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Northwestern University Feinberg School of Medicine
Peng Ji Lab

Publications

Learn more about the work that we do in the Peng Ji Laboratory through our recent publications.

  1. Prognostic significance of copy number gains of MYC detected by fluorescence in situ hybridization in large B-cell lymphoma. Zak T, Santana-Santos L, Gao J, Behdad A, Aqil B, Wolniak K, Lu X, Ji P, Chen Q, Chen Y-H, Karmali R, Sukhanova M. Leuk Lymphoma. 2024 Jan; 65(1): 26-36. https://doi.org/10.1080/10428194.2023.2264429 PMID: 37794791
  2. mDia formins form hetero-oligomers and cooperatively maintain murine hematopoiesis. Li Z, Su M, Xie X, Wang P, Bi H, Li E, Ren K, Dong L, Lv Z, Ma X, Liu Y, Zhao B, Peng Y, Liu J, Liu L, Yang J, Ji P, Mei Y. PLoS Genet. 2023 Dec; 19(12): e1011084-.https://doi.org/10.1371/journal.pgen.1011084.PMID: 38157491
  3. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation. Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. Blood. 2023 Jul; 142(1): 106-118.https://doi.org/10.1182/blood.2022018475 PMID: 37053547
  4. Clonal hematopoiesis and bone marrow inflammation. Xie X, Su M, Ren K, Ma X, Lv Z, Li Z, Mei Y, Ji P. Transl Res. 2023 May; 255: 159-170.https://doi.org/10.1016/j.trsl.2022.11.004PMID: 36347490
  5. Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
    Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P. J Clin Invest. 2023 Mar; 133(6): https://doi.org/10.1172/JCI159638 PMID: 36719747
  6. PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang Z-Y, Liu Y. Blood. 2023 Jan; 141(3): 244-259. https://doi.org/10.1182/blood.2022016580.PMID: 36206490
  7. Chromatin reconstruction during mouse terminal erythropoiesis.Bi H, Hou Y, Wang J, Xia Z, Wang D, Liu Y, Bao H, Han X, Ren K, Li E, Yue F, Ji P. iScience. 2022 Dec; 25(12): 105554-.https://doi.org/10.1016/j.isci.2022.105554.PMID: 36465116
  8. Clinicopathologic and genetic evaluation of B-lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 (iAMP21) in adult patients.Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M.Leuk Lymphoma. 2022 Dec; 63(13): 3200-3207. https://doi.org/10.1080/10428194.2022.2113524.PMID: 35995457
  9. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Hodzic D, Wu J, Krchma K, Jurisicova A, Tsatskis Y, Liu Y, Ji P, Choi K, McNeill H.PLoS Biol. 2022 Oct; 20(10): e3001811-.
    https://doi.org/10.1371/journal.pbio.3001811.PMID: 36215313
  10. Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia.Mei Y, Ren K, Liu Y, Ma A, Xia Z, Han X, Li E, Tariq H, Bao H, Xie X, Zou C, Zhang D, Li Z, Dong L, Verma A, Lu X, Abaza Y, Altman JK, Sukhanova M, Yang J, Ji P.J Clin Invest. 2022 Sep; 132(17):https://doi.org/10.1172/JCI152673.PMID: 35900794
  11. Carbon dots for the treatment of cancer-related anemia.Han X, Ji P.Blood Sci. 2022 Jul; 4(3): 174-175. https://doi.org/10.1097/BS9.0000000000000120.PMID: 36518596
  12. Proteome remodeling and organelle clearance in mammalian terminal erythropoiesis.Ren K, Li E, Ji P. Curr Opin Hematol. 2022 May; 29(3): 137-143.https://doi.org/10.1097/MOH.0000000000000707.PMID: 35441599
  13. Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation.Gao J, Gurbuxani S, Zak T, Kocherginsky M, Ji P, Wehbe F, Chen Q, Chen Y-H, Lu X, Jennings L, Frankfurt O, Altman J, Sukhanova M.Genes Chromosomes Cancer. 2022 Feb; 61(2): 71-80.https://doi.org/10.1002/gcc.23004.PMID: 34668265
  14. Paraneoplastic Thrombocytopenia.Kalas V, Johnson-Sasso C, Morency EG, Ji P, Manesh R, Patel AA.Am J Med. 2021 Aug; 134(8): 976-979.https://doi.org/10.1016/j.amjmed.2021.01.027.PMID: 33621535
  15. Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes.Gelarden I, Nguyen J, Gao J, Chen Q, Morales-Nebreda L, Wunderink R, Li L, Chmiel JS, Hrisinko M, Marszalek L, Momnani S, Patel P, Sumugod R, Chao Q, Jennings LJ, Zembower TR, Ji P, Chen Y-H.Hum Pathol. 2021 Jul; 113: 92-103.https://doi.org/10.1016/j.humpath.2021.04.010.PMID: 33905777
  16. Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.Feola M, Zamperone A, Moskop D, Chen H, Casu C, Lama D, Di Martino J, Djedaini M, Papa L, Martinez MR, Choesang T, Bravo-Cordero JJ, MacKay M, Zumbo P, Brinkman N, Abrams CS, Rivella S, Hattangadi S, Mason CE, Hoffman R, Ji P, Follenzi A, Ginzburg YZ.Commun Biol. 2021 May; 4(1): 517-.https://doi.org/10.1038/s42003-021-02046-9.PMID: 33941818
  17. Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation.Mei Y, Liu Y, Ji P. Blood Rev. 2021 Mar; 46: 100740-. https://doi.org/10.1016/j.blre.2020.100740.PMID: 32798012
  18. Membrane skeleton modulates erythroid proteome remodeling and organelle clearance. Liu Y, Mei Y, Han X, Korobova FV, Prado MA, Yang J, Peng Z, Paulo JA, Gygi SP, Finley D, Ji P. Blood. 2021 Jan; 137(3): 398-409.https://doi.org/10.1182/blood.2020006673.PMID: 33036023
  19. Finding erythroid stress progenitors: cell surface markers revealed.Ji P. Haematologica. 2020 Nov; 105(11): 2499-2501. https://doi.org/10.3324/haematol.2020.262493.PMID: 33131238
  20. Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza. Mei Y, Weinberg SE, Zhao L, Frink A, Qi C, Behdad A, Ji P. EClinicalMedicine. 2020 Sep; 26: 100475-. https://doi.org/10.1016/j.eclinm.2020.100475.PMID: 33089115
  21. Atypical lymphocytes in peripheral blood of patients with COVID-19. Weinberg SE, Behdad A, Ji P. Br J Haematol. 2020 Jul; 190(1): 36-39. https://doi.org/10.1111/bjh.16848.PMID: 32420613
  22. Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment. Mei Y, Han X, Liu Y, Yang J, Sumagin R, Ji P. Nat Commun. 2020 Jun; 11(1): 3172-.
    https://doi.org/10.1038/s41467-020-16911-4.PMID: 32576838
  23. FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.Sheng Y, Yu C, Liu Y, Hu C, Ma R, Lu X, Ji P, Chen J, Mizukawa B, Huang Y, Licht JD, Qian Z. Nat Commun. 2020 Feb; 11(1): 928-.
    https://doi.org/10.1038/s41467-020-14590-9. PMID: 32066721
  24. Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity. Klein O, Krier-Burris RA, Lazki-Hagenbach P, Gorzalczany Y, Mei Y, Ji P, Bochner BS, Sagi-Eisenberg R. J Allergy Clin Immunol. 2019 Oct; 144(4): 1074-1090. https://doi.org/10.1016/j.jaci.2019.06.028.PMID: 31279009
  25. Rats provide a superior model of human stress erythropoiesis. Zhang J, Liu Y, Han X, Mei Y, Yang J, Zhang ZJ, Lu X, Ji P. Exp Hematol. 2019 Oct; 78: 21-34.e3.https://doi.org/10.1016/j.exphem.2019.09.021. PMID: 31562902
  26. Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial. Gangat N, Marinaccio C, Swords R, Watts JM, Gurbuxani S, Rademaker A, Fought AJ, Frankfurt O, Altman JK, Wen QJ, Farnoud N, Famulare CA, Patel A, Tapia R, Vallapureddy RR, Barath S, Graf A, Handlogten A, Zblewski D, Patnaik MM, Al-Kali A, Dinh YT, Englund Prahl K, Patel S, Nobrega JC, Tejera D, Thomassen A, Gao J, Ji P, Rampal RK, Giles FJ, Tefferi A, Stein B, Crispino JD. Clin Cancer Res. 2019 Aug; 25(16): 4898-4906. https://doi.org/10.1158/1078-0432.CCR-19-1005.PMID: 31061068
  27. Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo W-L, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A. Cancer Discov. 2019 Jun; 9(6): 778-795. https://doi.org/10.1158/2159-8290.CD-18-1138. PMID: 30944118
  28. Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes. Zhao B, Liu H, Mei Y, Liu Y, Han X, Yang J, Wickrema A, Ji P. Cancer Med. 2019 Mar; 8(3): 1169-1174. https://doi.org/10.1002/cam4.1969.PMID: 30701702
  29. Targeting age-related inflammation in myelodysplastic syndromes. Mei Y, Ji P. Oncotarget. 2018 Oct; 9(83): 35376-35377. https://doi.org/10.18632/oncotarget.26266. PMID: 30459930
  30. USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J, Ji P, Crispino JD, Fang D.Blood. 2018 Jul; 132(4): 423-434. https://doi.org/10.1182/blood-2017-10-811760.PMID: 29844011
  31. Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS. Mei Y, Zhao B, Basiorka AA, Yang J, Cao L, Zhang J, List A, Ji P. Leukemia. 2018 Apr; 32(4): 1023-1033.
    https://doi.org/10.1038/leu.2017.326. PMID: 29263441
  32. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P. J Clin Invest. 2018 Jan; 128(1): 125-140. https://doi.org/10.1172/JCI94518.PMID: 29202466
  33. Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium. Mei Y, Feng G, Rahimi N, Zhao B, Zhang J, Cao L, Yang J, Gao J, Chen Y, Sumagin R, Muller WA, Zhang L, Ji P
    Blood Adv. 2017 Sep; 1(20): 1650-1656.https://doi.org/10.1182/bloodadvances.2017007906.PMID: 29296812 ISSN: 2473-9529
  34. EBV-negative aggressive NK-cell leukemia/lymphoma: a clinical and pathological study from a single institution. Gao J, Behdad A, Ji P, Wolniak KL, Frankfurt O, Chen Y-H. Mod Pathol. 2017 Aug; 30(8): 1100-1115.https://doi.org/10.1038/modpathol.2017.37. PMID: 28548121
  35. Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2. Li X, Mei Y, Yan B, Vitriol E, Huang S, Ji P, Qiu Y. Haematologica. 2017 Jun; 102(6): 984-994.https://doi.org/10.3324/haematol.2016.161513.PMID: 28255013
  36. Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice.Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y. Stem Cell Reports. 2017 Apr; 8(4): 991-1004.https://doi.org/10.1016/j.stemcr.2017.02.009.PMID: 28330618
  37. Correction: A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway.Zhang Z, Mao H, Du X, Zhu J, Xu Y, Wang S, Xu X, Ji P, Yu Y, Cao B, Han K, Hou T, Xu Z, Kong Y, Jiang G, Tang X, Qiao C, Mao X. Oncotarget. 2016 Dec; 7(49): 81972-.https://doi.org/10.18632/oncotarget.13803. PMID: 28082727
  38. Pericytes: new EPO-producing cells in the brain.Ji P. Blood. 2016 Nov; 128(21): 2483-2485.https://doi.org/10.1182/blood-2016-10-743880.PMID: 27884833
  39. Chromatin condensation during terminal erythropoiesis.Zhao B, Yang J, Ji P.Nucleus. 2016 Oct; 7(5): 425-429. https://doi.org/10.1080/19491034.2016.1226717. PMID: 27579498 ISSN: 1949-1034
  40. Erythropoietin-regulated oxidative stress negatively affects enucleation during terminal erythropoiesis. Zhao B, Mei Y, Yang J, Ji P. Exp Hematol. 2016 Oct; 44(10): 975-981. https://doi.org/10.1016/j.exphem.2016.06.249.PMID: 27364565
  41. Chromatin condensation during terminal erythropoiesis.Zhao B, Yang J, Ji P. Nucleus. 2016 Sep; 7(5): 425-429. https://doi.org/10.1080/19491034.2016.1226717.PMID: 27579498
  42. Chromatin condensation during terminal erythropoiesis.Zhao B, Yang J, Ji P. Nucleus (Austin, Tex.). 2016 Sep; 7(5): 425-429.PMID: 27579498
  43. Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening. Zhao B, Mei Y, Schipma MJ, Roth EW, Bleher R, Rappoport JZ, Wickrema A, Yang J, Ji P. DEVELOPMENTAL CELL. 2016 Mar; 36(5): 498-510.
    https://doi.org/10.1016/j.devcel.2016.02.001.ISSN: 1534-5807
  44. Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening.Zhao B, Mei Y, Schipma MJ, Roth EW, Bleher R, Rappoport JZ, Wickrema A, Yang J, Ji P. Dev Cell. 2016 Mar; 36(5): 498-510.
    https://doi.org/10.1016/j.devcel.2016.02.001. PMID: 26954545
  45. H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function. Zhao B, Tan TL, Mei Y, Yang J, Yu Y, Verma A, Liang Y, Gao J, Ji P. Sci Rep. 2016 Jan; 6: 19589-. https://doi.org/10.1038/srep19589
    .PMID: 26791933
  46. Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice. Mei Y, Zhao B, Yang J, Gao J, Wickrema A, Wang D, Chen Y, Ji P. Haematologica. 2016 Jan; 101(1): e1-e5.
    https://doi.org/10.3324/haematol.2015.134221.PMID: 26471482
  47. New insights into the mechanisms of mammalian erythroid chromatin condensation and enucleation. Ji P. Int Rev Cell Mol Biol. 2015; 316: 159-182. https://doi.org/10.1016/bs.ircmb.2015.01.006. PMID: 25805124 ISSN: 1937-6448
  48. Mouse fetal liver culture system to dissect target gene functions at the early and late stages of terminal erythropoiesis. Zhao B, Mei Y, Yang J, Ji P. J Vis Exp. 2014 Sep; (91): e51894-. https://doi.org/10.3791/51894. PMID: 25225899
  49. Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis. Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P
    Haematologica. 2014 Jul; 99(7): 1157-1167. https://doi.org/10.3324/haematol.2014.105809. PMID: 24747950
  50. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS. Keerthivasan G, Mei Y, Zhao B, Zhang L, Harris CE, Gao J, Basiorka AA, Schipma MJ, McElherne J, Yang J, Verma AK, Pellagatti A, Boultwood J, List AF, Williams DA, Ji P. Blood. 2014 Jul; 124(5): 780-790. https://doi.org/10.1182/blood-2014-01-552463. PMID: 24891322
  51. Plasmacytoid dendritic cells in chronic myelomonocytic leukemia. Ji P, Peterson LC. Blood. 2014 May; 123(21): 3220-. https://doi.org/10.1182/blood-2014-03-557587.PMID: 24977276
  52. Mammalian erythroblast enucleation requires PI3K-dependent cell polarization. Wang J, Ramirez T, Ji P, Jayapal SR, Lodish HF, Murata-Hori M. J Cell Sci. 2012 Jan; 125(Pt 2): 340-349. https://doi.org/10.1242/jcs.088286.PMID: 22331356
  53. Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation. Ji P, Lodish HF. Biochem Biophys Res Commun. 2012 Jan; 417(4): 1188-1192.
    https://doi.org/10.1016/j.bbrc.2011.12.105. PMID: 22226968
  54. Formation of mammalian erythrocytes: chromatin condensation and enucleation. Ji P, Murata-Hori M, Lodish HF. Trends Cell Biol. 2011 Jul; 21(7): 409-415. https://doi.org/10.1016/j.tcb.2011.04.003.PMID: 21592797
  55. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Sankaran VG, Menne TF, Šcepanovic D, Vergilio J-A, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. Proc Natl Acad Sci U S A. 2011 Jan; 108(4): 1519-1524. https://doi.org/10.1073/pnas.1018384108. PMID: 21205891
  56. Down-regulation of Myc is essential for terminal erythroid maturation. Jayapal SR, Lee KL, Ji P, Kaldis P, Lim B, Lodish HF. J Biol Chem. 2010 Dec; 285(51): 40252-40265.https://doi.org/10.1074/jbc.M110.181073. PMID: 20940306
  57. Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Ji P, Yeh V, Ramirez T, Murata-Hori M, Lodish HF. Haematologica. 2010 Dec; 95(12): 2013-2021.
    https://doi.org/10.3324/haematol.2010.029827. PMID: 20823130
  58. Rac GTPases play multiple roles in erythropoiesis. Ji P, Lodish HF. Haematologica. 2010 Jan; 95(1): 2-4. https://doi.org/10.3324/haematol.2009.015511.PMID: 20065075
  59. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.
    Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L. Nat Genet. 2010 Jan; 42(1): 83-88. https://doi.org/10.1038/ng.498. PMID: 19966802
  60. An AR-Skp2 pathway for proliferation of androgen-dependent prostate-cancer cells. Wang H, Sun D, Ji P, Mohler J, Zhu L. J Cell Sci. 2008 Aug; 121(Pt 15): 2578-2587.https://doi.org/10.1242/jcs.030742. PMID: 18628304 ISSN: 0021-9533
  61. Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2.Ji P, Jayapal SR, Lodish HF. Nat Cell Biol. 2008 Mar; 10(3): 314-321. https://doi.org/10.1038/ncb1693. PMID: 18264091
  62. Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing. Ji P, Sun D, Wang H, Bauzon F, Zhu L. Mol Cancer Ther. 2007 Feb; 6(2): 684-691.https://doi.org/10.1158/1535-7163.MCT-06-0538. PMID: 17308064 ISSN: 1535-7163
  63. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. Ji P, Goldin L, Ren H, Sun D, Guardavaccaro D, Pagano M, Zhu L. J Biol Chem. 2006 Aug; 281(33): 24058-24069.
    https://doi.org/10.1074/jbc.M603105200. PMID: 16774918 ISSN: 0021-9258
  64. Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression. Ji P, Zhu L. Cell Cycle. 2005 Mar; 4(3): 373-375. https://doi.org/10.4161/cc.4.3.1535.PMID: 15701969
  65. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L. Mol Cell. 2004 Oct; 16(1): 47-58.
    https://doi.org/10.1016/j.molcel.2004.09.029. PMID: 15469821 ISSN: 1097-2765