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Northwestern University Feinberg School of Medicine
Peng Ji Lab

Publications

Learn more about the work that we do in the Peng Ji Laboratory through our recent publications.

 

2025

  1. PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via p53-mediated degradation.Pan Wang, Xu Han, Kehan Ren, Ermin Li, Honghao Bi, Inci Aydemir, Madina Sukhanova, Yijie Liu, Jing Yang, Peng Ji.The Journal of Clinical Investigation.2025. PMID: 40338661
  2. DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death.Honghao Bi, Kehan Ren, Pan Wang, Ermin Li, Xu Han, Wen Wang, Jing Yang, Inci Aydemir, Kara Tao, Renee Ma, Lucy A Godley, Yan Liu, Vipul Shukla, Elizabeth T Bartom, Yuefeng Tang, Lionel Blanc, Madina Sukhanova, Peng Ji.Nature communications 16.Article number: 7195 (2025). PMID: 39464073.

2024

  1. Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment.Kehan Ren, Ermin Li, Inci Aydemir, Yijie Liu, Xu Han, Honghao Bi, Pan Wang, Kara Tao, Amy Ji, Yi-Hua Chen, Jing Yang, Madina Sukhanova, Peng Ji. Bloodadvances. 2024 Oct 29.2024013361.PMID: 39471483
  2. Pleckstrin-2 mediates the activation of AKT in prostate cancer and is repressed by androgen receptor.Xu Han, Ali Zhang, Pan Wang, Honghao Bi, Kehan Ren, Ermin Li, Ximing Yang, Inci Aydemir, Kara Tao, Jeffrey Lin, Sarki A Abdulkadir, Jing Yang, Peng Ji. Am J Pathol,2024 Oct;194(10):1986-1996. PMID: 39069167
  3. Prognostic significance of copy number gains of MYC detected by fluorescence in situ hybridization in large B-cell lymphoma. Zak T, Santana-Santos L, Gao J, Behdad A, Aqil B, Wolniak K, Lu X, Ji P, Chen Q, Chen Y-H, Karmali R, Sukhanova M. Leuk Lymphoma. 2024 Jan; 65(1): 26-36. PMID: 37794791

2023

  1. mDia formins form hetero-oligomers and cooperatively maintain murine hematopoiesis. Li Z, Su M, Xie X, Wang P, Bi H, Li E, Ren K, Dong L, Lv Z, Ma X, Liu Y, Zhao B, Peng Y, Liu J, Liu L, Yang J, Ji P, Mei Y. PLoS Genet. 2023 Dec; 19(12): e1011084-.PMID: 38157491
  2. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation. Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. Blood. 2023 Jul; 142(1): 106-118. PMID: 37053547
  3. Clonal hematopoiesis and bone marrow inflammation. Xie X, Su M, Ren K, Ma X, Lv Z, Li Z, Mei Y, Ji P. Transl Res. 2023 May; 255: 159-170.PMID: 36347490
  4. Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
  5. Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P. J Clin Invest. 2023 Mar; 133(6): PMID: 36719747
  6. PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang Z-Y, Liu Y. Blood. 2023 Jan; 141(3): 244-259. PMID: 36206490 

2022

  1. Chromatin reconstruction during mouse terminal erythropoiesis.Bi H, Hou Y, Wang J, Xia Z, Wang D, Liu Y, Bao H, Han X, Ren K, Li E, Yue F, Ji P. iScience. 2022 Dec; 25(12)105554-.PMID: 36465116
  2. Clinicopathologic and genetic evaluation of B-lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 (iAMP21) in adult patients.Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M.Leuk Lymphoma. 2022 Dec; 63(13): 3200-3207. PMID: 35995457
  3. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Hodzic D, Wu J, Krchma K, Jurisicova A, Tsatskis Y, Liu Y, Ji P, Choi K, McNeill H.PLoS Biol. 2022 Oct; 20(10): e3001811-.PMID: 36215313
  4. Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia.Mei Y, Ren K, Liu Y, Ma A, Xia Z, Han X, Li E, Tariq H, Bao H, Xie X, Zou C, Zhang D, Li Z, Dong L, Verma A, Lu X, Abaza Y, Altman JK, Sukhanova M, Yang J, Ji P.J Clin Invest. 2022 Sep; 132(17): PMID: 35900794
  5. Carbon dots for the treatment of cancer-related anemia.Han X, Ji P.Blood Sci. 2022 Jul; 4(3): 174-175. PMID: 36518596
  6. Proteome remodeling and organelle clearance in mammalian terminal erythropoiesis.Ren K, Li E, Ji P. Curr Opin Hematol. 2022 May; 29(3): 137-143.PMID: 35441599
  7. Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation.Gao J, Gurbuxani S, Zak T, Kocherginsky M, Ji P, Wehbe F, Chen Q, Chen Y-H, Lu X, Jennings L, Frankfurt O, Altman J, Sukhanova M.Genes Chromosomes Cancer. 2022 Feb; 61(2): 71-80. PMID: 34668265

2021

  1. Paraneoplastic Thrombocytopenia.Kalas V, Johnson-Sasso C, Morency EG, Ji P, Manesh R, Patel AA.Am J Med. 2021 Aug; 134(8): 976-979.PMID: 33621535
  2. Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes.Gelarden I, Nguyen J, Gao J, Chen Q, Morales-Nebreda L, Wunderink R, Li L, Chmiel JS, Hrisinko M, Marszalek L, Momnani S, Patel P, Sumugod R, Chao Q, Jennings LJ, Zembower TR, Ji P, Chen Y-H.Hum Pathol. 2021 Jul; 113: 92-103.PMID: 33905777
  3. Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.Feola M, Zamperone A, Moskop D, Chen H, Casu C, Lama D, Di Martino J, Djedaini M, Papa L, Martinez MR, Choesang T, Bravo-Cordero JJ, MacKay M, Zumbo P, Brinkman N, Abrams CS, Rivella S, Hattangadi S, Mason CE, Hoffman R, Ji P, Follenzi A, Ginzburg YZ.Commun Biol. 2021 May; 4(1): 517-.PMID: 33941818
  4. Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation.Mei Y, Liu Y, Ji P. Blood Rev. 2021 Mar; 46: 100740-. PMID: 32798012
  5. Membrane skeleton modulates erythroid proteome remodeling and organelle clearance. Liu Y, Mei Y, Han X, Korobova FV, Prado MA, Yang J, Peng Z, Paulo JA, Gygi SP, Finley D, Ji P. Blood. 2021 Jan; 137(3): 398-409. PMID: 33036023

2020

  1. Finding erythroid stress progenitors: cell surface markers revealed.Ji P. Haematologica. 2020 Nov; 105(11): 2499-2501.PMID: 33131238
  2. Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza. Mei Y, Weinberg SE, Zhao L, Frink A, Qi C, Behdad A, Ji P. EClinicalMedicine. 2020 Sep; 26: 100475-. PMID: 33089115
  3. Atypical lymphocytes in peripheral blood of patients with COVID-19. Weinberg SE, Behdad A, Ji P. Br J Haematol. 2020 Jul; 190(1): 36-39. PMID: 32420613
  4. Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment. Mei Y, Han X, Liu Y, Yang J, Sumagin R, Ji P. Nat Commun. 2020 Jun; 11(1): 3172-.PMID: 32576838
  5. FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.Sheng Y, Yu C, Liu Y, Hu C, Ma R, Lu X, Ji P, Chen J, Mizukawa B, Huang Y, Licht JD, Qian Z. Nat Commun. 2020 Feb; 11(1): 928-. PMID: 32066721

2019

  1. nucleating activity. Klein O, Krier-Burris RA, Lazki-Hagenbach P, Gorzalczany Y, Mei Y, Ji P, Bochner BS, Sagi-Eisenberg R. J Allergy Clin Immunol. 2019 Oct; 144(4): 1074-1090. PMID: 31279009
  2. Rats provide a superior model of human stress erythropoiesis. Zhang J, Liu Y, Han X, Mei Y, Yang J, Zhang ZJ, Lu X, Ji P. Exp Hematol. 2019 Oct; 78: 21-34.e3. PMID: 31562902
  3. Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial. Gangat N, Marinaccio C, Swords R, Watts JM, Gurbuxani S, Rademaker A, Fought AJ, Frankfurt O, Altman JK, Wen QJ, Farnoud N, Famulare CA, Patel A, Tapia R, Vallapureddy RR, Barath S, Graf A, Handlogten A, Zblewski D, Patnaik MM, Al-Kali A, Dinh YT, Englund Prahl K, Patel S, Nobrega JC, Tejera D, Thomassen A, Gao J, Ji P, Rampal RK, Giles FJ, Tefferi A, Stein B, Crispino JD. Clin Cancer Res. 2019 Aug; 25(16): 4898-4906. PMID: 31061068
  4. Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo W-L, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A. Cancer Discov. 2019 Jun; 9(6): 778-795. PMID: 30944118
  5. Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes. Zhao B, Liu H, Mei Y, Liu Y, Han X, Yang J, Wickrema A, Ji P. Cancer Med. 2019 Mar; 8(3): 1169-1174. PMID: 30701702

2018

  1. Targeting age-related inflammation in myelodysplastic syndromes. Mei Y, Ji P. Oncotarget. 2018 Oct; 9(83): 35376-35377.PMID: 30459930
  2. USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J, Ji P, Crispino JD, Fang D.Blood. 2018 Jul; 132(4): 423-434. PMID: 29844011
  3. Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS. Mei Y, Zhao B, Basiorka AA, Yang J, Cao L, Zhang J, List A, Ji P. Leukemia. 2018 Apr; 32(4): 1023-1033. PMID: 29263441
  4. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P. J Clin Invest. 2018 Jan; 128(1): 125-140. PMID: 29202466

2017

  1. Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium. Mei Y, Feng G, Rahimi N, Zhao B, Zhang J, Cao L, Yang J, Gao J, Chen Y, Sumagin R, Muller WA, Zhang L, Ji P. Blood Adv. 2017 Sep; 1(20): 1650-1656. PMID: 29296812 ISSN: 2473-9529
  2. EBV-negative aggressive NK-cell leukemia/lymphoma: a clinical and pathological study from a single institution. Gao J, Behdad A, Ji P, Wolniak KL, Frankfurt O, Chen Y-H. Mod Pathol. 2017 Aug; 30(8): 1100-1115. PMID: 28548121
  3. Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2. Li X, Mei Y, Yan B, Vitriol E, Huang S, Ji P, Qiu Y. Haematologica. 2017 Jun; 102(6): 984-994. PMID: 28255013
  4. Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice.Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y. Stem Cell Reports. 2017 Apr; 8(4): 991-1004. PMID: 28330618

2016

  1. Correction: A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway.Zhang Z, Mao H, Du X, Zhu J, Xu Y, Wang S, Xu X, Ji P, Yu Y, Cao B, Han K, Hou T, Xu Z, Kong Y, Jiang G, Tang X, Qiao C, Mao X. Oncotarget. 2016 Dec; 7(49):81972-.PMID: 28082727
  2. Pericytes: new EPO-producing cells in the brain.Ji P. Blood. 2016 Nov; 128(21): 2483-2485.PMID: 27884833
  3. Erythropoietin-regulated oxidative stress negatively affects enucleation during terminal erythropoiesis. Zhao B, Mei Y, Yang J, Ji P. Exp Hematol. 2016 Oct; 44(10): 975-981. PMID: 27364565
  4. Chromatin condensation during terminal erythropoiesis.Zhao B, Yang J, Ji P. Nucleus. 2016 Sep; 7(5): 425-429. PMID: 27579498
  5. Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening.Zhao B, Mei Y, Schipma MJ, Roth EW, Bleher R, Rappoport JZ, Wickrema A, Yang J, Ji P. Dev Cell. 2016 Mar; 36(5): 498-510.PMID: 26954545
  6. H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function. Zhao B, Tan TL, Mei Y, Yang J, Yu Y, Verma A, Liang Y, Gao J, Ji P. Sci Rep. 2016 Jan; 6: 19589-. PMID: 26791933
  7. Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice. Mei Y, Zhao B, Yang J, Gao J, Wickrema A, Wang D, Chen Y, Ji P. Haematologica. 2016 Jan; 101(1): e1-e5.PMID: 26471482

Before 2015

  1. New insights into the mechanisms of mammalian erythroid chromatin condensation and enucleation. Ji P. Int Rev Cell Mol Biol. 2015; 316: 159-182. PMID: 25805124 ISSN: 1937-6448
  2. Mouse fetal liver culture system to dissect target gene functions at the early and late stages of terminal erythropoiesis. Zhao B, Mei Y, Yang J, Ji P. J Vis Exp. 2014 Sep; (91): e51894-. PMID: 25225899
  3. Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis. Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P. Haematologica. 2014 Jul; 99(7): 1157-1167. PMID: 24747950
  4. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS. Keerthivasan G, Mei Y, Zhao B, Zhang L, Harris CE, Gao J, Basiorka AA, Schipma MJ, McElherne J, Yang J, Verma AK, Pellagatti A, Boultwood J, List AF, Williams DA, Ji P. Blood. 2014 Jul; 124(5): 780-790. PMID: 24891322
  5. Plasmacytoid dendritic cells in chronic myelomonocytic leukemia. Ji P, Peterson LC. Blood. 2014 May; 123(21): 3220-. PMID: 24977276
  6. Mammalian erythroblast enucleation requires PI3K-dependent cell polarization. Wang J, Ramirez T, Ji P, Jayapal SR, Lodish HF, Murata-Hori M. J Cell Sci. 2012 Jan; 125(Pt 2): 340-349. PMID: 22331356
  7. Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation. Ji P, Lodish HF. Biochem Biophys Res Commun. 2012 Jan; 417(4): 1188-1192.PMID: 22226968
  8. Formation of mammalian erythrocytes: chromatin condensation and enucleation. Ji P, Murata-Hori M, Lodish HF. Trends Cell Biol. 2011 Jul; 21(7): 409-415. PMID: 21592797
  9. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Sankaran VG, Menne TF, Šcepanovic D, Vergilio J-A, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. Proc Natl Acad Sci U S A. 2011 Jan; 108(4): 1519-1524. PMID: 21205891
  10. Down-regulation of Myc is essential for terminal erythroid maturation. Jayapal SR, Lee KL, Ji P, Kaldis P, Lim B, Lodish HF. J Biol Chem. 2010 Dec; 285(51): 40252-40265.PMID: 20940306
  11. Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Ji P, Yeh V, Ramirez T, Murata-Hori M, Lodish HF. Haematologica. 2010 Dec; 95(12): 2013-2021.PMID: 20823130
  12. Rac GTPases play multiple roles in erythropoiesis. Ji P, Lodish HF. Haematologica. 2010 Jan; 95(1): 2-4. PMID: 20065075
  13. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L. Nat Genet. 2010 Jan; 42(1): 83-88. PMID: 19966802
  14. An AR-Skp2 pathway for proliferation of androgen-dependent prostate-cancer cells. Wang H, Sun D, Ji P, Mohler J, Zhu L. J Cell Sci. 2008 Aug; 121(Pt 15): 2578-2587.PMID: 18628304 ISSN: 0021-9533
  15. Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2.Ji P, Jayapal SR, Lodish HF. Nat Cell Biol. 2008 Mar; 10(3): 314-321. PMID: 18264091
  16. Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing. Ji P, Sun D, Wang H, Bauzon F, Zhu L. Mol Cancer Ther. 2007 Feb; 6(2): 684-691.PMID: 17308064 ISSN: 1535-7163
  17. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. Ji P, Goldin L, Ren H, Sun D, Guardavaccaro D, Pagano M, Zhu L. J Biol Chem. 2006 Aug; 281(33): 24058-24069.PMID: 16774918 ISSN: 0021-9258
  18. Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression. Ji P, Zhu L. Cell Cycle. 2005 Mar; 4(3): 373-375.PMID: 15701969
  19. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L. Mol Cell. 2004 Oct; 16(1): 47-58. PMID: 15469821 ISSN: 1097-2765