Research

Major research areas include:

• Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions.
• Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes.
• The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
• Mimic human erythropoiesis using rat model

Recent Projects

• The roles of pleckstrin-2 as a functional node in erythropoiesis
• The role of mDia1 in the aberrant innate immune signaling in del(5q) myelodysplastic
• The role of Plek2 in the pathogenesis of myeloproliferative neoplasms
• The role of inflammatory bone marrow environment in the pathogenesis of MDS