Northwestern University Feinberg School of Medicine

Adriana Ferreira Lab

Selected Publications

1. Ferreira, A, Kosik, KS, Greengard, P, and Han, HQ.  Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. Science 264:977-979, 1994.

2. Ferreira, A, Han, H-Q, Greengard, P, and Kosik, K.S. Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture. Proc.Natl. Acad.Sci.USA  92: 9225-9229, 1995.

3. Ferreira, A, and Kosik, KS. Accelerated neuronal differentiation induced by p53 suppression. J. CellSci.  109: 1509-1516, 1996.

4. Ferreira, A, Lu, Q, Orecchio, L, and Kosik, KS. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Mol.Cell.Neurosci.  9: 220-234, 1997.

5. Ferreira, A. Abnormal synapse formation in agrin depleted hippocampal neurons. J.Cell Sci. 112: 4729-4738, 1999.

6. Ferreira, A, Kao, H-T, Feng, J, Rapoport, M, and Greengard, P. Synapsin III:  Developmental expression, subcellular localization and role in axonal elongation. J.Neurosci. 20: 3736-3744, 2000.

7. Mantych, KB, and Ferreira, A.Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons. J. Neurosci. 21: 6802-6809, 2001.

8. Rapoport, M, Dawson, HN, Binder, LI, Vitek, M, and Ferreira, A.Tau is essential for beta-amyloid induced neurotoxicity. Proc.Natl.Acad. Sci. USA. 99: 6364-6369, 2002.

9. Paganoni, S, and Ferreira, A. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J. Cell Sci. 118: 433-446, 2005.

10. Park, S-Y, and Ferreira, A. The generation of a 17 kDa neurotoxic fragment: An alternative mechanism by which tau mediates Ab-induced neurodegeneration. J. of Neurosci. 25: 5365-5375, 2005.

11. Kelly, B, Vassar, R, and Ferreira, A. Beta-amyloid-induced dynamin I depletion in hippocampal neurons: A potential mechanisms for early cognitive decline in Alzheimer’s disease. J. Biol. Chem. 280: 31746-31753, 2005.

12. Tournell, CE, Bergstrom, RA, and Ferreira, A. Progesterone-induced agrin expression in astrocytes modulates glia-neuron interactions leading to synapse formation. Neuroscience 141: 1327-1338, 2006.

13. Kelly, B, and Ferreira, A. Beta-amyloid-induced dynamin 1 degradation is mediated by NMDA receptors in hippocampal neurons. J. Biol. Chem. 281: 28079-28089, 2006.

14. Park, S-Y, Tournell, CE, Sinjoanu, RC, and Ferreira, A. Caspase 3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons. Neuroscience 144: 119-127, 2007.

15. Kelly, B, and Ferreira, A. Ab disrupted synaptic vesicle endocytosis in cultured hippocampal neurons. Neuroscience: 146: 60-70, 2007.

16. Bergstrom, RA, Sinjoanu, RC, and Ferreira, A. Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Neuroscience 149: 527-536, 2007.

17. Sinjoanu, RC, Kleinschmidt, S, Bitner, RS, Brioni, J, Moeller, A, and Ferreira, A. The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons. Neurochem. Intl. 53: 79-88, 2008.

18. Nicholson, A, and Ferreira, A. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J. Neuroscience 29: 4640-4651, 2009.

19. Paganoni, S, Bernstein, J, and Ferreira, A.ROR1-ROR2 complexes modulate synapse formation in hippocampal neurons. Neuroscience 165:1261-1274, 2010.

20. Nicholson, A, Riherd-Methner, DN, and Ferreira, A. Membrane cholesterol modulates beta-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of NMDA receptors. J. Biol. Chem. 286: 976-986, 2011.

21. Ferreira, A, and Bigio, EH. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol. Med. 17: 676-685, 2011.

22. Nicholson, A, and Ferreira, A. Cholesterol and neuronal susceptibility to beta-amyloid toxicity. Trends inCognitive Sciences 5: 35-56, 2011.

23. Nicholson, A, Wold, L, Walsh, D, and Ferreira, A.Beta-amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Mol. Med.18:178-185, 2012.

24. Ferreira, A.Calpain dysregulation in Alzheimer’s disease ISRN Biochemistry, vol. 2012, Article ID 728571, 12 pages, 2012. doi:10.5402/2012/728571.

25. Lang, AE, Riherd-Methner, DN, and Ferreira, A. Neuronal degeneration, synaptic  defects, and behavioral abnormalities in tau45-230 transgenic miceNeuroscience 275: 322-339, 2014.

26. Tunc-Ozcan, E, Ferreira, A, and Redei, EE. Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System. Alcohol Clin Exp Res. 40(6):1273-82, 2016.

27. Vintilescu CR, Afreen S, Rubino AE, and Ferreira AThe Neurotoxic TAU45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects. Mol Med 477-486, 2016.

28. Afreen S, Riherd Methner DN, and Ferreira A. Tau45-230 association with the cytoskeleton and membrane-bound organelles: Functional implications in neurodegeneration. Neuroscience 362:104-117, 2017. 

29. Afreen S, and Ferreira A. Altered Cytoskeletal Composition and Delayed Neurite Elongation in tau45-230-Expressing Hippocampal Neurons. J. Neuroscience 412:1-15, 2019.

Click here for complete list of publications

Book Chapters

1. Kosik, KS, Ferreira, A, Knowles, R, Leclerc, N, and Greenberg, S. Linking Amyloid Precursor protein processing and Tau-related Pathology in Alzheimer's Disease. In: Alzheimer's disease: Lessons from Cell Biology.  pp 230-240, 1995.

2. Ferreira, A, "Cytoskeletal Proteins in Neuronal Development" In:  Frontiers in cerebrovascular Disease: Mechanisms, Diagnosis and treatment. Ed. J.T. Robertson and T.S. Nowak. pp 211-216, 1998.

3. Ferreira, A, and Loomis, PA. Isolation and culture of primary neural cells.  In: "Cells: A laboratory Manual" Cold Spring Harbor Laboratory. Ed. by D. Spector, R. Goldman and L. Leinwand. pp 9.1- 9.13, 1998.

4. Caceres, A, Paglini, G, Quiroga, S, and Ferreira, A. Role of the Golgi apparatus during axonal formation. In: “Intracellular mechanisms for neuritogenesis”. Ed. by Ivan De Curtis.pp 136-154, 2006.

5. Ferreira, A, Sinjoanu, RC, Nicholson, A, Kleinschmidt, S. Ab toxicity in primary cultured neurons. In: “Alzheimer’s disease and frontotemporal dementia”. Ed. by Erik Roberson. Methods in Mol. Biol 160: 141-154, 2010.

6. Ferreira A, Afreen S. Methods related to studying tau fragmentation. Methods Cell Biol 141:245-258, 2017.