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Selected Publications

  1. Ferreira, A, Kosik, KS, Greengard, P, and Han, HQ.  Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. Science 264:977-979, 1994.
  2. Ferreira, A, Han, H-Q, Greengard, P, and Kosik, K.S. Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture. Proc. Natl. Acad. Sci. USA  92: 9225-9229, 1995.
  3. Ferreira, A, and Kosik, KS. Accelerated neuronal differentiation induced by p53 suppression. J. Cell Sci.  109: 1509-1516, 1996.
  4. Ferreira, A, Lu, Q, Orecchio, L, and Kosik, KS. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Mol. Cell. Neurosci.  9: 220-234, 1997.
  5. Ferreira, A. Abnormal synapse formation in agrin depleted hippocampal neurons. J. Cell Sci. 112: 4729-4738, 1999.
  6. Ferreira, A, Kao, H-T, Feng, J, Rapoport, M, and Greengard, P. Synapsin III:  Developmental expression, subcellular localization and role in axonal elongation. J. Neurosci. 20: 3736-3744, 2000.
  7. Mantych, KB, and Ferreira, A. Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons. J. Neurosci. 21: 6802-6809, 2001.
  8. Rapoport, M, Dawson, HN, Binder, LI, Vitek, M, and Ferreira, A. Tau is essential for beta-amyloid induced neurotoxicity. Proc. Natl. Acad. Sci. USA. 99: 6364-6369, 2002.
  9. Paganoni, S, and Ferreira, A. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J. Cell Sci. 118: 433-446, 2005.
  10. Park, S-Y, and Ferreira, A. The generation of a 17 kDa neurotoxic fragment: An alternative mechanism by which tau mediates Ab-induced neurodegeneration. J. of Neurosci. 25: 5365-5375, 2005.
  11. Kelly, B, Vassar, R, and Ferreira, A. Beta-amyloid-induced dynamin I depletion in hippocampal neurons: A potential mechanisms for early cognitive decline in Alzheimer’s disease. J. Biol. Chem. 280: 31746-31753, 2005.
  12. Tournell, CE, Bergstrom, RA, and Ferreira, A. Progesterone-induced agrin expression in astrocytes modulates glia-neuron interactions leading to synapse formation. Neuroscience 141: 1327-1338, 2006.
  13. Kelly, B, and Ferreira, A. Beta-amyloid-induced dynamin 1 degradation is mediated by NMDA receptors in hippocampal neurons. J. Biol. Chem. 281: 28079-28089, 2006.
  14. Park, S-Y, Tournell, CE, Sinjoanu, RC, and Ferreira, A. Caspase 3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons. Neuroscience 144: 119-127, 2007.
  15. Kelly, B, and Ferreira, A. Ab disrupted synaptic vesicle endocytosis in cultured hippocampal neurons. Neuroscience: 146: 60-70, 2007.
  16. Bergstrom, RA, Sinjoanu, RC, and Ferreira, A. Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Neuroscience 149: 527-536, 2007.
  17. Sinjoanu, RC, Kleinschmidt, S, Bitner, RS, Brioni, J, Moeller, A, and Ferreira, A. The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons. Neurochem. Intl. 53: 79-88, 2008.
  18. Nicholson, A, and Ferreira, A. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J. Neuroscience 29: 4640-4651, 2009.
  19. Paganoni, S, Bernstein, J, and Ferreira, A. ROR1-ROR2 complexes modulate synapse formation in hippocampal neurons. Neuroscience 165:1261-1274, 2010.
  20. Nicholson, A, Riherd-Methner, DN, and Ferreira, A. Membrane cholesterol modulates beta-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of NMDA receptors. J. Biol. Chem. 286: 976-986, 2011.
  21. Ferreira, A, and Bigio, EH. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol. Med. 17: 676-685, 2011.
  22. Nicholson, A, and Ferreira, A. Cholesterol and neuronal susceptibility to beta-amyloid toxicity. Trends in Cognitive Sciences 5: 35-56, 2011.
  23. Nicholson, A, Wold, L, Walsh, D, and Ferreira, A. Beta-amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Mol. Med.18:178-185, 2012.
  24. Ferreira, A. Calpain dysregulation in Alzheimer’s disease ISRN Biochemistry, vol. 2012, Article ID 728571, 12 pages, 2012. doi:10.5402/2012/728571.
  25. Lang, AE, Riherd-Methner, DN, and Ferreira, A. Neuronal degeneration, synaptic  defects, and behavioral abnormalities in tau45-230 transgenic miceNeuroscience 275: 322-339, 2014.
  26. Tunc-Ozcan, E, Ferreira, A, and Redei, EE. Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System. Alcohol Clin Exp Res. 40(6):1273-82, 2016.
  27. Vintilescu CR, Afreen S, Rubino AE, and Ferreira AThe Neurotoxic TAU45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects. Mol Med 477-486, 2016.
  28. Afreen S, Riherd Methner DN, and Ferreira A. Tau45-230 association with the cytoskeleton and membrane-bound organelles: Functional implications in neurodegeneration. Neuroscience 362:104-117, 2017. 
  29. Afreen S, and Ferreira A. Altered Cytoskeletal Composition and Delayed Neurite Elongation in tau45-230-Expressing Hippocampal Neurons. J. Neuroscience 412:1-15, 2019.


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Book Chapters

  1. Kosik, KS, Ferreira, A, Knowles, R, Leclerc, N, and Greenberg, S. Linking Amyloid Precursor protein processing and Tau-related Pathology in Alzheimer's Disease. In: Alzheimer's disease: Lessons from Cell Biology.  pp 230-240, 1995.
  2. Ferreira, A, "Cytoskeletal Proteins in Neuronal Development" In:  Frontiers in cerebrovascular Disease: Mechanisms, Diagnosis and treatment. Ed. J.T. Robertson and T.S. Nowak. pp 211-216, 1998.
  3. Ferreira, A, and Loomis, PA. Isolation and culture of primary neural cells.  In: "Cells: A laboratory Manual" Cold Spring Harbor Laboratory. Ed. by D. Spector, R. Goldman and L. Leinwand. pp 9.1- 9.13, 1998.
  4. Caceres, A, Paglini, G, Quiroga, S, and Ferreira, A. Role of the Golgi apparatus during axonal formation. In: “Intracellular mechanisms for neuritogenesis”. Ed. by Ivan De Curtis.pp 136-154, 2006.
  5. Ferreira, A, Sinjoanu, RC, Nicholson, A, Kleinschmidt, S. Ab toxicity in primary cultured neurons. In: “Alzheimer’s disease and frontotemporal dementia”. Ed. by Erik Roberson. Methods in Mol. Biol 160: 141-154, 2010.
  6. Ferreira A, Afreen S. Methods related to studying tau fragmentation. Methods Cell Biol 141:245-258, 2017.