Publications

Learn more about the Bonini Lab's key findings through our featured publications.

Redox-sensitive switches controlling macrophage inflammatory function

Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Gantner BN, Bonini MG. NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1. J Exp Med. 2015; Sep 21; 212(10): 1725-38. PMC4577833

Redox epigenetic reprogramming of the cancer cell transcriptome

Hart PC, Mao M, de Abreu AL, Ansenberger-Fricano K, Ekoue DN, Ganini D, Kajdacsy-Balla A, Diamond AM, Minshall RD, Consolaro ME, Santos JH, Bonini MG. MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun. 2015; Feb 5; 6: 6053. PMC4319569.

Zhu Y, Zou X, Dean AE, Brien JO, Gao Y, Tran EL, Park SH, Liu G, Kieffer MB, Jiang H, Stauffer ME, Hart R, Quan S, Satchell KJF, Horikoshi N, Bonini M, Gius D. Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter. Nat Commun. 2019; Jun 3; 10(1): 2399. PMC6546705

He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A. 2019; Nov 19; 116(47): 23534-41. PMC6876149

Metallic contaminants and breast cancer outcomes

Danes JM, Palma FR, Bonini MG. (2021) Arsenic and other metals as phenotype driving electrophiles in carcinogenesis. Semin Cancer Biol., 76 : 287-291.

Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG. (2020) Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. FASEB J. 34:16034-16048.