Northwestern University Feinberg School of Medicine

McNally Lab

About Our Lab

The McNally Laboratory identifies and studies mechanisms of mutations that cause genetic disease. Mutations in cytoskeletal and sarcomere proteins cause heart failure and muscle weakness. We use novel computational methods to analyze whole genome sequencing from humans to identify novel genes and alleles linked to human disease. We model these mutations in human cells using induced pluripotent stem cell technologies to determine how these mutations act. We are defining gene-gene interactions using genome analysis, genome editing, and quantitative trait locus mapping. 

Selected Publications

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Elizabeth McNally, MD, PhD

Elizabeth McNally, MD, PhD
Elizabeth J. Ward Professor and Director, Center for Genetic Medicine
Professor of Medicine (Cardiology) and Biochemistry and Molecular Genetics

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