Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions.
Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes.
The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Mimic human erythropoiesis using rat model
Recent Projects:
The roles of pleckstrin-2 as a functional node in erythropoiesis
The role of mDia1 in the aberrant innate immune signaling in del(5q) myelodysplastic
The role of Plek2 in the pathogenesis of myeloproliferative neoplasms
The role of inflammatory bone marrow environment in the pathogenesis of MDS