Northwestern University Feinberg School of Medicine

Melissa Brown Lab


Learn more about the work that we do in the Melissa Brown Laboratory through our recent publications.

  1. Brown MA, Weinberg RB  Mast Cells and Innate Lymphoid Cells: Underappreciated Players in CNS Autoimmune Demyelinating Disease.  Front Immunol  2018;9:514. doi:10.3389/fimmu.2018.00514
  2. Brown MA  Studies of Mast Cells: Adventures in Serendipity.  Front Immunol  2018;9:520. doi:10.3389/fimmu.2018.00520
  3. Russi AE, Ebel ME, Yang Y, Brown MA  Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility.  Proc Natl Acad Sci U S A  2018 02 13;115(7):E1520-E1529. doi:10.1073/pnas.1710401115
  4. Brown MA, Russi AE  (T)Betting on innate lymphoid cells in CNS inflammatory disease.  Nat Immunol  2017 Sep 19;18(10):1063-1064. doi:10.1038/ni.3839
  5. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH  Speaking out about gender imbalance in invited speakers improves diversity.  Nat Immunol  2017 04 18;18(5):475-478. doi:10.1038/ni.3707
  6. Russi AE, Walker-Caulfield ME, Guo Y, Lucchinetti CF, Brown MA  Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity.  J Autoimmun  2016 09;73:100-10. doi:10.1016/j.jaut.2016.06.015
  7. Russi AE, Walker-Caulfield ME, Brown MA  Mast cell inflammasome activity in the meninges regulates EAE disease severity.  Clin Immunol  2018 Apr;189:14-22. pii:S1521-6616(16)30068-7
  8. Hatfield JK, Brown MA  Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE.  Cell Immunol  2015 Oct;297(2):69-79. doi:10.1016/j.cellimm.2015.06.006
  9. Russi AE, Walker-Caulfield ME, Ebel ME, Brown MA  Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice.  J Immunol  2015 Jun 15;194(12):5609-13. doi:10.4049/jimmunol.1500068
  10. Walker-Caulfield ME, Hatfield JK, Brown MA  Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.  J Neuroimmunol  2015 Jan 15;278:112-22. doi:10.1016/j.jneuroim.2014.12.009
  11. Russi AE, Brown MA  The meninges: new therapeutic targets for multiple sclerosis.  Transl Res  2015 Feb;165(2):255-69. doi:10.1016/j.trsl.2014.08.005
  12. Wong LY, Hatfield JK, Brown MA  Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.  J Biol Chem  2013 Dec 06;288(49):35170-9. doi:10.1074/jbc.M113.481440
  13. Rao KN, Smuda C, Gregory GD, Min B, Brown MA  Ikaros limits basophil development by suppressing C/EBP-α expression.  Blood  2013 Oct 10;122(15):2572-81. doi:10.1182/blood-2013-04-494625
  14. Peng H, Katsnelson J, Yang W, Brown MA, Lavker RM  FIH-1/c-kit signaling: a novel contributor to corneal epithelial glycogen metabolism.  Invest Ophthalmol Vis Sci  2013 Apr 17;54(4):2781-6. doi:10.1167/iovs.12-11512
  15. Christy AL, Walker ME, Hessner MJ, Brown MA  Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.  J Autoimmun  2013 May;42:50-61. doi:10.1016/j.jaut.2012.11.003
  16. Brown MA, Hatfield JK  Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?  Front Immunol  2012;3:147. doi:10.3389/fimmu.2012.00147
  17. Walker ME, Hatfield JK, Brown MA  New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?  Biochim Biophys Acta  2012 Jan;1822(1):57-65. doi:10.1016/j.bbadis.2011.02.009
  18. Sayed BA, Walker ME, Brown MA  Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis.  J Immunol  2011 Mar 15;186(6):3294-8. doi:10.4049/jimmunol.1003574
  19. Sayed BA, Christy AL, Walker ME, Brown MA  Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment?  J Immunol  2010 Jun 15;184(12):6891-900. doi:10.4049/jimmunol.1000126
  20. Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA  Cutting edge: Ikaros is a regulator of Th2 cell differentiation.  J Immunol  2009 Jan 15;182(2):741-5
  21. Rao KN, Brown MA  Mast cells: multifaceted immune cells with diverse roles in health and disease.  Ann N Y Acad Sci  2008 Nov;1143:83-104. doi:10.1196/annals.1443.023
  22. Brown MA, Sayed BA, Christy A  Mast cells and the adaptive immune response.  J Clin Immunol  2008 Nov;28(6):671-6. doi:10.1007/s10875-008-9247-7
  23. Brown MA  IL-4 production by T cells: you need a little to get a lot.  J Immunol  2008 Sep 01;181(5):2941-2
  24. Sayed BA, Christy A, Quirion MR, Brown MA  The master switch: the role of mast cells in autoimmunity and tolerance.  Annu Rev Immunol  2008;26:705-39. doi:10.1146/annurev.immunol.26.021607.090320
  25. Christy AL, Brown MA  The multitasking mast cell: positive and negative roles in the progression of autoimmunity.  J Immunol  2007 Sep 01;179(5):2673-9
  26. Sayed BA, Brown MA  Mast cells as modulators of T-cell responses.  Immunol Rev  2007 Jun;217:53-64
  27. Gregory GD, Raju SS, Winandy S, Brown MA  Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE.  J Clin Invest  2006 May;116(5):1327-36