- Henning MS, Morham SG, Goff SP, Naghavi MH PDZD8 is a novel Gag-interacting factor that promotes retroviral infection. J Virol 2010 Sep;84(17):8990-5. doi:10.1128/JVI.00843-10
- Haedicke J, Brown C, Naghavi MH The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection. Proc Natl Acad Sci U S A 2009 Aug 18;106(33):14040-5. doi:10.1073/pnas.0900502106
- Haedicke J, de Los Santos K, Goff SP, Naghavi MH The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection. J Virol 2008 May;82(9):4665-70. doi:10.1128/JVI.02403-07
- Naghavi MH, Goff SP Retroviral proteins that interact with the host cell cytoskeleton. Curr Opin Immunol 2007 Aug;19(4):402-7
- Naghavi MH, Valente S, Hatziioannou T, de Los Santos K, Wen Y, Mott C, Gundersen GG, Goff SP Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells. EMBO J 2007 Jan 10;26(1):41-52
- Naghavi MH, Hatziioannou T, Gao G, Goff SP Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. Genes Dev 2005 May 01;19(9):1105-15
- Lemieux AM, Paré ME, Audet B, Legault E, Lefort S, Boucher N, Landry S, van Opijnen T, Berkhout B, Naghavi MH et al. T-cell activation leads to poor activation of the HIV-1 clade E long terminal repeat and weak association of nuclear factor-kappaB and NFAT with its enhancer region. J Biol Chem 2004 Dec 17;279(51):52949-60
- Naghavi MH, Nowak P, Andersson J, Sönnerborg A, Yang H, Tracey KJ, Vahlne A Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner. Virology 2003 Sep 15;314(1):179-89
- Estable MC, Naghavi MH, Kato H, Xiao H, Qin J, Vahlne A, Roeder RG MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. J Biomed Sci 2002;9(3):234-45
- Naghavi MH, Estable MC, Schwartz S, Roeder RG, Vahlne A Upstream stimulating factor affects human immunodeficiency virus type 1 (HIV-1) long terminal repeat-directed transcription in a cell-specific manner, independently of the HIV-1 subtype and the core-negative regulatory element. J Gen Virol 2001 Mar;82(Pt 3):547-559. doi:10.1099/0022-1317-82-3-547
- Su J, Naghavi MH, Jejcic A, Horal P, Furuta Y, Wu YP, Li SL, Hall WW, Goobar-Larsson L, Svennerholm B et al. The tripeptide glycyl-prolyl-glycine amide does not affect the early steps of the human immunodeficiency virus type 1 replication. J Hum Virol 2001;4(1):8-15
- Su J, Andersson E, Horal P, Naghavi MH, Palm A, Wu YP, Eriksson K, Jansson M, Wigzell H, Svennerholm B et al. The nontoxic tripeptide glycyl-prolyl-glycine amide inhibits the replication of human immunodeficiency virus type 1. J Hum Virol 2001;4(1):1-7
- Naghavi MH, Schwartz S, Sönnerborg A, Vahlne A Long terminal repeat promoter/enhancer activity of different subtypes of HIV type 1. AIDS Res Hum Retroviruses 1999 Sep 20;15(14):1293-303
- Naghavi MH, Salminen MO, Sönnerborg A, Vahlne A DNA sequence of the long terminal repeat of human immunodeficiency virus type 1 subtype A through G. AIDS Res Hum Retroviruses 1999 Mar 20;15(5):485-8
- Allander T, Gruber A, Naghavi M, Beyene A, Söderström T, Björkholm M, Grillner L, Persson MA Frequent patient-to-patient transmission of hepatitis C virus in a haematology ward. Lancet 1995 Mar 11;345(8950):603-7