Learn more about the work that we do in the McNally Laboratory through our selected publications below.

• Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD  Thrombospondin expression in myofibers stabilizes muscle membranes.  Elife 2016 Sep 26;5 PMID: 27669143, PMCID: PMC5063588
• Kim EY, Page P, Dellefave-Castillo LM, McNally EM, Wyatt EJ  Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease.  Skelet Muscle 2016;6:32 PMID: 27651888, PMCID: PMC5025576
• Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP  Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.  Sci Transl Med 2016 Aug 31;8(354):354ra115 PMID: 27582060, PMCID: PMC5266594
• Demonbreun AR, Quattrocelli M, Barefield DY, Allen MV, Swanson KE, McNally EM  An actin-dependent annexin complex mediates plasma membrane repair in muscle.  J Cell Biol 2016 Jun 20;213(6):705-18 PMID: 27298325, PMCID: PMC4915191
• Lamar KM, Bogdanovich S, Gardner BB, Gao QQ, Miller T, Earley JU, Hadhazy M, Vo AH, Wren L, Molkentin JD, McNally EM  Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.  PLoS Genet 2016 May;12(5):e1006019 PMID: 27148972, PMCID: PMC4858180
• Demonbreun AR, Allen MV, Warner JL, Barefield DY, Krishnan S, Swanson KE, Earley JU, McNally EM  Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption.  Am J Pathol 2016 Jun;186(6):1610-22 PMID: 27070822, PMCID: PMC4901136
• Lamar KM, Miller T, Dellefave-Castillo L, McNally EM  Genotype-Specific Interaction of Latent TGFβ Binding Protein 4 with TGFβ.  PLoS One 2016;11(2):e0150358 PMID: 26918958, PMCID: PMC4769137
• Gao QQ, Wyatt E, Goldstein JA, LoPresti P, Castillo LM, Gazda A, Petrossian N, Earley JU, Hadhazy M, Barefield DY, Demonbreun AR, Bönnemann C, Wolf M, McNally EM  Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping.  J Clin Invest 2015 Nov 2;125(11):4186-95 PMID: 26457733, PMCID: PMC4639981
• Demonbreun AR, Swanson KE, Rossi AE, Deveaux HK, Earley JU, Allen MV, Arya P, Bhattacharyya S, Band H, Pytel P, McNally EM  Eps 15 Homology Domain (EHD)-1 Remodels Transverse Tubules in Skeletal Muscle.  PLoS One 2015;10(9):e0136679 PMID: 26325203, PMCID: PMC4556691
• Ceco E, Bogdanovich S, Gardner B, Miller T, DeJesus A, Earley JU, Hadhazy M, Smith LR, Barton ER, Molkentin JD, McNally EM  Targeting latent TGFβ release in muscular dystrophy.  Sci Transl Med 2014 Oct 22;6(259):259ra144 PMID: 25338755, PMCID: PMC4337885
• Golbus JR, Puckelwartz MJ, Dellefave-Castillo L, Fahrenbach JP, Nelakuditi V, Pesce LL, Pytel P, McNally EM  Targeted analysis of whole genome sequence data to diagnose genetic cardiomyopathy.  Circ Cardiovasc Genet 2014 Dec;7(6):751-759 PMID: 25179549, PMCID: PMC4270910
• Goldstein JA, Bogdanovich S, Beiriger A, Wren LM, Rossi AE, Gao QQ, Gardner BB, Earley JU, Molkentin JD, McNally EM  Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.  Hum Mol Genet 2014 Dec 20;23(25):6722-31 PMID: 25070948, PMCID: PMC4303797
• Swaggart KA, Demonbreun AR, Vo AH, Swanson KE, Kim EY, Fahrenbach JP, Holley-Cuthrell J, Eskin A, Chen Z, Squire K, Heydemann A, Palmer AA, Nelson SF, McNally EM  Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair.  Proc Natl Acad Sci U S A 2014 Apr 22;111(16):6004-9 PMID: 24717843, PMCID: PMC4000833
• Fahrenbach JP, Stoller D, Kim G, Aggarwal N, Yerokun B, Earley JU, Hadhazy M, Shi NQ, Makielski JC, McNally EM  Abcc9 is required for the transition to oxidative metabolism in the newborn heart.  FASEB J 2014 Jul;28(7):2804-15 PMID: 24648545, PMCID: PMC4062826
• Puckelwartz MJ, Pesce LL, Nelakuditi V, Dellefave-Castillo L, Golbus JR, Day SM, Cappola TP, Dorn GW 2nd, Foster IT, McNally EM  Supercomputing for the parallelization of whole genome analysis.  Bioinformatics 2014 Jun 1;30(11):1508-13 PMID: 24526712, PMCID: PMC4029034
• Posey AD Jr, Swanson KE, Alvarez MG, Krishnan S, Earley JU, Band H, Pytel P, McNally EM, Demonbreun AR  EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development.  Dev Biol 2014 Mar 15;387(2):179-90 PMID: 24440153, PMCID: PMC3987670
• Flanigan KM, Ceco E, Lamar KM, Kaminoh Y, Dunn DM, Mendell JR, King WM, Pestronk A, Florence JM, Mathews KD, Finkel RS, Swoboda KJ, Gappmaier E, Howard MT, Day JW, McDonald C, McNally EM, Weiss RB, United Dystrophinopathy Project.  LTBP4 genotype predicts age of ambulatory loss in Duchenne muscular dystrophy.  Ann Neurol 2013 Apr;73(4):481-8 PMID: 23440719, PMCID: PMC4106425