Research

Major research areas include:

1) Mechanistic studies of terminal erythropoiesis under steady state and stress/disease conditions.

2) Studies of clonal hematopoiesis and the role of inflammation in the cell's intrinsic and extrinsic influences on clonal expansion. 

3) The role of Pleckstrin-2 (Plek2) signalosome in myeloproliferative neoplasms and other cancers. 

4) Spatial transcriptomic mapping of normal and abnormal hematopoietic tissues.

5) Development and application of induced pluripotent stem cell (iPSC)-derived bone marrow organoids.