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Publications

Learn more about the work that we do in the Peng Ji Laboratory through our recent publications.

  1. Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment.Kehan Ren, Ermin Li, Inci Aydemir, Yijie Liu, Xu Han, Honghao Bi, Pan Wang, Kara Tao, Amy Ji, Yi-Hua Chen, Jing Yang, Madina Sukhanova, Peng Ji. Bloodadvances. 2024 Oct 29:doi: 10.1182/bloodadvances.2024013361.PMID: 39471483
  2. Pleckstrin-2 mediates the activation of AKT in prostate cancer and is repressed by androgen receptor.Xu Han, Ali Zhang, Pan Wang, Honghao Bi, Kehan Ren, Ermin Li, Ximing Yang, Inci Aydemir, Kara Tao, Jeffrey Lin, Sarki A Abdulkadir, Jing Yang, Peng Ji. Am J Pathol,2024 Oct;194(10):1986-1996. doi: 10.1016/j.ajpath.2024.07.004. PMID: 39069167
  3. Prognostic significance of copy number gains of MYC detected by fluorescence in situ hybridization in large B-cell lymphoma. Zak T, Santana-Santos L, Gao J, Behdad A, Aqil B, Wolniak K, Lu X, Ji P, Chen Q, Chen Y-H, Karmali R, Sukhanova M. Leuk Lymphoma. 2024 Jan; 65(1): 26-36. https://doi.org/10.1080/10428194.2023.2264429 PMID: 37794791
  4. mDia formins form hetero-oligomers and cooperatively maintain murine hematopoiesis. Li Z, Su M, Xie X, Wang P, Bi H, Li E, Ren K, Dong L, Lv Z, Ma X, Liu Y, Zhao B, Peng Y, Liu J, Liu L, Yang J, Ji P, Mei Y. PLoS Genet. 2023 Dec; 19(12): e1011084-.https://doi.org/10.1371/journal.pgen.1011084.PMID: 38157491

  5. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation. Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. Blood. 2023 Jul; 142(1): 106-118.https://doi.org/10.1182/blood.2022018475 PMID: 37053547
  6. Clonal hematopoiesis and bone marrow inflammation. Xie X, Su M, Ren K, Ma X, Lv Z, Li Z, Mei Y, Ji P. Transl Res. 2023 May; 255: 159-170.https://doi.org/10.1016/j.trsl.2022.11.004PMID: 36347490
  7. Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P. J Clin Invest. 2023 Mar; 133(6): https://doi.org/10.1172/JCI159638 PMID: 36719747
  8. PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang Z-Y, Liu Y. Blood. 2023 Jan; 141(3): 244-259. https://doi.org/10.1182/blood.2022016580.PMID: 36206490
  9. Chromatin reconstruction during mouse terminal erythropoiesis.Bi H, Hou Y, Wang J, Xia Z, Wang D, Liu Y, Bao H, Han X, Ren K, Li E, Yue F, Ji P. iScience. 2022 Dec; 25(12):
  10. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Hodzic D, Wu J, Krchma K, Jurisicova A, Tsatskis Y, Liu Y, Ji P, Choi K, McNeill H.PLoS Biol. 2022 Oct; 20(10): e3001811-.
  11. Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia.Mei Y, Ren K, Liu Y, Ma A, Xia Z, Han X, Li E, Tariq H, Bao H, Xie X, Zou C, Zhang D, Li Z, Dong L, Verma A, Lu X, Abaza Y, Altman JK, Sukhanova M, Yang J, Ji P.J Clin Invest. 2022 Sep; 132(17):https://doi.org/10.1172/JCI152673.PMID: 35900794
  12. Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation.Gao J, Gurbuxani S, Zak T, Kocherginsky M, Ji P, Wehbe F, Chen Q, Chen Y-H, Lu X, Jennings L, Frankfurt O, Altman J, Sukhanova M.Genes Chromosomes Cancer. 2022 Feb; 61(2): 71-80.https://doi.org/10.1002/gcc.23004.PMID: 34668265
  13. Paraneoplastic Thrombocytopenia.Kalas V, Johnson-Sasso C, Morency EG, Ji P, Manesh R, Patel AA.Am J Med. 2021 Aug; 134(8): 976-979.https://doi.org/10.1016/j.amjmed.2021.01.027.PMID: 33621535
  14. Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes.Gelarden I, Nguyen J, Gao J, Chen Q, Morales-Nebreda L, Wunderink R, Li L, Chmiel JS, Hrisinko M, Marszalek L, Momnani S, Patel P, Sumugod R, Chao Q, Jennings LJ, Zembower TR, Ji P, Chen Y-H.Hum Pathol. 2021 Jul; 113: 92-103.https://doi.org/10.1016/j.humpath.2021.04.010.PMID: 33905777
  15. Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.Feola M, Zamperone A, Moskop D, Chen H, Casu C, Lama D, Di Martino J, Djedaini M, Papa L, Martinez MR, Choesang T, Bravo-Cordero JJ, MacKay M, Zumbo P, Brinkman N, Abrams CS, Rivella S, Hattangadi S, Mason CE, Hoffman R, Ji P, Follenzi A, Ginzburg YZ.Commun Biol. 2021 May; 4(1): 517-.https://doi.org/10.1038/s42003-021-02046-9.PMID: 33941818
  16. Membrane skeleton modulates erythroid proteome remodeling and organelle clearance. Liu Y, Mei Y, Han X, Korobova FV, Prado MA, Yang J, Peng Z, Paulo JA, Gygi SP, Finley D, Ji P. Blood. 2021 Jan; 137(3): 398-409.https://doi.org/10.1182/blood.2020006673.PMID: 33036023
  17. Atypical lymphocytes in peripheral blood of patients with COVID-19. Weinberg SE, Behdad A, Ji P. Br J Haematol. 2020 Jul; 190(1): 36-39. https://doi.org/10.1111/bjh.16848.PMID: 32420613
  18. FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.Sheng Y, Yu C, Liu Y, Hu C, Ma R, Lu X, Ji P, Chen J, Mizukawa B, Huang Y, Licht JD, Qian Z. Nat Commun. 2020 Feb; 11(1): 928-.
  19. Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity. Klein O, Krier-Burris RA, Lazki-Hagenbach P, Gorzalczany Y, Mei Y, Ji P, Bochner BS, Sagi-Eisenberg R. J Allergy Clin Immunol. 2019 Oct; 144(4): 1074-1090. https://doi.org/10.1016/j.jaci.2019.06.028.PMID: 31279009
  20. Rats provide a superior model of human stress erythropoiesis. Zhang J, Liu Y, Han X, Mei Y, Yang J, Zhang ZJ, Lu X, Ji P. Exp Hematol. 2019 Oct; 78: 21-34.e3.https://doi.org/10.1016/j.exphem.2019.09.021. PMID: 31562902
  21. Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial. Gangat N, Marinaccio C, Swords R, Watts JM, Gurbuxani S, Rademaker A, Fought AJ, Frankfurt O, Altman JK, Wen QJ, Farnoud N, Famulare CA, Patel A, Tapia R, Vallapureddy RR, Barath S, Graf A, Handlogten A, Zblewski D, Patnaik MM, Al-Kali A, Dinh YT, Englund Prahl K, Patel S, Nobrega JC, Tejera D, Thomassen A, Gao J, Ji P, Rampal RK, Giles FJ, Tefferi A, Stein B, Crispino JD. Clin Cancer Res. 2019 Aug; 25(16): 4898-4906. https://doi.org/10.1158/1078-0432.CCR-19-1005.PMID: 31061068
  22. Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo W-L, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A. Cancer Discov. 2019 Jun; 9(6): 778-795. https://doi.org/10.1158/2159-8290.CD-18-1138. PMID: 30944118
  23. Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes. Zhao B, Liu H, Mei Y, Liu Y, Han X, Yang J, Wickrema A, Ji P. Cancer Med. 2019 Mar; 8(3): 1169-1174. https://doi.org/10.1002/cam4.1969.PMID: 30701702
  24. USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J, Ji P, Crispino JD, Fang D.Blood. 2018 Jul; 132(4): 423-434. https://doi.org/10.1182/blood-2017-10-811760.PMID: 29844011
  25. Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS. Mei Y, Zhao B, Basiorka AA, Yang J, Cao L, Zhang J, List A, Ji P. Leukemia. 2018 Apr; 32(4): 1023-1033.
  26. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P. J Clin Invest. 2018 Jan; 128(1): 125-140. https://doi.org/10.1172/JCI94518.PMID: 29202466
  27. Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium. Mei Y, Feng G, Rahimi N, Zhao B, Zhang J, Cao L, Yang J, Gao J, Chen Y, Sumagin R, Muller WA, Zhang L, Ji P. Blood Adv. 2017 Sep; 1(20): 1650-1656.https://doi.org/10.1182/bloodadvances.2017007906.PMID: 29296812 ISSN: 2473-9529
  28. Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice.Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y. Stem Cell Reports. 2017 Apr; 8(4): 991-1004.https://doi.org/10.1016/j.stemcr.2017.02.009.PMID: 28330618
  29. Correction: A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway.Zhang Z, Mao H, Du X, Zhu J, Xu Y, Wang S, Xu X, Ji P, Yu Y, Cao B, Han K, Hou T, Xu Z, Kong Y, Jiang G, Tang X, Qiao C, Mao X. Oncotarget. 2016 Dec; 7(49): 81972-.https://doi.org/10.18632/oncotarget.13803. PMID: 28082727
  30. Chromatin condensation during terminal erythropoiesis.Zhao B, Yang J, Ji P.Nucleus. 2016 Oct; 7(5): 425-429. https://doi.org/10.1080/19491034.2016.1226717. PMID: 27579498 ISSN: 1949-1034
  31. Chromatin condensation during terminal erythropoiesis.Zhao B, Yang J, Ji P. Nucleus (Austin, Tex.). 2016 Sep; 7(5): 425-429.PMID: 27579498
  32. Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening. Zhao B, Mei Y, Schipma MJ, Roth EW, Bleher R, Rappoport JZ, Wickrema A, Yang J, Ji P. DEVELOPMENTAL CELL. 2016 Mar; 36(5): 498-510.
  33. Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening.Zhao B, Mei Y, Schipma MJ, Roth EW, Bleher R, Rappoport JZ, Wickrema A, Yang J, Ji P. Dev Cell. 2016 Mar; 36(5): 498-510.
  34. H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function. Zhao B, Tan TL, Mei Y, Yang J, Yu Y, Verma A, Liang Y, Gao J, Ji P. Sci Rep. 2016 Jan; 6: 19589-. https://doi.org/10.1038/srep19589
    .PMID: 26791933
  35. Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice. Mei Y, Zhao B, Yang J, Gao J, Wickrema A, Wang D, Chen Y, Ji P. Haematologica. 2016 Jan; 101(1): e1-e5.
  36. Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis. Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P
    Haematologica. 2014 Jul; 99(7): 1157-1167. https://doi.org/10.3324/haematol.2014.105809. PMID: 24747950
  37. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS. Keerthivasan G, Mei Y, Zhao B, Zhang L, Harris CE, Gao J, Basiorka AA, Schipma MJ, McElherne J, Yang J, Verma AK, Pellagatti A, Boultwood J, List AF, Williams DA, Ji P. Blood. 2014 Jul; 124(5): 780-790. https://doi.org/10.1182/blood-2014-01-552463. PMID: 24891322
  38. Mammalian erythroblast enucleation requires PI3K-dependent cell polarization. Wang J, Ramirez T, Ji P, Jayapal SR, Lodish HF, Murata-Hori M. J Cell Sci. 2012 Jan; 125(Pt 2): 340-349. https://doi.org/10.1242/jcs.088286.PMID: 22331356
  39. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Sankaran VG, Menne TF, Šcepanovic D, Vergilio J-A, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. Proc Natl Acad Sci U S A. 2011 Jan; 108(4): 1519-1524. https://doi.org/10.1073/pnas.1018384108. PMID: 21205891
  40. Down-regulation of Myc is essential for terminal erythroid maturation. Jayapal SR, Lee KL, Ji P, Kaldis P, Lim B, Lodish HF. J Biol Chem. 2010 Dec; 285(51): 40252-40265.https://doi.org/10.1074/jbc.M110.181073. PMID: 20940306
  41. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L. Nat Genet. 2010 Jan; 42(1): 83-88. https://doi.org/10.1038/ng.498. PMID: 19966802
  42. An AR-Skp2 pathway for proliferation of androgen-dependent prostate-cancer cells. Wang H, Sun D, Ji P, Mohler J, Zhu L. J Cell Sci. 2008 Aug; 121(Pt 15): 2578-2587.https://doi.org/10.1242/jcs.030742. PMID: 18628304 ISSN: 0021-9533
  43. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. Ji P, Goldin L, Ren H, Sun D, Guardavaccaro D, Pagano M, Zhu L. J Biol Chem. 2006 Aug; 281(33): 24058-24069.
  44. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L. Mol Cell. 2004 Oct; 16(1): 47-58.https://doi.org/10.1016/j.molcel.2004.09.029. PMID: 15469821 ISSN: 1097-2765