Northwestern University Feinberg School of Medicine

Mazzulli Laboratory

About Our Lab

The Mazzulli Lab is interested in determining how protein misfolding and amyloid formation results in cell death. Many chronic neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease are characterized by the accumulation of misfolded proteins within the nervous system. We use patient neurons derived from induced pluripotent stem cells (iPSC) coupled with analytic biochemical techniques to study protein accumulation and lysosomal clearance mechanisms.

Selected Publications

Cuddy LK, et al. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron, In Press, 2019, PMID: 31648898

Zunke F, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron, Jan 3rd, 2018. 97(1), 92-107e10. PMID:29290548

Mazzulli JR,  et al. Activation of b-Glucocerebrosidase Reduces Pathological a-Synuclein and Restores Lysosomal Function in Parkinson’s Patient Midbrain Neurons, J. Neurosci, Jul 20, 2016. 36(29):7693-706. PMID: 27445146

Mazzulli JR, et al. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.  PNAS, Feb 2, 2016. 113(7):1931-6. PMID: 26839413

Mazzulli JR, et al. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence.  Anal Chem, Feb 3, 2016, PMID: 26813311

Mazzulli JR, et al. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell. July 2011; 146, 37-52. PMID: 21700325.

Tsika E, et al. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J. Neurosci. 2010; 30:3409-3418. PMID: 20203200

View all Publications

Joseph R Mazzulli, PhD

Joseph R Mazzulli, PhD
Assistant Professor in the Ken and Ruth Davee Department of Neurology

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