Publications:
2024
McCabe M, Boya P, Chen RH, Chu CT, Colombo MI, Delgui L, Eskelinen EL, Hamasaki M, Hansen M, He C, Jäättelä M, Kimchi A, Kraft C, Kundu M, Melendez A, Pattingre S, Proikas-Cezanne T, Sebti S, Simon AK, Simonsen A, Tooze SA, Vaccaro MI, Wang X, White E, Zhao Y, Cuervo AM. Women in Autophagy: an initiative to promote gender parity in science. Nature Cell Biology. 26 (12). 2009-2012. 2024.
2023
Qiu X, Na L, Yang Q, Wu S, Li X, Pan X, Zhang X, Zeng J, Liao J, He C, Wang R, Zhao Y. The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy. 19 (11). 2884-2898. 2023.
Wu R, Park J, Qian Y, Shi Z, Hu R, Yuan Y, Xiong S, Wang Z, Yan G, Ong S-G, Song Q, Song Z, Mahmoud AM, Xu P, He C, Arpke RW, Kyba M, Shu G, Jiang Q, Jiang Y. Genetically prolonged beige fat in male mice confers long-lasting metabolic health. Nature Communications. 14 (1). 2731. 2023.
Kuramoto K, Liang H, Hong JH, He C. Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise. Cell Metabolism. 35 (4). 620-632. 2023. [Highlighted in Nature Reviews Endocrinology and Editors' Choice of Science Signaling]
2022
Hekman KE, Koss KM, Ivancic DZ, He C, Wertheim JA. Autophagy enhances longevity of induced pluripotent stem cell-derived endothelium via mTOR-independent ULK1 kinase. Stem Cells Translational Medicine. 11 (11). 1151-1164. 2022.
Yang S, Liu T, Hu C, Li W, Meng Y, Li H, Song C, He C, Zhou Y, Fan Y. Ginsenoside Compound K protects against obesity through pharmacological targeting of glucocorticoid receptor to activate lipophagy and lipid metabolism. Pharmaceutics. 14 (6). 1192. 2022.
An Z, Chiang W-C, Fernández ÁF, Franco LH, He C, Huang S-Y, Lee E, Liu Y, Sebti S, Shoji-Kawata S, Sirasanagandla S, Wang RC, Wei Y, Zhao Y, Vega-Rubin-de-Celis S. Beth Levine’s legacy: from the discovery of BECN1 to therapies. A mentees’ perspective. Frontiers in Cell and Developmental Biology. 10 (891332). 2022.
He C. Balancing nutrient and energy demand and supply via autophagy. Special Issue on Economies in Biology. Current Biology. 32 (12). R684-R696. 2022.
Kuramoto K and He C. Degradative and non-degradative roles of autophagy proteins in metabolism and metabolic diseases. Special Issue on Autophagy. Frontiers in Cell and Developmental Biology. 10 (844481). eCollection 2022.
2021
He C. Chaperone-mediated autophagy on the clock. Nature Cell Biology. 23 (12). 1220-1221. 2021.
Kuramoto K and He C. The secretory function of BECN1 in metabolic regulation. Autophagy. 17 (10). 3262-3263. 2021.
Kuramoto K, Kim YJ, Hong JH, He C. The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding. Cell Reports. 35 (8). 109184. 2021.
Kim YJ, Kong Q, Yamamoto S, Kuramoto K, Huang M, Wang N, Hong JH, Xiao T, Levine B, Qiu X, Zhao Y, Miller RJ, Dong H, Meltzer HY, Xu M, He C. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Science Advances. 7 (8). eabc8310. 2021.
He C. Mechanisms of autophagy: the machinery of macro-autophagy and points of control (Chapter 2). Autophagy in Health and Disease (Book). 2nd edition, edited by Beverly A. Rothermel and Abhinav Diwan. 2021.
2020
Sebti S, He C, Pattingre S, Meléndez A, Cuervo AM, Hardwick JM, Griffin DE. Remembering Beth Levine - the autophagy pioneer and woman extraordinaire. The FEBS Journal. 287 (20). 4314-4321. 2020.
An Z, … He C, … et al. Editorial: Beth Levine in memoriam. Autophagy. 16 (9). 1559-1583. 2020.
Wang J, Kaplan N, Wang S, Yang W, Wang L, He C, Peng H. Autophagy plays a positive role in induction of epidermal proliferation. The FASEB Journal. 34 (8). 10657-10667. 2020.
Priyadarshini M, Cole C, Oroskar G, Ludvik AE, Wicksteed B, He C, Layden BT. Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress. Am J Physiol Regul Integr Comp Physiol. 318 (4). R691-R700. 2020.
2019
Yang S, Yan J, Yang L, Meng Y, Wang N, He C, Fan Y, Zhou Y. Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance. Int J Biol Macromol. 126. 466-474. 2019.
2018
Kuramoto K and He C. The BECN1-BCL2 complex regulates insulin secretion and storage in mice. Autophagy. 14 (11). 2026-2028. 2018.
Yamamoto S*, Kuramoto K*, Wang N, Situ X, Priyadarshini M, Zhang W, Cordoba-Chacon J, Layden BT, He C. Autophagy differentially regulates insulin production and insulin sensitivity. Cell Reports. 23 (11). 3286-3299. 2018. (*Equal contribution)
Fernandez AF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang W-C, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B. Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 558 (7708). 136-140. 2018.
Wang S, Kobeissi A, Dong Y, Kaplan N, Yang W, He C, Zeng K, Peng H. miRs-103/107 regulate autophagy in the epidermis. Journal of Investigative Dermatology. pii: S0022-202X(18) 30115-5. 2018.
Fan Y, Sun L, Yang S, He C, Tai G, Zhou Y. The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration. Int J Biol Macromol. 106. 207-217. 2018.
2017
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLOS Genetics. 13 (8): e1006962. doi: 10.1371/journal.pgen.1006962. 2017.
Rocchi A and He C. Regulation of exercise-induced autophagy in skeletal muscle. Current Pathobiology Reports. 5 (2). 177–186. 2017.
Rocchi A and He C. Activating autophagy by aerobic exercise in mice. Journal of Visualized Experiments. Feb 3 (120). doi: 10.3791/55099. 2017.
Shi B, Huang Q, Birkett R, Koessler R, Dorfleutner A, Stehlik C, He C, Pope RM. Snapin is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 13 (2). 285-301. 2017.
Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, He C. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 13 (1). 41-56. 2017. PMCID: 5240827
2016
Park JK, Peng H, Katsnelson J, Yang W, Kaplan N, Dong Y, Rappoport JZ, He C, Lavker RM. MicroRNAs-103/107 coordinately regulate macropinocytosis and autophagy. Journal of Cell Biology. 215 (5). 667-85. 2016.
Kuramoto K*, Wang N*, Fan Y, Zhang W, Schoenen FJ, Frankowski KJ, Marugan J, Zhou Y, Huang S, He C. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 12 (9). 1460-71. 2016. PMCID: 5082783 (*Equal contribution)
2015
Rocchi A and He C. Emerging roles of autophagy in metabolism and metabolic disorders. Frontiers in Biology. 10 (2). 154-64. 2015.
2014
Zhang W and He C. Regulation of plasma membrane receptors by a new autophagy-related Beclin family member. Autophagy. 10 (8). 1472-3. 2014.
2013
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen E-L, Scherer PE, Whistler JL, Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 154 (5). 1085-99. 2013. PMID: 23954414
2012
He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 481, 511-5. 2012. PMCID: 3518436 [Highlighted in Science, Cell, Nature Reviews Molecular Cell Biology, Nature Reviews Endocrinology]
He C, Sumpter R, Jr., Levine B. Exercise induces autophagy in peripheral tissues and in the brain. Autophagy. 8 (10). 1548-51. 2012. PMCID: 3463459
2010
He C and Levine B. The Beclin 1 interactome. Current Opinion in Cell Biology. 22, 140-9. 2010. PMCID: 2854269
He C and Klionsky DJ. Analyzing autophagy in zebrafish. Autophagy. 6 (5), 642-44. 2010. PMID: 20495344
2009
He C, Bartholomew CR, Zhou W, Klionsky DJ. Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy. 5 (4), 520-6. 2009. PMCID: 2754832
He C and Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annual Review of Genetics. 43, 67-93. 2009. PMCID: 2831538
He C, Baba M, Klionsky DJ. Double duty of Atg9 self-association in autophagosome biogenesis. Autophagy. 5 (3), 385-7. 2009. PMCID: 2833293
Yorimitsu T, He C, Wang K, Klionsky DJ. Tap42-asscociated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy. 5 (5), 616-24. 2009. PMCID: 2738980
2008
He C, Baba M, Cao Y, Klionsky DJ. Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Molecular Biology of the Cell.19 (12), 5506-16. 2008. PMCID: 2592676
Monastyrska I, He C, Hoppe A, Klionsky DJ. Arp2 links autophagic machinery with the actin cytoskeleton. Molecular Biology of the Cell. 19 (5), 1962-75. 2008. PMCID: 2366845
2007
He C and Klionsky DJ. Atg9 trafficking in autophagy-related pathways. Autophagy. 3 (3), 271-4. 2007. PMID: 17329962
He C and Orvedahl A. 2007 Keystone symposium on autophagy in health and disease. (meeting report) Autophagy. 3 (5), 527-36. 2007. PMID: 17617735
2006
He C, Song H, Yorimitsu T, Monastyrska I, Yen W-L, Legakis JE, Klionsky DJ. Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. Journal of Cell Biology. 175 (6), 925-35. 2006. PMCID: 2064702 [Cover Illustration]
He C and Klionsky DJ. Autophagy and neurodegeneration. ACS Chemical Biology. 1 (4), 211–3. 2006. PMID: 17163674