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Learn more about the work that we do in the Melissa Brown Laboratory through our recent publications.

  1. Brown MA, Brown MJ, Gowda K, Webber N, Gueyikian S  Sclerotherapy, cryoablation, and surgical fixation of an intraosseous tibial venous malformation.  Radiol Case Rep  2023 Nov;18(11):3831-3836. doi:10.1016/j.radcr.2023.08.048
  2. Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S  et al.  GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.  medRxiv  2023 Oct 05;. pii:2023.10.04.23296543
  3. Shapiro JA, Gaonkar KS, Spielman SJ, Savonen CL, Bethell CJ, Jin R, Rathi KS, Zhu Y, Egolf LE, Farrow BK  et al.  OpenPBTA: The Open Pediatric Brain Tumor Atlas.  Cell Genom  2023 Jul 12;3(7):100340. pii:100340
  4. Chung EH, Petishnok LC, Conyers JM, Schimer DA, Vitek WS, Harris AL, Brown MA, Jolin JA, Karmon A, Styer AK  Virtual Compared With In-Clinic Transvaginal Ultrasonography for Ovarian Reserve Assessment.  Obstet Gynecol  2022 Apr 01;139(4):561-570. doi:10.1097/AOG.0000000000004698
  5. Mirzoeva S, Yang Y, Klopot A, Budunova I, Brown MA  Early Stress-Response Gene REDD1 Controls Oxazolone-Induced Allergic Contact Dermatitis.  J Immunol  2021 Oct 01;207(7):1747-1754. doi:10.4049/jimmunol.2100279
  6. Hayes CK, Wilcox DR, Yang Y, Coleman GK, Brown MA, Longnecker R  ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis.  PLoS Pathog  2021 Feb;17(2):e1009285. pii:e1009285
  7. Brown MA, Su MA  An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses.  J Immunol  2019 Apr 01;202(7):1927-1933. doi:10.4049/jimmunol.1801403
  8. Russi AE, Walker-Caulfield ME, Brown MA  Mast cell inflammasome activity in the meninges regulates EAE disease severity.  Clin Immunol  2018 Apr;189:14-22. doi:10.1016/j.clim.2016.04.009
  9. Brown MA, Weinberg RB  Mast Cells and Innate Lymphoid Cells: Underappreciated Players in CNS Autoimmune Demyelinating Disease.  Front Immunol  2018;9:514. pii:514
  10. Brown MA  Studies of Mast Cells: Adventures in Serendipity.  Front Immunol  2018;9:520. pii:520
  11. Russi AE, Ebel ME, Yang Y, Brown MA  Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility.  Proc Natl Acad Sci U S A  2018 Feb 13;115(7):E1520-E1529. doi:10.1073/pnas.1710401115
  12. Brown MA, Russi AE  (T)Betting on innate lymphoid cells in CNS inflammatory disease.  Nat Immunol  2017 Sep 19;18(10):1063-1064. doi:10.1038/ni.3839
  13. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A  et al.  Speaking out about gender imbalance in invited speakers improves diversity.  Nat Immunol  2017 Apr 18;18(5):475-478. doi:10.1038/ni.3707
  14. Russi AE, Walker-Caulfield ME, Guo Y, Lucchinetti CF, Brown MA  Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity.  J Autoimmun  2016 Sep;73:100-10. doi:10.1016/j.jaut.2016.06.015
  15. Hatfield JK, Brown MA  Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE.  Cell Immunol  2015 Oct;297(2):69-79. doi:10.1016/j.cellimm.2015.06.006
  16. Russi AE, Walker-Caulfield ME, Ebel ME, Brown MA  Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice.  J Immunol  2015 Jun 15;194(12):5609-13. doi:10.4049/jimmunol.1500068
  17. Russi AE, Brown MA  The meninges: new therapeutic targets for multiple sclerosis.  Transl Res  2015 Feb;165(2):255-69. doi:10.1016/j.trsl.2014.08.005
  18. Walker-Caulfield ME, Hatfield JK, Brown MA  Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.  J Neuroimmunol  2015 Jan 15;278:112-22. doi:10.1016/j.jneuroim.2014.12.009
  19. Wong LY, Hatfield JK, Brown MA  Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.  J Biol Chem  2013 Dec 06;288(49):35170-9. doi:10.1074/jbc.M113.481440
  20. Rao KN, Smuda C, Gregory GD, Min B, Brown MA  Ikaros limits basophil development by suppressing C/EBP-α expression.  Blood  2013 Oct 10;122(15):2572-81. doi:10.1182/blood-2013-04-494625
  21. Christy AL, Walker ME, Hessner MJ, Brown MA  Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.  J Autoimmun  2013 May;42:50-61. doi:10.1016/j.jaut.2012.11.003
  22. Peng H, Katsnelson J, Yang W, Brown MA, Lavker RM  FIH-1/c-kit signaling: a novel contributor to corneal epithelial glycogen metabolism.  Invest Ophthalmol Vis Sci  2013 Apr 17;54(4):2781-6. doi:10.1167/iovs.12-11512
  23. Brown MA, Hatfield JK  Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?  Front Immunol  2012;3:147. pii:147
  24. Walker ME, Hatfield JK, Brown MA  New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?  Biochim Biophys Acta  2012 Jan;1822(1):57-65. doi:10.1016/j.bbadis.2011.02.009
  25. Sayed BA, Walker ME, Brown MA  Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis.  J Immunol  2011 Mar 15;186(6):3294-8. doi:10.4049/jimmunol.1003574
  26. Sayed BA, Christy AL, Walker ME, Brown MA  Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment?  J Immunol  2010 Jun 15;184(12):6891-900. doi:10.4049/jimmunol.1000126
  27. Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA  Cutting edge: Ikaros is a regulator of Th2 cell differentiation.  J Immunol  2009 Jan 15;182(2):741-5
  28. Rao KN, Brown MA  Mast cells: multifaceted immune cells with diverse roles in health and disease.  Ann N Y Acad Sci  2008 Nov;1143:83-104. doi:10.1196/annals.1443.023
  29. Brown MA, Sayed BA, Christy A  Mast cells and the adaptive immune response.  J Clin Immunol  2008 Nov;28(6):671-6. doi:10.1007/s10875-008-9247-7
  30. Brown MA  IL-4 production by T cells: you need a little to get a lot.  J Immunol  2008 Sep 01;181(5):2941-2
  31. Sayed BA, Christy A, Quirion MR, Brown MA  The master switch: the role of mast cells in autoimmunity and tolerance.  Annu Rev Immunol  2008;26:705-39. doi:10.1146/annurev.immunol.26.021607.090320
  32. Christy AL, Brown MA  The multitasking mast cell: positive and negative roles in the progression of autoimmunity.  J Immunol  2007 Sep 01;179(5):2673-9
  33. Sayed BA, Brown MA  Mast cells as modulators of T-cell responses.  Immunol Rev  2007 Jun;217:53-64
  34. Gregory GD, Raju SS, Winandy S, Brown MA  Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE.  J Clin Invest  2006 May;116(5):1327-36