Publications

Learn more about the work that we do in the Mitchell Lab through our recent publications.

Ventrella R, Kim SK, Sheridan J, Grata A, Bresteau E, Hassan OA, Suva EE, Walentek P, Mitchell BJ Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion. Development 2023 Sep 1;150(17) PMID: 37602491, PMCID: PMC10482390
Zheng L, Adam SA, García-Anoveros J, Mitchell BJ, Bartles JR Espin overexpression causes stereocilia defects and provides an anti-capping effect on actin polymerization. Cytoskeleton (Hoboken) 2022 Jun;79(6-8):64-74 PMID: 35844198, PMCID: PMC9796729
Kulkarni S, Marquez J, Date P, Ventrella R, Mitchell BJ, Khokha MK Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells. Elife 2021 Jun 29;10 PMID: 34184636, PMCID: PMC8270640
Tasca A, Helmstädter M, Brislinger MM, Haas M, Mitchell B, Walentek P Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling. Dev Cell 2021 Feb 22;56(4):525-539.e6 PMID: 33400913, PMCID: PMC7904641
Kim SK, Brotslaw E, Thome V, Mitchell J, Ventrella R, Collins C, Mitchell B A role for Cep70 in centriole amplification in multiciliated cells. Dev Biol 2021 Mar;471:10-17 PMID: 33285087, PMCID: PMC7856201
Robinson AM, Takahashi S, Brotslaw EJ, Ahmad A, Ferrer E, Procissi D, Richter CP, Cheatham MA, Mitchell BJ, Zheng J CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia. Proc Natl Acad Sci U S A 2020 Jun 16;117(24):13571-13579 PMID: 32482850, PMCID: PMC7306751
Collins C, Majekodunmi A, Mitchell B Centriole Number and the Accumulation of Microtubules Modulate the Timing of Apical Insertion during Radial Intercalation. Curr Biol 2020 May 18;30(10):1958-1964.e3 PMID: 32243862, PMCID: PMC7239760
Fry E, Kim SK, Chigurapti S, Mika KM, Ratan A, Dammermann A, Mitchell BJ, Miller W, Lynch VJ Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth. Genome Biol Evol 2020 Mar 1;12(3):48-58 PMID: 32031213, PMCID: PMC7094797
Mercey O, Levine MS, LoMastro GM, Rostaing P, Brotslaw E, Gomez V, Kumar A, Spassky N, Mitchell BJ, Meunier A, Holland AJ Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nat Cell Biol 2019 Dec;21(12):1544-1552 PMID: 31792378, PMCID: PMC6913274
Choi J, Troyanovsky RB, Indra I, Mitchell BJ, Troyanovsky SM Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex. J Cell Biol 2019 Jul 1;218(7):2277-2293 PMID: 31147384, PMCID: PMC6605793
Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance. Am J Hum Genet 2019 Feb 7;104(2):229-245 PMID: 30665704, PMCID: PMC6372263
Werner M, Del Castillo U, Ventrella R, Brotslaw E, Mitchell B The small molecule AMBMP disrupts microtubule growth, ciliogenesis, cell polarity, and cell migration. Cytoskeleton (Hoboken) 2018 Oct;75(10):450-457 PMID: 30315640, PMCID: PMC6322664
Kim SK, Zhang S, Werner ME, Brotslaw EJ, Mitchell JW, Altabbaa MM, Mitchell BJ CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in the Xenopus ciliated epithelia. J Cell Biol 2018 May 7;217(5):1633-1641 PMID: 29514918, PMCID: PMC5940297
Kaplan N, Ventrella R, Peng H, Pal-Ghosh S, Arvanitis C, Rappoport JZ, Mitchell BJ, Stepp MA, Lavker RM, Getsios S EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. Invest Ophthalmol Vis Sci 2018 Jan 1;59(1):393-406 PMID: 29351356, PMCID: PMC5774870
Jaffe KM, Grimes DT, Schottenfeld-Roames J, Werner ME, Ku TS, Kim SK, Pelliccia JL, Morante NF, Mitchell BJ, Burdine RD c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Rep 2016 Mar 1;14(8):1841-9 PMID: 26904945, PMCID: PMC4775428
Silva E, Betleja E, John E, Spear P, Moresco JJ, Zhang S, Yates JR 3rd, Mitchell BJ, Mahjoub MR Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry. Mol Biol Cell 2016 Jan 1;27(1):48-63 PMID: 26538025, PMCID: PMC4694761
Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 2015 Jun 5;348(6239):1155-60 PMID: 25931445, PMCID: PMC4764081
Werner ME, Mitchell JW, Putzbach W, Bacon E, Kim SK, Mitchell BJ Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1. J Cell Biol 2014 Aug 4;206(3):367-76 PMID: 25070955, PMCID: PMC4121976
Klos Dehring DA, Vladar EK, Werner ME, Mitchell JW, Hwang P, Mitchell BJ Deuterosome-mediated centriole biogenesis. Dev Cell 2013 Oct 14;27(1):103-12 PMID: 24075808, PMCID: PMC3816757
Schwend T, Jin Z, Jiang K, Mitchell BJ, Jia J, Yang J Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling. J Biol Chem 2013 Nov 8;288(45):32809-32820 PMID: 24072710, PMCID: PMC3820914
Chien YH, Werner ME, Stubbs J, Joens MS, Li J, Chien S, Fitzpatrick JA, Mitchell BJ, Kintner C Bbof1 is required to maintain cilia orientation. Development 2013 Aug;140(16):3468-77 PMID: 23900544, PMCID: PMC3737724
Zariwala MA, Gee HY, Kurkowiak M, Al-Mutairi DA, Leigh MW, Hurd TW, Hjeij R, Dell SD, Chaki M, Dougherty GW, Adan M, Spear PC, Esteve-Rudd J, Loges NT, Rosenfeld M, Diaz KA, Olbrich H, Wolf WE, Sheridan E, Batten TF, Halbritter J, Porath JD, Kohl S, Lovric S, Hwang DY, Pittman JE, Burns KA, Ferkol TW, Sagel SD, Olivier KN, Morgan LC, Werner C, Raidt J, Pennekamp P, Sun Z, Zhou W, Airik R, Natarajan S, Allen SJ, Amirav I, Wieczorek D, Landwehr K, Nielsen K, Schwerk N, Sertic J, Köhler G, Washburn J, Levy S, Fan S, Koerner-Rettberg C, Amselem S, Williams DS, Mitchell BJ, Drummond IA, Otto EA, Omran H, Knowles MR, Hildebrandt F ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. Am J Hum Genet 2013 Aug 8;93(2):336-45 PMID: 23891469, PMCID: PMC3738827
Werner ME, Mitchell BJ Using Xenopus skin to study cilia development and function. Methods Enzymol 2013;525:191-217 PMID: 23522471, PMCID: PMC4319646
Werner ME, Mitchell BJ Planar cell polarity: microtubules make the connection with cilia. Curr Biol 2012 Dec 4;22(23):R1001-4 PMID: 23218005, PMCID:
Werner ME, Mitchell BJ Understanding ciliated epithelia: the power of Xenopus. Genesis 2012 Mar;50(3):176-85 PMID: 22083727, PMCID: PMC3294091
Werner ME, Hwang P, Huisman F, Taborek P, Yu CC, Mitchell BJ Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells. J Cell Biol 2011 Oct 3;195(1):19-26 PMID: 21949415, PMCID: PMC3187709
Wallingford JB, Mitchell B Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev 2011 Feb 1;25(3):201-13 PMID: 21289065, PMCID: PMC3034894
Dammermann A, Pemble H, Mitchell BJ, McLeod I, Yates JR 3rd, Kintner C, Desai AB, Oegema K The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev 2009 Sep 1;23(17):2046-59 PMID: 19656802, PMCID: PMC2751977
Mitchell B, Stubbs JL, Huisman F, Taborek P, Yu C, Kintner C The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin. Curr Biol 2009 Jun 9;19(11):924-9 PMID: 19427216, PMCID: PMC2720401
Park TJ, Mitchell BJ, Abitua PB, Kintner C, Wallingford JB Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nat Genet 2008 Jul;40(7):871-9 PMID: 18552847, PMCID: PMC2771675
Mitchell B, Jacobs R, Li J, Chien S, Kintner C A positive feedback mechanism governs the polarity and motion of motile cilia. Nature 2007 May 3;447(7140):97-101 PMID: 17450123, PMCID:
Woodruff JB, Mitchell BJ, Shankland M Hau-Pax3/7A is an early marker of leech mesoderm involved in segmental morphogenesis, nephridial development, and body cavity formation. Dev Biol 2007 Jun 15;306(2):824-37 PMID: 17433288, PMCID:
Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl 2005 Mar 18;44(13):1987-90 PMID: 15724259, PMCID:
Mitchell B, Crews ST Expression of the Artemia trachealess gene in the salt gland and epipod. Evol Dev 2002 Sep-Oct;4(5):344-53 PMID: 12356264, PMCID: